Vitamin D Deficiency in Patients Hospitalized for Heart Failure Living in the Tropics

de Oliveira Lucian Batista,de Figueiredo Martins Siqueira Mariana Andrade,de Macedo Gadêlha Rafael Buarque,Garcia Jessica,Bandeira Francisco 대한심부전학회 2024 International Journal of Heart Failure Vol.6 No.2

Background and Objectives Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increased risk of heart failure (HF) and unfavorable outcomes. The present study investigated the prevalence of vitamin D deficiency (VDD) and its relationship with cardiometabolic parameters in patients hospitalized for HF living in the city of Recife (latitude 8° South). Methods Analytical cross-sectional study, with men and women aged 40–64 years. The HF group was recruited during hospitalization due to decompensation. A matched control group was recruited from the general endocrine clinics. Vitamin D status was assessed by measuring serum 25-hydroxyvitamin D (25OHD), considering deficiency when 25OHD <20 ng/mL (<50 nmol/L). Results A total of 243 patients were evaluated (HF group: 161, control group: 82). Lower serum 25OHD levels were observed in the HF group (25.2±9.4 vs. 30.0±7.7ng/mL; p<0.001), as well as a higher prevalence of VDD (27.3% vs. 9.8%; prevalence ratio, 2.80; 95% confidence interval, 1.38–5.67; p=0.002). In patients with HF, VDD was associated with diabetes mellitus (65.9% vs. 41.0%; p=0.005) and female sex (65.9% vs. 44.4%; p=0.015). In the subgroup with VDD, higher values of hemoglobin A1c (7.9% [6.0–8.9] vs. 6.2% [5.7–7.9]; p=0.006) and dyslipidemia were also observed. Conclusions We found higher rates of VDD in patients hospitalized for HF and this was associated with deleterious laboratory metabolic parameters. Background and Objectives Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increased risk of heart failure (HF) and unfavorable outcomes. The present study investigated the prevalence of vitamin D deficiency (VDD) and its relationship with cardiometabolic parameters in patients hospitalized for HF living in the city of Recife (latitude 8° South). Methods Analytical cross-sectional study, with men and women aged 40–64 years. The HF group was recruited during hospitalization due to decompensation. A matched control group was recruited from the general endocrine clinics. Vitamin D status was assessed by measuring serum 25-hydroxyvitamin D (25OHD), considering deficiency when 25OHD <20 ng/mL (<50 nmol/L). Results A total of 243 patients were evaluated (HF group: 161, control group: 82). Lower serum 25OHD levels were observed in the HF group (25.2±9.4 vs. 30.0±7.7ng/mL; p<0.001), as well as a higher prevalence of VDD (27.3% vs. 9.8%; prevalence ratio, 2.80; 95% confidence interval, 1.38–5.67; p=0.002). In patients with HF, VDD was associated with diabetes mellitus (65.9% vs. 41.0%; p=0.005) and female sex (65.9% vs. 44.4%; p=0.015). In the subgroup with VDD, higher values of hemoglobin A1c (7.9% [6.0–8.9] vs. 6.2% [5.7–7.9]; p=0.006) and dyslipidemia were also observed. Conclusions We found higher rates of VDD in patients hospitalized for HF and this was associated with deleterious laboratory metabolic parameters.

Cytotoxicity, Acute, and Subacute Study of Hydroalcoholic Root Extract of Carissa spinarum L. on Wistar Rats

Komlan M. Dossou-Yovo,Aboudoulatif Diallo,Povi Lawson-Evi,Tchin Darré,Batomayena Bakoma,Kwashie Eklu-Gadégbéku 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.7

