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Erçelik Zübeyde Ezgi,Çağlar Seda 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.2
Purpose: The purpose of this review was to assess the effect of active video games among overweight and obese adolescents. Methods: A systematic review and meta-analysis were conducted using records from the English-language electronic databases MEDLINE, the Web of Science, and PubMed. These databases were searched from January 2010 to December 2020 using the keywords (adolescent*) AND (overweight OR obese *) AND (active video games OR exergaming * OR video game*). Results: Five articles met the inclusion criteria. Four studies were conducted in the United States of America and 1 study was conducted in Canada. In addition, all included articles had a randomized controlled trial study design. It was determined that the sample size of the studies was 30–46 participants and there were a total of 195 overweight and obese adolescents across the included studies. Active video gaming was negatively associated with changes in body mass index percentile (mean difference [MD], -1.77; 95% confidence interval [CI], -2.55 to -0.99; P<0.001) and total cholesterol (MD, -11.16; 95% CI, -16.64 to -5.68; P<0.001). Conclusion: Playing active video games can reduce both the body mass index percentile and total cholesterol in overweight and obese adolescents. Active video games can provide a different method for combating childhood obesity. High-quality randomized controlled trials are recommended to assess the impact of game-based interventions.
Ersöz Gonca,Simona Rapposelli,Faruk Darıcı,Maria Digiacomo,Zehra Yılmaz 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9
‘Compound A’ (4ı-(N-(4-acetamidobenzyl))-2,2- dimethyl-2,3-dihydro-5ıH-spiro[chromene-4,2ı-[1,4]oxazinan]- 5ı-one) is a new spiro-cyclic benzopyran activator of the mitochondrial ATP-dependent potassium channels (mitoKATP). We researched the effect of compound A on ischemia/reperfusion (I/R)-induced ventricular arrhythmias. We also tested the hypothesis that the application of the activation of mitoKATP in combination with the inhibition of sarcolemmal ATP-dependent potassium channels (sarcKATP) may produce a stronger antiarrhythmic effect. In anesthetized rats, myocardial ischemia was performed by ligating the left main coronary artery followed by reperfusion. At a dose of 10 mg/kg, compound A significantly decreased arrhythmia scores and the total length of arrhythmias, whereas this was found to be ineffective at a dose of 3 mg/kg. Pre-treatment with 5-HD, a selective mitoKATP blocker, abolished the antiarrhythmic effect of compound A. Both diazoxide, a selective mitoKATP opener and HMR 1098, a selective sarcKATP blocker, significantly decreased the total length of arrhythmias. However, the combination of neither diazoxide nor compound A with HMR 1098 showed no additional therapeutic benefit. These results reveal that compound A may have a dose-dependent antiarrythmic effect, which is more pronounced than the antiarrhythmic effect of diazoxide. The antiarrhythmic effect of compound A may possibly depend on mitoKATP activation.
Ersöz Eda,Altintas Yildirim Ozlem 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.5
In this study, silver (Ag)-doped zinc oxide (ZnO) nanofiber photocatalysts were synthesized using electrospinning method. To understand the effect of Ag doping on the photocatalytic efficiencies, ZnO nanofibers were prepared with diff erent load- ing ratios (0, 0.3, 0.5, 1.0 at.% Ag). The synthesized nanofibers were characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), ultraviolet–visible (UV–Vis) spectroscopy and photoluminescence (PL) spectroscopy techniques. The photocatalytic performances of the fibers were first evaluated by measuring the photodegradation of methylene blue (MB) under the UV light irradiation. It was found that the amount of dopant ions has a crucial effect on the degradation process of MB. The results show that 0.5 at.% Ag dopant dosage is the ideal to achieve maximum catalytic efficiency against MB dye molecules with nearly complete decolorization just after 75 min UV light irradiation. During the degradation process, the substitutional incorporation of dopant ions provides better photocatalytic efficiency due to forming higher number of charge carriers and so delaying the recombination process. The recycling experiments for MB dye degradation were performed to determine the conservation of the catalytic efficiency and chemical stability of the nanofibers. To compare the photocatalytic efficiency of nanofibers against different dye molecules, the degradation performance of 0.5 at.% Ag-doped ZnO nanofibers was also experimentally examined by the measuring the photocatalytic degradation rates of various harmful organic dyes such as Rhodamine B (RhB) and methylene orange (MO) under the UV light irradiation. It was found that the photodegradation rates of RhB and MO synthetic dye solutions are determined as follows: ~ 66% and ~ 51% decomposition after 120 min UV light irradiation, respectively. A possible mechanism for the improvement of the photocatalytic performance of ZnO nanofibers by Ag loading is proposed.
