Cefixime 경구제제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic cefixime(Pofixim^(®), Kwangmyung Pharmaceutical Co.) capsule to the cefixime capsule(Suprax^(®), Dong-A Pharmaceutical Co.) as a reference drug. Single dose of 100 mg cefixime was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 14 hours and plasma concentration of cefixime was measured by well validated reverse phase high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of cefixime can be declared bioequivalent with the reference, both formulations in 100 mg capsule.

Simvastatin 정제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic simvastatin tablet(Dongsung Pharmaceutical Co.) to the simvastatin tablet(Zocor^(®), MSD Korea Co.) as a reference drug. Single dose of 20 mg simvastatin was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of simvastatin was measured by well validated LC-MS/MS. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of simvastatin is bioequivalent with the reference, both formulations in 20 mg tablet.

한국인에서의 CYP2E1 유전자형

권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Cytochrome P4502E1 (CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine (NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, fluorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predisposition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 42 hepatocellular carcinoma patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroform extraction method. The allelic frequencies of c1 and c2 in healthy volunteers were 0.85 and 0.15, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 in healthy volunteers.

Aceclofenac 경구제제의 생물학적 동등성 연구

권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic aceclofenac(Anacle^(®), Korea Pharma Co.) tablet to the aceclofenac tablet(Arital^(®), DaeWoong Pharmaceutical Co.) as a reference drug. Single dose of 100 mg aceclofenac was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of aceclofenac was measured by well validated reverse phase high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of aceclofenac is bioequivalent with the reference, both formulations in 100 mg tablet.

조합화학을 이용한 Y(As,Nb,P,V)O_4 청색 발광 형광체의 합성 및 광 특성 분석

전일운,손기선,박희동,유승곤 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.1

조합화학기법을 이용하여 청색 발광을 하는 YRO_4(R=As, Nb, P, V)계 형광체를 합성하였다. 합성한 형광체는 254㎚ 및 147㎚ 여기 하에서의 발광 세기에 관한 사면체 라이브러리를 완성하였다. 254㎚로 여기 시켰을 때, YAsO_4를 중심으로 높은 발광 세기를 보였고, Y(As_0.4P_04V_0.2)O_4의 조성으로 1,200℃에서 합성하였을 때 가장 높은 발광 세기를 보였다. 그러나, 147㎚로 여기시켰을 경우에는 YPO_4를 중심으로 해서 높은 발광 세기를 나타내었다. The YRO_4(R=As, Nb, P, V)blue emitting phosphors were prepared by the combinatorial chemistry method. The quaternary combinatorial library was designed to investigate the luminescence of the host material under UV and VUV excitations(254, 147㎚). In view of the luminescence yield, YAsO_4 rich region was found to be optimum under 254㎚ excitation. It was found that the phosphor synthesized at 1,200℃ with Y(As_0.4P_0.4V_0.2)O_4 composition had a maximum emission intensity. However, the results under 147㎚ excitation were different from those of 254㎚ excitation, the samples of the composition containing a large amount of YPO_4 shows the high emission intensity.

한국인에서의 CYP2C19 유전자형의 다형성

권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The S-mephenytoin 4'-hydroxylase (CYP2C19) metabolizes a number of clinically used drugs and shows a marked interethnic difference in the incidence of the poor metabolizer (PM). In the present study, we genotyped 215 healthy unrelated Koreans (64 females, aged 20-41 yr, residing in Chungcheong province) for functionally defective alleles, CYP2C19_(m1) and CYP2C19_(m2). Detection of the normal (CYP2C19_(wt)) and defective alleles was performed by polymerase chain reaction/restriction enzyme analysis. The genomic DNA was isolated from peripheral blood. The allelic frequencies of the wild-type (CYP2C19_(wt)) and CYP2C19_(m1) were 72.6% and 27.4%, and the wild-type (CYP2C19_(wt)) and CYP2C19_(m2) were 85.1% and 14.9%, respectively. For each CYP2C19_(m1) and CYP2C19_(m2), the observed numbers of three genotypes were similar to those calculated in accordance with the Hardy-Weinberg equation. The frequencies of homozygotes for CYP2C19_(m1), CYP2C19_(m2) and compound heterozygotes were 9.7%, 2.8% and 4.2%, respectively. The mutants of CYP2C19 were identified in 36 subjects (16.7%). These results suggest that frequency of mutants of CYP2C19 in Koreans resembled the Orientals rather than Caucasians.

HPLC-MS/MS를 이용하여 혈장 중 레보티인정의 정량분석

채석,오형근,이상선,김형기,손동렬,염윤기,맹주양,권준택 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2

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Film Temperature and Effectiveness Measurements on a Cylindrical Leading Edge Film Cooling Model

Dong Kee Sohn,Shuye Teng,Je Chin Han 대한기계학회 1998 Heat transter conference Vol.6 No.1

터보펌프 인듀서의 흡입성능에 대한 직경과 회전속도의 영향

손동기(Dong Kee Sohn),구현철(Hyun Chul Koo),차봉준(Bong Jun Cha),양수석(Soo Seok Yang),이대성(Dae Sung Lee) 한국유체기계학회 2001 유체기계 연구개발 발표회 논문집 Vol.- No.-

The turbopump inducer cavitation is very important for the success of a liquid rocket engine. In this study the performance test and cavitation performance test were carried out at various rotational speed with two different diameter inducers. The rotational speed were varied 4000, 6000, 8000 rpm and the variation to the diameter of an inducer were taken as design size and 2 times enlarged size.<br/> The major results of the present study were as follows.<br/> 1. The hydraulic performance results showed that the similarity was met over the entire test range of the present study.<br/> 2. The blade thickness effect was examined and showed that the increased blade thickness resulted in decreased efficiency and worse cavitation performance for large tip clearance.<br/> 3. The cavitation performance test results showed that the breakdown NPSH increases as the flow coefficient and does not affected by the rotational speed.

Control of boundary layer by ionic wind for heat transfer

Shin, Dong Ho,Jang, Dong Kyu,Sohn, Dong Kee,Ko, Han Seo Elsevier 2019 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.131 No.-

<P><B>Abstract</B></P> <P>In this study, local convection heat transfer technology was investigated using ionic wind. The characteristics of ionic wind using wire and plate electrodes are studied by experiment and numerical method. A particle image velocimetry (PIV) test was conducted in a wind tunnel to observe the flow behavior by the ionic wind on the heated surface. A new boundary layer was formed on the heated surface which was controlled by the ionic wind, regardless of the Reynolds number of bulk flow. The surface averaged heat transfer coefficient with the ionic wind increased by 11% at low Reynolds number (100–200) and decreased by 19% at high Reynolds number (2500–3500). It was also found that the zigzag type of wire arrangement enhanced the heat transfer coefficient by 40% compared with the single wire. It is thus concluded that ionic wind can be used for enhancing the convection heat transfer rate or insulating the local surface according to its operating condition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Control of boundary layer by the ionic wind for heat transfer has been investigated experimentally. </LI> <LI> Particle image velocimetry was used to analyze the effect of the ionic wind on the boundary layer. </LI> <LI> Due to the ionic wind, the heat transfer coefficient increased by 11% in laminar condition. </LI> <LI> The zigzag type of multiple wires arrangement enhanced 40% of the heat transfer coefficient. </LI> </UL> </P>