Randomized Control Study of Nedaplatin or Cisplatin Concomitant with Other Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer

Li, Chun-Hong,Liu, Mei-Yan,Liu, Wei,Li, Dan-Dan,Cai, Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Objective: To observe the short-term efficacy, long-term survival time and adverse responses with nedaplatin (NDP) or cisplatin (DDP) concomitant with other chemotherapy in treating non-small cell lung cancer. Materials and Methods: A retrospective, randomized, control study was conducted, in which 619 NSCLC patients in phases III and IV who were initially treated and re-treated were randomly divided into an NDP group (n=294) and a DDP group (n=325), the latter being regarded as controls. Chemotherapeutic protocols (CP/DP/GP/NP/TP) containing NDP or DDP were given to both groups. Patients in both groups were further divided to evaluate the clinical efficacies according to initial and re-treatment stage, pathological pattern, type of combined chemotherapeutic protocols, tumor stage and surgery. Results: The overall response rate (ORR) and disease control rate (DCR) in the NDP group were 48.6% and 95.2%, significantly higher than in the DDP group at 35.1% and 89.2%, respectively (P<0.01). In NSCLC patients with initial treatment, squamous carcinoma and phase III, there were significant differences in ORR and DCR between the groups (P<0.05), while ORR was significant in patients with adenocarcinoma, GP/TP and in phase IIIa (P<0.05). There was also a significant difference in DCR in patients in phase IIIb (P<0.05). According to the statistical analysis of survival time of all patients and of those in clinical phase III, the NDP group survived significantly longer than the DDP group (P<0.01). The rates of decreased hemoglobin and increased creatinine, nausea and vomiting in the NDP group were evidently lower than in DDP group (P<0.05). Conclusion: NDP concomitant with other chemotherapy is effective for treating NSCLC, with higher clinical efficacy than DDP concomitant with chemotherapy, with advantages in prolonging survival time and reducing toxic and adverse responses.

Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9

Li Guodong,Li Dan,Wu Chun,Li Shengnan,Chen Feng,Li Peng,Ko Chung-Nga,Wang Wanhe,Lee Simon Ming-Yuen,Lin Ligen,Ma Dik-Lung,Leung Chung-Hang 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

In hypoxia and hyperglycemia, SET7/9 plays an important role in controlling HIF-1α methylation and regulating the transcription of HIF-1α target genes, which are responsible for angiogenesis and wound healing. Here, we report the Ir(III) complex Set7_1a bearing acetonitrile (ACN) ligands as a SET7/9 methyltransferase inhibitor and HIF-1α stabilizer. Interestingly, Set7_1a could engage SET7/9 and strongly inhibit SET7/9 activity, especially after preincubation with homocysteine (Hcy), which is elevated in diabetes. We hypothesize that Set7_1a exchanges ACN subunits for Hcy to disrupt the interaction between SET7/9 and SAM/SAH, which are structurally related to Hcy. Inhibition of SET7/9 methyltransferase activity by Set7_1a led to reduced HIF-1α methylation at the lysine 32 residue, causing increased HIF-1α level and recruitment of HIF-1α target genes that promote angiogenesis, such as VEGF, GLUT1, and EPO, in hypoxia and hyperglycemia. Significantly, Set7_1a improved wound healing in a type 2 diabetic mouse model by activating HIF-1α signaling and downstream proangiogenic factors. To our knowledge, this is the first Hcy-targeting iridium compound shown to be a SET7/9 antagonist that can accelerate diabetic wound healing. More importantly, this study opens a therapeutic avenue for the treatment of diabetic wounds by the inhibition of SET7/9 lysine methyltransferase activity.

