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RISS 인기검색어
- 검색키워드
- 저자 : D L. Peng (검색결과 90 건)
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Intracranial Stenting of Subacute Symptomatic Atherosclerotic Occlusion Versus Stenosis
Lü,, Peng-Hua,Park, Jee Won,Park, Soonchan,Kim, Jong Lim,Lee, Deok Hee,Kwon, Sun Uck,Kim, Jong Sung,Yun, Sung-Cheol,Suh, Dae Chul Ovid Technologies Wolters Kluwer -American Heart A 2011 Stroke Vol.42 No.12
<B>Background and Purpose-</B><P>Limited data are available concerning the outcome of angioplasty/stenting for subacute atherosclerotic intracranial artery occlusion, which is often associated with progressive symptom development in the salvageable brain under ischemic threat due to poor collateral blood supply.</P><B>Methods-</B><P>Among 177 patients who underwent angioplasty and/or stenting for severe symptomatic intracranial steno-occlusion, 26 had subacute atherosclerotic intracranial artery occlusion. Outcome after stenting (N=22) was assessed according to procedural success (return of antegrade flow and residual stenosis <50%), adverse event (any stroke or death) rate, and restenosis (>50%) using weighted Cox proportional hazards regression in the overall cohort and in separate subgroups.</P><B>Results-</B><P>Successful recanalization was achieved in 95%. Three adverse events (13.6%) occurred among patients undergoing stenting for occlusion, including 2 major strokes and 1 nonprocedure-related death. Good outcome (modified Rankin Scale ≤2) was achieved in 73%. In the overall cohort, no significant difference was observed between the occlusion and stenosis groups in terms of the risk of adverse events (hazard ratio for the occlusion group, 1.055; 95% CI, 0.29-3.90) or the risk of restenosis (hazard ratio for the occlusion group, 1.2; 95% CI, 0.19-7.72). A trend toward a higher rate of adverse events was observed in older age (>65 years), progressive worsening, balloon-expandable stent, and no history of a preprocedural P2Y12 assay.</P><B>Conclusions-</B><P>In a cohort of patients undergoing angioplasty/stenting for subacute atherosclerotic intracranial artery occlusion, no significant difference in the rates of adverse events was observed. However, several factors, including age, tended to be associated with a higher event rate.</P>
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JIEGANG PENG,S. XUE,Z. YAN,X. WU,L. ZHAN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.6
In this work, we studied FePt-C nanogranular films were fabricated for ultrahigh density perpendicular recording media towards 1 Tbits/in^2. For the optimized growth conditions, we achieved a Fe_(52)Pt_(48)-C50% granular film with uniform grain size of 6.4 ± 1.5 nm, shown in the TEM image. It also has an excellent MH loop shape with a perpendicular coercivity of 20 kOe, and squareness of 1.We studied the thermal stability of the optimized film and obtained the energy barrier Eb of 340 k_BT at room temperature, meaning that excellent thermal stability as magnetic recording media.
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A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples
Chen, Han,Li, Chunyan,Peng, Xinxin,Zhou, Zhicheng,Weinstein, John N.,Caesar-Johnson, Samantha J.,Demchok, John A.,Felau, Ina,Kasapi, Melpomeni,Ferguson, Martin L.,Hutter, Carolyn M.,Sofia, Heidi J.,Ta Elsevier 2018 Cell Vol.173 No.2
<P><B>Summary</B></P> <P>The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 8928 tumor samples across 33 cancer types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed in most cancers. Across cancer types, global enhancer activity was positively associated with aneuploidy, but not mutation load, suggesting a hypothesis centered on “chromatin-state” to explain their interplay. Integrating eQTL, mRNA co-expression, and Hi-C data analysis, we developed a computational method to infer causal enhancer-gene interactions, revealing enhancers of clinically actionable genes. Having identified an enhancer ∼140 kb downstream of PD-L1, a major immunotherapy target, we validated it experimentally. This study provides a systematic view of enhancer activity in diverse tumor contexts and suggests the clinical implications of enhancers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Systematic analysis of enhancer expression across ∼9,000 samples of 33 cancer types </LI> <LI> Global enhancer activation positively correlates with aneuploidy but not mutations </LI> <LI> A computational method that infers causal enhancer-target-gene relationships </LI> <LI> Enhancers as key regulators of therapeutic targets, including PD-L1 </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
