Flexural Performance of Composite Beams Using High-Strength Steel and High-Strength Concrete

Hao Du,Xiamin Hu,Danrong Shi,Wei Xue 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.1

The composite beams having high-strength steel (HSS) and high-strength concrete (HSC) can fully exploit the mechanical behavior of both materials. However, the published research on the structural behavior of composite beams using HSS and HSC is limited. In order to study the infl uences of shear connection degree and concrete strength on the fl exural performance of composite beams using HSS and HSC, four composite beam specimens were constructed and loaded under four-point bending test in the present study. The test results showed that the failure mechanism of the fully connected composite beams was the bending failure of steel beam and crushing failure of concrete slab. The failure mode of the partially connected composite beams was the shear failure of stud connectors and bending failure of steel beam. The composite beams having 65% and 162% shear connection degree achieved the load bearing capacity of 18.8% and 25.3% higher than the composite beam having 38% shear connection degree. With the shear connection degree increased, the bending bearing capacity of the composite beam was enhanced. The concrete strength had no obvious impact on the fl exural capacity of the composite beam having HSS and HSC. Moreover, the analytical models were put forward to predict the fl exural capacity and bending stiff ness of the composite beam using HSS and HSC.

Blocking Bcl-2 Leads to Autophagy Activation and Cell Death of the HEPG2 Liver Cancer Cell Line

Du, Peng,Cao, Hua,Wu, Hao-Rong,Zhu, Bao-Song,Wang, Hao-Wei,Gu, Chun-Wei,Xing, Chun-Gen,Chen, Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Apoptosis may be induced after Bcl-2 expression is inhibited in proliferative cancer cells. This study focused on the effect of autophagy activation by ABT737 on anti-tumor effects of epirubicin. Methods: Cytotoxic effects of ABT737 on the HepG2 liver cancer cell line were assessed by MTT assay and cell apoptosis through flow cytometry. Mitochondrial membrane potential was measured by fluorescence microscopy. Monodansylcadaverin (MDC) staining was used to detect activation of autophagy. Expression of p53, p62, LC3, and Beclin1, apoptotic or autophagy related proteins, was detected by Western blotting. Results: ABT737 and epirubicin induced growth inhibition in HepG2 cells in a dose- and time-dependent manner. Both ABT737 and epirubicin alone could induce cell apoptosis with a reduction in mitochondrial membrane potential as well as increased apoptotic protein expression. Further increase of apoptosis was detected when HepG2 cells were co-treated with ABT373 and epirubicin. Furthermore, our results demonstrated that ABT373 or epirubicin ccould activate cell autophagy with elevated autophagosome formation, increased expression of autophagy related proteins and LC3 fluorescent puncta. Conclusions: ABT737 influences cancer cells through both apoptotic and autophagic mechanisms, and ABT737 may enhance the effects of epirubicin on HepG2 cells by activating autophagy and inducing apoptosis.

Study on Phase-Segregated Active Power Filter using PLECS

Ying-Hao Zhang,Hyoung-Lok Oh,Han-Jun Lim,Wen-Hao Zhang,Du-Sik Kim 전력전자학회 2013 전력전자학술대회 논문집 Vol.2013 No.7

