소형 트럭용 글로우 플러그 보조 직분식 메탄올 엔진 개발

유철호(C.H. Yu),이종순(J.C.Lee),신동현(D.H.Shin),노석홍(S.H.Noh),강인식(I.S.Kang) 한국자동차공학회 1993 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

NOx and Particulates from Diesel engines are the main causes of air pollution in city areas. However. the reduction of both NOx and Particulates simultaneously is not easily realized.<br/> Vehicles powered by Diesel-type Methanol engine are under development to reduce emissions and are under fleet test.<br/> Physical and chemical properties of Methanol are compared to use Methanol as a fuel in a Diesel-type engine. Ignition assistance systems in Diesel-type Methanol engine are also compared because ignition assistance system is needed due to poor self-ignition property of Methanol.<br/> The way to solve technical problems of Diesel-type Methanol engines are presented as follows; stable self-ignition property under wide operating conditions. combustion improvement, reduction of power consumption and reliability for glow plug by reservoir<br/> -type glow plug and by EGR at low load. combustion improvement and elevation of conversion rate of catalyst by throttling at no load, reduction methed of formaldehyde emission.<br/>

Rebamipide attenuates Helicobacter pylori CagA-induced self-renewal capacity via modulation of β-catenin signaling axis in gastric cancer-initiating cells

Kang, D.W.,Noh, Y.N.,Hwang, W.C.,Choi, K.Y.,Min, D.S. Pergamon Press 2016 Biochemical pharmacology Vol.113 No.-

<P>Rebamipide, a mucosal-protective agent, is used clinically for treatment of gastritis and peptic ulcers induced by Helicobacter pylori (H. pylori) which is associated with increased risk of gastric cancer. Although rebamipide is known to inhibit the growth of gastric cancer cells, the action mechanisms of rebamipide in gastric carcinogenesis remains elusive. Here, we show that rebamipide suppresses H. pylori CagA-induced beta-catenin and its target cancer-initiating cells (C-IC) marker gene expression via upregulation of miRNA-320a and -4496. Rebamipide attenuated in vitro self-renewal capacity of H. pylori CagA-infected gastric C-IC via modulation of miRNA-320a/-4496-beta-catenin signaling axis. Moreover, rebamipide enhanced sensitivity to chemotherapeutic drugs in CagA-expressed gastric C-IC. Furthermore, rebamipide suppressed tumor-initiating capacity of gastric C-IC, probably via suppression of CagA-induced C-IC properties. These data provide novel insights for the efficacy of rebamipide as a chemoprotective drug against H. pylori CagA-induced carcinogenic potential. (C) 2016 Elsevier Inc. All rights reserved.</P>

SUPPRESSION OF THE TETRAGONAL DISTORTION IN THIN Pb(Zr, Ti)$O_3$/MgO(100)

Kang, H.C.,Noh, D.Y.,Je, J.H. The Korean Vacuum Society 1997 Applied Science and Convergence Technology Vol.6 No.1

The paraelectric cubic-to-ferroelectric tetragonal phase transition of the thin Pb(Zr, Ti)$O_3$ (PZT) films grown on MgO(001) substrate was investigated in a series of synchrotron x-ray scattering experiments. As the thickness of the film decreases the transition temperature and the amount of the tetragonal distortion were decreased continuously Different from only the c-domains were existent in the thinnest 25nm thick film. Based on this we propose a model for the domain structure of the tetragonal PZT/MgO(100) film that is very different from the ones suggested in literature. We attribute the suppression of the transition to the substrate field that prefers the c-type domains near the interface and suppresses the tetragonal distortion to minimize the film-substrate lattice mismatch.

Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus): Molecular and functional characterization and immune responsive mRNA expression analysis

Godahewa, G.I.,Perera, N.C.N.,Bathige, S.D.N.K.,Nam, B.H.,Noh, J.K.,Lee, J. Academic Press 2016 FISH AND SHELLFISH IMMUNOLOGY Vol.55 No.-