Carissa spinarum L. (Apocynaceae) is used traditionally, in Africa, to treat many diseases such as malaria, sickle cell anemia, epilepsy, helminthoses, and sexual weakness. The aim of this study is to investigate the cytotoxicity on Artemia salina, the acute and subacute (28 days) oral toxicity of C. spinarum hydroalcoholic root extract on Wistar rats. The cytotoxicity was performed on A. salina larvae. The acute and subacute toxicity was performed using Organization of Economic Cooperation and Development guideline. Malondiadehyde as lipoperoxidation marker was evaluated and expressed according to tissue proteins. The cytotoxicity has shown that the lethal concentration 50 (LC50) was 0.9 mg/mL. The limit test dose of 5000 mg/kg did not provoke death or toxicity signs. For the subacute toxicity, no signs of toxicity or mortality were observed during the experiment. Results of biochemical and hematological parameters have not shown any treatment-related abnormalities, except a significant decrease of alkaline phosphatase at 1000 mg/kg (P < .05) and an increase of chloride ion level at 500 mg/kg (P < .01). There was no significant difference between the treated group and the control group concerning the malondialdehyde concentration, the body weight, and the organs relative weight (P < .05), except for testis at 500 mg/kg (P < .05). According to our results, the hydroalcoholic extract of C. spinarum roots is safe when administrated at 500 mg and 1000 mg/kg to Wistar rats for 28 days.

Improved single-step extraction performance of aqueous biphasic systems using novel symmetric ionic liquids for the decolorisation of toxic dye effluents

Aleksandra Dimitrijevic´,Ana Joci c,Nebojša Zec,Aleksandar Tot,Snežana Papovi c,Slobodan Gadžuri c,Milan Vraneš,Tatjana Trtic´-Petrovic 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.76 No.-

The novel aqueous biphasic systems based on symmetric imidazolium ionic liquids (IL-ABSs) for theextraction of toxic and resistive dyes from water was studied. The cation symmetricity of ILs stronglyinfluence the outstanding ability of 1,3-dibutylimidazolium dicyanamide, [bbim][dca], to generate ABSwith the exceptionally low amount of eco-friendly citrate salt. A remarkable potential of [bbim][dca]/citrate based ABS to remove Orange II from wastewater with concentration up to 1000 fold and efficiencyabove 99.4% in a single step was achieved. The improved safety of proposed method nominates it aspromising future strategy for pollution prevention.

지식의 경험

GAD 아키텍츠(GAD Architects) 현대건축사 2018 월간 CONCEPT Vol.- No.231

Axial Run-Out of a Spinning Flexible Disk Close to a Rotating Rigid Wall

Gad, A.M.,Rhim, Y.C. IEEE 2009 IEEE transactions on magnetics Vol.45 No.5

<P>The present work is a numerical and experimental study about the behavior of flexible disks with different thicknesses and different material properties rotating close to fixed and co-rotating rigid flat-stabilizers in open air. The Navier-Stokes equations along with the continuity equation are used to model the fluid flow in the air film between the flexible disk and the rigid stabilizer whereas a linear plate theory is used to model the lateral displacement of the flexible disk. An experimental test-rig is designed to investigate the effects of the rotation speed, the initial gap height and the inlet-hole size on the axial run-out of the different flexible disks. Finally, a comparison between the experimental and the numerical results is made.</P>

Experimental and Numerical Study on the Dynamic Behavior of a Spinning Flexible Disk Close to a Rotating Rigid Wall (3 pages)

Gad, A.M.M.,Rhim, Y.C. JAPAN SOCIETY OF APPLIED PHYSICS 2009 Japanese journal of applied physics Vol.48 No.3

N-terminal tail of a viral histone H4 encoded in <i>Cotesia plutellae</i> bracovirus is essential to suppress gene expression of host histone H4

Gad, W.,Kim, Y. Blackwell Publishing Ltd 2009 INSECT MOLECULAR BIOLOGY Vol.18 No.1

