http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Choe, Mun Myong,Kang, Hun Chol,Kim, In Chul,Li, Hai Su,Wu, Ming Gen,Lee, Im Shik The Korean Society of Weed ScienceThe Turfgrass So 2017 Weed & Turfgrass Science Vol.6 No.1
The mutation rate of proline in the position 197 (Pro197) in acetohydroxy acid synthase (AHAS) is highest among sulfonylurea (SU) herbicide-resistance mutants. Therefore, it is significant to investigate the resistance mechanism for the mutation and to develop the herbicides specific to the mutants. SU herbicide resistance mechanism of the mutants, 197Ser, 197Thr and 197Ala, in AHAS were targeted for designing new SU-herbicide. We did molecular dynamics (MD) simulation for understanding SU herbicide-resistance mechanisms of AHAS mutants and designed new herbicides with docking and MD evaluations. We have found that mutation to 197Ala and 197Ser enlarged the entrance of the active site, while 197Thr contracted. Map of the root mean square derivation (RMSD) and radius gyrations (Rg) revealed the domain indicating the conformations for herbicide resistant. Based on the enlarging-contracting mechanism of active site entrance, we designed new herbicides with substitution at the heterocyclic moiety of a SU herbicide for the complementary binding to the changed active site entrances of mutants, and designed new herbicides. We confirmed that our screened new herbicides bonded to both AHAS wild type and mutants with higher affinity, showing more stable binding conformation than the existing herbicides.
Mun Myong Choe,Hun Chol Kang,In Chul Kim,Hai Su Li,Ming Gen Wu,Im Shik Lee 한국잔디학회 2017 Weed & Turfgrass Science Vol.6 No.1
The mutation rate of proline in the position 197 (Pro197) in acetohydroxy acid synthase (AHAS) is highest among sulfonylurea (SU) herbicide-resistance mutants. Therefore, it is significant to investigate the resistance mechanism for the mutation and to develop the herbicides specific to the mutants. SU herbicide resistance mechanism of the mutants, 197Ser, 197Thr and 197Ala, in AHAS were targeted for designing new SU-herbicide. We did molecular dynamics (MD) simulation for understanding SU herbicide-resistance mechanisms of AHAS mutants and designed new herbicides with docking and MD evaluations. We have found that mutation to 197Ala and 197Ser enlarged the entrance of the active site, while 197Thr contracted. Map of the root mean square derivation (RMSD) and radius gyrations (Rg) revealed the domain indicating the conformations for herbicide resistant. Based on the enlarging-contracting mechanism of active site entrance, we designed new herbicides with substitution at the heterocyclic moiety of a SU herbicide for the complementary binding to the changed active site entrances of mutants, and designed new herbicides. We confirmed that our screened new herbicides bonded to both AHAS wild type and mutants with higher affinity, showing more stable binding conformation than the existing herbicides.
Jee Hye Lee,Chang Hwan Kim,Chul Myong Choe,Tae Hoon Choi 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.3
Purpose: To evaluate the clinical symptoms of patients with dry eyes, based on the ocular surface disease index (OSDI) and analyze the relationship between OSDI and various ocular surface parameters. Methods: This was a retrospective study that included 45 eyes of 45 dry eye patients who visited the Seoul Nune Eye Hospital from August 2017 to December 2017. The patients were assessed by non-invasive keratography for the first break-up time, lipid layer thickness (LLT), tear osmolarity, tear matrix metalloproteinase-9 immunoassay as well as with the conventional Schirmer I test and fluorescein break-up time. The patient’s symptoms were evaluated by the OSDI questionnaires and correlations were analyzed based on the parameters described above. Results: There were significant negative correlations between OSDI and non-invasive keratography for the first break-up time (p = 0.038, r = -0.330), and LLT (p = 0.005, r = -0.426). However, there were no significant correlations between OSDI and fluorescein break-up time, Schirmer I score, and tear osmolarity (p = 0.173, 0.575, and 0.844 respectively). OSDI was not significantly different between matrix metalloproteinase-9 positive and negative groups (p = 0.768). Conclusions: Non-invasive examinations such as non-invasive keratograph break-up time and interferometry of LLT can be efficient tools for evaluating dry eye symptoms.
고도근시 환자에서 부분결합간섭계와 초음파를 이용한 생체측정
정진권,최철명,유용성,이성진.JK Chung. M.D.. Chul Myong Choe. M.D.. Yong Sung You. M.D.. Sung Jin Lee. M.D. 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: To compare the refractive outcome of clear lens extraction employing partial coherence interferometry data with that of applanation ultrasonography. Methods: Thirty eyes of 17 patients with axial length greater than 26 mm who underwent clear lens extraction were enrolled in this study. IOL power was measured using IOLMaster and conventional ultrasonography. Differences between predicted refraction and actual refraction were compared and analyzed according to the biometry method and IOL power calculation formulas. Results: Axial length according to IOLMaster measurement (29.23±1.40 mm) was significantly longer than that measured by ultrasonography (28.68±1.32 mm) (p=0.000). The difference between actual and predicted refraction was 0.75±0.40 diopter by SRK/T with IOLMaster and 0.44±0.52 diopter by SRK/T with A-scan. The standard errors of the two measurement methods were 0.08 and 0.10, respectively. Eighty-five percent and one hundred percent of patients were within 1 diopter, as measured by SRK/T with IOLMaster and with A-scan, respectively. Conclusions: The use of the IOLMaster with the SRK/T formula may be an accurate method of IOL calculation in cases of high myopes, if surgeon factors are corrected for.