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Eunji Lee,Soon Hyung Kwon,Poo Reum Choi,Ji Chul Jung,Myung-Soo Kim 한국탄소학회 2015 Carbon Letters Vol.16 No.2
Activated carbons (ACs) were prepared by activation of coal tar pitch (CTP) in the range of 700°C-1000°C for 1-4 h using potassium hydroxide (KOH) powder as the activation agent. The optimal activation conditions were determined to be a CTP/KOH ratio of 1:4, activation temperature of 900°C, and activation time of 3 h. The obtained ACs showed increased pore size distribution in the range of 1 to 2 nm and the highest specific capacitance of 122 F/g in a two-electrode system with an organic electrolyte, as measured by a charge-discharge method in the voltage range of 0-2.7 V. In order to improve the performance of the electric double-layer capacitor electrode, various mixtures of CTP and petroleum pitch (PP) were activated at the optimal activation conditions previously determined for CTP. Although the specific capacitance of AC electrodes prepared from CTP only and the mixtures of CTP and PP was not significantly different at a current density of 1 A/g, the AC electrodes from CTP and PP mixtures showed outstanding specific capacitance at higher current rates. In particular, CTP-PP61 (6:1 mixture) had the highest specific capacitance of 132 F/g, and the specific capacitance remained above 90% at a high current density of 3 A/g. It was found that the high specific capacitance could be attributed to the increased micro-pore volume of ACs with pore sizes from 1 to 2 nm, and the high power density could be attributed to the increased meso-pore volume.
Eunji Choi,Sangeun Lee,Bui Cam Nhung,Mina Su,Boyoung Park,Jae Kwan Jun,Kui Son Choi 한국역학회 2017 Epidemiology and Health Vol.39 No.-
OBJECTIVES: Assessing long-term success and efficiency is an essential part of evaluating cancer control programs. The mortality-to-incidence ratio (MIR) can serve as an insightful indicator of cancer management outcomes for individual nations. By calculating MIRs for the top five cancers in Organization for Economic Cooperation and Development (OECD) countries, the current study attempted to characterize the outcomes of national cancer management policies according to the health system ranking of each country. METHODS: The MIRs for the five most burdensome cancers globally (lung, colorectal, prostate, stomach, and breast) were calculated for all 34 OECD countries using 2012 GLOBOCAN incidence and mortality statistics. Health system rankings reported by the World Health Organization in 2000 were updated with relevant information when possible. A linear regression model was created, using MIRs as the dependent variable and health system rankings as the independent variable. RESULTS: The linear relationships between MIRs and health system rankings for the five cancers were significant, with coefficients of determination ranging from 49 to 75% when outliers were excluded. A clear outlier, Korea reported lower-than-predicted MIRs for stomach and colorectal cancer, reflecting its strong national cancer control policies, especially cancer screening. CONCLUSIONS: The MIR was found to be a practical measure for evaluating the long-term success of cancer surveillance and the efficacy of cancer control programs, especially cancer screening. Extending the use of MIRs to evaluate other cancers may also prove useful.
Fabrication of dihydroxyflavone-conjugated hyaluronic acid nanogels for targeted antitumoral effect
Choi, Yu Ri,Kim, Hyun-Jong,Ahn, Guk Young,Lee, Min Jeong,Park, Ju Ri,Jun, Dae-Ryong,Ryu, Tae-Kyoung,Park, Joo Woong,Shin, Eunji,Choi, Sung-Wook Elsevier 2018 Colloids and Surfaces B Vol.171 No.-
<P><B>Abstract</B></P> <P>We prepared hyaluronic acid (HA)-based nanogels conjugated with dihydroxyflavone (DHF) and evaluated their cellular uptake and antitumoral efficiency. 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) was used as a conjugation agent for esterification between DHF and HA as well as crosslinking among HA. The conjugations were confirmed by nuclear magnetic resonance spectroscopy, UV/vis spectroscopy, and high-performance liquid chromatography. The size and Zeta-potential of the DHF/HA nanogels were reduced with an increase in the concentration of DMTMM due to the involvement of more HA molecules for the conjugation reactions. The DHF/HA nanogel with a smaller size was greatly taken up by two kinds of tumor cells (HeLa and HepG2), compared to NIH3T3. The cell viabilities were reduced to approximately 60% for HeLa and HepG2 cells after 48 h post treatment with DHF/HA nanogels.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hyaluronic acid molecules are conjugated among themselves in nanogel form. </LI> <LI> Dihydroxyflavones are conjugated to hyaluronic acid nanogels. </LI> <LI> A low concentration of a conjugation agent leads to the nanogel size reduction. </LI> <LI> The nanogel specifically reduced the viability of tumor cells to approximately 60%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Choi, Eunji,Oh, Jungju,Lee, Dahee,Lee, Jaewon,Tan, Xiaonan,Kim, Minkyung,Kim, Gyeungyun,Piao, Chunxian,Lee, Minhyung Elsevier 2018 Journal of controlled release Vol.279 No.-
