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Antimicrobial and docking studies of (-)-catechin derivatives
Kumar, Deepak,Poornima, M.,Kushwaha, R.N.,Won, Tae-Jin,Ahn, Chuljin,Kumar, C. Ganesh,Jang, Kiwan,Shin, Dong-Soo The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.4
Antimicrobial activities of (-)-catechin derivatives were assayed for their antibacterial and antifungal activities against gram positive, gram negative bacteria, and fungi. Most of the compounds significantly active among which Compounds 1a, 1b, and 1c showed excellent antibacterial for both gram negative and gram positive bacteria, these compounds also exhibited excellent antifungal activity more than the standard drug. Molecular docking studies of Compounds 1a and 1b established good binding affinity with ATP-binding pocket of DNA gyrase and are in favor of the observed biological activity. These data collectively suggest that Compounds 1a and 1b could serve as a novel antimicrobial agent.
( Kumar C. Ganesh ),( Avijeet Kamle ),( Poornima Mongolla ),( Joveeta Joseph ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.9
A fungal strain, Aspergillus terreus strain GA2, isolated from an agricultural field cultivating sweet sorghum, produced feruloyl esterase using maize bran. In order to obtain maximum yields of feruloyl esterase, the solid state fermentation (SSF) conditions for enzyme production were standardized. Effective feruloyl esterase production was observed with maize bran as substrate followed by wheat bran, coconut husk, and rice husk among the tested agro-waste crop residues. Optimum particle size of 0.71- 0.3 mm and moisture content of 80% favored enzyme production. Moreover, optimum feruloyl esterase production was observed at pH 6.0 and a temperature of 30oC. Supplementation of potato starch (0.6%) as the carbon source and casein (1%) as the nitrogen source favored enzyme production. Furthermore, the culture produced the enzyme after 7 days of incubation when the C:N ratio was 5. Optimization of the SSF conditions revealed that maximum enzyme activity (1,162 U/gds) was observed after 7 days in a production medium of 80% moisture content and pH 6.0 containing 16 g maize bran [25% (w/v)] of particle size of 0.71-0.3 mm, 0.6% potato starch, 3.0% casein, and 64 ml of formulated basal salt solution. Overall, the enzyme production was enhanced by 3.2-fold as compared with un-optimized conditions.
Wind flow modification by a jet roof for mitigation of snow cornice formation
Ganesh Kumar,Ajay Gairola,Aditya Vaid 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.2
The snow cornice mass on the formation zone had triggered avalanches which led to the loss of human life and property. Snow cornice is formed due to flow separation on the leeward side. Effect of lee slope is more prominent in the formation of snow cornices as compared to the windward slope. The analysis of wind flow pattern has been carried out to evaluate the performance of a jet roof. Computational Fluid Dynamics (CFD) analysis of wind flow over a 2D hill model was carried out using RNG based k- turbulence models available in ANSYS Fluent. Effect of varying leeward hill slope (1:2 to 1:6) on flow separation for the given windward slope was observed and a critical slope of 1:4 was found at which the separation zone ceased to exist. The modification of wind flow over a hill due to the installation of jet roof was simulated. It was observed that jet roof had significantly modified the wind flow pattern around hill ridgeline and ultimately snow cornice formation had mitigated. The results of the wind flow pattern were validated with the wind data collected at the experimental site, Banihal Top (Jammu and Kashmir, India). The wind flow simulation over the hill and mitigation of cornice formation by the jet roof has been explained in the present paper.
Ganesh Kumar Chellamani,Premanand Venkatesh Chandramani 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.2
Home energy management system (HEMS) is a section of demand response (DR), that plays an imperative role in the residential areas towards appliance management for the enhancement of energy efciency and grid stability. In this article, a methodical home energy management system (Methodical-HEMS) was proposed based upon K-means, a machine learning algorithm and satin bowerbird optimization (SBO) algorithm to optimize the scheduling of appliances within a 24-h period. The K-means algorithm is used for defning the discrete comfort window (DCW) for schedulable appliance, while SBO algorithm is used for defning the suitable time slots for the schedulable appliance to operate within the DCW. MethodicalHEMS is considered for a single home with the day ahead time of use pricing, to minimize the overall electricity bill (EB) and to satisfy the consumer’s comfort. The performance of Methodical-HEMS is evaluated with other heuristic algorithms, including a particle swarm optimization algorithm, grey wolf optimization algorithm, artifcial bee colony algorithm and genetic algorithm. The simulation outcomes demonstrate that, the SBO based HEMS algorithm efectually reduces the overall EB from ₹ 29.14/day to ₹ 22.84/day, minimizes the peak-to-average ratio by 10.28% and remains uncompromising on the consumer’s comfort.
Synthesis and characterization of Na-X and Na-A zeolites and adsorption removal of Cu(II)
( Ganesh Kumar Reddy ),최유림,김동수,( Koduru Janardhan Reddy ),장윤영,양재규 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Chronic exposure to high levels of copper can damage the liver and kidneys and may lead to Wilson’s disease, other genetic disorders, and even death. Na-X and Na-A zeolites were synthesized from waste coal fly ash by fusion method. Prepared zeolites such as Na-X and Na-A were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) surface area analysis and cation exchange capacity (CEC) were investigated. The adsorption removal of Copper (II) by Na-X and Na-A and the adsorption capacity of Cu(II) comparable with commercial zeolites. The adsorption of Copper (II) on zeolites was studied as initial metal concentration, Solution pH, Contact time and ionic strengths. The experimental data of adsorption were interpreted in terms of Freundlich and Langmuir equations and adsorption kinetics data of removal of Copper (II) were studied via pseudo first order and pseudo second order models.
Antimicrobial and docking studies of (2)-catechin derivatives
Deepak Kumar,M. Poornima,R. N. Kushwaha,원태진,안철진,C. Ganesh Kumar,장기완,신동수 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.4
Antimicrobial activities of (-)-catechin derivatives were assayed for their antibacterial and antifungal activities against gram positive, gram negative bacteria, and fungi. Most of the compounds significantly active among which Compounds 1a, 1b, and 1c showed excellent antibacterial for both gram negative and gram positive bacteria, these compounds also exhibited excellent antifungal activity more than the standard drug. Molecular docking studies of Compounds 1a and 1b established good binding affinity with ATP-binding pocket of DNA gyrase and are in favor of the observed biological activity. These data collectively suggest that Compounds 1a and 1b could serve as a novel antimicrobial agent.