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Active Muscle and Whole Body Lactate Kinetics after Endurance Training in Men
( Bryan C. Bergman ),( Eugene E. Wolfel ),( Gail E. Butterfield ),( Gary D. Lopaschuk ),( Gretchen A. Casazza ),( Michael A. Horning ),( George A. Brooks ) 한국스포츠정책과학원(구 한국스포츠개발원) 1999 International Journal of Applied Sports Sciences Vol.11 No.1
We evaluated the hypotheses that endurance training decreases arterial lactate concentration ([lactate]a) during continuous exer-cise by decreasing net lactate release (L) and appearance rates (Ra) and increasing metabolic clearance rate (MCR). Measurements were made at two intensities before [45 and 65% peak O2 consumption (VO2peak)] and after training [65% pretraining VO2peak, same absolute workload (ABT), and 65% posttraining VO2peak, same relative intensity (RLT)]. Nine men (27.4 2.0 yr) trained for 9 wk on a cycle ergometer, 5 times/wk at 75% VO2peak, Compared with the 65% VO2peak:, pretraining condition (4.75 0.4 mM), [lactate]a decreased at ABT (41%) and RLT (21%) (P,0.05). L decreased at ABT but not at RLT. Leg lactate uptake and oxidation were unchanged at ABT but increased at RLT. MCR was unchanged at ABT but increased at RLT. We conclude that 1) active skeletal muscle is not solely responsible for elevated [lactate]a; and 2) training increases leg lactate clearance, decreases whole body and leg lactate production at a given moderate-intensity power output, and increases both whole body and leg lactate clearance at a high relative power output.
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Gene A. Spiller,Monica Spiller,Jon A. Story,Tanya A. Lodics,Margaret Pollack,Sharon Monyan,Gail Butterfield 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.2
The effect of increasing doses of sun-dried raisins (SDR) on intestinal transit time (TT), fe-cal weight (FW), and fecal bile acids (FBA) was investigated in 16 healthy adults (6 men and10 women). In three cycles of 2 weeks each, subjects consumed 84, 126, or 168 g/day of SDR.Four-day fecal collections were performed during the second week of each cycle, and TT, FW,and FBA were measured. FW (mean 6 SEM), increased from 168 6 14 g/day without raisins(cycle 1), with a TT of 54 6 6 hours, to 20 6 24 g/day with 168 g/day raisins (cycle 4), with aTT of 42 6 6 hours. Intermediate increases in FW and decreases in TT were observed for cy-cles 2 and 3. A physiologically meaningful decrease in TT (less than 2 days), to 4 6 6 hours,was reached at cycle 2 (not statistically significant). FBA, a possible indicator of colon cancerrisk, showed a significant decrease, from 1.00 6 0.18 mg/g wet feces at baseline to 0.38 6 0.07mg/g in cycle 2 (P , .005), and remained low in cycles 3 and 4. Major decreases were observedin cycle 2 for fecal lithocholic (P , .02), deoxycholic (P , .002), chenodeoxycholic , and cholicacids, and their concentrations remained low in cycles 3 and 4. Two servings of raisins perday (84 g/day), a relatively small change in diet, can cause beneficial changes in colon func-tion and may decrease the risk for colon cancer.87
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