Reduced Fertility and Fecundity among Patients with Bipolar I Disorder and Schizophrenia in Egypt

Hader Mansour,Kareem Kandil,Warda Fathi,Mai Elassy,Ibtihal Ibrahim,Hala Salah,Amal Yassin,Hanan Elsayed,Salwa Tobar,Hala El-Boraie,Ahmed Eissa,Mohamed Elhadidy,Nahed E. Ibrahim,Wafaa El-Bahaei,Vishwaj 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.3

Objective To evaluate reproduction among patients with bipolar I disorder (BP1) or schizophrenia (SZ) in Egypt. Methods BP1 patients (n=113) were compared with community based, demographically balanced controls (n=124) and SZ patients (n=79, DSM-IV). All participants were evaluated using structured interviews and corroborative data were obtained from relatives. Standard indices of procreation were included in multivariate analyses that incorporated key demographic variables. Results Control individuals were significantly more likely to have children than BP1 or SZ patients (controls 46.8%, BP1 15.9%, SZ 17.7%), but the BP1-SZ differences were non-significant. The average number of children for BP1 patients (0.37±0.9) and SZ patients (0.38±0.9) was significantly lower than for controls (1.04±1.48) (BP1 vs controls, p<0.001; SZ vs controls, p<0.001). The frequency of marriages among BP1 patients was nominally higher than the SZ group, but was significantly lower than controls (BP1: 31.9% SZ: 27.8% control: 57.3%). Even among married individuals, BP1 (but not SZ) patients were childless more often than controls (p=0.001). The marital fertility, i.e., the average number of children among patients with conjugal relationships for controls (1.8±1.57) was significantly higher than BP1 patients (1.14±1.31, p=0.02), but not significantly different from SZ patients (1.36±1.32, p=0.2). Conclusion Selected reproductive measures are significantly and substantially reduced among Egyptian BP1 patients. The reproductive indices are similar among BP1 and SZ patients, suggesting a role for general illness related variables. Regardless of the cause/s, the impairment constitutes important, under-investigated disability. Objective To evaluate reproduction among patients with bipolar I disorder (BP1) or schizophrenia (SZ) in Egypt. Methods BP1 patients (n=113) were compared with community based, demographically balanced controls (n=124) and SZ patients (n=79, DSM-IV). All participants were evaluated using structured interviews and corroborative data were obtained from relatives. Standard indices of procreation were included in multivariate analyses that incorporated key demographic variables. Results Control individuals were significantly more likely to have children than BP1 or SZ patients (controls 46.8%, BP1 15.9%, SZ 17.7%), but the BP1-SZ differences were non-significant. The average number of children for BP1 patients (0.37±0.9) and SZ patients (0.38±0.9) was significantly lower than for controls (1.04±1.48) (BP1 vs controls, p<0.001; SZ vs controls, p<0.001). The frequency of marriages among BP1 patients was nominally higher than the SZ group, but was significantly lower than controls (BP1: 31.9% SZ: 27.8% control: 57.3%). Even among married individuals, BP1 (but not SZ) patients were childless more often than controls (p=0.001). The marital fertility, i.e., the average number of children among patients with conjugal relationships for controls (1.8±1.57) was significantly higher than BP1 patients (1.14±1.31, p=0.02), but not significantly different from SZ patients (1.36±1.32, p=0.2). Conclusion Selected reproductive measures are significantly and substantially reduced among Egyptian BP1 patients. The reproductive indices are similar among BP1 and SZ patients, suggesting a role for general illness related variables. Regardless of the cause/s, the impairment constitutes important, under-investigated disability.

