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Fujikawa, T.,Takatori, N.,Kuwajima, M.,Kim, G.J.,Nishida, H. Academic Press 2011 Developmental biology Vol.355 No.2
Mechanisms that regulate the number of cells constituting the body have remained largely elusive. We approached this issue in the ascidian, Halocynthia roretzi, which develops into a tadpole larva with a small number of cells. The embryonic cells divide 11 times on average from fertilization to hatching. The number of cell division rounds varies among tissue types. For example, notochord cells divide 9 times and give rise to large postmitotic cells in the tadpole. The number of cell division rounds in partial embryos derived from tissue-precursor blastomeres isolated at the 64-cell stage also varied between tissues and coincided with their counterparts in the intact whole embryos to some extent, suggesting tissue-autonomous regulation of cell division. Manipulation of cell fates in notochord, nerve cord, muscle, and mesenchyme lineage cells by inhibition or ectopic activation of the inductive FGF signal changed the number of cell divisions according to the altered fate. Knockdown and missexpression of Brachyury (Bra), an FGF-induced notochord-specific key transcription factor for notochord differentiation, indicated that Bra is also responsible for regulation of the number of cell division rounds, suggesting that Bra activates a putative mechanism to halt cell division at a specific stage. The outcome of precocious expression of Bra suggests that the mechanism involves a putative developmental clock that is likely shared in blastomeres other than those of notochord and functions to terminate cell division at three rounds after the 64-cell stage. Precocious expression of Bra has no effect on progression of the developmental clock itself.
Measurement ofCPasymmetries inB0→K0π0decays
Fujikawa, M.,Yusa, Y.,Dalseno, J.,Hazumi, M.,Sumisawa, K.,Aihara, H.,Arinstein, K.,Aulchenko, V.,Aushev, T.,Aziz, T.,Bakich, A. M.,Balagura, V.,Barberio, E.,Belous, K.,Bhardwaj, V.,Bischofberger, M.,B American Physical Society 2010 PHYSICAL REVIEW D - Vol.81 No.1
P110β in the ventromedial hypothalamus regulates glucose and energy metabolism
Teppei Fujikawa,최윤희,양동주,신동민,Jose Donato Jr.,Daisuke Kohno,Charlotte E. Lee,Carol F. Elias,Syann Lee,김기우 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic glucose and energy homeostasis. PI3K is composed of different subunits, each of which has several unique isoforms. However, the role of the PI3K subunits and isoforms in the ventromedial hypothalamus (VMH), a prominent site for the regulation of glucose and energy homeostasis, is unclear. Here we investigated the role of subunit p110β in steroidogenic factor-1 (SF-1) neurons of the VMH in the regulation of metabolism. Our data demonstrate that the deletion of p110β in SF-1 neurons disrupts glucose metabolism, rendering the mice insulin resistant. In addition, the deletion of p110β in SF-1 neurons leads to the whitening of brown adipose tissues and increased susceptibility to diet-induced obesity due to blunted energy expenditure. These results highlight a critical role for p110β in the regulation of glucose and energy homeostasis via VMH neurons.
A Time Integration Method for Analysis of Dynamic Systems Using Domain Decomposition Technique
Takeshi Fujikawa,Etsujiro Imanishi 대한기계학회 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.1S
This paper presents a precise and stable time integration method for dynamic analysis of vibration or multi body systems A total system is divided into several subsystems and their responses are calculated separately, while the coupling effect is treated equivalently as constant force during time steps By using Iterative procedure to Improve equivalent coupling forces, a precise and stable solution is obtained Some examples such as a seismic response and multi body analyses were carried out to demonstrate Its usefulness<br/>
Tatsuo Fujikawa,Ryuji Sugiura,Rie Nishikata,Tetsuya Nishimoto 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
The peak mean contact pressure and the total transferred energy are discussed as the dominant parameters of bruise tolerance by blunt impact in order to obtain safety criteria for robot design in human-robot interaction. Impact tests are conducted using live pigs with the permission of the ethical committee. A 25 mm-diameter cylindrical impactor is used to represent moving parts of robots. Samples of soft tissue are stained, and capillary damages are investigated by microscopy. The results show that there is no capillary damage if the peak mean contact pressure is less than 1.3 MPa and the total transferred energy is less than 87 kJ/m2. The probability of injury as a function of these parameters is obtained using logistic regression of the the experiment results.