Clinical Analysis of Stages of HBV Infection in 100 Cases of Lymphoma

Tang, Yang,Sun, Li-Guang,Liu, Chun-Shui,Li, Yu-Ying,Jin, Chun-Hui,Li, Dan,Bai, Ou Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Objective: HBV infection may cause damage to the immune system and induce lymphomas as a result. Some scholars have indicated that HBsAg(+) reflecting HBV infection may have a relationship with lymphoma development. This study was designed to find out the specific stage of HBV infection which may be related to lymphoma. Methods: HBV serum markers, including HBsAg, HBsAb, HBeAg, HBeAb, HBcAb were tested among 100 lymphoma patients and 100 other patients who were diagnosed with non-lymphoma diseases in the First Hospital of Jilin University from 2010.1.1 to 2012.12.31. Three subgroups were established depending on different combinations of HBV serum markers. Subgroup 1 was HBsAg(+) representing the early stage of HBV infection. Subgroup 2 was HbsAb(+) representing convalescence and Subgroup 3 was "HbsAg and HbsAb negative combined with other positive markers" representing the intermediate stage of HBV infection. Chi square tests were used to compare the rates of three subgroups in lymphoma and control groups. Results: The rates of Subgroup were 13% and 5% respectively, an association between HBsAg and lymphoma being found (P<0.05). There was no difference between rate of Subgroup 2 of lymphoma group (15%) and that of control group (16%). In lymphoma group and control group, the rate of Subgroup 3 was different (12% vs 4%). This evidence was not specific to T cell lymphoma, B cell lymphoma or Hodgkin's lymphoma. Conclusions: Among serum markers of HBV, the combination of serum markers representing the early stage and intermediate stage of HBV infection have a relationship with lymphoma. Convalescence from HBV infection appears to have no relationship with lymphoma.

Comparative analysis of type 2 diabetes-associated gut microbiota between Han and Mongolian people

Shu-chun Li,Yao Xiao,Ri-tu Wu,Dan Xie,Huan-hu Zhao,Gang-yi Shen,En-qi Wu 한국미생물학회 2021 The journal of microbiology Vol.59 No.7

Due to the different rates of diabetes in different ethnic groupsand the structural differences in intestinal microbiota, thisstudy evaluated the changes in diabetes-related intestinal microbiotain two ethnic groups. Fifty-six stool samples werecollected from subjects from the Han and Mongolian ethnicgroups in China, including participants without diabetes(non-diabetic, ND) and with type 2 diabetes (T2D). The 16SrDNA gene V3 + V4 area was extracted from microbiota,amplified by PCR, and used to perform high-throughput sequencingand screen differential microbiota associated withethnicity. The results showed that there were 44 T2D-relatedbacterial markers in the Han subjects, of which Flavonifractor,Alistipes, Prevotella, Oscillibacter, Clostridium XlVa,and Lachnospiracea_incertae_sedis were most closely relatedto diabetes. There were 20 T2D-related bacterial markers inthe Mongolian subjects, of which Fastidiosipila and Barnesiellawere most closely related to diabetes. The commonmarkers of T2D bacteria in the two ethnic groups were Papillibacterand Bifidobacterium. There were 17 metabolic pathwayswith significant differences between the ND and T2Dgroups in the Han group, and 29 metabolic pathways in theMongolian group. The glutamatergic metabolic pathway wasthe only common metabolic pathway in two ethnic groups. The composition and function of diabetes-related bacteriawere significantly different among the different ethnic groups,which suggested that the influence of ethnic differences shouldbe fully considered when studying the association betweendiabetes and bacteria. In addition, the common bacterialmarkers found in diabetic patients of different ethnic groupsin this study can be used as potential targets to study the pathogenesisand treatment of diabetes.