<P>The complement system serves conventional role in the innate defense against common invading pathogens. Complement factor D (CfD) is vital to alternative complement pathway activation in cleaving complement factor B. This catalytic reaction forms the alternative C3 convertase that is crucial for complement-mediated pathogenesis. In this study, rock bream (Oplegnathus fasciatus) CfD (OfCfD) was characterized and OfCfD mRNA expression was investigated. OfCfD encodes 277 amino acids (aa) for a 30-kDa polypeptide. A domain analysis of the deduced OfCfD aa sequence showed a single serine protease trypsin superfamily domain, a serine active region, three active sites, and three substrate-binding sites. Pairwise sequence comparisons indicated that OfCfD has the highest identity (84.5%) with Oreochromis niloticus CID. The phylogenetic tree revealed a common ancestral origin of CfD members, with fish CfD distinct from other vertebrate orthologs. The structural arrangement of the OfCfD gene (2451 bp) contained five exons interrupted by four introns. A spatial transcriptional analysis indicated that OfCfD transcripts constitutively expressed in all of the examined rock bream tissues, and that they were highest in the spleen and liver. In addition, OfCfD transcripts were immunologically upregulated by lipopolysaccharide (LPS) (12 h p.i.), Streptococcus iniae (12 h p.i.), rock bream iridovirus (RBIV) (6-12 h p.i.), and poly I:C (6 h p.i.) in spleen tissue. OfCfD is a trypsin protease and its recombinant protein showed strong protease activity similar to that of trypsin, indicating its catalytic function in the alternative pathway. Together, our findings suggest that OfCfD might be involved in immune responses in rock bream. (C) 2016 Elsevier Ltd. All rights reserved.</P>

Novel Mn^II coordination compounds constructed from benzoate and various bipyridyl ligands: Magnetic property and catalytic activity

Hwang, I.H.,Jo, Y.D.,Kim, H.Y.,Kang, J.,Noh, J.Y.,Hyun, M.Y.,Kim, C.,Kim, Y.,Kim, S.J. Pergamon Press 2012 Polyhedron Vol.42 No.1

Three new Mn<SUP>II</SUP>-benzoates coordination polymers containing various bipyridyl ligands (3,3'-dipicoylamine (3), 3-methylisoquinoline (4), and 4,4'-dithiopyridine (5)) and a [Mn<SUB>6</SUB>(O<SUB>2</SUB>CPh)<SUB>10</SUB>(μ<SUB>4</SUB>-OH)<SUB>2</SUB>(CH<SUB>3</SUB>OH)<SUB>3</SUB>(H<SUB>2</SUB>O)].1.5(C<SUB>4</SUB>H<SUB>4</SUB>N<SUB>2</SUB>) cluster (1) have prepared and their structures were determined. The bipyridyl ligands can act as bridging ligands to produce 1-D or 2-D polymeric compounds. The pyrazine produced a Mn<SUB>6</SUB> cluster molecule, and 3-methylisoquinoline did a benzoate-bridged 1-D Mn<SUP>II</SUP> compound. The Mn<SUB>6</SUB> cluster (1) and 1-D Mn<SUP>II</SUP> compounds (3) and (4) show antiferromagnetic property. The compounds 1, 3, and 4 have catalyzed efficiently the transesterification of a variety of esters, while 5 has displayed a very slow conversion. The thermal stabilities of these complexes were also examined.

Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice

Kim, Y.H.,Hwang, J.H.,Kim, K.S.,Noh, J.R.,Choi, D.H.,Kim, D.K.,Tadi, S.,Yim, Y.H.,Choi, H.S.,Lee, C.H. Elsevier Science Publishers 2015 Journal of hepatology Vol.63 No.1

Background & Aims: Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure. Prolonged c-Jun N-terminal kinase (JNK) activation plays a central role in APAP-induced liver injury and growth arrest, and DNA damage-inducible 45 beta (Gadd45β) is known to inhibit JNK phosphorylation. Metformin has recently been shown to have hepatoprotective effects. The aim of the present study is to investigate whether metformin mitigates APAP-induced hepatotoxicity and to ascertain the molecular basis of this effect. Methods: We used APAP- and/or metformin-treated Gadd45β knockout (KO) mice and wild type (WT) C57BL/6J control mice. Primary mouse hepatocytes were isolated from WT and Gadd45β KO mice were used for in vitro study. Results: Metformin pretreatment protected against APAP toxicity with decreased liver damage, and inhibited APAP-induced prolonged hepatic JNK phosphorylation in WT mice. Gadd45β expression was increased after APAP treatment, and the expression of Gadd45β was further enhanced by metformin. The effects of metformin on APAP-induced liver injury and JNK phosphorylation were abolished in Gadd45β KO mice. Notably, subtoxic doses of APAP caused cell death and sustained JNK phosphorylation in Gadd45β-deficient primary hepatocytes. In parallel, APAP increased mortality, severe liver injury, and JNK activation in Gadd45β KO mice. Interestingly, metformin administered after APAP treatment protected against APAP-evoked hepatotoxicity in WT mice, but not in Gadd45β KO mice. Conclusions: This study is the first to demonstrate that metformin shows protective and therapeutic effects against APAP overdose-evoked hepatotoxicity via Gadd45β-dependent JNK regulation. Metformin would be a promising therapeutic strategy for treatment of APAP overdose.

