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- 저자 : Jon A. Story (검색결과 2 건)
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Modified Soybean Affects Cholesterol Metabolism in Rats Similarly to a Commercial Cultivar
Elizabethe A. Esteves,Josefina Bressan,Neuza M.B. Costa,Hercia S.D. Martino,Shawn S. Donkin,Jon A. Story 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.11
The consumption of soy protein lowers blood cholesterol in humans and animals. Breeding may alter the physiological effects of soybeans, such as its cholesterol-lowering property. Our hypothesis is that breeding affects the hypocholesterolemic effect of soy by modulating the expression of key hepatic enzymes related to cholesterol and bile acid biosynthesis, as well as altering fecal neutral and acidic steroid excretion. Therefore the aim of this study was to evaluate the effect of a new Brazilian soybean cultivar (UFV-116), lacking lipoxygenases 2 and 3, compared with a commercial cultivar (OCEPAR-19), on 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and cholesterol 7α-hydroxylase (CYP7A) mRNA expression and fecal steroid output in rats. Thirty-six male rats were fed UFV-116, OCEPAR-19, or casein as the protein source, with or without addition of dietary cholesterol (0.25%). Blood and liver cholesterol, HMGR and CYP7A mRNA abundance, and fecal excretion of steroids were measured. Blood and liver cholesterol levels were lowered by both soybean cultivars, with and without cholesterol, but UFV-116 was more effective when included in the cholesterol-free diet. Both soy diets promoted lower levels of HMGR mRNA, higher levels of CYP7A mRNA, and higher excretion of fecal secondary bile acids. There was higher fecal neutral steroid output when cholesterol was added to all diets. These data show that both soybean cultivars acted similarly in lowering serum and hepatic cholesterol; therefore, breeding did not affect the hypocholesterolemic effect of the new cultivar.
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Gene A. Spiller,Monica Spiller,Jon A. Story,Tanya A. Lodics,Margaret Pollack,Sharon Monyan,Gail Butterfield 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.2
The effect of increasing doses of sun-dried raisins (SDR) on intestinal transit time (TT), fe-cal weight (FW), and fecal bile acids (FBA) was investigated in 16 healthy adults (6 men and10 women). In three cycles of 2 weeks each, subjects consumed 84, 126, or 168 g/day of SDR.Four-day fecal collections were performed during the second week of each cycle, and TT, FW,and FBA were measured. FW (mean 6 SEM), increased from 168 6 14 g/day without raisins(cycle 1), with a TT of 54 6 6 hours, to 20 6 24 g/day with 168 g/day raisins (cycle 4), with aTT of 42 6 6 hours. Intermediate increases in FW and decreases in TT were observed for cy-cles 2 and 3. A physiologically meaningful decrease in TT (less than 2 days), to 4 6 6 hours,was reached at cycle 2 (not statistically significant). FBA, a possible indicator of colon cancerrisk, showed a significant decrease, from 1.00 6 0.18 mg/g wet feces at baseline to 0.38 6 0.07mg/g in cycle 2 (P , .005), and remained low in cycles 3 and 4. Major decreases were observedin cycle 2 for fecal lithocholic (P , .02), deoxycholic (P , .002), chenodeoxycholic , and cholicacids, and their concentrations remained low in cycles 3 and 4. Two servings of raisins perday (84 g/day), a relatively small change in diet, can cause beneficial changes in colon func-tion and may decrease the risk for colon cancer.87
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