재외한인의 정치세력화 가능성 모색

이춘호(Lee, Chun-ho),리단(Li Dan) 전남대학교 글로벌디아스포라연구소 2010 디아스포라 연구 Vol.4 No.2

지구화(globalization)는 하나의 세계라는 통일적 의미를 내포하지만 다른 한편으로 세계 속의 경쟁이라는 의미도 가진다. 이러한 경쟁에 있어 다문화적, 다언어적 특성을 지닌 디아스포라(diaspora)는 거주국과 모국 간에 삼각관계를 형성하며 정치 · 경제적으로 중요한 가교 역할을 담당하고 있다. 한국 역시 19세기 후반부터 시작된 이민의 역사로 인해 디아스포라 자원을 가지고 있다. 한인 디아스포라는 현지화와 적응의 단계를 지나 정치세력화의 단계에 다다르고 있다. 이러한 정치세럭은 거주국의 정책형성 뿐만 아니라 모국의 이익과 정책에도 영향을 미치고 있다. 디아스포라 정치는 거주국의 구성원으로서 모국에 대한 이해관계를 거주국의 정책형성에 투영하는 일련의 과정이라고 설명할 수 있다. 디아스포라는 모국에 대한 정체성과 거주국에 대한 정체성의 이중적 정체성을 가지고 있다. 이 연구에서는 이러한 재미한인(Korean-American)의 정치적 지위와 활동에 관한 내용을 연구하고자 한다. 이를 위해 재미한인의 투표참여와 단체 활동을 실태를 살펴보았다. 연구 결과 디아스포라 정치를 통해 재외한인사회를 거주국과의 정치적 · 경제적 협력에 있어 중요한 가교역할을 수행하는 모국과 동반자적 위치로 인식하게 되었으며, 국제사회에서 다양한 이해관계로 인해 해결하기 어려운 문제를 국내문제로 전환시킴으로 보다 저항이 적은 방법으로 국제협력을 이끌어 내는 사례를 살펴볼 수 있었다. Globalization contains the unitive meaning called one world, but on the other hans, has significance called competition in the middle of the world. In this competition, diaspora, which has multi-cultural and multi-linguistic characteristics, forms the triangle between the residing country and the native country, and is playing a role of important bridge politically and economically. Even Korea has resource of diaspora thanks to history of immigration, which has been started from the latter half of the 19th century. Korean diaspora is reaching the stage of politicalization with passing through the stage of localization and adaptation. This political power not only forms policy of the residing country, but also has influence even upon benefits and policy of the native country. The purpose of this study is to research into the contents on political standing and activity in these Korean-Americans. For this, it will examine Korean-Americans" participation in vote and realities of group activity. Also, the potentiality for politicalization in Korean-Americans will be tried to be pursued. This study will be able to be suggestion of direction, which will proceed with advancing hereafter, along with opportunity of confirming substantial problems about politicalization in Korean-Americans. Also, by grasping the actual condition for Korean-Americans" current participation in politics within the residing country and by suggesting direction, this study will be able to be conducive to activity of strengthening politicalization in overseas Koreans in other regions such as China and Russia.

Azohydromonas aeria sp. nov., isolated from air

Han Xue,Chun-gen Piao,Dan-ran Bian,Min-wei Guo,Yong Li 한국미생물학회 2020 The journal of microbiology Vol.58 No.7

A grey pink colored bacterium, strain t3-1-3T, was isolated from the air at the foot of the Xiangshan Mountain in Beijing, China. The cells are aerobic, Gram-stain-negative, non-sporeforming, motile and coccoid-rod shaped (0.9–1.2 × 1.9–2.1 μm). Strain t3-1-3T was catalase-positive and oxidase-negative and this strain grew at 4–42°C (optimum 28°C), a pH of 4.0–9.0 (optimum pH 7.0) and under 0–2% (w/v) NaCl (optimum 0–1% NaCl). A phylogenetic analysis based on 16S rRNA gene sequences revealed that strain t3-1-3T was closely related to Azohydromonas riparia UCM-11T (97.4% similarity), followed by Azohydromonas australica G1-2T (96.8%) and Azohydromonas ureilytica UCM-80T (96.7%). The genome of strain t3-1-3T contains 6,895 predicted protein-encoding genes, 8 rRNA genes, 62 tRNA genes and one sRNA gene, as well as five potential biosynthetic gene clusters, including clusters of genes coding for non-ribosomal peptide synthetase (NRPS), bacteriocin and arylpolyene and two clusters of genes for terpene. The predominant cellular fatty acids (> 10.0% of the total) in strain t3-1-3T were summed feature 3 (C16:1ω7c and/or C16:1ω6c, 37.8%), summed feature 8 (C18:1ω7c and/or C18:1ω6c, 29.7%) and C16:0 (17.3%). Strain t3-1-3T contained ubiquinone-8 (Q-8) as the predominant respiratory quinone. The polar lipids of strain t3-1-3T comprised phosphatidyl ethanolamine (PE), phosphatidyl glycerol (PG), diphosphatidyl glycerol (DPG), an unidentified glycolipid (GL), an unidentified aminophospholipid (APL), two unidentified phospholipid (PL1-2) and five unidentified lipid (L1-5). The DNA G + C content of the type strain is 70.3%. The broader range of growth temperature, assimilation of malic acid and trisodium citrate, presence of C18:3ω6c and an unidentified glycolipid and absence of C12:0 2-OH and C16:0iso differentiate strain t3-1-3T from related species. Based on the taxonomic data presented in this study, we suggest that strain t3-1-3T represents a novel species within the genus Azohydromonas, for which the name Azohydromonas aeria sp. nov. is proposed. The type strain of Azohydromonas aeria is t3-1-3T (= CFCC 13393T = LMG 30135T).

