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Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways
Chang Xu,Liangchang Li,Chongyang Wang,Jingzhi Jiang,Li Li,Lianhua Zhu,Shan Jin,Zhehu Jin,Jung Joon Lee,Guanhao Li,Guanghai Yan 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4
Background: The effect of ginsenoside Rh2 (G-Rh2) on mast cell-mediated anaphylaxis remains unclear. Herein, we investigated the effects of G-Rh2 on OVA-induced asthmatic mice and on mast cell-mediatedanaphylaxis. Methods: Asthma model was established for evaluating airway changes and ear allergy. RPMCs and RBL-2H3 were used for in vitro experiments. Calcium uptake, histamine release and degranulation weredetected. ELISA and Western blot measured cytokine and protein levels, respectively. Results: G-Rh2 inhibited OVA-induced airway remodeling, the production of TNF-a, IL-4, IL-8, IL-1b andthe degranulation of mast cells of asthmatic mice. G-Rh2 inhibited the activation of Syk and Lyn in lungtissue of OVA-induced asthmatic mice. G-Rh2 inhibited serum IgE production in OVA induced asthmaticmice. Furthermore, G-Rh2 reduced the ear allergy in IgE-sensitized mice. G-Rh2 decreased the earthickness. In vitro experiments G-Rh2 significantly reduced calcium uptake and inhibited histaminerelease and degranulation in RPMCs. In addition, G-Rh2 reduced the production of IL-1b, TNF-a, IL-8, andIL-4 in IgE-sensitized RBL-2H3 cells. Interestingly, G-Rh2 was involved in the FcεRI pathway activation ofmast cells and the transduction of the Lyn/Syk signaling pathway. G-Rh2 inhibited PI3K activity in adose-dependent manner. By blocking the antigen-induced phosphorylation of Lyn, Syk, LAT, PLCg2, PI3KERK1/2 and Raf-1 expression, G-Rh2 inhibited the NF-kB, AKT-Nrf2, and p38MAPK-Nrf2 pathways. However, G-Rh2 up-regulated Keap-1 expression. Meanwhile, G-Rh2 reduced the levels of p-AKT,p38MAPK and Nrf2 in RBL-2H3 sensitized IgE cells and inhibited NF-kB signaling pathway activation byactivating the AKT-Nrf2 and p38MAPK-Nrf2 pathways. Conclusion: G-Rh2 inhibits mast cell-induced allergic inflammation, which might be mediated by theAKT-Nrf2/NF-kB and p38MAPK-Nrf2/NF-kB signaling pathways
Guanghai Shen,Phan Van Kiem,Xing-Fu Cai,Gao Li,Nguyen Tien Dat,Yeon A Choi,Young Mi Lee,박용기,Young Ho Kim 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.6
A new biflavonol glycoside named as solanoflavone (1) was isolated from aerial part of Solanum melongena. The chemical structure was elucidated as isorhamnetin-3-O-β-D-glucopyranoside-( 4'→O→4''')-galangin-3''-O-β-D-glucopyranoside on the basis of physicochemical and spectroscopic methods, including 2D NMR spectral techniques.
Anticomplement Activity of Compounds Isolated from the Roots of Euphorbia kansui
Gao Li,Jung-Hee Kim,Guanghai Shen,Joongku Lee,Hyeong-Kyu Lee,오세량 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
The anticomplement activity-guided fractionation of the methanol extract of Euphorbia kansui L. resulted in isolation of three diterpenes, two triterpenes, and two sterols (1-7) from ethyl acetate fraction. By spectroscopic analysis, their chemical structures were elucidated as: β-amyrin (1); kansuiphorin C (2); 3-O-(2'E,4'Z-decadienoyl)-ingenol (3); 3-O-(2,3-dimethylbutyryl)-13-O-ndodecanoyl-13-hydroxyingenol (4); β-sitosterol (5); α-euphol (6); β-sitosterol-3-O-β-Dglucopyranoside (7). These compounds were investigated in vitro for their anticomplement activity against the classical pathway of the complement system, with compounds 2-4 exhibiting significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8, 89.5±5.5, and 152.1±6.2 μM.
Shen Guanghai,Kiem Phan Van,Cai Xing-Fu,Li Gao,Dat Nguyen Tien,Choi Yeon A,Lee Young Mi,Park Yong Ki,Kim Young Ho The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.6
A new biflavonol glycoside named as solanoflavone (1) was isolated from aerial part of Solanum melongena. The chemical structure was elucidated as isorhamnetin-3-O-$\beta$-D-glucopyranoside-(4'$\to$O$\to$4"')-galangin-3"-O-$\to$-D-glucopyranoside on the basis of physicochemical and spectroscopic methods, including 2D NMR spectral techniques.