Erçelik Zübeyde Ezgi,Çağlar Seda 대한소아내분비학회 2022 Apem Vol.27 No.2
Purpose: The purpose of this review was to assess the effect of active video games among overweight and obese adolescents.Methods: A systematic review and meta-analysis were conducted using records from the English-language electronic databases MEDLINE, the Web of Science, and PubMed. These databases were searched from January 2010 to December 2020 using the keywords (adolescent*) AND (overweight OR obese *) AND (active video games OR exergaming * OR video game*).Results: Five articles met the inclusion criteria. Four studies were conducted in the United States of America and 1 study was conducted in Canada. In addition, all included articles had a randomized controlled trial study design. It was determined that the sample size of the studies was 30–46 participants and there were a total of 195 overweight and obese adolescents across the included studies. Active video gaming was negatively associated with changes in body mass index percentile (mean difference [MD], -1.77; 95% confidence interval [CI], -2.55 to -0.99; p<0.001) and total cholesterol (MD, -11.16; 95% CI, -16.64 to -5.68; p<0.001).Conclusion: Playing active video games can reduce both the body mass index percentile and total cholesterol in overweight and obese adolescents. Active video games can provide a different method for combating childhood obesity. High-quality randomized controlled trials are recommended to assess the impact of game-based interventions.
Mirac Berke Topcu Ersöz,Emre Mumcu 대한치과보철학회 2022 The Journal of Advanced Prosthodontics Vol.14 No.6
PURPOSE. Four and six implant-supported fixed full-arch prostheses with various framework materials were assessed under different loading conditions. MATERIALS AND METHODS. In the edentulous maxilla, the implants were positioned in a configuration of four to six implant modalities. CoCr, Ti, ZrO2,and PEEK materials were used to produce the prosthetic structure. Using finite element stress analysis, the first molar was subjected to a 200 N axial and 45°oblique force. Stresses were measured on the bone, implants, abutment screw, abutment, and prosthetic screw. The Von Mises, maximum, and minimum principal stress values were calculated and compared. RESULTS. The maximum and minimum principal stresses in bone were determined as CoCr < ZrO2 < Ti < PEEK. The Von Mises stresses on the implant, implant screw, abutment, and prosthetic screws were determined as CoCr < ZrO2 < Ti < PEEK. The highest VonMises stress was 9584.4 Mpa in PEEK material on the prosthetic screw under 4 implant-oblique loading. The highest maximum principal stress value in bone wasfound to be 120.89 Mpa, for PEEK in 4 implant-oblique loading. CONCLUSION. For four and six implant-supported structures, and depending on the loading condition, the system accumulated different stresses. The distribution of stress was reduced in materials with a high elastic modulus. When choosing materialsfor implant-supported fixed prostheses, it is essential to consider both the number of implants and the mechanical and physical attributes of the framework material.
Yi gitcan Sümbelli,Özlem Biçen Ünlüer,Arzu Ersöz,Rıdvan Say 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.76 No.-
In this study, binanoenzyme (BNE) was synthesized using FateDH and Cyt-C in same bionano-interface;by formation of formate dehydrogenase-co-cytochrome C by using ANADOLUCA method. Thesynthesized novel binanoenzyme was embedded into HEMA based cryogel column and the conversionof CO2 to formic acid was investigated by using this cryogel column. To maintain the conversion, CO2saturated water was passed through the cryogel column and the converted formic acid was analyzedusing HPLC. The parameters which has an effect on conversion such as pH, sample volume and CO2concentration were analyzed. The results showed that the conversion process was succeeded effectively.