<P><B>Abstract</B></P> <P>The receptor for advanced glycation end-products (RAGE) is involved in tumor angiogenesis. Inhibition of RAGE might be an effective anti-angiogenic therapy for cancer. In this study, a cationic RAGE-binding peptide (RBP) was produced as an antagonist of RAGE, and a ternary-complex consisting of RBP, polyethylenimine (2 kDa, PEI2k), and a suicide gene (pHSVtk) was developed as a gene delivery system with dual functions: the anti-tumor effect of pHSVtk and anti-angiogenic effect of RBP. As an antagonist of RAGE, RBP decreased the secretion of vascular-endothelial growth factor (VEGF) in activated macrophages and reduced the tube-formation of endothelial cells <I>in vitro</I>. In <I>in vitro</I> transfection assays, the RBP/PEI2k/plasmid DNA (pDNA) ternary-complex had higher transfection efficiency than the PEI2k/pDNA binary-complex. In an intracranial glioblastoma animal model, the RBP/PEI2k/pHSVtk ternary-complex reduced α-smooth muscle actin expression, suggesting that the complex has an anti-angiogenic effect. In addition, the ternary-complex had higher pHSVtk delivery efficiency than the PEI2k/pHSVtk and PEI25k/pHSVtk binary-complexes in an animal model. As a result, the ternary-complex induced apoptosis and reduced tumor volume more effectively than the PEI2k/pHSVtk and PEI25k/pHSVtk binary-complexes. In conclusion, due to its dual anti-tumor and anti-angiogenesis effects, the RBP/PEI2k/pHSVtk ternary-complex might be an efficient gene delivery system for the treatment of glioblastoma.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Choi, Eunji,Cho, Eun-Bum,Jaroniec, Mietek The Royal Society of Chemistry 2017 Journal of Materials Chemistry A Vol.5 No.40
<P>Periodic mesoporous organosilicas were prepared using 1,2-bis(triethoxysilyl)ethane (BTEE) in the presence of a poly(ethylene oxide)-<I>b</I>-poly(d,l-lactic acid-<I>co</I>-glycolic acid)-<I>b</I>-poly(ethylene oxide) triblock copolymer (LGE538) template under strongly and weakly acidic conditions. White solid powders were obtained even under weakly acidic conditions using iron chloride hexahydrate. Small angle X-ray scattering (SAXS) and nitrogen adsorption isotherms showed a highly ordered hexagonal (<I>p</I>6<I>mm</I>) mesostructure and a high specific surface area of around 1000 m<SUP>2</SUP>g<SUP>−1</SUP>. The hydrothermal stability of these materials was also investigated because it is a crucial factor in their usage in the chemical industry. The powders were placed in sealed vials inside a convection oven at 373 K for 4 weeks. The hydrothermally treated samples were analyzed every week over the 4 weeks using SAXS and nitrogen adsorption. Solid-state<SUP>29</SUP>Si CP-MAS NMR analysis was also performed to observe the stability of siloxane bonds over the 4 weeks of hydrothermal treatment. The results indicate that the ethane-silica samples show quite good stability, which makes them attractive as catalysts or supporting materials for up to one month.</P>
Eunji Choi,Kelly L. Reddy-Best 한국복식학회 2021 International journal of costume and fashion Vol.21 No.2
The purpose of this research was to critically examine beauty ideals, specifically those related to race and racial hierarchies, with a focus on fashion magazines published in South Korea targeting South Korean women. We used the content analysis method to examine Céci magazine from 2013 to 2017. This magazine is highly popular, widely circulated in South Korea, and produced by a South Korean publisher. Each individual pictured in the magazine was coded into four categories: race, skin color, hair color, and facial characteristics. Descriptive statistics and Pearson’s chi-square were used to analyze the data. Overall, the magazines featured more Asian than White individuals, yet Asians conformed to significantly more White than Asian beauty ideals as well as other beauty ideals that are mostly unnatural to Asian women.