Clinico-Pathological Significance of MHC-I Type Chain-associated Protein A Expression in Oral Squamous Cell Carcinoma

Wang, Jie,Li, Chao,Yang, Dan,Jian, Xin-Chun,Jiang, Can-Hua Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

The current research concerns the clinicopathological significance of MHC class I chain-related protein A (MICA) expression in oral squamous cell carcinomas (OSCCs). The expression and location of MICA protein in 14 normal oral mucous and 45 cancerous and para-cancerous tissues were assessed by immunohistochemistry and levels of MICA mRNA expression in 29 cancerous and para-cancerous tissues were determined by the real-time polymerase chain reaction. Data were analyzed with the SPSS16.0 software package. MICA was found to be located in the cytoplasm and plasma membrane. Expression was higher in para-cancerous than in cancerous tissues (P < 0.05). However, no statistical difference was found between the following: 1) para-cancerous tissue with normal mucosa; 2) normal mucosa with cancerous tissue;and 3) among different clinicopathological parameters in OSCC (P > 0.05). The level of MICA mRNA was higher in OSCCs than in para-cancerous tissues, and was correlated with the regional lymph node status and disease stage (P < 0.05). The levels of MICA protein and mRNA expression differ among normal oral mucosa, para-cancerous tissue, and cancerous tissue. MICA may contribute to the tumorigenesis and progression of OSCC.

Distortional Buckling Analysis of I-Steel Concrete Composite Beams Subjected to Hogging Moment

Lili Liu,Lizhong Jiang,Chun-dan Li,Wang-Bao Zhou,Lei-xin Nie 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.3

Bending-torsional distortion buckling is one of the most critical buckling modes of steel–concrete composite beams when they are working under hogging moment. The rotational and lateral restraint stiff ness provided by the steel web to the steel bottom fl ange are the key factors to determine this form of buckling. Firstly, the formula for solving the elastic rotational restraint stiff ness of the composite fl ange of steel beam upper fl ange and concrete slab to the steel web is derived. Then, the equivalent lateral and rotational restraint stiff ness of the steel bottom fl ange subjected to hogging moment are thoroughly studied. Considering the rotation restraint eff ect of the composite fl ange, this paper provides the calculation formula for the critical bending moment of I-steel concrete composite beams (I-SCCB) under hogging moment. Fifteen examples are considered to calculate the critical bending moment of the I-SCCB under hogging moment with the simplifi ed analytical method introduced in this paper. The results are compared with the ones derived by ANSYS numerical analyses and relevant research of other scholars. The infl uence of the arrangement of the shear studs on the critical bending moment of the I-SCCB is investigated. It is concluded that the results given by the simplifi ed analytical method are in good agreement with the ones obtained by the ANSYS fi nite element numerical method. Both methods show that the critical load of the distortional buckling of the I-SCCB under hogging moment is less aff ected by the member’s length. The critical bending moment of distortional buckling of the I-SCCB signifi cantly increases with the presence of shear studs. However, once shear studs are used, it tends to be stable with the increase of equivalent restrained torsional rotational stiff ness at the top edge of the steel web.

