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Chunna Liu,Huijiao Lin,Liu Jiawei,Yao Wang,Chunmei Wang,Jinghui Sun,Chunyan Yu,Ying Dong,Wenyue Zhuang,Shu Jing,JianGuang Chen,He Li 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.8
Free radical accumulation in the body will cause oxidative stress damages including the renal damage. Schisandrae Sphenantherae Fructus (Schisandra), a traditional Chinese herbal medicine, has been used throughout the world. Anwulignan, a monomer extracted from Schisandra, has been shown in our previous studies to possess antioxidant and protective effects on the liver, brain and spleen damages in the aging mice. However, its effect on the renal damage caused by aging is not clear. This study showed that anwulignan could significantly increase the kidney index, the creatinine clearance, the activities of superoxide dismutase, catalase and glutathione peroxidase; reduce the urinary protein concentration, the serum urea nitrogen and creatinine content, the content of malondialdehyde and 8-hydroxylated deoxyguanosine in the renal tissue; and improve the renal tissue damage. Moreover, anwulignan increased the production of Nrf2, HO-1 and NQO1 proteins and decreased the production level of Keap1 protein in the renal tissue in the D-galactose induced aging mice. These results suggest that anwulignan significantly alleviates the renal damage by its antioxidant effect through regulating the production of Nrf2/ARE pathway-related proteins in the renal tissue in the D-galactose induced aging mice.
Xinrong Liu,Yongquan Liu,Zhongping Yang,Chunmei He 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.5
Pile-Beam-Arch (PBA) method is an effective approach to control the surface settlement induced by excavation to construct the subway station, especially when the station is located in the urban area with dense buildings. Based on the numerical analysis model of practical engineering, the whole construction stages of the subway station built by PBA method are simulated in this paper. The mechanical performance of supporting structures (such as piles, beams, arches, secondary lining and backfill concrete) and surface settlement characteristics during construction are investigated. The results show that the pre-supporting system of piles, beams and arches is formed in the stage of soil excavation under main tunnel arch; Station hall plate and backfill concrete are two key structures to ensure the support stiffness of PBA supporting system. In addition, compared to the bottom-up method, the top-down method for the secondary lining construction can obviously reduce the internal force of supporting structures and the surface settlement. Combined with in-situ monitoring data, three increase stages of surface settlement and the corresponding settlement ratio are gained and the characteristic of surface settlement trough is also analysed. This study is helpful for further understanding the support mechanism of PBA method and the increase law of the ground settlement during the construction of the station built by PBA method.
The Superiority of 68 Ga-FAPI-04 over 18F-FDG in a Case of Gallbladder Cancer
Chunmei Guo,Dengsai Peng,Ya Liu,Liming Chen,Zhanwen Huang 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.5
A 56-year-old man presented with vague upper abdominal pain for more than 4 months. His abdominal ultrasound and MRI showed thickening of the neck and base of the gallbladder and nodule formation at the base of the gallbladder. 18F-FDG PET/CT revealed intense FDG uptake in the base of the gallbladder and multiple lymph nodes. 68 Ga-FAPI-04 PET/CT not only showed intense FAPI uptake in the above mentioned FDG-avid lesions but also showed intense FAPI uptake in the neck lesion of the gallbladder and some other additional lymph nodes. Finally, histopathological examination confirmed poorly differentiated tubular adenocarcinoma of the neck and base of the gallbladder. Our case illustrated that 68 Ga-FAPI-04 PET/CT may outperform 18F-FDG PET/CT in the detection of gallbladder cancer primary and metastatic lesions.
Liu Yongshi,Lei Jie,Ji Xiang,Li Chunmei,Chen Xiaoxia,Wang Juan,Dong Jiajia,Zhang Hongpei,Li Yan 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background Non-small cell lung cancer (NSCLC) is characterized by high morbidity and mortality in the world. Growth and differentiation factor 15 (GDF15) has been proved to play an important role in regulating tumor progression. However, the influence of GDF15 on NSCLC remains unclear. Objective We aimed to investigate the regulatory role of GDF15 in NSCLC. Methods The correlation between GDF15 expression and prognosis, stage of NSCLC was examined with bioinformatics method. The cell proliferation was detected with CCK8 and EdU staining. Wound healing, Transwell, flow cytometry assays were used to measure cell migration, invasion, and apoptosis, respectively. Results High expression of GDF15 is correlated with worse survival and malignant progression of NSCLC. Knockdown of GDF15 restrained the proliferation, invasion, migration, but accelerated apoptosis of lung cancer cells through regulating PTEN/PI3K/AKT signaling pathway. sh-GDF15 suppressed epithelial mesenchymal transition (EMT) process and promoted the chemotherapy sensitivity of lung cancer cells. Conclusion GDF15 plays an important role in NSCLC progression. GDF15 mediated PTEN/PI3K/AKT signaling pathway might be the potential therapeutic targets for the prevention and treatment of GDF15.
