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Jia Zheng,Chong-De Wu,Jun Huang,Rong-Qing Zhou,Xue Pin Liao 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.3
The volatile compounds in Chinese soy sauce moromi cultured by different fermentation processes [lowsalt solid-state fermentation (LSSF), high-salt dilute-state fermentation (HSDF), and high-salt constant temperature fermentation (HSCT)] were determined by GC-MS. The LSSF moromi had the highest total concentration of volatile compounds, followed by HSCT and HSDF moromi. Volatiles such as ethyl linoleate and ethyl oleate dominated in HSCT moromi. 2,3-Butanediol and 2,6-dimethylpyrazine were present at high content in LSSF moromi. The hierarchal cluster analysis (HCA) and principal component analysis (PCA) were employed to investigate the fermentation process effect on the category of samples. Based on HCA,HSCT (a1 and a2) and HSDF (b1 and b2) clustered in 1group, and LSSF (c1 and c2) located in another group. PCA illustrated that each kind of samples correlating with specific volatile compound groups were clearly differentiated according to their fermentation processes. The results suggest that GC-MS together with multivariate analyses could provide practical reference to recognize different Chinese soy sauces moromi.
Exosomes from CIITA-Transfected CT26 Cells Enhance Anti-tumor Effects
Fan, Wen,Tian, Xing-De,Huang, E.,Zhang, Jia-Jun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Aim: To study anti-tumor effects of exosomes from class II transactivator (CIITA) gene transfected CT26 cells. Methods: In this study, we established an MHC class II molecule-expressing murine colon cancer cell line (CT26-CIITA) by transduction of the CIITA gene. Immune effects in vitro and tumor protective results in vivo were tested and monitored. Results: Exosomes from CT26-CIITA cells were found to contain a high level of MHC class II protein. When loaded on dendritic cells (DCs), exosomes from CT26-CIITA cells significantly increased expression of MHC class II molecules, CD86 and CD80, as compared to exosomes from CT26 cells. In vitro assays using co-culture of immunized splenocytes and exosome-loaded DCs demonstrated that CIITA-Exo enhanced splenocyte proliferation and IFN-${\gamma}$ production of CD4+T cells, while inhibiting IL-10 secretion. In addition, compared to exosomes from CT26 cells, CT26-CIITA-derived exosomes induced higher TNF-${\alpha}$ and IL-12 mRNA levels. A mouse tumour preventive model showed that CT26-CIITA derived exosomes significantly inhibited tumour growth in a dose-dependent manner and significantly prolonged the survival time of tumour-bearing mice. Conclusion: Our findings indicate that CT26-CIITA-released exosomes are more efficient to induce anti-tumour immune responses, suggesting a potential role of MHC class II-containing tumour exosomes as cancer vaccine candidates.
Yu-Qiang Sun,De-Jun Jia 국제이네비해양경제학회 2018 International Journal of e-Navigation and Maritime Vol.10 No.1
During an up-righting project for a capsized ship, the dynamic effect enlarges the tensions of cables. The cable tensions which are calculated based on statics and the safety evaluation which is based on these tensions cannot ensure the safety of the up-righting project. Due to the above reasons, a numerical simulation project is applied to investigate the dynamic effect on cable tensions of up-righting projects and evaluate the safety of up-righting project in current research. Firstly, a theoretical equation of the quasi-static up-righting project model is established in current research and is solved. Subsequently, the precision of the numerical simulation method applied in current research is checked by comparing cable tensions which are calculated by theoretical model and numerical simulation method. The cable tensions in different cases are solved by the numerical simulation method which accounts for dynamic effect in order to investigate the relationship between cable tensions and capsized ship weights, cable stiffness and winding-in speed. Finally, the safety of up-righting project is evaluated based on all the cable tensions calculated. It is pointed out that cable tension increases with the value of capsized ship weight, cable stiffness or winding-in speed approximately. The safety coefficients of cable in some high winding-in speeds are bellow 1.0. The results indicate that the dynamic effect is significant and should be accounted for during the up-righting project.
Study of the Ultimate Load Capacity of K-Type Tube-Gusset Plate Connections
Yan-Zhong Ju,Jia-Yang Li,De-Hong Wang,Jun-Feng Bai 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.2
In order to investigate the ultimate load capacity of K-type tube-gusset plate connections with stiff ened plate, the static tests of fi ve full-scale specimens were conducted in this study. The results indicate that the end stiff ened plate is critical for improving the load capacity of the connections. In addition, the parametric nonlinear fi nite element analysis of the K-type tube-gusset plate specimens was performed with account of such non-dimensional parameters as chord diameter-to-thickness ratio ( γ ), plate width-to-chord diameter ratio ( α ), plate thickness-to-chord thickness ratio ( 1 ), stiff ened plate thickness ( t d ), and nominal-to-yield stress ratio ( η ). The above analysis implies that the ultimate load capacity decreases with the increment of γ and increases with the increment of α and 1 , while it is only slightly aff ected by the stiff ened plate thickness. Compare the results of the fi nite element analysis with assessment by design guides existing. Based on the former results, an equation for estimating the load capacity of K-type tube-stiff ened gusset plate is proposed.
Yang, Xiao-Fei,Sun, Ai-Ning,Yin, Jia,Cai, Cheng-Sen,Tian, Xiao-Peng,Qian, Jun,Chen, Su-Ning,Wu, De-Pei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
A monosomal karyotype (MK), defined as ${\geq}2$ autosomal monosomies or a single monosomy in the presence of additional structural abnormalities, was recently identified as an independent prognostic factor conveying an extremely poor prognosis in patients with acute myeloid leukemia (AML). In the present study, after excluding patients with t(15;17), t(8;21), inv(16) and normal karyotypes, 324 AML patients with cytogenetic abnormalities were the main subject of analysis. The incidences of MK were 13% in patients aged 15 to 60 years and 18% in those between 15 and 88 years old. MK was much more prevalent among elderly patients (p < 0.001) and was significantly associated with the presence of -7, -5, del(5q), abn12p, abn17p, -18 or 18q-, -20 or 20q- and CK (for all p < 0.001 except for abn12p p=0.009), and +8 or +8q was less frequent in MK+ AML(p=0.007). No correlation was noted between monosomal karyotype and FAB subtype (p > 0.05); MK remained significantly associated with worse overall survival among patients with complex karyotype (p=0.032); A single autosomal monosomy contributed an additional negative effect in OS of patients with structural cytogenetic abnormalities (P=0.008). This report presents the prevalence, feature and prognostic impact of MK among a large series of Chinese AML patients from a single center for the first time.