Yavaş Cüneyd,Doğan Mustafa,Eröz Recep,Türegün Kübra 한국유전학회 2024 Genes & Genomics Vol.46 No.5
Background Nemaline Myopathy (NM) is a rare genetic disorder that affects muscle function and is characterized by the presence of nemaline rods in muscle fibers. These rods are abnormal structures that interfere with muscle contraction and can cause muscle weakness, respiratory distress, and other complications. NM is caused by variants in several genes, including TNNT1, which encodes the protein troponin T1. NM is inherited in an autosomal recessive pattern. The prevalence of heterozygous TNNT1 variants has been reported to be 1/152,000, indicating that the disease is relatively rare. Objective Investigation of TNNT1 gene variants that may cause cretin kinase elevation. Methods Detailed family histories and clinical data were recorded. Whole exome sequencing was performed and family segregation was done by Sanger sequencing. Results In this study, we report a 5-year-old girl with a novel variant recessive congenital TNNT1 myopathy. The patient had a novel homozygous (c.271_273del) deletion in the TNNT1 gene that is associated with creatine kinase elevation, which is a marker of muscle damage. Conclusion This case expands the phenotypic spectrum of TNNT1 myopathy and highlights the importance of genetic testing and counseling for families affected by this rare disorder. In this study provides valuable insights into the genetic basis of NM and highlights the importance of early diagnosis and management for patients with this rare disorder. Further research is needed to better understand the pathophysiology of TNNT1 myopathy and to develop effective treatments for this debilitating condition. Background Nemaline Myopathy (NM) is a rare genetic disorder that affects muscle function and is characterized by the presence of nemaline rods in muscle fibers. These rods are abnormal structures that interfere with muscle contraction and can cause muscle weakness, respiratory distress, and other complications. NM is caused by variants in several genes, including TNNT1, which encodes the protein troponin T1. NM is inherited in an autosomal recessive pattern. The prevalence of heterozygous TNNT1 variants has been reported to be 1/152,000, indicating that the disease is relatively rare. Objective Investigation of TNNT1 gene variants that may cause cretin kinase elevation. Methods Detailed family histories and clinical data were recorded. Whole exome sequencing was performed and family segregation was done by Sanger sequencing. Results In this study, we report a 5-year-old girl with a novel variant recessive congenital TNNT1 myopathy. The patient had a novel homozygous (c.271_273del) deletion in the TNNT1 gene that is associated with creatine kinase elevation, which is a marker of muscle damage. Conclusion This case expands the phenotypic spectrum of TNNT1 myopathy and highlights the importance of genetic testing and counseling for families affected by this rare disorder. In this study provides valuable insights into the genetic basis of NM and highlights the importance of early diagnosis and management for patients with this rare disorder. Further research is needed to better understand the pathophysiology of TNNT1 myopathy and to develop effective treatments for this debilitating condition.
Kamburoğlu Kıvanç,Samunahmetoğlu Erçin,Eratam Nejlan,Sönmez Gül,Karahan Sevilay 대한영상치의학회 2022 Imaging Science in Dentistry Vol.52 No.1
Purpose: This study compared the effectiveness of complementary metal-oxide semiconductors (CMOS) and photostimulable phosphor (PSP) plates as intraoral imaging systems in terms of time efficacy, patient comfort, and subjective image quality assessment in real clinical settings. Materials and Methods: Fifty-eight patients (25 women and 33 men) were included. Patients were referred for a full-mouth radiological examination including 1 bitewing radiograph (left and right) and 8 periapical radiographs for each side (left maxilla/mandible and right maxilla/mandible). For each patient, 1 side of the dental arch was radiographed using a CMOS detector, whereas the other side was radiographed using a PSP detector, ensuring an equal number of left and right arches imaged by each detector. Clinical application time, comfort/pain, and subjective image quality were assessed for each detector. Continuous variables were summarized as mean±standard deviation. Differences between detectors were evaluated using repeated-measures analysis of variance. P<0.05 was accepted as significant. Results: The mean total time required for all imaging procedures with the CMOS detector was significantly lower than the mean total time required for imaging procedures with PSP (P<0.05). The overall mean patient comfort scores for the CMOS and PSP detectors were 4.57 and 4.48, respectively, without a statistically significant difference (P>0.05). The performance of both observers in subjectively assessing structures was significantly higher when using CMOS images than when using PSP images for all regions (P<0.05). Conclusion: The CMOS detector was found to be superior to the PSP detector in terms of clinical time efficacy and subjective image quality.
Gülen Tekin,Gülin Ersöz,Süheyda Atalay 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-
The study focused on synthesis of BiOI/g-C3N4 heterojunction photocatalysts by various methods toinvestigate their physicochemical properties as well as their performances on photocatalytic treatmentof sugar processing wastewater. The heterojunction catalysts possessed enhanced catalytic activity comparedto the pristine BiOI and g-C3N4. In-situ growth of BiOI on g-C3N4 was determined as the mostpromising method when the pH of the synthesis medium was adjusted to 10. This method provided amore homogeneous distribution and smaller size for the BiOI clusters that formed a unique flower shapewhich enhanced the catalytic activity remarkably. This depicts that synthesis conditions are especiallyimportant to obtain desired physicochemical properties for a photocatalyst since it has a key role inthe crystal structure of BiOI. The optimum nominal weight ratio was determined as 75:25 for BiOI andg-C3N4, respectively by considering the superior morphology and the highest photocatalytic activityfor 45.30% and 23.40% total saccharide (TSC) and total organic carbon (TOC) removal, respectively. Thephotocatalytic mechanism depicted that charge separation in the heterojunction structure was accomplishedvia the new S-scheme and the oxidation of saccharides and intermediates followed differentpathways by reacting with different radicals.