Drug distribution management system based on IoT
Zeliang Liu,Chunmei Zhang,Hui Peng,Qin Xu,Yubao Gao 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.2
In hospitals and pharmacies, the distribution of medicines is an important part. Any mistakes, misses, fake medicines and expired medicines can cause medical accidents. With the widespread application of the Internet of Things technology (IoT), traditional drug distribution methods need to be upgraded. This article proposes a drug distribution management scheme based on the Internet of Things technology. In the production of drugs, a flexible RFID tag was printed on the packaging box, which stored a series of information such as drug name, dosage, raw materials, efficacy, production date, expiration date, and manufacturer. The use of a drug distribution management system combined with RFID readers can identify drug information and effectively prevent the occurrence of erroneous, missed, counterfeit, and expired drugs. It can also improve management efficiency, reduce management costs, and control management risks. Through the circuit design and software system development, the test results show that this solution is effective and feasible, the proposed method can achieve the expected results.
Yuan Liu,Yanmei Liao,Yintao Long,Yuxiang Qian,Shengqiang Nie,Yi Wang,Jia Zeng,Chunmei Zhang,Linbo Tian,Jun Luo 한국고분자학회 2022 폴리머 Vol.46 No.3
It is a considerable challenge for expanding the applications of self-healing polyurethane because of the dilemma in balancing its mechanical and self-healing properties. Herein, a series of self-healing polyurethane systems (PUT-x) with short-range ordered rigid aromatic structures were synthesized by simply adjusting two kinds of diisocyanates, and by ingenious addition of aromatic chain extender. We hope to regulate the π-π interactions and further to manipulate the properties of obtained polyurethanes via adjusting the amount of the benzene rings in the molecular chains of the PUT-x systems. The PUT-5 with decent self-healing ability, optimal mechanical properties, acceptable thermal stability and favorable transparency was selected to incorporate liquid metal and fluorescent powder to fabricate conductive wire and anti-counterfeiting film. Significantly, the liquid metal could be recycled from the conductive wire conveniently without using strong acids or strong bases. Moreover, PUT-5 exemplarily withstood long-term soaking in normal saline, and no deformation could be identified.
Shuang Liu,Chunmei Duan,Wuneng Zhou 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.9
This paper deals with the stochastic stability problem of the closed-loop system under deception attacks based on an adaptive event-triggering scheme (AETS) with saturation constraint. Some novel stability criteria related to networked control systems under deception attacks are devised by taking the fixed threshold which is difficult to adapt to changeable systems into account. An adaptive event-triggering scheme with saturation constraint involving a threshold variable with system states is proposed to reduce network load, and the desired controller gain matrix is obtained by employing the linear matrix inequalities (LMIs) technique. Moreover, the LyapunovKrasovskii method is used to obtain sufficient conditions for ensuring the stability of the system. In the end, the simulation results are shown to indicate the validity of the proposed method.
Study on Determination of Demand Intensity for Tourist Transit of Open Expressway Service Area
Yong Liu,Ying Lin,Runmin Zhang,Chunmei Zhong 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4
In order to forecast the demand intensity for tourist transit of open expressway service area more accurately, according to the generation principle of tourism intensity, fully considering the influence of three forces including tourists travel demand thrust, tourism cities attraction and travel cost resistance on the strength of tourism, combining gravity model and giving a new meaning to the supply and demand parameters of the prediction model, this paper proposed a new model based on the three interaction forces to predict the demand intensity for tourist transit. In the face of lack of the status quo of tourism data, in order to verify the validity of the model, the method transforming the tourist receipts of tourist city into tourist traffic generation of a particular city was put forward. Finally, in the instance of Shuifu city of Yunnan province, this paper predicted the strength of tourists to travel in Shuifu. Numerical results showed that the model can be calibrated by the instance data and well explain the generation and distribution mechanism of traffic. This work can provide a certain basis for traffic service facilities planning.