AUTOMATION AND OPTIMIZATION OF TEST APPLICATION FOR JTAG-BASED DESIGNS

Castrodale, Grant L.,Ghazale, Silvio E. Bou,Kanopoulos, Nick 대한전자공학회 1989 ICVC : International Conference on VLSI and CAD Vol.1 No.1

The Joint Test Action Group JTAG has proposed a standard test interface based on boundary scan which gives serial access to the components on a board. Due to the serial nature of boundary scan, the time it takes to apply test vectors increases tremendously over the traditional in-circuit testing. We propose techniques for applying the vectors to reduce the test application time. Analytical expressions for the application time of each of the techniques are derived based on the connectivity of the chips, the length of the test vectors of each chip, and the I/O pin count and location within the boundary scan path. These formulas are used to determine which technique to use for the automatic translation of chip-level sets to a board-level test set. Since the boundary scan interface is being standardized, it becomes possible to provide automatic vector translation and optimization of test application for any board designed according to the standard.

Stem Cell Tracing Through MR Molecular Imaging

Rasoul Yahyapour,Bagher Farhood,Ghazale Graily,Abolhasan Rezaeyan,Saeed Rezapoor,Hamid Abdollahi,Mohsen Cheki,Peyman Amini,Hengameh Fallah,Masoud Najafi,Elahe Motevaseli 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.3

Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent’s toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI.

Poster Session : PS 0348 ; Epidemiology and Public Health : Comparison of Health Related Quality of Life Between Two Groups of Veteran and Non-Veteran Spinal Cord Injured Patients

( Payman Salamati ),( Reza Rostami ),( Soheil Saadat ),( Taher Taheri ),( Maryam Tajabadi ),( Ghazale Ranjbari ),( Zohrehsadat Naji ),( Saba Jafarpour ),( Vafa Rahimi Movaghar ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Patients with spinal cord injury (SCI) have a lower health related quality of life (HRQOL) in comparison with both healthy controls and the normal population. The aim of this study was to compare HRQOL between two groups of veteran and non-veteran SCI patients. Methods: Male paraplegic non-veterans who had sustained complete SCI before the year 1988 and were residents of Tehran province, Iran, and a similar group of SCI veterans were enrolled in this study. The participants were interviewed based on the Iranian version of SF-36 questionnaire by two psychologists. Eight sub-scales and two physical and mental component summaries of the instrument were assessed. We used chi-square, odds ratio, Mann-Whitney U, independent t-test, and linear regression for analysis. Results: Overall, 25 veterans and 22 non-veterans were enrolled in the study. The mean age, time since injury, and presence of comorbid illnesses were not signifi cantly different between veterans and non-veterans. A greater number of veterans were married (P=0. 003) and employed (P=0. 047). On average, veterans had more years of formal education than non-veterans (P=0. 001). The mean (SD) bodily pain sub-scale was 72. 73(31. 253) for non-veterans and 49. 7(28. 287) for veterans (P=0. 011). Absence of comorbid illnesses was associated with a better physical component summary (P<0. 001). Employment was associated with a better mental component summary (P=0. 022). Conclusions: We did not fi nd any difference in HRQOL between the two groups except for the bodily pain sub-scale. Further studies with larger sample sizes are recommended.

Immunogenicity of glycine nanoparticles containing a chimeric antigen as Brucella vaccine candidate

Ghazal karevan,Kazem Ahmadi,Ramezan Ali Taheri,Mahdi Fasihi-Ramandi 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.1

Purpose: Brucellosis as a worldwide zoonotic illness affect domestic animals and humans doesn’t have any vaccine for the prevention of infection in humans yet. The aim of this study was to evaluate the specific immune response following the administration of glycine nanoparticles as adjuvant and delivery system of a chimeric antigen contained trigger factor, Omp31, and Bp26 in murine model. Materials and Methods: The chimeric antigen of Brucella was cloned and expressed in Escherichia coli (E. coli) BL21 (DE3). Purification and characterization of recombinant protein was conducted through Ni-NTA (nickel-nitrilotriacetic acid) agarose, SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis), and Western blot. Nanoparticle characteristics including morphology, particle size distribution, zeta potential, protein retention rate, and release rate were measured in vitro. Subsequently, nanoparticle contained antigen was administered to mice and blood sample was taken to measured the antibody level. Results: The protein retention in the nanoparticles was successfully done and the nanoparticle characteristics were appropriate. The average size of glycine particles containing antigen was about 174 nm, and the absorption of protein was approximately 61.27% of the initial value, with a release rate of approximately 70% after 8 hours. Enzyme-linked immunosorbent assay result proved that the immunized sera of mice which were administered with nano-formula contains high levels of antibodies (immunoglobulin G) against recombinant chimeric antigen and also a high level of mucosal antibody (immunoglobulin A) in the oral group, which showed a desirable immunity against Brucella. Conclusion: The results showed that chimeric antigen-loaded glycine nanoparticles can act as a vaccine candidate for inducing the cellular and humoral immune response against brucellosis.

