http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Dayarathne, H.N.P.,Jeong, Sanghyun,Jang, Am Elsevier 2019 Desalination Vol.461 No.-
<P><B>Abstract</B></P> <P>One of the major problems of seawater reverse osmosis (SWRO) process is the formation of inorganic scales (calcium carbonate, CaCO<SUB>3</SUB>) and calcium sulfate, CaSO<SUB>4</SUB>)) on the membrane surface, which degrades the filtration performance. Antiscalants have been applied to SWRO plants to overcome the scaling problem. In this study, we used the air micro-nano bubbles (MNBs) as a chemical-free scale inhibition method to improve the overall membrane performance in the comparison with the commercially available antiscalants. During four days of continuous experiments with MNBs, the permeate fluxes declined to 86.5(0.4)% and 83.0(0.5)% with CaCO<SUB>3</SUB> and CaSO<SUB>4</SUB> containing feed solutions, respectively. These values were higher than those obtained with the use of antiscalants in the feed water (CaCO<SUB>3</SUB>–63.5(0.4)% and CaSO<SUB>4</SUB>–55.8(1.0)%). Membrane fouling characterization results showed that the MNBs efficiently controlled the scaling development on the membrane surface without any chemical addition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Air micro-nano bubbles (MNBs) inhibit calcium crystal formation on SWRO membranes. </LI> <LI> Continuous MNBs application is effective to improve the SWRO performances. </LI> <LI> Scaling inhibition of MNBs is better than antiscalant used in this study. </LI> <LI> MNBs helps to achieve a chemical-free SWRO operation. </LI> <LI> MNBs can reduce the operational cost and the environmentally negative impacts. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Dayarathne, H.N.P.,Choi, J.,Jang, A. Elsevier Scientific Pub. Co 2017 Desalination Vol. No.
Concentration polarization (CP) is a major operational challenge for reverse osmosis (RO) desalination because it results in decreased permeate flux and increased transmembrane pressure (TMP). In this study, lab-scale and pilot-scale cross-flow filtration experiments were performed to evaluate the impact of air micro-nano bubbles (MNBs) on permeate flux, TMP and solute rejection. Results indicated that MNBs can increase permeate flux recovery up to 100%. Also, the permeate flux and solute rejection were increased up to 24.62% and 0.8%, respectively. These results are attributed to the disruption of the CP layer by MNBs. Furthermore, since this is a non-chemical, membrane cleaning in place (CIP) method, this does not contribute to environmental pollution, making it a more applicable cleaning method.
Dayarathne Lakshi A.,Jasmadi,Ko Seok-Chun,Yim Mi-Jin,Lee Jeong Min,Kim Ji-Yul,Oh Gun-Woo,Lee Dae-Sung,Jung Won-Kyo,Lee Sei-Jung,Je Jae-Young 한국미생물·생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.8
The current study aimed to determine whether Strongylocentrotus intermedius (S. intermedius) extract (SIE) exerts anti-obesity potentials employing 3T3-L1 cells as in vitro model. Herein we reported that treatment of SIE for 6 days reduced lipid accretion and triglyceride content whereas it increased the release of free glycerol. The inhibited lipid accumulation and induced lipolysis were evidenced by the downregulation of lipogenesis proteins, such as fatty acid synthase and lipoprotein lipase, and the upregulation of hormone-sensitive lipase expression. Furthermore, the downregulation of adipogenic transcription factors, including peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein α, and sterol regulatory element-binding protein 1, highlights that reduced lipid accumulation is supported by lowering adipocyte differentiation. Additionally, treatment activates brown adipocyte phenotype in 3T3-L1 cells by inducing expression of brown adipose tissue-specific proteins, such as uncoupling protein 1 and peroxisome proliferator-activated receptor-γ coactivator 1α. Moreover, SIE induced the phosphorylation of AMP-activated protein kinase (AMPK). The pharmacological approach using AMPK inhibitor revealed that the restraining effect of SIE on adipogenesis and promotion of adipocyte browning were blocked. In GC-MS analysis, SIE was mainly composed of cholest-5-en-3-ol (36.71%) along with saturated and unsaturated fatty acids which have favorable anti-obesity potentials. These results reveal that SIE has the possibility as a lipid-lowering agent for the intervention of obesity.
