도시공원을 활용한 산림치유프로그램이 고령노인의 우울과 기억감퇴에 미치는 영향 -곤지암 도자공원을 사례로

이은진 ( Eunjin Lee ),박봉주 ( Bongju Park ),왕금옥 ( Geumok Wang ),이현홍 ( Hyunhong Lee ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.6

본 연구는 생활권내 도시공원을 활용한 산림치유프로그램이 고령노인의 우울과 주관적 기억감퇴에 미치는 영향을 알아보고자 하였다. 연구대상자는 경기도 K시에 거주중인 75세 이상의 여성 고령노인 10명이었으며 주1회 2시간씩 총 7회의 산림치유 프로그램을 실시하였다. 본 프로그램의 효과를 검증하기 위해 단축형 노인우울 척도(GDSSF-K)와 주관적 기억감퇴 설문지(SMCQ)를 프로그램 전후에 평가하였다. 자료 분석에는 SPSS ver 18.0을 사용하였으며 Shapiro-Wilk test로 정규성을, Wilcoxon signed rank test로 통계검증을 실시하였다. 분석결과 도시공원에서 산림치유프로그램이 고령노인의 우울 완화에 긍정적인 효과가 있음을 확인했다. 이는 지역사회 노인을 위한 복지 서비스에 유용하게 이용될 수 있을 것으로 사료된다. The purpose of study was to find out the effects of forest healing programs using urban parks in the living area on depression and subjective memory loss in older old people. The subjects of this study were 10 elderly women aged 75 or older living in K city, Gyeonggi-do, and a total of seven times forest healing programs were conducted once a week for two hours. In order to verify the effectiveness of this program, the Geriartric Depress Scale Short Form-Korea Version (GDSSF-K) and the Subjective Memory Complaints Questionnaire (SMCQ) were used to evaluate before and after the program. SPSS ver 18.0 was used for data analysis, normality was performed with the Shapiro-Wilk test, and statistical verification was performed with the Wilcoxon signed rank test. Forest healing programs at urban parks in the living area have been confirmed to have a positive effect on depression relief for older old people. It is thought that this can be usefully used for welfare services for the elderly in the community.

Enzymatic Process for High-Yield Turanose Production and Its Potential Property as an Adipogenesis Regulator

Park, Min-Oh,Lee, Byung-Hoo,Lim, Eunjin,Lim, Ji Ye,Kim, Yuri,Park, Cheon-Seok,Lee, Hyeon Gyu,Kang, Hee-Kwon,Yoo, Sang-Ho American Chemical Society 2016 Journal of agricultural and food chemistry Vol.64 No.23

<P>Turanose is a sucrose isomer naturally existing in honey and a promising functional sweetener due to its low glycemic response. In this study, the extrinsic fructose effect on turanose productivity was examined in Neisseria amylosucrase reaction. Turanose was produced, by increasing the amount of extrinsic fructose as a reaction modulator, with high concentration of sucrose substrate, which resulted in 73.7% of production yield. In physiological functionality test, lipid accumulation in 3T3-L1 preadipocytes in the presence of high amounts of pure glucose was attenuated by turanose substitution in a dose-dependent manner. Turanose treatments at concentrations representing 50%, 75%, and 100% of total glucose concentration in cell media significantly reduced lipid accumulation by 18%, 35%, and 72%, respectively, as compared to controls. This result suggested that turanose had a positive role in controlling adipogenesis, and enzymatic process of turanose production has a potential to develop a functional food ingredient for controlling obesity and related chronic diseases.</P>

Inhibition of Apoptosis by Elaeocarpus sylvestris in Mice Following Whole-body Exposure to Ionizing Radiation: Implications for Radioprotectors

Eunjin Park,Nam Ho Lee,Gin-nae Ahn,Jong Seok Baik,Jehee Lee,Kyu-Kye Hwang,Jae Woo Park,Youngheun Jee 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4

Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1, 2, 3, 4, 6-penta-O-galloyl-beta-D-glucose (PGG), is reported to have the ability to scavenge oxygen radicals, thereby protecting rat neuronal cells from oxidative damage. The potential of an E.S. extract, which contains a rich PGG, to protect radiosensitive lymphocytes and intestinal crypt cells from radiation injury induced by a single whole-body irradiation (WBI) in vivo was investigated. Our results demonstrated that in immune cells, E.S. treatment decreased the percent of tail DNA, a parameter of DNA damage, compared with levels in untreated, irradiated controls. Furthermore, apoptosis was significantly decreased in lymphocytes and intestinal crypt cells of E.S.-treated mice compared with irradiated controls. These results suggest that the E.S. extract can strengthen the radioresistance of radiosensitive lymphocytes and crypt cells by preventing apoptosis. Therefore, it was concluded that E.S. extract has the radioprotective effects in vivo through an inhibition of apoptosis.

