Every Single Cell Clones from Cancer Cell Lines Growing Tumors In Vivo May Not Invalidate the Cancer Stem Cell Concept

Fengzhi Li 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.4

We present the result of our research on the tumorigenic ability of single cell clones isolated from an aggressive murine breast cancer cell line in a matched allografting mouse model. Tumor formation is basically dependent on the cell numbers injected per location. We argue that in vivo tumor formation from single cell clones, isolated in vitro from cancer cell lines, may not provide conclusive evidence to disprove the cancer stem cell (CSC) theory without additional data.

Facile Synthesis of Flower-Like AgI/BiOBr Z-Scheme Nanocomposite with Enhanced Photocatalytic Activity for Degradation of 17α-Estradiol (EE2)

Lingxin Li,Han Li,Yanju Long,Shan Wang,Yu Chen,Sifeng Zhang,Lulu Wang,Lijun Luo,Fengzhi Jiang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.1

In the present work, a direct Z-scheme AgI/BiOBr heterojunction displaying improved photocatalytic activity was designed by a chemical bath deposition method. The obtained photocatalysts were systematically characterized through XRD, SEM, XPS, BET and UV-Vis diffuse reflectance spectroscopy. The synthesized AgI/BiOBr photocatalyst displayed superior photocatalytic performance in the case of 17α-ethinylestradiol (EE2), where 97.0% compound has been removed within 9 min of irradiation. The rate constant using AgI/BiOBr photo-catalyst was 16.0 and 138.7 times more than that of pure AgI and BiOBr, respectively. Furthermore, the photocatalytic mechanism was investigated. The results of this study indicated that AgI/BiOBr was a stable and efficient photocatalyst, with promising practical applications.

Spatial Variations of Climate-Driven Trends of Water Vapor Pressure and Relative Humidity in Northwest China

Fengzhi Shi,Chengyi Zhao,Xu Zhou,Xinhu Li 한국기상학회 2019 Asia-Pacific Journal of Atmospheric Sciences Vol.55 No.2

The interaction between climate change trends and water cycle variables is complex. The spatial distributions and trends of hydroclimatic variables (precipitation, temperature, water vapor pressure, and relative humidity) at 65 stations in Xinjiang in 1961–2011 were analyzed. Five meteorological stations were selected for a detailed analysis of the changes in climatic factors. We explored the relationship between water vapor pressure, relative humidity, temperature, and precipitation using nonparametric methods [the block bootstrap (B-B) method, Mann-Kendall (MK) test, and a generalized additive model (GAM)] for data from 1940 to 2011. The results showed that temperature, precipitation, and water vapor pressure at most stations increased over the period studied, while relative humidity decreased in the north of Xinjiang, and increased in the south. The results indicated that the temperature and water vapor pressure were elevated. At the same time, there was a large spatiotemporal heterogeneity of precipitation and relative humidity among the five stations. The water vapor pressure had a significant positive relationship with temperature and relative humidity, but the temperature trend with relative humidity displayed a negative relationship. The relationship of the precipitation and temperature trends with water vapor and relative humidity was either positive or negative. The most significant controlling factor for the climate variables was relative humidity, which was governed by water vapor pressure in the study area. Further investigations are needed to better understand the climatic influences in other complex physiographic landscapes, and to determine reliable mechanisms to more effectively integrate water cycle variables, high resolution data, and climatic modeling.

Effectiveness of craniotomy and long- term survival in 35 patients with gestational trophoblastic neoplasia with brain metastases: a clinical retrospective analysis

Yuan Li,Weidi Wang,Xirun Wan,Fengzhi Feng,Yong-Lan He,Junjun Yang,Yang Xiang 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.3