<P>Abstract</P><P>An endoparasitoid wasp, <I>Cotesia plutellae</I>, possesses a symbiotic bracovirus (CpBV), which facilitates parasitism of a specific host, such as larvae of the diamondback moth, <I>Plutella xylostella</I>. A viral histone H4 (CpBV-H4) has been found in the CpBV genome and its gene product plays a role in impairing the host insect cellular immune response. Based on its high similarity to histone H4 of <I>P. xylostella</I> apart from its extended N-terminal tail, it has been suspected to alter host gene expression. Histone subunits were purified from parasitized <I>P. xylostella</I> larvae and found to contain both host and viral H4s, confirming a previous report of a possible epigenetic mode of action. Moreover, this study showed that the host H4 levels in the parasitized larvae clearly decreased during the parasitization period, whereas CpBV-H4 levels maintained a significant level without significant changes. To understand the decrease of host H4 levels, transcription levels of host H4 were monitored by quantitative reverse-transcriptase PCR (RT-PCR) and showed a significant decrease in parasitized <I>P. xylostella </I>larvae, whereas no significant change of the mRNA level was detected in nonparasitized larvae. This transcriptional control of host H4 expression was also observed by inducing transient expression of CpBV-H4 in nonparasitized <I>P. xylostella</I>. Moreover, co-injection of CpBV-H4 and its specific double-stranded RNA recovered the host H4 expression level. To identify a functional domain of CpBV-H4 involved in the transcriptional control, the extended N-terminal tail of CpBV-H4 was removed by preparing a truncated viral H4 construct in an expression vector by deleting the N-terminal tail of 38 amino acid residues and inducing its expression in nonparasitized <I>P. xylostella </I>larvae. The truncated CpBV-H4 clearly lost its inhibitory effects on host H4 transcription. Moreover, the presence of CpBV-H4 affects the spreading of host haemocytes by an epigenetic effect, which is at least partly restored in larvae expressing the truncated version of CpBV-H4. This study suggests that the viral H4 encoded in CpBV can alter host gene expression with its extended N-terminal tail.</P>

Long-Term (5 Years), High Daily Dosage of Dietary Agmatine—Evidence of Safety: A Case Report

Gad M. Gilad,Varda H. Gilad 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.11

There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatment for neuropathic pain. These studies have ushered in the use of dietary agmatine as a nutraceutical. However, in view of information paucity, assessment of long-term safety of oral agmatine treatment is now clearly required. The authors of this report undertook to assess their own health status during ongoing consumption of a high daily dosage of oral agmatine over a period of 4–5 years. A daily dose of 2.67 g agmatine sulfate was encapsulated in gelatin capsules; the regimen consists of six capsules daily, each containing 445mg, three in the morning and three in the evening after meals. Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. All measurements thus far remain within normal values and good general health status is sustained throughout the study period, up to 5 years. This case study shows for the first time that the recommended high dosage of agmatine may be consumed for at least 5 years without evidence of any adverse effects. These initial findings are highly important as they provide significant evidence for the extended long-term safety of a high daily dosage of dietary agmatine—a cardinal advantage for its utility as a nutraceutical.

Passive-Damping of the Axial Run-Out for High Speed Rotating Flexible Optical Disk Using the Idea of Damping Orifice

Gad, Abdelrasoul M. M.,Rhim, Yoon Chul IOP Publishing 2010 Japanese journal of applied physics Vol.49 No.8

Technical design of an axial injection low-energy carbon beam line

Gad Khaled M. M.,Namgoong Ho,Ghergherehchi Mitra,Chai Jong-Seo 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.84 No.9

Ongoing research and development eff orts are being conducted at Sungkyunkwan University—Korea with the objective of creating an Atomic Mass Spectrometer (AMS) cyclotron that presents a more compact and cost-eff ective alternative to the conventional Tandem AMS system. The construction of cyclotrons frequently encounters diffi culties, mostly arising from instabilities and substantial losses of ion beams, particularly during the injection phase that usually depends on an axial injection mechanism. In this paper, we undertake an in-depth investigation into the comprehensive design exploration of a low-energy carbon ion beam line. The optimization processes were done using Trace3D, TOSCA, and OpticExpert codes. The TOSCA software, in particular, enabled the use of three-dimensional simulations related to the complicated behavior of ion beams. The presented paper off ers an in-depth examination of the beam line, illustrating the engineering elements of essential optical parts, such as quadrupoles and dipoles. Following the production process, all of the beam line parts were subjected to extensive testing. The fi nal results, including magnetic fi eld measurements and fi eld gradients, showed an excellent match with our physical models. At the same time, a thermal study of the air-cooled quadrupole coils was carried out using the ANSYS APDL program. The construction of beam line has been done. An analysis of beam measurements will be carried out and subsequently compared to the calculated models. The objective of this comparison analysis is to ascertain the most optimal design method, with a focus on achieving effi ciency and reliability in the fi nal beam line system.