Fault Diagnosis Method of Escalator Step System Based on Vibration Signal Analysis
Fuqiang You,Dianlong Wang,Chunhua Chen,Guanghai Li 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.10
For the problem that escalator fault diagnosis is difficult to realize, this paper proposes a fault diagnosis method based on vibration signal analysis. The vibration signal is collected from three parts: step guide rail, main drive shaft and main engine. The wavelet threshold denoising algorithm based on Ensemble Empirical Mode Decomposition (EEMD) is used to denoise the vibration signal. The signal characteristics are extracted, and the fault detection is performed through the Support Vector Machine (SVM) fault detection model. For the fault signal, the improved envelope spectrum analysis method is used to extract the characteristic frequency and corresponding amplitude to form the characteristic vector, and the Support Vector Machine for Particle Swarm Optimization (PSO-SVM) algorithm is used to identify the location of the fault. The experimental results show that this method has high accuracy in the fault diagnosis of escalator step system.
Resilient Routing Overlay Network Construction with Super-Relay Nodes
( Shengwen Tian ),( Jianxin Liao ),( Tonghong Li ),( Jingyu Wang ),( Guanghai Cui ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.4
Overlay routing has emerged as a promising approach to improve reliability and efficiency of the Internet. The key to overlay routing is the placement and maintenance of the overlay infrastructure, especially, the selection and placement of key relay nodes. Spurred by the observation that a few relay nodes with high betweenness centrality can provide more optimal routes for a large number of node pairs, we propose a resilient routing overlay network construction method by introducing Super-Relay nodes. In detail, we present the K-Minimum Spanning Tree with Super-Relay nodes algorithm (SR-KMST), in which we focus on the selection and connection of Super-Relay nodes to optimize the routing quality in a resilient and scalable manner. For the simultaneous path failures between the default physical path and the overlay backup path, we also address the selection of recovery path. The objective is to select a proper one-hop recovery path with minimum cost in path probing and measurement. Simulations based on a real ISP network and a synthetic Internet topology show that our approach can provide high-quality overlay routing service, while achieving good robustness.
Growth Mechanism and Electrochemical Properties of Porous Hollow Tin Oxide Nanospheres
Youwen Yang,Dongming Ma,Ting Cheng,Yuanhao Gao,Guanghai Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.6
"Porous hollow SnO2 nanospheres were prepared by means of enforced Sn2+ hydrolysis method under hydrochloric acid medium. These hollow nanospheres with an average diameter of 220 nm had a very thin shell thickness of about 40 nm and were surrounded by elongated octahedral-like nanoparticles with the apex oriented outside. The experimental conditions, such as HCl content, reaction temperature and time directly dominated the morphology, structure and crystallinity of the obtained samples. A pre-oxidation-nucleation-growth mechanism and inside-out Ostwald-ripening method was proposed on the basis of the previous research and time-dependent experiments. Electrochemical tests showed that the porous hollow SnO2 nanospheres exhibited improved cycling performance for anode materials of lithium-ion batteries, which retained a high reversible capacity of 540.0 mAhg-1 , and stable cyclic retention at 120th cycle."
Effect of FTY-720 on Pulmonary Fibrosis in Mice via the TGF-β1 Signaling Pathway and Autophagy
Jin Yuying,Liu Weidong,Gao Ge,Song Yilan,Liu Hanye,Li Liangchang,Zhou Jiaxu,Yan Guanghai,Cui Hong 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.4
We investigated whether FTY-720 might have an effect on bleomycin-induced pulmonary fibrosis through inhibiting TGF-β1 pathway, and up-regulating autophagy. The pulmonary fibrosis was induced by bleomycin. FTY-720 (1 mg/kg) drug was intraperitoneally injected into mice. Histological changes and inflammatory factors were observed, and EMT and autophagy protein markers were studied by immunohistochemistry and immunofluorescence. The effects of bleomycin on MLE-12 cells were detected by MTT assay and flow cytometry, and the related molecular mechanisms were studied by Western Blot. FTY-720 considerably attenuated bleomycin-induced disorganization of alveolar tissue, extracellular collagen deposition, and α-SMA and E-cadherin levels in mice. The levels of IL-1β, TNF-α, and IL-6 cytokines were attenuated in bronchoalveolar lavage fluid, as well as protein content and leukocyte count. COL1A1 and MMP9 protein expressions in lung tissue were significantly reduced. Additionally, FTY- 720 treatment effectively inhibited the expressions of key proteins in TGF-β1/TAK1/P38MAPK pathway and regulated autophagy proteins. Similar results were additionally found in cellular assays with mouse alveolar epithelial cells. Our study provides proof for a new mechanism for FTY-720 to suppress pulmonary fibrosis. FTY-720 is also a target for treating pulmonary fibrosis.