Objective: To investigate the clinical characteristics, treatments, and prognostic factors among patients with gestational trophoblastic neoplasia (GTN) exhibiting brain metastases who underwent craniotomy. Methods: Thirty-five patients with GTN who had brain metastases and subsequently underwent craniotomies between January 1990 and December 2018 at Peking Union Medical College Hospital were identified using the GTN database. Their clinical manifestations, treatments, outcomes, and prognostic factors were retrospectively analyzed. Results: All 35 patients underwent decompressive craniotomy, hematoma removal, and metastatic tumor resection combined with multiagent chemotherapy. Eighty percent (28/35) achieved complete remission, 11.4% (4/35) achieved partial remission, and 8.6% (3/35) had progressive disease. Not counting 2 patients who were lost to follow-up, 81.8% of the patients (27/33) were alive after a median follow-up of 72 months. The 5-year overall survival rate was 80.4%. Univariate analysis revealed that a history of chemotherapy failure (p=0.020) and a >1-week interval between craniotomy and chemotherapy commencement (p=0.027) were adverse risk factors for survival. Multivariate analysis showed that previous chemotherapy failure remained an independent risk factor for poor survival (odds ratio=11.50; 95% confidence interval=1.55–85.15; p=0.017). Conclusion: Decompressive craniotomy is a life-saving option if metastatic hemorrhage and intracranial hypertension produce a risk of cerebral hernia in patients with GTN who have brain metastases. Higher survival rates and improved prognoses can be achieved through perioperative multidisciplinary cooperation and timely standard postoperative chemotherapy.

Preparation of corn straw based spongy aerogel for spillage oil capture

Yuan Li,Xiaodong Liu,Weijie Cai,Yafeng Cao,Yanfeng Sun,Fengzhi Tan 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.5

This work mainly focused on the preparation of a low-cost, ultralight absorbent from renewable corn straw and filter paper via a facile and environmental-friendly approach containing high-shear blending and freeze-drying operation. The physicochemical properties of aerogel were thoroughly examined by several characterization techniques. The satisfactory hydrophobicity of the spongy aerogel was attributed to the formation of polysiloxane on the surface of methyltrimethoxysilane (MTMS) by the silanization reaction. Owing to its superior features, such as ultralow density, high porosity, desirable hydrophobicity, the corn straw based spongy aerogel exhibited a remarkable absorption capacity for both crude oil (36 g/g) and common organic solvents including carbon tetrachloride (CCl4, 45 g/g), dimethyl sulphoxide (DMSO, 24 g/g), N, N-dumethylformamide (DMF, 45 g/g). This might shed light on the design of efficient adsorbent for oil spills and organic pollutants to meet with the sustainable development.

Rotational behavior of exposed column bases with different base plate thickness

Yao Cui,Fengzhi Wang,Hao Li,Satoshi Yamada 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.32 No.4

Exposed column base connections are used in low- to mid-rise steel moment resisting frames. This paper is to investigate the effect of the base plate thickness on the exposed column base connection strength, stiffness, and energy dissipation. Five specimens with different base plate thickness were numerically modelled using ABAQUS software. The numerical model is able to reproduce the key characteristics of the experimental response. Based on the numerical analysis, the critical base plate thickness to identify the base plate and anchor rod yield mechanism is proposed. For the connection with base plate yield mechanism, the resisting moment is carried by the flexural bending of the base plate. Yield lines in the base plate on the tension side and compression side are illustrated, respectively. This type of connection exhibits a relatively large energy dissipation. For the connection with anchor rod yield mechanism, the moment is resisted through a combination of bearing stresses of concrete foundation on the compression side and tensile forces in the anchor rods on the tension side. This type of connection exhibits self-centering behavior and shows higher initial stiffness and bending strength. In addition, the methods to predict the moment resistance of the connection with different yield mechanisms are presented. And the evaluated moment resistances agree well with the values obtained from the FEM model.

Influence of raw material grain composition on the properties of fused silica ceramics

Qingtao Wang,Sen Li,Huaqin Yu,Fengzhi Li,Huijun Xu,Haibo Qiao,Juncheng Liu,Qingyang Du 한양대학교 세라믹연구소 2017 Journal of Ceramic Processing Research Vol.18 No.8

Fused silica ceramics were prepared by slip casting method with various particle sizes (d50 ≈ 2.31 μm, 19.79 μm, and 71.46 μm)from three types of fused silica powder. The influence of raw material grain composition on the viscosity of slurry, bulk density,porosity, water absorption, and flexural strength of the fused silica ceramics was investigated. The slurry viscosity wasmeasured by an XND-1 viscometer. The bulk density, porosity, and water absorption of the sintered samples were obtainedby the Archimedes method. The flexural strength was measured by a three-point bending test. The phase composition andmicrostructure of the samples were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Theresults show that when the grain composition was 5 : 3 : 2, slurry viscosity was 150.79 mPa·s with solid content of 75%, thefused silica ceramic particles were packed most tightly and demonstrate bulk density of 2.02 g/cm3, porosity of 6.99%, waterabsorption of 3.47%, and flexural strength of 51.27 MPa.