Numerical analysis for structure-pile-fluid-soil interaction model of fixed offshore platform

Raheem, Shehata E. Abdel,Aal, Elsayed M. Abdel,AbdelShafy, Aly G.A.,Mansour, Mahmoud H.,Omar, Mohamed Techno-Press 2020 Ocean systems engineering Vol.10 No.3

In-place analysis for offshore platforms is required to make proper design for new structures and true assessment for existing structures. In addition, ensure the structural integrity of platforms components under the maximum and minimum operating loads and environmental conditions. In-place analysis was carried out to verify the robustness and capability of structural members with all appurtenances to support the applied loads in either operating condition or storm conditions. A nonlinear finite element analysis is adopted for the platform structure above the seabed and the pile-soil interaction to estimate the in-place behavior of a typical fixed offshore platform. The SACS software is utilized to calculate the natural frequencies of the model and to obtain the response of platform joints according to in-place analysis then the stresses at selected members, as well as their nodal displacements. The directions of environmental loads and water depth variations have an important effect on the results of the in-place analysis behavior. The influence of the soil-structure interaction on the response of the jacket foundation predicts is necessary to estimate the loads of the offshore platform well and real simulation of offshore foundation for the in-place analysis. The result of the study shows that the in-place response investigation is quite crucial for safe design and operation of offshore platform against the variation of environmental loads.

Structural performance assessment of fixed offshore platform based on in-place analysis

Raheem, Shehata E. Abdel,Aal, Elsayed M. Abdel,AbdelShafy, Aly G.A.,Mansour, Mahmoud H.,Omar, Mohamed Techno-Press 2020 Coupled systems mechanics Vol.9 No.5

In-place analysis for offshore platforms is essentially required to make proper design for new structures and true assessment for existing structures. The structural integrity of platform components under the maximum and minimum operating loads of environmental conditions is required for risk assessment and inspection plan development. In-place analyses have been executed to check that the structural member with all appurtenances robustness and capability to support the applied loads in either storm condition or operating condition. A nonlinear finite element analysis is adopted for the platform structure above the seabed and the pile-soil interaction to estimate the in-place behavior of a typical fixed offshore platform. The analysis includes interpretation of dynamic design parameters based on the available site-specific data, together with foundation design recommendations for in-place loading conditions. The SACS software is utilized to calculate the natural frequencies of the model and to obtain the response of platform joints according to in-place analysis then the stresses at selected members, as well as their nodal displacements. The directions of environmental loads and water depth variations have important effects on the results of the in-place analysis behavior. The result shows that the in-place analysis is quite crucial for safe design and operation of offshore platform and assessment for existing offshore structures.

Inducing Potential Mutants in Bread Wheat Using Different Doses of Certain Physical and Chemical Mutagens

Ghada M.Sh.M. Abaza,Hassan A. Awaad,Zakaria M. Attia,Khalid S. Abdel-lateif,Mohamed A. Gomaa,Safy M.Sh.M. Abaza,Elsayed Mansour 한국육종학회 2020 Plant Breeding and Biotechnology Vol.8 No.3

Mutation is an effective strategy not only for creating novel variation into crop genome but also for direct releasing adapted and high-yielding genotypes. The current work explores inducing genetic variability in bread wheat using physical and chemical mutagens. Three wheat cultivars were treated by three mutagens; gamma irradiation (five doses; 250, 300, 350, 400 and 450 Gray); laser ray (three treatments; 1, 1.5, and 2 hour exposure) and EMS (three concentrations; 0.2, 0.3 and 0.4%). Besides, a combination of physical (laser) and chemical (EMS) mutagens using middle range of each treatment (1.5 hour laser and 0.3% EMS) was attempted to be applied. The treated seeds were sown in the first season and 4050 M1 plants were harvested. The harvested seeds were sown in the second season, and 78750 M2 plants were obtained. The selection was performed in second season (M2) based on morpho-physiological and yield traits; flag leaf area, flag leaf chlorophyll content, plant height, spike length, grain yield per plant and its components. Based on evaluated traits fourteen mutants were selected to be evaluated in the third generation (M3). The results indicated that the used mutagens had direct impact and significantly improved agronomic traits in derivative mutants compared to their parent cultivars. Moreover, the maximum increment in yield related traits were obtained by 0.4% EMS, 1 and 2 hour-laser, 350-Gy, 1.5 hour × 0.3% EMS and 250-Gy. The obtained results highlighted the importance of these doses of applied mutagens to induce useful genetic variability in bread wheat for improving grain yield and contributing traits.