OPTIMIZED FAST TERMINAL SLIDING MODE CONTROL FOR A HALF-CAR ACTIVE SUSPENSION SYSTEMS

Ghazally Ibrahim Yousif Mustafa,Haoping Wang,Yang Tian 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.4

This paper presents an optimized sliding mode controller (OPSMC) for vibration control of active suspension systems. The proposed controller consists of two parts: the first is the fast terminal sliding mode controller which performs fast convergence, and the second is the particle swarm optimization algorithm which is used to achieve the optimal controller’s\' parameters. The merit of OPSMC has quite simple structure and easy to be regulated, as well as improve the tracking performance. The half-car active suspension systems with non-linearity such as the parameters variation and external disturbance are simultaneously taken into account to provide a realistic framework. The control objective is to deal with the classical conflict between minimizing vertical and angular chassis accelerations to increase the ride comfort. Versus, to keep minimum dynamic wheel loads and suspension deflections to ensure the ride safety. Finally, to show the performance of the proposed OPSMC, the comparison with a recently developed efficient method called optimization and static output-feedback control (OPSOFC) is conducted with different roads disturbances.

Microstructure, Mechanical, and In Vitro Performance of a Novel Combination of Layered Double Hydroxides and Polycaprolactone Electrospun/3D Printed Scaffolds for Bone Tissue Engineering

Ghazal Belgheisi,Masoumeh Haghbin Nazarpak,Mehran Solati‑Hashjin 한국섬유공학회 2023 Fibers and polymers Vol.24 No.9

Currently, material synthesis and processing developments allow the design of increasingly advanced scaffolds for bone tissue engineering. The purpose of this study is to fabricate hybrid scaffolds by embedding electrospun polycaprolactone (PCL) or layered double hydroxides (LDH)/PCL nanofiber mats into 3D printed circular PCL grids with 400 µm strands using a PCL solution as glue. Structural analysis revealed that LDH increased surface roughness in PCL mats in addition to reducing fiber diameter. FESEM images showed that the size of the 3D printed strands and pores was about the same as in the original design, and nanofiber mats were flawlessly placed between the 3D printed grids. The porosity of the scaffolds was determined through BET analysis. Young’s modulus of the scaffolds was determined using a compressive test conducted in dry and wet conditions. Hybrid scaffolds with LDH/PCL nanofiber mats showed significantly higher Young’s modulus than 3D printed grids and hybrid scaffolds with PCL nanofiber mats (P < 0.05). In vitro studies showed the positive effect of LDH on enhancing hybrid scaffolds’ bioactivity and biodegradation rate. The calcium/phosphate ratio in the hybrid scaffold containing LDH was closer to the stoichiometric calcium/phosphate ratio in natural bone. MG-63 cell lines were cultured to assess the scaffold’s biocompatibility. Cell adhesion, alkaline phosphatase activity, and calcium deposition were significantly enhanced in hybrid scaffolds with LDH/PCL nanofiber mats. Considering the results, this hybrid scaffold exhibits favorable bone tissue engineering characteristics.

Passivity-Based Structured Model Predictive Control with Guaranteed Stability

Ghazal Montaseri,Mohammad Javad Yazdanpanah,Ali Khaki-Sedigh 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10

In this paper, a model predictive control scheme for a class of nonlinear systems is presented. In the proposed algorithm, the new cost function for MPC is defined. This cost function is inspired by the structure of passivity-based control. By simple tuning of weighting matrices, the asymptotic stability is guaranteed. Moreover, a closed-form solution to the optimal control problem is calculated via representing the nonlinear system in the state-dependent coefficient form of the state-space model. This point is of great importance in online applications. To demonstrate its efficiency, the passivity-based structured MPC is applied to control a rotational motion of a rigid body.

SPECTRAL ANALYSIS OF TIME SERIES IN JOINT SEGMENTS OF OBSERVATIONS

Ghazal, M.A.,Elhassanein, A. Korean Society of Computational and Applied Mathem 2008 Journal of applied mathematics & informatics Vol.26 No.5

Spectral analysis of a strictly stationary r-vector valued time series is considered under the assumption that some of the observations are missed due to some random failure. Statistical properties and asymptotic moments are derived. Asymptotic normality is discussed.

PERIODOGRAM ANALYSIS WITH MISSING OBSERVATIONS

Ghazal, M.A.,Elhassanein, A. 한국전산응용수학회 2006 Journal of applied mathematics & informatics Vol.22 No.1

Estimation of the spectral measure, covariance and spectral density functions of a strictly stationary r-vector valued time series is considered, under the assumption that some of the observations are missed. The modified periodograms are calculated using data window. The asymptotic normality is studied.

Hormone Immunoassay Interference: A 2021 Update

Ghazal Khaldoun,Brabant Severine,Prie Dominique,Piketty Marie-Liesse 대한진단검사의학회 2022 Annals of Laboratory Medicine Vol.42 No.1

Immunoassays are powerful qualitative and quantitative analytical techniques. Since the first description of an immunoassay method in 1959, advances have been made in assay designs and analytical characteristics, opening the door for their widespread implementation in clinical laboratories. Clinical endocrinology is closely linked to laboratory medicine because hormone quantification is important for the diagnosis, treatment, and prognosis of endocrine disorders. Several interferences in immunoassays have been identified through the years; although some are no longer encountered in daily practice, cross-reaction, heterophile antibodies, biotin, and anti-analyte antibodies still cause problems. Newer interferences are also emerging with the development of new therapies. The interfering substance may be exogenous (e.g., a drug or substance absorbed by the patient) or endogenous (e.g., antibodies produced by the patient), and the bias caused by interference can be positive or negative. The consequences of interference can be deleterious when clinicians consider erroneous results to establish a diagnosis, leading to unnecessary explorations or inappropriate treatments. Clinical laboratories and manufacturers continue to investigate methods for the detection, elimination, and prevention of interferences. However, no system is completely devoid of such incidents. In this review, we focus on the analytical interferences encountered in daily practice and possible solutions for their detection or elimination.