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Jakub Mesinovic,Jackson J. Fyfe,Jason Talevski,Michael J. Wheeler,Gloria K.W. Leung,Elena S. George,Melkamu T. Hunegnaw,Costas Glavas,Paul Jansons,Robin M. Daly,David Scott 대한당뇨병학회 2023 Diabetes and Metabolism Journal Vol.47 No.6
Type 2 diabetes mellitus (T2DM) and sarcopenia (low skeletal muscle mass and function) share a bidirectional relationship. The prevalence of these diseases increases with age and they share common risk factors. Skeletal muscle fat infiltration, commonly referred to as myosteatosis, may be a major contributor to both T2DM and sarcopenia in older adults via independent effects on insulin resistance and muscle health. Many strategies to manage T2DM result in energy restriction and subsequent weight loss, and this can lead to significant declines in muscle mass in the absence of resistance exercise, which is also a first-line treatment for sarcopenia. In this review, we highlight recent evidence on established treatments and emerging therapies targeting weight loss and muscle mass and function improvements in older adults with, or at risk of, T2DM and/or sarcopenia. This includes dietary, physical activity and exercise interventions, new generation incretin-based agonists and myostatin-based antagonists, and endoscopic bariatric therapies. We also highlight how digital health technologies and health literacy interventions can increase uptake of, and adherence to, established and emerging treatments and therapies in older adults with T2DM and/or sarcopenia.
Environmental Control of Chemical Composition of the Secondary Hydroxyapatite from Japan
Kashima, Naruhiko,Tazaki, Kazue,Fyfe, W.S. The Speleological Society 1998 Journal of the speleological society of korea Vol.8 No.2
The mineral hydroxyapatite is very common species in secondary phosphates originating from guanos(HILL et at., 1997). Several mineralogical analyses of spelean hydroxyapatite exist(e.g., KASHIMA, 1968, 1979 ; MAKI et at., 1977 ; SUH et at., 1978 ; WANG, 1982 a, b), whereas detailedeochemical composition of secondary hydroxy apatites has not been reported in Japan.(omitted)
Microbe Hunting: A Curious Case of Cryptococcus
Bartlett Karen H.,Kidd Sarah,Duncan Colleen,Chow Yat,Bach Paxton,Mak Sunny,MacDougall Laura,Fyfe Murray Korean Society of Environmental Health 2005 한국환경보건학회지 Vol.31 No.3
C. neoformans-associated cryptococcosis is primarily a disease of immunocompromised persons, has a world-wide distribution, and is often spread by pigeons in the urban environment. In contrast, C. gattii causes infection in normal hosts, has only been described in tropical and semi-tropical areas of the world, and has a unique niche in river gum Eucalyptus trees. Cryptococcosis is acquired through inhalation of the yeast propagules from the environment. C. gattii has been identified as the cause of an emerging infectious disease centered on Vancouver Island, British Columbia, Canada. No cases of C. gattii-disease were diagnosed prior to 1999; the current incidence rate is 36 cases per million population. A search was initiated in 2001 to find the ecological niche of this basidiomycetous yeast. C. gattii was found in the environment in treed areas of Vancouver Island. The highest percentage of colonized-tree clusters were found around central Vancouver Island, with decreasing rates of colonization to the north and south. Climate, soil and vegetation cover of this area, called the Coastal Douglas fir biogeoclimatic zone, is unique to British Columbia and Canada. The concentration of airborne C. gattii was highest in the dry summer months, and lowest during late fall, winter, and early spring, months which have heavy rainfall. The study of the emerging colonization of this organism and subsequent cases of environmentally acquired disease will be informative in planning public health management of new routes of exposure to exotic agents in areas impacted by changing climate and land use patterns.
