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Oh, Jae-Won,Lee, Chang-Ho,Hong, Sup,Bae, Dae-Sung,Cho, Hui-Je,Kim, Hyung-Woo The Society of Naval Architects of Korea 2014 International Journal of Naval Architecture and Oc Vol.6 No.3
This paper concerns the kinematic characteristics of a coupling device in a deep-seabed mining system. This coupling device connects the buffer system and the flexible pipe. The motion of the buffer system, flexible pipe and mining robot are affected by the coupling device. So the coupling device should be considered as a major factor when this device is designed. Therefore, we find a stable kinematic device, and apply it to the design coupling device through this study. The kinematic characteristics of the coupling device are analyzed by multi-body dynamics simulation method, and finite element method. The dynamic analysis model was built in the commercial software DAFUL. The Fluid Structure Interaction (FSI) method is applied to build the deep-seabed environment. Hydrodynamic force and moment are applied in the dynamic model for the FSI method. The loads and deformation of flexible pipe are estimated for analysis results of the kinematic characteristics.
( Dae-woon Jeong ),( Won-jun Jang ),( Jae-oh Shim ),( Hyun-seog Roh ) 한국폐기물자원순환학회(구 한국폐기물학회) 2016 한국폐기물자원순환학회 추계학술발표논문집 Vol.2016 No.-
The purpose of this study was to investigate the effect of the preparation method on CeO<sub>2</sub>-promoted Cu/γ -Al<sub>2</sub>O<sub>3</sub> catalysts for the high temperature shift reaction using simulated waste-derived syngas (H<sub>2</sub> + CO). To investigate the effect of preparation method on the CeO<sub>2</sub>-promoted Cu/γ-Al<sub>2</sub>O<sub>3</sub> catalyst, we compared catalytic performance over Ce/Cu/γ-Al<sub>2</sub>O<sub>3</sub>, Ce-Cu/γ-Al<sub>2</sub>O<sub>3</sub>, Cu/Ce/γ-Al<sub>2</sub>O<sub>3</sub>, and Cu/γ-Al<sub>2</sub>O<sub>3</sub> catalysts, and tried to explain the differences in catalytic performance with various characterization methods. The physico-chemical properties of the CeO<sub>2</sub>-promoted catalysts were characterized using surface spectroscopies such as BET, XRD, TPR, XPS, Raman spectroscopy, photoluminescence spectroscopy, and N<sub>2</sub>O-chemisorption. The catalyst characterizations were correlated with activity results in the high temperature shift reaction.
Optimization of Metal Substituted Spinel Ferrite Catalysts for Waste-Derived Synthesis Gas
( Dae-woon Jeong ),( Won-jun Jang ),( Jae-oh Shim ),( Hyun-seog Roh ) 한국폐기물자원순환학회(구 한국폐기물학회) 2016 한국폐기물자원순환학회 춘계학술발표논문집 Vol.2016 No.-
The purpose of this study was to prepare directly the magnetite of spinel ferrite catalysts using glycine assisted sol-gel combustion method and to compare the catalytic activity of Ni, Co, Mn, Mg, and Zn substituted spinel ferrite catalysts for the high temperature shift reaction (HTS). Selected metal ions (Ni, Co, Mn, Mg, and Zn) were introduced into iron oxide (spinel lattice) and the resulting materials screened for catalytic performance for the HTS reaction using waste-derived synthesis gas. The active phase of spinel ferrite catalysts was directly prepared by the glycine assisted sol-gel combustion method under a reducing atmosphere. Among the synthesized catalysts, NiFe2O4 catalyst exhibited the highest CO conversion (X<sub>CO</sub> = 81%) with long term stability even at a very high gas hourly space velocity of 40,057h<sup>-1</sup>. This result was mainly due to the inverse spinel structure and easier reducibility of NiFe<sub>2</sub>O<sub>4</sub> catalyst. The properties of metal ferrite spinel have been analyzed by Brunauer-Emmett-Teller (BET) method, X-raydiffraction (XRD), and temperature programmed reduction (TPR).
Basic, Research : Role of 5-hydroxytryptamine Receptor 2A Antagonist in Hepatic Fibrosis
( Dae Won Jun ),( Waqar Khalid Saeed ),( Tae Yeob Kim ),( Joo Hyun Sohn ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Ho Soon Choi ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: The aim of this study was to determine whether 5-HT2A receptor antagonists affect the activation or apoptosis of HSCs in vitro and/or in vivo. Methods: For the in vitro experiments, the viability, apoptosis and wound healing ability of LX-2 cells were examined after treatment with various 5-HT2A receptor antagonists. Levels of HSC activation markers (procollagen type I, α-SMA, TGF-β and Smad 2/3) were measured. For in vivo experiments, rats were divided into three groups: control group, cirrhosis, 5-HT2A antagonist group. Results: 5-HT2A receptors expression was essentially absent in inactive LX-2 cells but was induced in activated LX-2 cells. Expression of the 5-HT2A and 5-HT2B receptors was significantly decreased by sarpogrelate, with a somewhat greater effect on the 5-HT2A receptor. Similar results were obtained with primary hepatic stellate cells. There was a time and dose dependent decrease in sarpogrelate-treated cell proliferation compared to untreated cells (P<0.05). Ketanserin and ritanserin also had anti-proliferative effects. Ketanserin and sarpogrelate significantly increased HSC apoptosis, with the effect strongest for ketanserin in TUNEL assay. The expression of α-SMA was decreased by sarpogrelate in a dose dependent manner. LX-2 cell migration was significantly suppressed in sarpogrelate or ketanserin- treated cultures and wound healing was delayed compared to cultures treated with only PDGF. There was less severe periportal and septal fibrosis in the rats in the treatment group, but the difference was not statistically significant in Masson`s trichrome stain. But expression of α-SMA was lower in the treatment group than in the cirrhotic group (61.0±7.2% vs 136.7±11.7%, P<0.05), and the treatment group expression was lower than in the disease group (58.9±0.8% vs 118.2±18.2%, P<0.05). Conclusions: 5-HT2A receptor antagonists can reduce inflammation and the activation of HSCs in this cirrhotic model.
