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후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의
김건형,강차영,윤혁수,도남용,조성일,임성철 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.
Oxyfunctionalization of Citrus Flavonoids by Monophenol Monooxygenase
Gun Su CHA,Chan Mi PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Flavonoids are polyphenolic secondary metabolites with diverse chemical structures found in plants. Citrus fruits are notably rich in flavonoid compounds and represent an important source of dietary flavonoids, including hesperidin, hesperetin, naringin, naringenin, diosmin, quercetin, rutin, and others. These flavonoids are present in many citrus fruits, such as, grapefruit, lemons, limes, mandarins, and oranges. They have been reported to have beneficial effects on human health, including antioxidant, anti-inflammatory, and anti-cancer activities. Monophenol monooxygenase is a Cu-containing oxidoreductase which is capable of utilizing various phenolic compounds as the substrate. Based on the broad substrate spectrum, this enzyme has been used various fields such as bioremediation, biosensor, and chemical synthesis. Here, an enzymatic strategy for oxyfunctional citrus flavonoids production was devised, and the products were analyzed using HPLC and LC-MS. Citrus flavonoids were oxidized by monooxygenase and L-ascorbic acid contributed to regioselective production. These results suggest that monophenol monooxygenase can be a useful tool for oxyfunctionalization of citrus flavonoids.