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e-SELECT Investigators,Urban, P.,Abizaid, A.,Banning, A.,Bartorelli, A.L.,Baux, A.C.,Dzavik, V.,Ellis, S.,Gao, R.,Holmes, D.,Jeong, M.H.,Legrand, V.,Neumann, F.J.,Nyakern, M.,Spaulding, C.,Worthley, S Elsevier Biomedical 2011 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.57 No.13
Objectives: The aim of this study was to ascertain the 1-year incidence of stent thrombosis (ST) and major bleeding (MB) in a large, unselected population treated with sirolimus-eluting stents (SES). Background: Stent thrombosis and MB are major potential complications of drug-eluting stent implantation. Their relative incidence and predisposing factors among large populations treated worldwide are unclear. Methods: The SES were implanted in 15,147 patients who were entered in a multinational registry. We analyzed the incidence of: 1) definite and probable ST as defined by the Academic Research Consortium; and 2) MB, with the STEEPLE (Safety and efficacy of Enoxaparin in PCI) definition, together with their relation to dual antiplatelet therapy (DAPT) and to 1-year clinical outcomes. Results: The mean age of the sample was 62 +/- 11 years, 30.4% were diabetic, 10% had a Charlson comorbidity index ≥3, and 44% presented with acute coronary syndrome or myocardial infarction. At 1 year, the reported compliance with DAPT as recommended by the European Society of Cardiology guidelines was 86.3%. Adverse event rates were: ST 1.0%, MB 1.0%, mortality 1.7%, myocardial infarction 1.9%, and target lesion revascularization 2.3%. Multivariate analysis identified 9 correlates of ST and 4 correlates of MB. Advanced age and a high Charlson index were associated with an increased risk of both ST and MB. After ST, the 7-day and 1-year all-cause mortality was 30% and 35%, respectively, versus 1.5% and 10% after MB. Only 2 of 13,749 patients (0.015%) experienced both MB and ST during the entire 1-year follow-up period. Conclusions: In this worldwide population treated with ≥1 SES, the reported compliance with DAPT was good, and the incidence of ST and MB was low. Stent thrombosis and MB very rarely occurred in the same patient. (The e-SELECT Registry: a Multicenter Post-Market Surveillance; NCT00438919)
Wind structure and codification
Holmes, J.D.,Baker, C.J.,English, E.C.,Choi, E.C.C. Techno-Press 2005 Wind and Structures, An International Journal (WAS Vol.8 No.4
The paper describes the work of the Working Group on Wind Structure, one of the International Codification Working Groups set up by the International Association of Wind Engineering in 1999. The topics of terrain and exposure, shielding and shelter, topographic effects, tropical cyclone and hurricane wind structure, and thunderstorm wind structure, are described with emphasis on their codification in wind loading codes and standards. Recommendations from the working group are given.
Extreme wind prediction and zoning
Holmes, J.D.,Kasperski, M.,Miller, C.A.,Zuranski, J.A.,Choi, E.C.C. Techno-Press 2005 Wind and Structures, An International Journal (WAS Vol.8 No.4
The paper describes the work of the IAWE Working Group WGF - Extreme Wind Prediction and Zoning, one of the international codification working groups set up in 2000. The topics covered are: the international database of extreme winds, quality assurance and data quality, averaging times, return periods, probability distributions and fitting methods, mixed wind climates, directionality effects, the influence of orography, rare events and simulation methods, long-term climate change, and zoning and mapping. Recommendations are given to promote the future alignment of international codes and standards for wind loading.
Sun-Joo Hong,D. E. Holmes,L. H. Piette. Korean Chemical Society 1971 대한화학회지 Vol.15 No.5
An ESR study has been made on free radicals produced in frozen aqueous solutions (ices) of glycine, DL-${\alpha}$-alanine, DL-serine, L-cysteine, DL-leucine and DL-isoleucine by gamma-irradiation at dry ice temperature. All free radicals induced were decayed concomitant to the successive annealing but the radical species which is believed to be dominant seems to be stable even near the melting point of the ice. These dominant species were found to be identical to those resulted from direct action of radiation in the solid at room temperature. Small but significant changes in the spectra of glycine and DL-${\alpha}$-alanine were observed by varying the microwave power. These results seem to support the view that the spectra obtained were composite consisting of more than two different resonances having different power saturation characteristics. The relative contribution of unidentified resonances to the composite spectra was greater for solutions of low concentration. These resonances are assumed to be induced by indirect effects, mainly hydrogen abstraction by radiation produced hydroxyl radicals and also C-N bond cleavage by hydrated electrons.
Evolution of strain throughout gallium nitride deposited on silicon carbide
김지현,M.A. Mastro,N.D. Bassim,J.A. Freitas Jr.,M.E. Twigg,C.R. Eddy Jr.,D.K. Gaskill,R.L. Henry,R.T. Holm,P.G. Neudeck,A.J. Trunek,J.A. Powell 한양대학교 세라믹연구소 2007 Journal of Ceramic Processing Research Vol.8 No.5
During GaN growth on an on-axis SiC substrate, a large density of dislocations (~109 cm−2) is unavoidably generated by the GaN/SiC misfit, uncontrolled misorientation in the substrate and defects present at the surface of the substrate. Recently a unique SiC substrate was developed with step-free and stepped mesas as well as continuous surface areas similar to a standard wafer all in close proximity. It is now possible to isolate the influence of defects and steps on the deposition of GaN on SiC. This paper provides a link between the dislocation environment and the strain state in the GaN film as well as the change of this strain with increasing thickness.