Lakshi A. Dayarathne,Sachithra S. Ranaweera,Premkumar Natraj,Priyanka Rajan,이영재,Chang-Hoon Han 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.6
Background: Naringin and its aglycone naringenin are citrus-derived flavonoids with several pharmacological effects. On the other hand, the mechanism for the anti-diabetic effects of naringenin and naringin are controversial and remain to be clarified further. Objective: This study examined the relationship between glucose uptake and AMP-activated protein kinase (AMPK) phosphorylation by naringenin and naringin in high glucose-treated HepG2 cells. Methods: Glucose uptake was measured using the 2-NBDG fluorescent d-glucose analog. The phosphorylation levels of AMPK and GSK3β (Glycogen synthase kinase 3 beta) were observed by Western blotting. Molecular docking analysis was performed to evaluate the binding affinity of naringenin and naringin to the γ-subunit of AMPK. Results: The treatment with naringenin and naringin stimulated glucose uptake regardless of insulin stimulation in high glucose-treated HepG2 cells. Both flavonoids increased glucose uptake by promoting the phosphorylation of AMPK at Thr172 and increased the phosphorylation of GSK3β. Molecular docking analysis showed that both naringenin and naringin bind to the γ-subunit of AMPK with high binding affinities. In particular, naringin showed higher binding affinity than the true modulator, AMP with all three CBS domains (CBS1, 3, and 4) in the γ-subunit of AMPK. Therefore, both naringenin and naringin could be positive modulators of AMPK activation, which enhance glucose uptake regardless of insulin stimulation in high glucose-treated HepG2 cells. Conclusions: The increased phosphorylation of AMPK at Thr172 by naringenin and naringin might enhance glucose uptake regardless of insulin stimulation in high glucose treated HepG2 cells.
Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes
Lakshi A. Dayarathne,Sachithra S. Ranaweera,Premkumar Natraj,Priyanka Rajan,이영재,한창훈 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.4
Background: Naringenin and its glycoside naringin are well known citrus flavonoids with several therapeutic benefits. Although the anti-adipogenic effects of naringenin and naringin have been reported previously, the detailed mechanism underlying their anti-adipogenesis effects is poorly understood. Objectives: This study examined the anti-adipogenic effects of naringenin and naringin by determining differential gene expression patterns in these flavonoids-treated 3T3-L1 adipocytes. Methods: Lipid accumulation and triglyceride (TG) content were determined by Oil red O staining and TG assay. Glucose uptake was measured using a 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose fluorescent d-glucose analog. The phosphorylation levels of AMP-activated protein kinase (AMPK) and acetyl Co-A carboxylase (ACC) were observed via Western blot analysis. Differential gene expressions in 3T3-L1 adipocytes were evaluated via RNA sequencing analysis. Results: Naringenin and naringin inhibited both lipid accumulation and TG content, increased phosphorylation levels of both AMPK and ACC and decreased the expression level of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) in 3T3-L1 adipocytes. RNA sequencing analysis revealed that 32 up-regulated (> 2-fold) and 17 down-regulated (< 0.6-fold) genes related to lipid metabolism, including Acaca, Fasn, Scd1, Mogat1, Dgat, Lipin1, Cpt1a, and Lepr, were normalized to the control level in naringenin-treated adipocytes. In addition, 25 up-regulated (> 2-fold) and 25 down-regulated (< 0.6-fold) genes related to lipid metabolism, including Acaca, Fasn, Fabp5, Scd1, Srebf1, Hmgcs1, Cpt1c, Lepr, and Lrp1, were normalized to the control level by naringin. Conclusions: The results indicate that naringenin and naringin have anti-adipogenic potentials that are achieved by normalizing the expression levels of lipid metabolism-related genes that were perturbed in differentiated 3T3-L1 cells.
Priyanka Rajan,Premkumar Natraj,Sachithra S. Ranaweera,Lakshi A. Dayarathne,Young Jae Lee,Chang-Hoon Han 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1
Background: Flavonoids are natural polyphenols found widely in citrus fruit and peel that possess anti-adipogenic effects. On the other hand, the detailed mechanisms for the anti-adipogenic effects of flavonoids are unclear. Objectives: The present study observed the anti-adipogenic effects of five major citrus flavonoids, including hesperidin (HES), narirutin (NAR), nobiletin (NOB), sinensetin (SIN), and tangeretin (TAN), on AMP-activated protein kinase (AMPK) activation in palmitate (PA)-treated HepG2 cells. Methods: The intracellular lipid accumulation and triglyceride (TG) contents were quantified by Oil-red O staining and TG assay, respectively. The glucose uptake was assessed using 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) assay. The levels of AMPK, acetyl-CoA carboxylase (ACC), and glycogen synthase kinase 3 beta (GSK3β) phosphorylation, and levels of sterol regulatory element-binding protein 2 (SREBP-2) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression were analyzed by Western blot analysis. The potential interaction between the flavonoids and the γ-subunit of AMPK was investigated by molecular docking analysis. Results: The flavonoid treatment reduced both intracellular lipid accumulation and TG content in PA-treated HepG2 cells significantly. In addition, the flavonoids showed increased 2-NBDG uptake in an insulin-independent manner in PA-treated HepG2 cells. The flavonoids increased the AMPK, ACC, and GSK3β phosphorylation levels and decreased the SREBP-2 and HMGCR expression levels in PA-treated HepG2 cells. Molecular docking analysis showed that the flavonoids bind to the CBS domains in the regulatory γ-subunit of AMPK with high binding affinities and could serve as potential AMPK activators. Conclusion: The overall results suggest that the anti-adipogenic effect of flavonoids on PA-treated HepG2 cells results from the activation of AMPK by flavonoids.