Nontraumatic Myositis Ossificans After Spontaneous Subarachnoid Hemorrhage: A Case Report

Park Eunjin,Park Junghyeon,Chang So-youn,Kim Youngkook 대한뇌신경재활학회 2024 뇌신경재활 Vol.17 No.1

Myositis ossificans is uncommon in patients with nontraumatic brain injuries. This report presents a challenging case in which myositis ossificans was diagnosed and treated by medical management in a patient who was unable to complain of any symptoms due to akinetic mutism that occurred after nontraumatic subarachnoid hemorrhage. The patient had intermittent high-grade fever, and laborator y tests showed elevated C-reactive protein and D-dimer levels without clinical signs of infection two months after subarachnoid hemorrhage. Lower-extremity venography using computed tomography was performed to rule out deep venous thrombosis. There was no thrombus, but right vastus medialis muscle showed inflammator y change with faint multilayered cur vilinear hyperdense rims. The administration of indomethacin helped prevent abnormal bone formation. For the early detection of myositis ossificans, careful obser vation of clinical presentation and a high index of clinical suspicion is necessar y in brain-injured patients. Further, elevated serum inflammator y markers accompanied by elevated alkaline phosphatase can be a critical clue. Early computed tomography helps identif y early ‘string sign’ prior to characteristic ossification. Our report highlights that the myositis ossificans is remediable by early detection and appropriate nonsurgical management

Synthesis and biological evaluation of <i>N</i>9-<i>cis</i>-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors

Park, Sun Jun,Kim, Eunjin,Yoo, Miyoun,Lee, Joo-Youn,Park, Chi Hoon,Hwang, Jong Yeon,Ha, Jae Du Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.18

<P><B>Abstract</B></P> <P>A novel 6-aminopurine scaffold bearing an <I>N</I>9-<I>cis</I>-cyclobutyl moiety was designed using structure-based molecular design based on two known CDK inhibitors, dinaciclib and Cmpd-27. A series of novel 6-aminopurine compounds was prepared for structure–activity relationship (SAR) studies of CDK2 and CDK5 inhibitors. Among the compounds synthesized, compound <B>8l</B> displayed potent CDK2 and CDK5 inhibitory activities with low nanomolar ranges (IC<SUB>50</SUB> =2.1 and 4.8nM, respectively) and showed moderate cytotoxicity in HCT116 colon cancer and MCF7 breast cancer cell lines. Here, we report the synthesis and evaluation of novel 6-aminopurine derivatives and present molecular docking models of compound <B>81</B> with CDK2 and CDK5.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

[P8-274] Radioprotective Effect of Fucoidan against Hematopoietic and Small Intestinal Stem Cells of γ-ray Irradiated Mice

Eunjin Park,Song Mo Jeon,Ginnae Ahn,Youngheun Jee 한국식품영양과학회 2008 한국식품영양과학회 학술대회발표집 Vol.2008 No.10

Fisetin Protects C2C12 Mouse Myoblasts from Oxidative Stress-Induced Cytotoxicity through Regulation of the Nrf2/HO-1 Signaling

Park Cheol,Cha Hee-Jae,Kim Da Hye,Kwon Chan-Young,Park Shin-Hyung,Hong Su Hyun,Bang EunJin,Cheong Jaehun,Kim Gi-Young,Choi Yung Hyun 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5

Fisetin is a bioactive flavonol molecule and has been shown to have antioxidant potential, but its efficacy has not been fully validated. The aim of the present study was to investigate the protective efficacy of fisetin on C2C12 murine myoblastjdusts under hydrogen peroxide (H2O2)-induced oxidative damage. The results revealed that fisetin significantly weakened H2O2-induced cell viability inhibition and DNA damage while blocking reactive oxygen species (ROS) generation. Fisetin also significantly alleviated cell cycle arrest by H2O2 treatment through by reversing the upregulation of p21WAF1/CIP1 expression and the downregulation of cyclin A and B levels. In addition, fisetin significantly blocked apoptosis induced by H2O2 through increasing the Bcl-2/Bax ratio and attenuating mitochondrial damage, which was accompanied by inactivation of caspase-3 and suppression of poly(ADP-ribose) polymerase cleavage. Furthermore, fisetin-induced nuclear translocation and phosphorylation of Nrf2 were related to the increased expression and activation of heme oxygenase-1 (HO-1) in H2O2- stimulated C2C12 myoblasts. However, the protective efficacy of fisetin on H2O2-mediated cytotoxicity, including cell cycle arrest, apoptosis and mitochondrial dysfunction, were greatly offset when HO-1 activity was artificially inhibited. Therefore, our results indicate that fisetin as an Nrf2 activator effectively abrogated oxidative stress-mediated damage in C2C12 myoblasts.