현실적 직무소개(Realistic Job Previews)와 이직의도의 관계에 대한 연구

두운호(Du Yun Hao),신수영(Shin Soo Young) 한국인적자원관리학회 2016 인적자원관리연구 Vol.23 No.4

최근의 지식기반 경영환경에서는 인적자원의 효율적 활용과 더불어 인재를 유지할 수 있는 방안이 인적자원관리의 중요한 이슈로 떠오르고 있다. 즉, 구성원의 이탈로 인해 생기는 막대한 손실은 기업에게 치명적인 악영향을 미칠 수 있고, 이에 따라 조직에서는 입직단계의 사람들에게 과장되고 이상적인 기대를 갖게 하기 보다는 진실한 정보를 균형있게 제공하는 현실적 직무소개의 필요성이 제기되었다. 현실적 직무소개란 입사자들이 조직에 진입하여 적응하는 과정에서 조직과 직무에 관련된 정보를 정확하게 제공받음으로써 조직과 직무에 대한 비현실적 기대감을 현실적으로 변화시킬 수 있다는 개념이다. 본 논문에서는 개인-직무적합성(P-J fit) 관점과 조기업무적응(early work adjustment) 가설을 기반으로 현실적 직무소개가 어떻게 이직의도에 영향을 미치는가를 탐색하고자 한다. 그동안 선행연구에서는 현실적 직무소개와 조직유효성 사이의 관계에 집중할 뿐 현실적 직무소개가 이직의도에 영향을 미치는 과정을 탐색한 실증연구는 부족하였다. 따라서 본 논문에서는 현실적 직무소개의 긍정적 효과를 설명할 수 있는 효과적 대응전략(coping strategy)에 초점을 맞춰 이직의도에 영향을 미치는 과정을 밝히고자 한다. 이를 위해 재직기간 3년 미만의 종업원을 대상으로 총 177부의 설문지를 사용하여 가설을 검증하였다. 분석결과, 현실적 직무소개는 역할명료성에 정(+)의 관계가 있는 것으로 나타났고, 역할명료성은 이직의도와 부(-)의 관계가 있는 것으로 나타났다. 또한, 현실적 직무소개가 이직의도에 미치는 영향에 있어 역할명료성의 매개효과를 분석한 결과, 역할명료성의 부분매개효과가 지지되었다. 즉, 현실적 직무소개는 그 자체로도 이직의도를 줄일 수 있지만 역할명료화 등의 적극적인 대응전략을 통해 더 큰 효과를 발휘할 수 있는 것으로 밝혀졌다. The purpose of this study is to examine the effect of Realistic Job Previews(RJPs) to reduce employees’ turnover intention. By exploring the relationship among RJPs, role clarification and turnover intention, we attempted to explain the coping strategy during the organizational socialization process. With the data from 177 employees who worked less than 3 years in local Korean companies, we tested three hypotheses. According to the test results, RJPs has a positive relationship with role clarification. This suggests that organizations providing accurate, sufficient and symmetrical information will positively affect employees’ behavior during the introductory period. In addition, role clarification negatively affects turnover intention. This shows that if individuals have clearer responsibilities and duties, they will be less inclined to leave the job. Lastly, role clarification has a partial mediating effect on the relationship between Realistic Job Previews and turnover intention. This shows that even though Realistic Job Previews has a negative effect on turnover intention, employees are also influenced by other organizational mechanisms such as the role clarification.

Study on the Seismic Optimization Scheme of Steel Bundled-Tube Structure with Vertical Setback

Yong Hao,Feng Chen,Yun-hui Han,Xue-qian Hao,Chun-hui Du,Qiu-yu Ding 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.2

In order to improve the seismic performance of vertical setback steel bundled-tube structure and meet the dynamic multi-objective requirements of seismic performance-based design, the optimization effects under rare earthquakes on the zone of fortification intensity 7 and 8 in China are researched by improving members stiffness and adding dampers in the weak parts of structure, based on dynamic elastic-plastic analysis. The results show that: 1) Under rare earthquakes on the zone of fortification intensity 7, increasing the stiffness of weak skirt beam can improve the seismic performance of spiral and symmetrical setback structure; 2) For the spiral setback structure, under rare earthquakes on the zone of fortification intensity 7, the damper can only be arranged at the junction of the first layer of the setback frame unit and the frame unit without setback. However, under rare earthquakes on the zone of fortification intensity 8, it is not advisable to install dampers at the weak areas; 3) After incorporating dampers at the weak areas of symmetrical setback structure, the optimized members experienced a reduction in stress levels, significantly decreased the inter-layer displacement angles with a maximum reduction of 43%, and the optimization effect is significant.

Optimized geometric error sensitivity analysis approach based on stream-ofvariation theory in multi-axis precise motion platform

Hao Tang,Chang Ping Li,Jia Chen,Huimin Kang,Tae Jo Ko,Mianke Du 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.10

In this paper, an optimized error sensitivity analysis (ESA) approach based on stream-of-variation (SOV) theory in multi-axis precise motion platform (MPMP) is introduced. Unlike the conventional ESA method, this approach utilizes stream-of-variation theory to establish error model firstly. By regarding each axis as a station, the error propagation and deviation accumulation processes are clear station by station. Through obtaining the deviations after each station, the sensitive stations can be developed, and corresponding error terms are collected. Thus, by analyzing the appearance frequency of the errors, a precise sensitive order can be developed, and a sensitivity results with different steps is given. Through ignoring the insensitive and irrelevant errors, the computational volume of error model can be saved, and the efficiency can be improved. A case study about a typical MPMP used in laser welding system (LWS) is carried out, and the results indicate that the optimized ESA approach is more efficient and accurate, and it is flexible as well. This ESA approach is not only accurate in developing sensitive levels, but also balancing the systematic accuracy and working efficiency, which is helpful to provide informative guide to engineers.