Mortality of Major Cancers in Guangxi, China: Sex, Age and Geographical Differences from 1971 and 2005

Deng, Wei,Long, Long,Li, Ji-Lin,Zheng, Dan,Yu, Jia-Hua,Zhang, Chun-Yan,Li, Ke-Zhi,Liu, Hai-Zhou,Huang, Tian-Ren Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

The incidence and mortality rates of liver and nasopharyngeal cancer in Guangxi province of China have always been among the highest in the world, and cancer is one of the major diseases that pose a threat to the health of residents in Guangxi. However, no systematic study has been performed to evaluate the time trends in the structure of cancer-related deaths and cancer mortality. In this study, we reveal sex, age and geography differences of cancers mortality between three death surveys (1971 to 1973, 1990 to 1992, and 2004 to 2005). The results show that the standardized mortality rate of cancer in Guangxi residents has risen from 43.3/100,000 to 84.2/100,000, the share of cancer deaths in all-cause deaths has increased from 13.3% to 20.7%, and cancer has become the second most common cause of death. The five major cancers, liver cancer, lung cancer, gastric cancer, nasopharyngeal cancer and colorectal cancer, account for 60% of all the cancer deaths. Cancers with growing mortality rates over the past 30 years include lung cancer, colorectal cancer, liver cancer and female breast cancer, of which lung cancer is associated with the sharpest rise in mortality, with a more than 600% rise in both men and women. Cancer death in Guangxi residents occurs mainly in the elderly population above 45 years of age, especially in people over the age of 65. The areas with the highest mortality rates for liver cancer and nasopharyngeal cancer, which feature regional high incidences, include Chongzuo and Wuzhou. Therefore, for major cancers such as liver cancer, lung cancer, gastric cancer, nasopharyngeal cancer and female breast cancer in Guangxi, we can select high-risk age groups as the target population for cancer prevention and control efforts in high-prevalence areas in a bid to achieve the ultimate goal of lowering cancer mortality in Guangxi.

中国物流业发展特点及发展因素分析

李莲,花(Li, Lian-Hua),韩,丹(Han, Dan),金春洙(Kim, Chun-Soo) 글로벌경영학회 2013 글로벌경영학회지 Vol.10 No.2

随着中国经济的快速发展,社会上出现了大量物流需求,中国物流业从无到有,获得了快速发展。 目前,中国现代物流业作为国家“十一五”和“十二五”规划的大力发展产业倍受注目。中国加入WTO 以后,跨国物流企业进军中国市场,影响着中国物流市场的竞争格局。由于中国物流业发展起步晚, 中国又经历了经济转轨的特殊时期,因此,中国物流业形成了自身特有的特点,在转向现代物流业过 程中遇到一些问题。针对问题,一方面需要政府进一步改善基础设施,构建适合物流企业发展的政策 环境,另一方面企业本身要不断提升自身竞争力,不仅要参与国内竞争,还要走出去参与到国际竞争 中去,实现向有序的高质量的现代化物流业转换。 With the rapid development of China’s economy, there are a large number of logistics demand in the society, as a result, China’s logistics industry emerge and develop. China s modern logistics industry is the focus of Eleventh Five-Year Plan and Twelfth Five-Year Plan. After China s access to WTO,multinational logistics enterprises entered the China’s logistics market which affect market competition pattern. As China’s logistics industry starts late, China has undergone a special period of economic transformation, therefore, China s logistics industry formed its own unique characteristics, in the trend of modern logistics industry,we encountered some problems. To solve the problem, on one hand, the government need improve the basic facilities to construct the logistics enterprises in the development of policy environment, on the other hand, the enterprise itself should continuously upgrade their competitiveness, not only to participate in domestic competition, but also go to participate in the international competition, to achieve the orderly high quality of the modern logistics industry transformation.