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Gene A. Spiller,Monica Spiller,Jon A. Story,Tanya A. Lodics,Margaret Pollack,Sharon Monyan,Gail Butterfield 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.2
The effect of increasing doses of sun-dried raisins (SDR) on intestinal transit time (TT), fe-cal weight (FW), and fecal bile acids (FBA) was investigated in 16 healthy adults (6 men and10 women). In three cycles of 2 weeks each, subjects consumed 84, 126, or 168 g/day of SDR.Four-day fecal collections were performed during the second week of each cycle, and TT, FW,and FBA were measured. FW (mean 6 SEM), increased from 168 6 14 g/day without raisins(cycle 1), with a TT of 54 6 6 hours, to 20 6 24 g/day with 168 g/day raisins (cycle 4), with aTT of 42 6 6 hours. Intermediate increases in FW and decreases in TT were observed for cy-cles 2 and 3. A physiologically meaningful decrease in TT (less than 2 days), to 4 6 6 hours,was reached at cycle 2 (not statistically significant). FBA, a possible indicator of colon cancerrisk, showed a significant decrease, from 1.00 6 0.18 mg/g wet feces at baseline to 0.38 6 0.07mg/g in cycle 2 (P , .005), and remained low in cycles 3 and 4. Major decreases were observedin cycle 2 for fecal lithocholic (P , .02), deoxycholic (P , .002), chenodeoxycholic , and cholicacids, and their concentrations remained low in cycles 3 and 4. Two servings of raisins perday (84 g/day), a relatively small change in diet, can cause beneficial changes in colon func-tion and may decrease the risk for colon cancer.87
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