Microbe hunting: a Curious Case of Cryptococcus
Karen H. Bartlett,Sarah Kidd,Colleen Duncan,Yat Chow,Paxton Bach,Sunny Mak,Laura MacDougall,Murray Fyfe 한국환경보건학회 2005 한국환경보건학회지 Vol.31 No.3
C. neoformans-associated cryptococcosis is primarily a disease of immunocompromised persons, has a world-wide distribution, and is often spread by pigeons in the urban environment. In contrast, C. gattii causes infection in normal hosts, has only been described in tropical and semi-tropical areas of the world, and has a unique niche in river gum Eucalyptus trees. Cryptococcosis is acquired through inhalation of the yeast propagules from the environment.C. gattii has been identified as the cause of an emerging infectious disease centered on Vancouver Island, British Columbia, Canada. No cases of C. gattii-disease were diagnosed prior to 1999; the current incidence rate is 36 cases per million population. A search was initiated in 2001 to find the ecological niche of this basidiomycetous yeast.C. gattii was found in the environment in treed areas of Vancouver Island. The highest percentage of colonized-tree clusters were found around central Vancouver Island, with decreasing rates of colonization to the north and south. Climate, soil and vegetation cover of this area, called the Coastal Douglas fir biogeoclimatic zone, is unique to British Columbia and Canada. The concentration of airborne C. gattii was highest in the dry summer months, and lowest during late fall, winter, and early spring, months which have heavy rainfall. The study of the emerging colonization of this organism and subsequent cases of environmentally acquired disease will be informative in planning public health management of new routes of exposure to exotic agents in areas impacted by changing climate and land use patterns.
Insect Response to Climate Change: What are We Testing for?
Jung M.-P.,Andrew N.R.,Hill S.J.,Binns M.,Ridley E.V.,Bahar M.H.,Khusro M.,Yates M.,Fyfe C. 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.10
Understanding how researchers are tackling globally important issues, such as climate change, is crucial to identify whether current research is comprehensive enough to make substantive predictions about general responses to climate change. We assessed the type of studies being conducted by researchers to understand the impacts of climate change on insects, published. Most published research is generated from Europe and North America and being dedicated to core data analysis, with reviews being highly produced. Temperature – only is the main climate change factor being analysed, with most researchers are assessing changes in abundance or distribution/range shifts. Of most concern is the number of studies which do not specifically identify a climate change factor (ie just arm wave), the lack of studies on Hemimetabolous insects and the need for more studies to assess specific mechanistic responses to climate change.
June-Yi Lee,J. Marotzke,G. Bala,L. Cao,S. Corti,J. P. Dunne,F. Engelbrecht,E. Fischer,J. C. Fyfe,C. Jones,A. Maycock,J. Mutemi,O. Ndiaye,S. Panickal,T. Zhou,Maycock,J. Mutemi,O. Ndiaye,S. Panickal,T. 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.10
The chapter 4 of Working Group I contribution to the IPCC Sixth Assessment Report assesses simulations of future global climate change, spanning time horizons from the near term (2021-2040),mid-term (2041-2060), and long term (2081-2100) out to the year 2300. The chapter assesses physical indicators of global climate change, such as global surface air temperature, global land precipitation, Arctic sea-ice area and global mean sea level. Furthermore, the chapter covers indices and patterns of properties and circulation not only for mean fields but also for modes of variability that have global significance. Changes are assessed relative to both the recent past (1995-2014) and the 1850-1900 approximation to the pre-industrial period. The projections assessed in the chapter are mainly based on a new range of scenarios, the Shared Socio-economic Pathways (SSPs) used in the Coupled Model Intercomparison Project Phase 6 (CMIP6). Additional lines of evidence enter the assessment, especially for change in globally averaged surface air temperature and global mean sea level, while assessment for changes in other quantities is mainly based on CMIP6 results. After section 4.2 on the methodologies used in the assessment, Section 4.3 assesses projected changes inkey global climate indicators throughout the 21<SUP>st</SUP> century. Section4.4. covers near-term climate change and Section 4.5 assesses mid-term andlong-term climate change. Section 4.6 addresses the climate implications of climate policies including patterns of climate change expected for various global warming levels, climate goals, overshoot, and path-dependence, as well as the climate response the climate response to mitigation, Carbon Dioxide Removal, and Solar Radiation Modification. Section 4.7 assesses very long-term changes up to 2300 and climate-change commitment and the potential for irreversibility and abrupt climate change. The chapter concludes with Section4.8 on the potential for low-probability-high-impact changes.