Synthesis and Anti-inflammatory Activity of Certain Piperazinylthienylpyridazine Derivatives

Hanan M. Refaat,Omneya M. Khalil,Hanan H. Kadry 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7

In this study, a novel series of 2-(4-substituted piperazin-l-ylmethyl)-6-(thien-2-yl)-2H-pyridazin- 3-ones (3a-f), 2-(4-substituted piperazin-l-yl carbonylmethyl)-6-(thien-2-yl)-2H-pyridazin-3-ones (4a-c) and 2-[2-(4-substituted piperazin-l-ylcarbonylethyl)]-6-(thien-2-yl)-2H-pyridazin-3-ones (5a,b) were prepared from 6-(thien-2-yl)-2H- pyridazin-3-one (1). In addition, 3-(4-substituted piperazin-l-ylcarbonyl methyl thio)-6-(thien-2-yl) pyridazines (6a-c) and 3-[2-(4-substitutedpiperazin- l-ylcarbonyl ethylthio]-6-(thien-2-yl) pyridazines (7a,b) were synthesized. Furthermore, 5-(4-substituted piperazin-l-ylmethyl)-6-(thien-2-yl)-2H-pyridazin-3-ones (12a,b) were prepared. The structures of the new compounds were confirmed by elemental analysis as well as by 1H-NMR, IR and MS data. Some of the newly prepared compounds were subjected to evaluation for their anti-inflammatory activity against carrageenan-induced paw edema at a dose of 10 mg/kg using indomethacin as the reference standard.

Avoiding Ambiguities in Arabic Software User Requirements

Hanan Elazhary 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.6

Errors in requirements elicitation cause much more expensive errors in later phases of software engineering. A major source of errors is the ambiguity of the natural languages initially used to write the user requirements. Most of the research studies in the literature have focused on ambiguity detection and correction after the user requirements are written. A better approach would be avoiding the introduction of ambiguities while the user requirements are being written to reduce time and cost. Unfortunately, this problem has been overlooked in the literature except for few research studies concerned with the English language. This paper is concerned with the Arabic language due to its complex structure and because the ambiguity of Arabic user requirements is a serious problem hindering the production of quality software in the middle east. The paper studies main sources of ambiguities in the Arabic language in addition to best practices in writing Arabic user requirements to avoid the introduction of ambiguities as suggested by interviewed Arabic software engineers or as suggested in the literature for English user requirements. Accordingly, the paper suggests a set of best practices suitable for Arabic user requirements based on both practical experience and theoretical background. Examples are provided for justification. Human subject testing and empirical evaluation have shown the effectiveness of the proposed practices.

On the Fekete-Szegö Problem for Starlike Functions of Complex Order

Hanan Darwish,Abdel-Moniem Lashin,Bashar Al Saeedi 경북대학교 자연과학대학 수학과 2020 Kyungpook mathematical journal Vol.60 No.3

For a non-zero complex number b and for m and n in N0 = {0, 1, 2, ...} let Ψn,m(b) denote the class of normalized univalent functions f satisfying the condition [1 + 1/b(Dn+mf(z)/Dnf(z) − 10]>0 in the unit disk U, where Dnf(z) denotes the Salagean operator of f. Sharp bounds for the Fekete-Szegö functional [a3 − µa22] are obtained.

FTIR study of gamma and electron irradiated high-density polyethylene for high dose measurements

Hanan Al-Ghamdi,Khaled Farah,Aljawharah Almuqrin,Faouzi Hosni 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.1

A reliable and well-characterized dosimetry system which is traceable to the international measurementsystem, is the key element to quality assurance in radiation processing with cobalt-60 gamma rays, Xrays,and electron beam. This is specifically the case for health-regulated processes, such as the radiationsterilization of single use medical devices and food irradiation for preservation and disinfestation. Polyethylene is considered to possess a lot of interesting dosimetric characteristics. In this work, adetailed study has been performed to determine the dosimetric characteristics of a commercialized highdensitypolyethylene (HDPE) film using Fourier transformed infrared spectrometry (FTIR). Correlationshave been established between the absorbed dose and radiation induced infrared absorption in polyethylenehaving a maximum at 965 cm 1 (transvinylene band) and 1716 cm 1 (ketone-carbonyl band). We have found that polyethylene dose-response is linear with dose for both bands up to1000 kGy. Fortransvinylene band, the dose-response is more sensitive if irradiations are made in helium. While, forketone-carbonyl band, the dose-response is more sensitive when irradiations are carried out in air. Thedose-rate effect has been found to be negligible when polyethylene samples are irradiated with electronbeam high dose rates. The irradiated polyethylene is relatively stable for several weeks after irradiation.

Moxifloxacin-Gelrite In Situ Ophthalmic Gelling System against Photodynamic Therapy for Treatment of Bacterial Corneal Inflammation

Hanan M. El-Laithy,Amira A. El-Adly,Meriana Shoukry,Demiana I. Nesseem 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.10

In this study, six in situ gelling formulations based on Gelrite were prepared and evaluated for the retained ophthalmic delivery of Moxifloxacin (Mox). The effectiveness of the best developed formula G5 was compared with photodynamic therapy (PDT), the recent expanding approach for the treatment of ophthalmologic disorders after the assessment of optimum photodynamic inactivation parameters that permit efficient pathogens eradication. It was found that, Staphylococcus aureus (S. aureus) (Gram-positive) was more susceptible to effective lethal photosensitization that reaches 93.5% reduction in viable count than Escherichia coli (E. coli) (Gramnegative) of 76.1% using 3 mg/mL Hematoporphyrin (HP), illuminated by 630 nm Light Emitting Diode (LED) at 9 J/cm^2 and incubated for 15 min. Following topical instillation of G5 to rabbits corneas, higher amount of Mox was retained in the aqueous humor up to 24 h with significant 6-fold increase in the C_max and AUC_(0-∞) compared to vigamox^® commercial eye drops. After post corneal infection with S. aureus, both approaches were effectively treating the infection without causing ocular irritation or collateral damage to corneal tissue where G5 showed remarkable improvement after four days compared to seven days of PDT treatment.

