http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Han, Oksoo,Kim, Choonkeun,Kim, Wonyoung The Korea Science and Technology Center 1999 BMB Reports Vol.32 No.1
In an effort to understand the function of the eryBVⅡ gene in the erythromycin biosynthetic gene cluster, we overexpressed the eryBVⅡ gene in E. coli and TDP-6-deoxy-L-threo-D-glycero-4 hexulose was used as a substrate of the overexpressed EryBVⅡ enzyme. The enzymatic reaction product was chemically modified by reduction and peracetylation. Structural analysis of the derivatized enzymatic products by GC-Mass Spectrophotometry indicated that TDP-6-deoxy-L-threo-D-glycero-4-hexulose could be converted into its epimer by EryBVⅡ enzyme. Based on this result, TDP-6-deoxy-threo-D-glycero-4-hexulose was indeed the substrate of EryBVⅡenzyme and the function of the eryBVⅡ gene was confirmed.
Anti-oxidant activities of kiwi fruit extract on carbon tetrachloride-induced liver injury in mice
Kang, Wonyoung,Yang, Heekyoung,Hong, Hyun Ju,Han, Chang Hoon,Lee, Young Jae The Korean Society of Veterinary Science 2012 大韓獸醫學會誌 Vol.52 No.4
The kiwi (Actinidia deliciosa) is well known to contain anti-oxidants. In this study, we investigated the anti-oxidant effects of kiwi extract on carbon tetrachloride ($CCl_4$) induced liver injury in BALB/c mice. The radical scavenging effect of 80% methanol extract of Halla-Gold kiwi was observed. For the animal study, mice were randomly divided into four groups: normal group, $CCl_4$-induced model group, kiwi extract administered group, and silymarin treated group. The kiwi extract was provided daily for 10 days. At the 24 h after last administration, $CCl_4$ was injected. The kiwi extract showed strong inhibitory effect of DPPH radicals and superoxide scavenging. In animal study, administration of $CCl_4$ resulted in significantly elevated plasma levels of ALT and AST but they decreased in kiwi-extract pretreated group. Anti-oxidant enzymes such as GSH-px and GSH-rd were restored in the kiwi extract treatment group. Histopathological degeneration was also prevented in the kiwi extract treated group compared with of the control group, which exhibited $CCl_4$-induced hepatotoxicity. On the basis of the obtained results, it can be concluded that kiwi extract showed protective effects, not only as anti-oxidant effects, but also in the protection of hepatotoxicity in $CCl_4$-intoxicated mice.
한국판 다차원 상태 지루함 척도(K-MSBS)의 타당화
한보람(Boram Han),송원영(Wonyoung Song) 한국문화융합학회 2023 문화와 융합 Vol.45 No.12
This study aimed to validate the Multidimensional State Boredom Scale (MSBS) developed by Fahlman et al. (2013). A revised preliminary scale, based on input from the original author Eastwood, was used with 146 college students. Exploratory factor analysis revealed 29 items distributed across four factors. Confirmatory factor analysis was conducted on both the four-factor model and the original author's five-factor model, using data from 279 university students. The five-factor 29-item scale was deemed more appropriate. Internal consistency for reliability was high at .966, and test-retest reliability(n=45) at 3-4 week intervals was .61. Validity was assessed through correlations between state boredom and boredom proneness, depression, and impulsivity. Significant correlations were found, supporting both criterion and convergent validity. This study will contribute to the validation of a boredom measure that will be relevant to clinical difficulties and can be utilized in the prevention and treatment of psychological problems. 이 연구의 목적은 Fahlman, Mercer-Lynn, Flora와 Eastwood(2013)이 개발한 다차원 상태 지루함 척도(MSBS)를 타당화하는 것이다. 원저자인 Eastwood의 의견에 기반하여 번안한 예비문항을 통해 전국대학생 146명의 자료를 수집하여 탐색적 요인분석을 실시한 결과 4요인의 29문항으로 선정되었다. 이후 수집된 전국 대학생 279명의 자료를 활용하여 4요인 모형과 원저자의 5요인 모형에 대해 확인적 요인분석을 실시해 비교한 결과, 5요인의 29문항이 더 적합하게 나타났다. 더불어 신뢰도 검증을 위한 내적합치도는 .966으로 나타났고, 3~4주 간격으로 확인한 검사-재검사 신뢰도(n=45)는 .61이었으며, 타당도 검증을 위해 살펴본 상태 지루함과 권태 성향, 우울, 충동성 간의 상관이 유의미하여 준거타당도와수렴타당도가 입증되었다. 이 연구는 임상적 어려움과 관련이 있는 지루함을 측정할 수 있는 척도를 타당화한 것으로 심리적 문제의 예방 및 치료에 활용할 수 있을 것이다.
성인 초기 여성의 미래 불안 대처유형 척도 개발 및 타당화
한영광(Yeongkwang Han),송원영(Wonyoung Song) 한국문화융합학회 2020 문화와 융합 Vol.42 No.4
이 연구의 목적은 성인 초기 여성의 미래 불안 대처 유형 척도를 개발하고 신뢰도와 타당도를 검증하여 활용하는 것이다. 관련 문헌 개관과 기존 척도들을 통해 95문항을 추출하였고, 두 차례의 전문가 검토와 안면 타당도를 거쳐 36문항을 선정하였다. 예비조사 및 본조사를 통해 최종적으로 9문항을 선정하여 확인적 요인분석을 실시하였다. 조사에는 예비조사에 성인 초기 여성 93명, 본조사에 155명이 온라인으로 참여하였다. 하위요인은 3요인으로 정서적 대처, 언어적 대처, 초자연적 대처로 명명하였다. 개발한 척도는 양호한 검사-재검사 신뢰도, 내적합치도를 보였고, 요인구조도 적합한 것으로 검증되었다. 또한 다차원적 대처 척도와는 양호한 상관을, Novaco 분노 척도와는 낮은 상관을 보여 기존 척도들과 적절한 수렴 및 변별 타당도를 보여주었다. 논의에서는 개발된 척도의 의의와 제한점, 향후 활용 방안들을 제시하였다. The aim of this study is to develop a future anxiety coping scale for emerging adulthood women, and to test its reliability and validity. First, 95 items were selected based on a literature review and related scales, and these were rearranged into 36 items through face validity and content validity. Then, after a preliminary study (n=93) and the main study (n=155), a 9-item scale was developed. The final scale comprises 3 subscales-emotional coping, verbal coping, and supernatural coping and has appropriate test-retest reliability, good internal consistency, and factor structure. With respect to convergent and discriminant reliability, it has a high correlation with a multiphasic coping scale, and low with the Novaco anger scale. Based on these results, the study presents its implication and limitation, and discusses ideas for further research.
An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts
Cho, Sung-Yup,Kang, Wonyoung,Han, Jee Yun,Min, Seoyeon,Kang, Jinjoo,Lee, Ahra,Kwon, Jee Young,Lee, Charles,Park, Hansoo Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.2
Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes. Despite recent advances in high-throughput sequencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies. Patient-derived xenografts (PDX), which are established by the transfer of patient tumors into immunodeficient mice, serve as a platform for co-clinical trials by enabling the integration of clinical data, genomic profiles, and drug responsiveness data to determine precisely targeted therapies. PDX models retain many of the key characteristics of patients' tumors including histology, genomic signature, cellular heterogeneity, and drug responsiveness. These models can also be applied to the development of biomarkers for drug responsiveness and personalized drug selection. This review summarizes our current knowledge of this field, including methodologic aspects, applications in drug development, challenges and limitations, and utilization for precision cancer medicine.