http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Cyong,Jong Chol (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Reversal effects of Kampo medicine on pathogenesis of diabetes
Cyong, Jong Chol 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Jong-Chol Cyong. Department of Bioregulatory Function, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. Reveral effects of Kampo medicine on pathogenesis of diabetes. Proceedings of International Symposium on East-West Medicine. 110-116, 1999.-purpose Traditional medicine has defined an exhausted condition with polyuria due to over-drinking, over-eating. And as "shoukatsu<消渴>"(emaciation-thirst) from the ancient times. It is considered that "shou-katsu" would obviously correspond to diabetes mellitus in modern medicine. We have attempted bridge building by the common understanding of the pathogenesis of diabetes in Kampo medicine and modern medicine. Material and Method We have selected six formulae, Mao-to(痲黃湯), Shimbu-to(眞武湯), Ninjin-to(人蔘湯), Shigyaku-san (四逆散), Keishi-to(桂枝湯)and Shimotsu-to(四物湯), which contain relatively fewer kinds of crude drugs. We consider these formulae to be the basis of various herbal combinations. We administered these six formulae to three different types of experimental mice affected by type ` diabetes. 1)BALB/C diabetic mice with destruction of pancreatic islet inducedby single high doses of streptozotocin(STZ); 2) C57BL/Ks mice with T cell mediated autoimmune diabetes induced by single low doses of STZ(MLDSTZ); 3)NOD/Shi spontaneously diabetic mice. In addition, we clinically Investigated outpatients with type 2 diabetes who received the combination therapy of Kampo medicines. Results and Discussion. The Ninjin-to(人蔘湯) could reverse the decrease of weight in MLDSTZ induced diabetes mice, improve their general status, and significantly inhibit the development of diabetes. But we observed lymphatic infiltration of the pancreatic islets in both the control group and the Ninjin-to treated group. We found great changes in the Ninjin-to reated group when we analyzed the functions of the lymphocytes in detail. The Ninjin-to reated group when we analyzed the functions of the lymphocytes in detail. The Ninjin-to treatment could reduce the increase of INF□-producing cells, measurement of the expression of INFγand IL-4 in the CD4 cells stimulated by anti-CD3/CD28. Type 1 diabetes causes an augment in the Th¹ helper function, and the Ninjin-to may control the balance of Th¹and Th²by suppressing of Th1 function. We found that the incidence of diabetes could be prevented in NOD mice by the administration of the Ninjin-to for 24 weeks. We also observed a significant improvement in glucose tolerance and the regression of insulitis. It has not yet been reported that a preventive drug for diabetes has been developed in Western medicine. Anti-heat shock protein(HSP) antibodies are produced before the expression of advanced glycation endproduct(AGE) in human type 1 diabetes. The values of anti-HSP antibodies have been increased in untreated NOD mice, according to the progression of diabetes. However, the expression of anti-HSP antibodies was significantly decreased in the group of mice treated by the Ninjin-to, We also observed artherosclerosis in the main arteries when normal mice immunized by bacterial HSP took the lipid loading diet, It is suggested that anti-HSP protein antibodies may be expressed both in diabetes and in artheroslerosis. Anti-HSP antibodies were frequently found in the serum of patients with diabetes. The administration of Hachimi-jio-gan(八味地黃丸)for two weeks could reduce this expression of anti-HSP antibodies. The destroyed islet cells in STZ-induced diabetic mice were observed to be regenerated in an extremely short time after the administration of Mao-to(麻黃湯)to these mice. In addition, Zokumei-to(統命湯), which has the combined formulae of Ninjin-to and Mao-to could significantly decrease HbA1c in the patient with diabetes. Conclusion We found that simple Kampo formulae such as Ninjin-to or Mao-to may have potent preventive effects against diabetes and artherosclerosis, and may restore thepancreatic islets. Advanced research in Kampo medicnes may show novel ways for the prevention and treatment of diabetes mellitus.
-
Effect of Kampo Formulations on Visual Evoked Potentials
Uebaba,Kazuo,Cyong,Jong Chol,Xu,Feng Hao 慶熙大學校韓醫科大學韓醫學硏究所 1998 慶熙韓醫大論文集 Vol.21 No.1
For the assesslllent of pharmacological actions of Kampo formulation on cerebral higher function, visual evoked potentials(VEP) were measured before and after administration of 6 main Kampo formulation to 7 healthy male adults. As result, Mao-to induced a progressive significant prolongation of latency of P100 and continuous decrease of amplitude of N145(p<0.005 bypaired t-test same as following chages), while Shinbu-to induced time dependent significant prolongation of latency of N145 and transient decrease of amplitude of P100 and N145 at 60 minutes after administration. Shigyaku-san induced prolongation of latency of both of N75 and P100, transient decrease of N75 and continuous decrease of P100. Keishi-to showed a progressive prolongation of latency of P100, while Ninjin-to showed neither significant changes of latency or amplitude. Mao-to, Keishi-to, Shigyaku-san and Shinbu-to showed significant prolongation of latency, while Shimotu-to and Ninjin-to showed nonsignificant change of latency of VEP. Furthermore, Mao-to showed a progressive significant decrease of amplitude of VEP, in turn Shinbu-to showed a progressive significant increase, while Ninjin-to and Keishi-to showed no change of these parameters of VEP.
-
-
양한철,나경수,산전양성,성하진,정종철 한국농화학회 1989 Applied Biological Chemistry (Appl Biol Chem) Vol.32 No.4
Water-soluble crude polysaccharide (CAP-0) obtained from the Capsici Fructus(the fruits of Capsium annuum L.) showed a potent anti-complementary activity. The anti-complementary activity did not change by pronase digestion of CAP-0, but decreased by the periodate oxidation. CAP-0 was fractionated into four polysaccharide fractions, CAP-1, 2, 3 and 4, by the addition of cetyltrimethylammonium bromide. CAP-1, showing the highest anti-complementary activity, was refractioned by anion-exchange chromatography to give three major fractions(CAP-1-III, IV and V). CAP-1-III was shown to have low anti-complementary activity, but CAP-1-IV and V had high activity. CAP-1-III and IV were purified on Sephadex G-100 to give each two fractions(CAP-1-IIIa and IIIb, CAP-1-IVa and IVb), respectively. From the results of gel filtration and electrophoresis, these four fractions and CAP-1-V were found to be homogeneous polysaccharides. High molecular polysaccharies(M.W. CAP-1-IIIa 70,000, IVa 195,000, V 140,000) showed relatively higher anti-complementary activity than low molecular polysaccharides(CAP-1-IIIb and IVb).
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
