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Quantum Chemical Consideration of CO Adsorption over Cation Exchanged Faujasite
Park, Doo Seon,Kim, Jong Taik,Kim, Myung Chul,Hong, Sang Phyo 한국화학공학회 1990 NICE Vol.8 No.4
CNDO/2 calculation for atomic charges Wiberg bond orders and adsorption energies of CO molecules on the cluster model whose Si/Al ratio varied were carried out. The data for the normal cluster and dealuminated cluster were compared. Decationization energies of the canons increased with the charge densities of canon and number of aluminum involved. Adsorption process of CO on the monovalent canons such as , Li^-, Na^+ and divalent canons, Be^(2+), Ca^(2+), and Mg^(2-) was supposed to be occurring by the donation of non-bonded electrons from CO. The decationization energies of canons obviously decreased by the dealumination process. Adsorption energies of CO on the canons generally decreased ache dealumination took place except the case of H^+ and Na^+.
( Doo Han Song ),( Seong Eun Park ),( Yong Ho Jang ),( Hyuk Pyo Lee ),( Soo Jeon Choi ),( Sang Bong Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: There is a rare method to diagnose drug-induced pneumonitis so that can be diagnosed by careful documentation of the past medical history without other causes of pneumonitis. Non-steroidal anti-androgen, which is an important treatment for prostate cancer, rarely induces interstitial pneumonitis. In addition, bicalutamide-induced interstitial pneumonitis has rarely been reported. This paper reports the case of a prostate cancer patient who had been treated with bicalutamide, and then expired due to complications from interstitial pulmonary in. ltrates and respiratory failure. Case: A 77 year-old man was admitted in emergency room for dyspnea for one month. He was diagnosed prostate cancer 7 years ago and had undergone radical retropubic prostatectomy. After the operation, two years ago he was treated with casodex® (bicalutamide) for a period of 3 months followed by an additional treatment with bicalude®(bicalutamide) for 4 months. Lung auscultation revealed bilateral fine crackles, and arterial blood gas showed pH 7.4, PCO2 29.5 mmHg, PO2 37.3 mmHg, SaO2 72.5%, which revealed acute respiratory failure. Chest radiography showed diffuse in filtration in bilateral peripheral and lower lung fields (fig.1). Likewise, computed tomography showed diffuse ground glass opacities and some patchy consolidation with interlobular septal thickening in bilateral peripheral and lower lung fields(fig.2). No bacterium was identified, and the patient did not respond to empirical antibiotic therapy. Since the patient`s diagnosis were suspected as a bicalutamide-induced interstitial pneumonitis, bicalutamide was stopped and methylprednisolone was started. However, after a temporary improvement, the patient suffered a rapid respiratory failure along with sepsis complications which led to his expiry. Conclusion: In comparison to the other cases, this is a special case involving severe respiratory failure which required ventilator care. Therefore, the patient did not fully recover; rather complications occurred which resulted in the expiry.
Park, Doo-Sang,Oh, Hyun-Woo,Heo, Sun-Yeon,Jeong, Won-Jin,Shin, Dong-Ha,Bae, Kyung-Sook,Park, Ho-Yong The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.5
Burkholderia sp. HY-10 isolated from the digestive tracts of the longicorn beetle, Prionus insularis, produced an extracellular lipase with a molecular weight of 33.5 kDa estimated by SDS-PAGE. The lipase was purified from the culture supernatant to near electrophoretic homogenity by a one-step adsorption-desorption procedure using a polypropylene matrix followed by a concentration step. The purified lipase exhibited highest activities at pH 8.5 and $60^{\circ}C$. A broad range of lipase substrates, from $C_4\;to\;C_{18}$ p-nitrophenyl esters, were hydrolyzed efficiently by the lipase. The most efficient substrate was p-nitrophenyl caproate ($C_6$). A 2485 bp DNA fragment was isolated by PCR amplification and chromosomal walking which encoded two polypeptides of 364 and 346 amino acids, identified as a lipase and a lipase foldase, respectively. The N-terminal amino acid sequence of the purified lipase and nucleotide sequence analysis predicted that the precursor lipase was proteolytically modified through the secretion step and produced a catalytically active 33.5 kDa protein. The deduced amino acid sequence for the lipase shared extensive similarity with those of the lipase family 1.2 of lipases from other bacteria. The deduced amino acid sequence contained two Cystein residues forming a disulfide bond in the molecule and three, well-conserved amino acid residues, $Ser^{131},\;His^{330},\;and\;Asp^{308}$, which composed the catalytic triad of the enzyme.
Doo-Sang Park,Chan-Seok Yeon,Chuleui Jung,Ki-Jeong Hong,Hyun Woo-Oh 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
Rapid identification of pest species found under quarantine is an important factor in preventing an economic loss of agricultural commodities. In this study, we analyzed RNA-Seq of the larvae of C. sasakii, G. molesta and G. dimorpha, which are serious pests in several fruits in Korea and are difficult to discriminate by species in their larval stage because of lack of a morphological character. To select immunological diagnostic markers, discriminating the larvae of C. sasakii from the G. molesta and G. dimorpha, RNA-Seq was performed for the larvae of the three insects. The 454 pyrosequencing generated 3,058-4,686 contigs for each three pest species, which assembled into 2,584-3,970 isotigs with average lengths of 829-1,244 bp. Functional annotation of the sequencing results generated 774 orthologs for the three pest species, and 12 isotigs were finally registered as candidate markers for species discrimination through bioinformatical screening, literature search, and gene expression study. The selected candidates include serine proteases, serpins, 27 kDa glycoprotein and storage protein with a constitutive gene expression in their larvae, pupae and adult stage.
Doo Jin Choi,Jae Kweon Park,Sung Min Kim,Woo Jung Kim,Hye Ran Moon,Yong Il Park 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
A novel polysialic acid-specific endo-sialidase referred to Endo-PS was purified from the culture filtrate of Pseudomonas fluorescens JK-0412 to apparent homogeneity and has a subunit molecular mass of 20 kDa. The purified enzyme Endo-PS has a molecular weight of 110 kDa by native-PAGE, suggesting that the active enzyme is a hexamer. Although 12 residues of N-terminal amino acid sequence of Endo-PS showed 75% identity with 21-kDa chitin binding protein CBP21 of Serratia marcescens 2170, no significant homology with other known proteins was observed. The specific activity of Endo-PS toward an artificial substrate 4-methylumbelliferyl-sialic acid (4-MU-Neu5A) was determined to be 16 nmole/mg/min with Km value of 0.08 mM. The enzyme was maximally active at an optimal temperature of 37℃ and pH 8. It possesses the ability to only hydrolyze natural substrate α2-8 linked homo-polysialic acid (or colominic acid), but not α2-3 or α2-6 sialyllactoses. Under optimal condition, sialyloligosaccharides ranging from dimer up to 30 residues long liberated from the cleavage of polysialic acid in the function of time were identified by high performance anion-exchange chromatography (HPAEC). Taken together these results suggest that the biochemical properties of Endo-PS purified from the culture filtrate of P. fluorescens JK-0412 are specificfor polysialic acid, referred as a novel endo-polysialidase, reporting first about the properties of non-pathogenic bacterial-derived endo-sialidase.