Modeling and Code Generation of Android Applications Using Acceleo

Hanane BENOUDA,Redouane ESSBAI,Mostafa AZIZI,Mimoun MOUSSAOUI 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.3

The development of mobile applications becomes increasingly popular in our daily life due to the intensive use of applications in mobile devices like smartphones and tablets. The diversity and variety of mobile operating systems (Android, iOS, Black Berry, Windows Phone, etc.) make software engineers in front of a big challenge to develop the same application for these different platforms. This paper presents a methodology based on the Model Driven Architecture (MDA) to develop mobile applications according to the principle “develops once, use everywhere”. Our approach exploits UML modeling and Acceleo to generate specific code in order to accelerate and facilitate the development of mobile applications.

Neighborhoods of certain subclasses of analytic functions with negative coefficients

Hanan E. Darwish,Mohamed K. Aouf 대한수학회 2011 대한수학회보 Vol.48 No.4

The main object of this paper is to prove several inclusion relations associated with (j,δ )-neighborhoods of various subclasses defined by Salagean operator by making use of the familiar concept of neighborhoods of analytic functions. Special cases of some of these inclusion relations are shown to yield known results.

The Helicobacter pylori Ferric Uptake Regulator (Fur) Is Essential for Growth Under Sodium Chloride Stress

Hanan Gancz,D. Scott Merrell 한국미생물학회 2011 The journal of microbiology Vol.49 No.2

Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.

Structural design of steel fibre reinforced concrete in-filled steel circular columns

Hanan H. Eltobgy 국제구조공학회 2013 Steel and Composite Structures, An International J Vol.14 No.3

This paper presents the behavior and design of axially loaded normal and steel fiber reinforced concrete in-filled steel tube (SFRCFT) columns, to examine the contribution of steel fibers on the compressive strength of the composite columns. Non-linear finite element analysis model (FEA) using ANSYS software has been developed and used in the analysis. The confinement effect provided by the steel tube is considered in the analysis. Comparisons of the analytical model results, along with other available experimental outputs from literature have been done to verify the structural model. The compressive strength and stiffness of SFRC composite columns were discussed, and the interpretation of the FEA model results has indicated that, the use of SFRC as infill material has a considerable effect on the strength and stiffness of the composite column. The analytical model results were compared with the existing design methods of composite columns – (EC4, AISC/LRFD and the Egyptian code of Practice for Steel Construction, ECPSC/LRFD). The comparison indicated that, the results of the FEA model were evaluated to an acceptable limit of accuracy. The code design equations were modified to introduce the steel fiber effect and compared with the results of the FEA model for verification.

Integrating Entrepreneurship in Translator Training : A Project-Based Case Study

Hanan Sharaf,Dine M. Ahmed 한국외국어대학교 통번역연구소 2022 한국외국어대학교 통번역연구소 학술대회 Vol.2022 No.01

In contemporary research on translator training and education, emphasis is largely placed on the translation process and translation competence acquisition. A broader social constructivist approach to translator training is needed to pay more attention towards strengthening the social connections within which translators are embedded and towards addressing a multi-dimensional translator competence rather than translation competence (Kiraly, 2013). Thus, shifting the initial traditional focus on linguistic skills to a more comprehensive set of competencies that can better prepare the freshly graduated translators to venture confidently into the Language Service Providers market is needed. Entrepreneurial skills are among the most significant skills translators should acquire in the 21st Century. The 2030 Agenda for Sustainable Development pays close attention to entrepreneurship as a means for creating decent work opportunities, improving the quality of life, promoting sustainable economic development, and fostering innovation. While the UN 2018 World Youth Report commends efforts for introducing entrepreneurship to educational programs in both developed and developing countries, it still calls for further studies to evaluate the effectiveness and value of such programs. Although there is a growing interest among institutions of higher education in Egypt to integrate entrepreneurship education in their programs, in fulfillment of the Egypt Vision 2030 and consequently the global SDGs, this interest remains confined mostly to the science majors like engineering, computer science, or even pharmacy and dentistry. Translator training in Egypt mostly focuses on developing the linguistic skills of translators and in best cases their technology and soft skills. To introduce entrepreneurship into translator training, it is not just enough to combine specific skills of business planning and management to linguistic and soft skills, there should be a shift in the teaching and learning methodologies and the roles assumed by students and instructors (Lackeus, 2015). This article presents a case study of a project that integrates entrepreneurship education in a quasi-professional practice setting within a legal translation course for senior students of the translation minor, at an Egyptian private university. The study adopts a post-modern relativistic qualitative methodology as advocated by Kiraly (2013, 2014) to investigate the newly emerging translator competence. Interviews are also conducted to further consolidate the research findings. The study aims to provide insights into curriculum development for translation undergraduate programs promoting entrepreneurship education and student-centered learning. In addition, the study proposes a model of translator competence that befits the new changes in the LSP market and contributes to the 2030 Agenda.