Rosmarinic acid potentiates ATRA-induced macrophage differentiation in acute promyelocytic leukemia NB4 cells

Heo, S.K.,Noh, E.K.,Yoon, D.J.,Jo, J.C.,Koh, S.,Baek, J.H.,Park, J.H.,Min, Y.J.,Kim, H. North-Holland ; Elsevier Science Ltd 2015 european journal of pharmacology Vol.747 No.-

Rosmarinic acid (RA, an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid) has a number of biological activities, but little is known about anti-leukemic activities of RA combined with all-trans retinoic acid (ATRA) against acute promyelocytic leukemia (APL) cells. We examined the differentiation marker, CD11b, in bone marrow cells (BMC) of an APL patient, in NB4 cells (APL cell line), and in normal BMC and peripheral blood mononuclear cells (PBMC) of healthy subjects by flow cytometric analysis. ATRA/RA induced expression of CD11b in the BMC of the APL patient and in NB4 cells, but not in normal BMC or PBMC. Therefore, we realized that RA potentiated ATRA-induced macrophage differentiation in APL cells. Further characterization of the induced macrophages showed that they exhibited morphological changes and were able to phagocytose and generate reactive oxygen species. Th also had typical expression of C-C chemokine receptor type 1 (CCR1), CCR2, and intercellular adhesion molecule-1 (ICAM-1). Moreover, the expression of CD11b<SUP>+</SUP> and CD14<SUP>+</SUP> cells depended on ERK-NF-κB axis activation. Together, these results indicate that RA potentiates ATRA-induced macrophage differentiation in APL cells. Thus, RA may play an important role as an appurtenant differentiation agent for functional macrophage differentiation in APL. Additionally, the differentiated macrophages might have a normal life span and, they could die. These data indicate that co-treatment with RA and ATRA has potential as an anti-leukemic therapy in APL.

A Clinical Study on the Anti-hypertensive Effect of Barnidipine HCl in Hypertensive Patients with Renal Disease

Kwon, K. H 大韓臨床藥理學會 1996 臨床藥理學會誌 Vol.4 No.2

Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): Molecular characterization, genomic arrangement and immune responses upon pathogenic stresses

Godahewa, G.I.,Wickramaarachchi, W.D.N.,Whang, I.,Bathige, S.D.N.K.,Lim, B.S.,Choi, C.Y.,De Zoysa, M.,Noh, J.K.,Lee, J. Elsevier 2014 Veterinary immunology and immunopathology Vol. No.

Carboxypeptidases (CPs) are proteases that hydrolyze C-terminal peptide bonds. They are involved in regulating the complement system of the immune system. Here, we report the molecular characterization and immune response of two carboxypeptidases, named carboxypeptidase A (Rb-CPA) and carboxypeptidase N1 (Rb-CPN1), from rock bream. The genomic sequence of Rb-CPA contains 12 exons interrupted by 11 introns, while the genomic sequence of Rb-CPN1 has 9 exons and 8 introns. The cDNA sequence of Rb-CPA encodes a 421-amino-acid (AA) polypeptide (48kDa), and the cDNA of Rb-CPN1 encodes a 448-AA polypeptide (51kDa). The amino acid sequences of Rb-CPA and Rb-CPN1 were found to harbor two characteristic Zn-binding signature domains and a peptidase-M14 Zn carboxypeptidase site. Pairwise analysis revealed that Rb-CPA and Rb-CPN1 had the highest identity with the corresponding proteins from Anoplopoma fimbria (87.6%) and Dicentrarchus labrax (96.9%), respectively. qPCR results indicated that Rb-CPA and Rb-CPN1 were constitutively expressed mainly in the kidney, heart, liver, and head kidney. Both genes were transcriptionally regulated in the liver upon challenge with pathogenic bacteria (Streptococcus iniae, Edwardsiella tarda), rock bream iridovirus (RBIV), and the immune modulators polyinosinic:polycytidylic acid and lipopolysaccharide. Taken together, our findings suggest that Rb-CPA and Rb-CPN1 have immune-related functions in rock bream.

자발형성 InAs/GaAs 양자점의 구조 및 성장 특성

김형석,서주형,박찬경,이상준,노삼규,송진동,박용주,이정일 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.3

Self-assembled InAs/GaAs quantum dots (QDs) were grown by molecular beam epitaxy and the growth characteristics of QDs were studied using field emission gun-electron transmission microscope. The shapes and optical properties of QDs changed according to spacer layers thickness due to the strain between InAs and GaAs layers. The QDs with 50 nm thick GaAs spacer layers were distributed randomly along the growth direction and changed from dome to flat-pyramidal shape after capping with GaAs. However, QDs with 10 nm thick spacer layers were vertically aligned up to the fifth period and the dome-shape was maintained after capping. The density, distribution and crystalline defects depending on growth conditions were also investigated.