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Xiaotong Liu,홍성인,박세진,DELAPENAJUNEBRYAN,Haiyan Che,윤서영,김동현,김종민,Mudan Cai,Victoria Risbrough,Mark A. Geyer,신찬영,정재훈,박해일,류재환,류종훈 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7
We previously reported that oroxylin A, ac-aminobutyric acid A (GABAA) receptor antagonist,ameliorates drugs-induced memory impairments. We synthesizedseveral oroxylin A derivatives in efforts to find asubstance that has pro-cognitive effects as well as improvessensorimotor gating. The aim of the present study is toinvestigate the effect of a novel oroxylin A derivative,5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one (DMPC), on pharmacological models of schizophrenia,which exhibit memory impairment and sensorimotor gatingdeficit. Memory impairment was induced by scopolamine,a muscarinic receptor antagonist, or MK-801, an N-methyl-Daspartatereceptor antagonist. Sensorimotor gating deficitswere induced by MK-801 and measured by prepulse inhibition(PPI) of the acoustic startle response task. DMPC treatment(20 mg/kg) significantly attenuated scopolamine- or MK-801-induced memory impairment and it even enhanced cognitiveperformance of normal animals. Furthermore, DMPC significantlyameliorated MK-801-induced PPI deficits in theacoustic startle response task. In an in vitro study, DMPC(20 lM) inhibited intracellular Cl- influx induced by muscimol,a selective GABAA receptor agonist. These results suggestthat DMPC would be a potential candidate for alleviatingcognitive dysfunction and sensorimotor gating deficits inschizophrenia, and that its effects may be mediated, in part, viablockade of the GABAergic neurotransmitter system.
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Irene Joy I. dela Peña,홍은영,DELAPENAJUNEBRYAN,김희진,Chrislean Jun Botanas,홍예슬,황예슬,문병석,정재훈 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.11
Milk has long been known and used to promote sleep. The sleep-promoting effect of milk has been attributed to its psychological associations (i.e., the memory of a mother giving milk at bedtime) and its rich store of sleep-promoting constituents (e.g., tryptophan). Studies have shown that milk harvested at night (Night milk) contains exceptionally high amounts of tryptophan and melatonin. In the present study, we evaluated the psychopharmacological properties of Night milk, particularly its probable sleep-promoting/enhancing, and anxiolytic effects. Night milk was orally administered to ICR mice at various concentrations (100, 200, or 300mg/kg). An hour after administration, assessment of its sedative (open-field and rotarod tests) and sedative sleep-potentiating effects (pentobarbital-induced sleeping test) was conducted. For comparison, the effects of Day milk (daytime milking) were also assessed. In addition, the effects of Night milk on anxiety behavior (elevated plus maze [EPM] test) and electroencephalographic (EEG) waves were evaluated. Night milk-treated animals exhibited decreased spontaneous locomotion (open-field test) and impaired motor balance and coordination (rotarod test). Furthermore, Night milk shortened the sleep onset and prolonged the sleep duration induced by pentobarbital sodium. These effects were comparable to that of diazepam. In addition, Night milk significantly increased the percentage of time spent and entries into the open arms of the EPM, indicating that it also has anxiolytic effects. No significant changes in EEG waves were observed. Altogether, these findings suggest that Night milk is a promising natural aid for sleep- and anxiety-related disturbances.
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