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강원도에서 토양과 기후 데이터베이스를 이용한 청보리의 재배 적지 구분
김경대 ( K D Kim ),성경일 ( K I Sung ),주진호 ( J H Joo ),김병완 ( B W Kim ),팽경륜 ( J L Peng ),이배훈 ( B H Lee ),잘일가세미네자드 ( J G Nejad ),조무환 ( M H Jo ),임영철 ( Y C Lim ) 강원대학교 농업생명과학연구원(구 농업과학연구소) 2013 강원 농업생명환경연구 Vol.25 No.3
본 연구는 토양과 기후 데이터베이스를 이용하여 조사료 재배적지 기준 설정 연구의 일환으로 청보리를 대상으로 강원도에서의 재배가능지역을 추정하였다. 토양요인항목으로는 토양 물리성인 토성, 배수, 경사, 유효토심 및 암반노출, 토양화학성인 토양산도, 토양염류도 및 유기물함량을 선정하고 기준값 및 가중치를 설정하였다. 기후요인항목으로는 1월 일최저온도 평균, 3-5월의 평균온도, 9-12월의 5℃ 이상 일수, 10-5월의 강수일수와 강수량 그리고 3월에서 5월까지의 일조시간을 선정하고 기준값 및 가중치를 설정하였다. 토양요인의 관점에서 강원도에서 청보리의 재배가능지 및 재배최적지는 영동지방의 경우 고성, 속초, 양양, 강릉, 동해 및 삼척이며 주로 경사가 완만한 해안지역에 분포하고 있었다. 영서지방은 철원, 양구, 춘천, 원주, 횡성, 평창 및 정선에 주로 분포하고 있었다. 기후요인의 관점에서 강원도는 대부분이 50점이상이었으며, 재배가능지는 고성, 속초, 양양, 강릉, 동해 및 삼척의 해안지역과 철원, 양구, 춘천, 원주, 횡성, 평창 및 정선 일부 지역이 포함되었다. 이상의 결과로부터 강원도에서 토양과 기후요인을 고려한 청보리의 재배가능지 및 재배최적지는 영동지방의 고성, 속초, 양양, 강릉, 동해 및 삼척의 해안지역을 중심으로 가능하였고, 영서지방의 철원, 양구, 춘천, 원주, 횡성, 평창 및 정선 일부지역에서 재배가능지로 나타나고 있다. 향후 청보리의 재배적지 연구를 위해서는 일조시간에 대한 전자정보의 확보가 이루어진다면, 더욱 정밀한 청보리 재배 적지의 예상이 가능할 것으로 판단된다. As a part of establishing suitability classification for forage production, use of the national soil and climate database was attempted for Whole crop barley (Hordeum vulgare var. hexastichon (L.) Asch.) in Gangwon Province. The soil data base were from Heugtoram of the National Academy of Agricultural Science, and the climate data base were from the National Center for Agro-Meteorology, respectively. Soil physical properties including soil texture, drainage, slope available depth and surface rock contents, and soil chemical properties including soil acidity and salinity, organic matter content were selected as soil factors. The criteria and weighting factors of these elements were scored. Climate factors including average daily minimum temperature in January, average temperature from March to May, the number of days of which average temperature was higher than 5℃ from September to December, the number of days of precipitation and its amount from October to May of the following year, and sunshine hours from March to May were selected, and criteria and weighting factors were scored. The electronic maps were developed with these scores using the national data base of soil and climate. Based on soil scores, the area of Goseong, Sogcho, Yangyang, Gangreung, Donghea and Samcheog in east coastal region with gentle slope were classified as the possible and/or the proper area for Whole crop barley cultivation in Gangwon Province. The lands with gentle or moderate slope of Cheolwon, Yanggu, Chuncheon, Wonju, Hweongseong, Pyungchang and Jeongsun in west side slope of Taebaeg mountains were classified as the possible and/or proper area as well. Based on climate score, the east coastal area of Goseong, Sogcho, Yangyang, Gangreung and Samcheog could be classified as the possible or proper area. Most area located on west side of the Taebaeg mountains were classified as not suitable for Whole crop barley production. In scattered area in Cheolwon, Yanggu, Chuncheon, Wonju, Hweongseong, Pyungchang and Jeongsun, where the scores exceeded 50, the Whole crop barley cultivation should be carefully managed for good production. As a results, based on soil with climate the area of Goseong, Sogcho, Yangyang, Gangreung, Donghea and Samcheog in east coastal region with gentle slope and some area of Cheolwon, Yanggu, Chuncheon, Wonju, Hweongseong, Pyungchang and Jeongsun were classified as the possible and/or the proper area for Whole crop barley cultivation in Gangwon Province. For better application of electronic maps of whole crop barley, acurate study will be possible if a data comfirmed on th shine hours is achieved.