Cellular Particle Swarm Scheduling Algorithm for Virtual Resource Scheduling of Cloud Computing

Hao Yuan,Changbing Li,Maokang Du 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.3

The virtual resource scheduling is an important topic in the field of cloud computing. Based on particle swarm scheduling algorithm, this paper introduces cellular automata theory to construct a new cellular particle swarm scheduling algorithm. This approach through mathematical modeling for virtual resource scheduling of cloud computing and complete the final search configuration based on directional optimization objective function. Experimental results show that the proposed method has more excellent scheduling performance, in the case of changes in resources, can be also kept stable scheduling balance.

Network Analyses of Gene Expression following Fascin Knockdown in Esophageal Squamous Cell Carcinoma Cells

Du, Ze-Peng,Wu, Bing-Li,Xie, Jian-Jun,Lin, Xuan-Hao,Qiu, Xiao-Yang,Zhan, Xiao-Fen,Wang, Shao-Hong,Shen, Jin-Hui,Li, En-Min,Xu, Li-Yan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Fascin-1 (FSCN1) is an actin-bundling protein that induces cell membrane protrusions, increases cell motility, and is overexpressed in various human epithelial cancers, including esophageal squamous cell carcinoma (ESCC). We analyzed various protein-protein interactions (PPI) of differentially-expressed genes (DEGs), in fascin knockdown ESCC cells, to explore the role of fascin overexpression. The node-degree distributions indicated these PPI sub-networks to be characterized as scale-free. Subcellular localization analysis revealed DEGs to interact with other proteins directly or indirectly, distributed in multiple layers of extracellular membrane-cytoskeleton/ cytoplasm-nucleus. The functional annotation map revealed hundreds of significant gene ontology (GO) terms, especially those associated with cytoskeleton organization of FSCN1. The Random Walk with Restart algorithm was applied to identify the prioritizations of these DEGs when considering their relationship with FSCN1. These analyses based on PPI network have greatly expanded our comprehension of the mRNA expression profile following fascin knockdown to future examine the roles and mechanisms of fascin action.

Mobile Cloud Computation Offloading Switch Based on Decision Value Model

Hao.Yuan,Changbing. Li,Maokang. Du 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.9

A method had been constructed for mobile cloud computation offloading switch based on decision value model. In this method, two important ratios had been built: one is the calculation ratio which are offloaded on a proxy server completed tasks time and at the mobile node completed tasks time. Another is the calculation ratio which is offloaded on proxy server completed tasks energy and at the mobile node completed tasks energy. And then, decision value function was produced by combining with these two ratios. Finally, consider the optimization switch problem of computing tasks between different proxy servers. Experimental results show that the proposed method has a smaller time consumption and energy consumption by comparing with random offloading switch and minimum time-based offloading switch, and battery remaining of mobile node can be used rationally.

Hybrid energy storage bidirectional DC–DC converter based on Hermite interpolation and linear active disturbance rejection control

Hao Zheng,Guiping Du,Yanxiong Lei,Ruijing Wang 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.6

The steady and transient performance of a bidirectional DC–DC converter (BDC) is the key to regulating bus voltage and maintaining power balance in a hybrid energy storage system. In this study, the state of charge of the energy storage element (ESE) is used to calculate the converter current control coefficient (CCCC) via Hermite interpolation. Moreover, the charging and discharging currents of the BDC are controlled by the CCCC. Thus, the ESE runs in the best working region. The linear active disturbance rejection control is used in the current inner loop of BDC to solve the problems of slow dynamic response and parameter tuning in traditional PI control. The method can deal with the great transient response and a vast range of uncertainties, improve the BDC response speed by more than 20%, compensate for the unbalanced power timely, reduce the bus voltage fluctuation, and enhance the disturbance immunity of the system. The proposed method is verified by simulations and experiments.