2D Laplace-Domain Waveform Inversion of Field Data Using a Power Objective Function

Park, Eunjin,Ha, Wansoo,Chung, Wookeen,Shin, Changsoo,Min, Dong-Joo Springer-Verlag 2013 Pure and applied geophysics Vol.170 No.12

A mixture of fucoxanthin and punicic acid prevents obesity in high-fat diet-induced obese mice

PARK Eunjin,YOO Hwan-Soo 한국특수교육학회 2014 한국특수교육학회 학술대회 Vol.2014 No.-

Between Two Worlds : Identity Problems of Nineteenth-Century Black American Methodist Missionaries to Africa

Park, Eunjin 한국미국사학회 2002 미국사연구 Vol.16 No.-

19세기 초 미국의 흑인들을 아프리카로 되돌려 보내 그들만의 나라를 건설하여 살도록 하기 위한 취지에서 만들어진 식민지 라이베리아는 미국 교회들의 아프리카 선교를 촉진하였다. 그러나 ‘백인들의 무덤’이라고 일컬어질 정도로 풍토병이 심각했던 아프리카의 기후로 인해 아프리카 선교를 위해 자원하는 백인들 은 그리 많지 않았다. 아프리카 기후에 태생적 적응력을 갖고 있다고 믿어지던 흑인들을 아프리카 선교를 위한 선교사로 채용한 것은 바로 이러한 배경에서였다. 본 논문은 미국 교회들 중 가장 많은 흑인 선교사들을 채용했던 감리교의 경우를 통해 흑인 선교사들의 정체성 문제를 다루었다. 아프리카 선교 현장에서 흑인 선교사들의 정체성을 규정할 수 있는 가능성은 두 가지였다. 하나는 선교 대상인 아프리카 본토인들과 인종적으로 동일시하는 것이었고, 다른 하나는 백인 선교사 ‘동료들’과 문화적으로 동일시하는 것이었다. 먼저, 본국 선교본부는 흑인 선교사들의 정체성을 인종적으로 규정하려는 태도 가 역력했다. 비록 필요와 편의에 의해 흑인 선교사들을 채용하기는 했지만, 그 리고 비록 아프리카 본토인들에 비해서 상대적으로 더 문명화되긴 했지만, 그들 은 태어나면서부터 열등한 인종이었다. 따라서 그들의 주된 의무는 백인 선교사 들을 보조하는 것이었다. 그러나 흑인 선교사들로서는 자신들을 아프리카인들과 동일시할 이유가 전혀 없었다. 무엇보다 ‘선교사’로서의 임무와 역할이 선교 대 상과의 차별화를 전제로 한 것이었으며 자신들을 파견한 나라의 주류 문화를 ‘대 표’하는 것을 전제로 한 것이었다. 따라서 선교사로서 아프리카 본토인들을 단순 히 문화적 승급이 필요한 미개하고 야만스러운 사람들로 보는 것은 당연한 일이었다. 또한 실제 선교사역을 하면서 경험한 바대로의 아프리카 풍습은 흑인 선교사들로 하여금 더더욱 자신들과 선교대상자들의 문화적 ‘우열’을 확인시켜줄 뿐이었다. 흑인 선교사들의 정체성에 대한 견해의 차이는 아프리카 선교에 치명적인 결과를 초래하였다. 더 이상 백인 자원자들을 구할 수 없게 된 19세기 중반에 이르러 아프리카 선교는 전적으로 흑인 선교사들에 의해 수행될 수밖에 없게 되었다. 그동안의 선교 경험과 기여를 미루어볼 때 흑인 선교사들은 자신들에게 진정한 자율권을 본부가 보장해줄 것을 기대하고 또 요구하였다. 그러나 선교지에 영구 적으로 정착하여 살고 있던 흑인 선교사들이 선교자금을 유용할 가능성에 대해 항상 우려하고 있었던 본부로서는 흑인 선교사들에게 선교자금의 운용에 있어서 자율성을 부여할 수가 없었다. 더욱이 그들은 태생적으로 열등하지 않은가. 따라 서 선교 본부는 부득이 임시방편으로 흑인 지도력 밑에 아프리카 선교를 맡기기 는 했어도, 점점 더 세밀하게 선교사역과 자금 운영에 있어서 일일이 지시하고 보고하게 하였다. 이러한 상호 불신은 결국 선교의 효율성 저하를 초래하게 되었으며, 선교본부는 아프리카 선교 실패의 원인을 흑인 선교사들의 무능, 불성실 및 부패로 돌리게 되었다. 결국 미국에서의 사회적, 인종적 편견으로부터 자유로워지고 자신들의 능력을 증명할 수 있는 기회를 맞았던 흑인 선교사들의 기대는 실현되지 못하였다.