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Peng, Y.L.,Guo, Y.M.,Yuan, J.M. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.8
Two experiments were conducted to examine the effects of dietary inclusion of xylose on growth performance, nutrient digestibility and xylose absorption in the portal-drained viscera of broiler chicks. In Exp. 1, ninety male 14 day-old broilers were used to study the effects of different inclusion levels (0, 5, 10, 20 and 40%) of D-xylose in the semi-purified diets on the growth and nutrient digestibility of broilers. In Exp. 2, One hundred and eight male broilers, fed by precision feeding at 22 day-old, were used to investigate the absorption and transportation of dietary xylose in the portal-drained viscera of broiler. The results of Exp. 1 indicated that the growth of broilers was gradually decreased as the xylose level increased (p<0.01). With the xylose supplementation increased, the moisture in broiler excreta was gradually elevated (p<0.01), AME and the digestibilities of crude protein and ether extract were significantly reduced and the digestibilities of xylose and arabinose were also decreased (p<0.01). The results of Exp. 2 showed that the concentrations of ribose, xylose and galactose in serum were significantly influenced by different dietary levels of xylose (p<0.01), but there's no apparent difference among rhamnose, glucose and arabinose (p>0.05). The xylose concentration in serum was highest in Vena Cava, middle in Portal Vein and lowest in Ulnar Vein within 6 h after precision feeding. And then the xylose concentration in Portal Vein and Ulnar Vein were higher than that of Vena Cava. The concentration of ribose, xylose and galactose in serum were also significantly changed with time prolongation (p<0.01). The concentration of xylose in serum was highest in the 40% xylose treatment, middle in the 20% xylose group and lowest in the control group. The glycogen contents in liver and muscle were linearly decreased as the level of xylose increased (p<0.01). The higher the dietary level of xylose was, the lower digestibility of dietary xylose was (p<0.10). 40% xylose markedly decreased the digestibility of dietary glucose (p<0.01). In conclusion, high levels of xylose in the diets inhibited the growth and nutrient digestibility of broiler. The outputs of xylose from the hydrolyzation of wheat-based diet by xylanase should have no adverse effects on broiler performance.
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Peng, Y.L.,Guo, Y.M.,Yuan, J.M. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.2
Two experiments were conducted with broilers to investigate the feasibility of microbial phytase replacing partial inorganic phosphorus supplementation and the synergistic effects of xylanase (320 FTU/kg) supplementation alone or in combination with phytase (750 U/kg) replacing 0.08% dietary inorganic phosphorus, on the growth performance and utilization of nutrients in broilers fed wheat-based diets. In Experiment 1, 540 broilers were fed five diets for 6 weeks. Diets C0 and C1 were corn-based diets and 0.08% inorganic P supplementation was replaced with 750 U phytase/kg feed in Diet C1. Diets W0, W1 and W2 were wheat-based diets supplemented with microbial phytase 0, 750, 750 U/kg feed and 0, 0.08% and 0.16% dietary inorganic P were replaced, respectively. In Experiment 2, 432 broilers were divided into four treatments to determine the synergistic effects of supplemental xylanase and phytase replacing 0.08% inorganic P. Four experimental diets were arranged according to a $2{\times}2$ factorial design. The results indicated that addition of phytase increased the digestibility of phytic P by 31.0 to 55%, dramatically decreased the excretion of phytic P and total P by 31.6 to 55.0% and 13.8 to 32.9%, respectively (p<0.01). It is feasible to completely replace 0.08% inorganic phosphorus supplementation with microbial phytase 750 U/kg in corn- or wheat-based diets for broilers. Addition of xylanase alone or in combination with phytase replacing 0.08% dietary inorganic P, increased body weight gain and feed utilization efficiency of broilers fed wheat-based diets (p<0.10) and decreased overall mortality (p<0.10). In the groups of birds supplementing xylanase 320 FTU/kg feed, a marked elevation of the dietary AME was observed (p<0.05). Addition of phytase replacing 0.08% dietary inorganic phosphorus, concurrently with xylanase supplementation had additive effects on the apparent digestibility of dietary phytic P and overall feed conversion ratio (p<0.05).
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