( Dae Hyun Lim ),( Mimi Kim ),( Dae Won Jun ),( Min Jung Kwak ),( Jai Hoon Yoon ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Ho Soon Choi ),( Bo Kyeong Kang ) 대한소화기학회 2021 Gut and Liver Vol.15 No.1
Background/Aims: To date, studies on various noninvasive techniques have been suggested to evaluate the degree of liver fibrosis. We aimed to investigate the diagnostic performance of serum asialo α1-acid glycoprotein (AsAGP) in the diagnosis of liver cirrhosis compared with chronic hepatitis for clinically useful result. Methods: We conducted a case-control study of 96 patients with chronic liver disease. Chronic hepatitis was defined as the presence of chronic liver disease on ultrasonography, with a liver stiffness of less than 5.0 kPa as shown on magnetic resonance elastography (MRE). Liver cirrhosis was defined as liver stiffness of more than 5.0 kPa on MRE. The serum AsAGP concentration was compared between the two groups. Results: Serum AsAGP levels were significantly higher in patients with cirrhosis than in those with chronic hepatitis (1.83 μg/mL vs 1.42 μg/mL, p<0.001). Additionally, when comparing patients in each cirrhotic group (Child-Pugh grades A, B, and C) to those with chronic hepatitis, AsAGP levels were significantly higher in all the cirrhotic groups (p<0.05, p<0.01, p<0.001, respectively). The sensitivity and specificity of AsAGP for detecting cirrhosis were 79.2% and 64.6%, respectively, and the area under the curve value was 0.733. The best diagnostic cutoff to predict cirrhosis was 1.4 μg/mL. AsAGP and bilirubin were found to be independent risk factors for the prediction of cirrhosis in the logistic regression analysis. Conclusions: Serum AsAGP showed an acceptable diagnostic performance in predicting liver cirrhosis. (Gut Liver 2021;15:109-116)
( Dae-woon Jeong ),( Won-jun Jang ),( Jae-oh Shim ),( Yeol-lim Lee ),( Kyung-won Jeon ),( Hyun-suk Na ),( Hak-min Kim ),( Hyun-seog Roh ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
The present study focuses on the performance of metal ferrite catalysts integrated with mesoporous alumina for the high temperature water-gas shift reaction of waste-derived synthesis gas. Ni, Co, and Cu were employed as doped metals for the target reaction in this study. Pure magnetite integrated alumina for HT-WGS was also tested as a reference catalyst. Among the prepared catalysts, copper ferrite integrated with mesoporous alumina showed the highest CO conversion (69%) and 100% selectivity to CO<sub>2</sub> at a very high GHSV of 42,000 h<sup>-1</sup>. The improved performance of the catalyst is correlated with its easier reducibility. In addition, honeycomb-like mesopores Al<sub>2</sub>O<sub>3</sub> also exhibited a beneficial effect on the rapid diffusion of reactants.
Oh, Keunhee,Kim, Sae Rom,Kim, Dae-Kyum,Seo, Myung Won,Lee, Changjin,Lee, Hak Mo,Oh, Ju-Eun,Choi, Eun Young,Lee, Dong-Sup,Gho, Yong Song,Park, Kyong Soo American Chemical Society 2015 ACS NANO Vol.9 No.12
<P>The current diabetes mellitus pandemic constitutes an important global health problem. Reductions in the mass and function of β-cells contribute to most of the pathophysiology underlying diabetes. Thus, physiological control of blood glucose levels can be adequately restored by replacing functioning β-cell mass. Sources of functional islets for transplantation are limited, resulting in great interest in the development of alternate sources, and recent progress regarding cell fate change <I>via</I> utilization of extracellular vesicles, also known as exosomes and microvesicles, is notable. Thus, this study investigated the therapeutic capacity of extracellular vesicle-mimetic nanovesicles (NVs) derived from a murine pancreatic β-cell line. To differentiate insulin-producing cells effectively, a three-dimensional <I>in vivo</I> microenvironment was constructed in which extracellular vesicle-mimetic NVs were applied to subcutaneous Matrigel platforms containing bone marrow (BM) cells in diabetic immunocompromised mice. Long-term control of glucose levels was achieved over 60 days, and differentiation of donor BM cells into insulin-producing cells in the subcutaneous Matrigel platforms, which were composed of islet-like cell clusters with extensive capillary networks, was confirmed along with the expression of key pancreatic β-cell markers. The resectioning of the subcutaneous Matrigel platforms caused a rebound in blood glucose levels and confirmed the source of functioning β-cells. Thus, efficient differentiation of therapeutic insulin-producing cells was attained <I>in vivo</I> through the use of extracellular vesicle-mimetic NVs, which maintained physiological glucose levels.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-12/acsnano.5b02997/production/images/medium/nn-2015-02997m_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b02997'>ACS Electronic Supporting Info</A></P>