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Association Analysis between Five Microsatellite Loci and Litter Size in Small Tail Han Sheep
Chu, M.X.,Wang, J.Z.,Wang, A.G.,Li, N.,Fu, J.L. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.11
The objective of the present study was to explore associations between five microsatellites linked to $Fec^B$ and $FecX^I$ genes and litter size in Small Tail Han sheep. The polymorphisms of five microsatellite loci, OarAE101, BM1329, BMS2508, TGLA54 and TGLA68 were detected in 244 ewes of Small Tail Han sheep. Analysis of association between three microsatellite loci (BMS2508, BM1329 and OarAE101) located in the 10 cM region covering the $Fec^B$ gene (Booroola gene) and litter size in Small Tail Han sheep indicated that BMS2508 had significant effect on litter size in the second parity (p<0.05), but no significant effect on litter size in the first parity (p>0.05), while the other two microsatellite loci had no significant effect on litter size in both the first and the second parity in Small Tail Han sheep (p>0.05). At microsatellite locus BMS2508, least squares means in the second parity of genotypes 101/111 and 99/109 were significantly higher than those of genotypes 99/99, 99/101, 99/111 and 99/115 (p<0.05); least squares mean in the second parity of genotype 101/111 was significantly higher than that of genotypes 109/111 and 111/111 (p<0.05). Results of this study also indicated that two microsatellite loci (TGLA54 and TGLA68) that confined the 28.7 cM region covering the $FecX^I$ gene (Inverdale gene) did not affect litter size in both the first and the second parity in Small Tail Han sheep significantly (p>0.05). The information found in the present study is very important for improving the reproductive performance in sheep breeds by marker assisted selection.
Peng Fu,Zhi-Jun Xu,Ruiqing Chu,Wei Li,Qian Xie,Guo-Zhong Zang 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Eu_2O_3 (0―0.8 wt.%)-doped 0.82Bi_0.5Na_0.5TiO_3―0.18Bi_0.5K_0.5TiO_3 (BNKT18) lead-free piezoelectric ceramics were synthesized by conventional solid-state processes. The compositional dependence of phase structure and electrical properties of the BNKT18 ceramics was studied. X-ray diffraction (XRD) data shows that 0.2―0.8 wt.% Eu_2O_3 has diffused into the lattice of BNKT18 ceramics and forms a pure perovskite phase. SEM images indicate that the grain size of BNKT18 ceramics decreases with the increase of Eu_2O_3 content, and all the modified ceramics have a clear grain boundary and a uniformly distributed grain size. At room temperature, the ferroelectric and piezoelectric properties of the BNKT18ceramics have been improved with the addition of Eu_2O_3, and the BNKT18 ceramics doped with 0.4 wt.%Eu_2O_3 have the highest piezoelectric constant (d_33 = 145 pC/N), highest relative dielectric constant (ε_r = 1134) and lower dissipation factor (tan δ = 0.045) at a frequency of 10 kHz. The BNKT18 ceramics doped with 0.2 wt.% Eu_2O_3 have the highest planar coupling factor (k_p = 0.251). The temperature dependence of the relative dielectric constant shows T_m increases with the addition of Eu_2O_3.
Structural and dielectric properties in the (Ba1−xCax)(Ti0.95Zr0.05)O3 ceramics
Wei Li,Zhi-Jun Xu,Ruiqing Chu,Peng Fu,Guo-Zhong Zang 한국물리학회 2012 Current Applied Physics Vol.12 No.3
Lead-free (Ba1-xCax)(Ti0.95Zr0.05)O3 (x = 0.05e0.40) (BCZT) ceramics were prepared by solid-state reaction technique. XRD results show that the samples in the composition range of 0.05 ≤ x ≤ 0.25 exhibit pure perovskite structures and undergo a polymorphic phase transitions from orthorhombic to tetragonal phase around room temperature. The biphasic structures are detected at x ≥ 0.30 and the dielectric peaks become broad and dielectric constants decrease with increasing Ca content. Ca replacement at Ba site leads to diffuseness, whereas Ca occupancy at Ti site leads to decrease of the Tc.
Shu-Li Cheng,Fu-Chi Yang,Hsuan-Te Chu,Chia-Kuang Tsai,Shih-Chieh Ku,Yu-Ting Tseng,Ta-Chuan Yeh,Chih-Sung Liang 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.12
Objective Schizophrenia has been associated with dysfunction of the hypothalamic-pituitary-adrenal axis. Furthermore, alterations in neurotrophic factors might contribute to the pathogenesis of schizophrenia. We aimed to evaluate the effects of a simulated laughter intervention on the levels of cortisol and BDNF and to determine whether the effects associated with simulated laughter could be sustained after discontinuation of the intervention. Methods In this randomized controlled study, patients with schizophrenia according to DSM-IV clinical criteria were randomly assigned to receive either 8-week-long simulated laughter intervention (n=32) or treatment-as-usual group (control group, n=27). The serum levels of BDNF and cortisol were measured at baseline, week 8, and four weeks after discontinuation (week 12) of the intervention program. Results After an 8-week simulated laughter intervention, the laughter group had significantly higher levels of BDNF; however, four weeks after discontinuation of the intervention, the levels of BDNF significantly dropped. Interestingly, the levels of cortisol did not change significantly at week 8, but they were significantly elevated at week 12. The levels of BDNF and cortisol in the control group did not change significantly between week 0 and week 8. Conclusion These findings suggest that the simulated laughter intervention has an early effect on neurogenesis with a significant delayed effect on stress regulation in subjects with schizophrenia.
Che-Sheng Chu,Shu-Li Cheng,Ya-Mei Bai,Tung-Ping Su,Shih-Jen Tsai,Tzeng-Ji Chen,Fu-Chi Yang,Mu-Hong Chen,Chih-Sung Liang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.9
Objective Individuals with dementia are at a substantially elevated risk for mortality; however, few studies have examined multimorbidity patterns and determined the inter-relationship between these comorbidities in predicting mortality risk.Methods This is a prospective cohort study. Data from 6,556 patients who were diagnosed with dementia between 1997 and 2012 using the Taiwan National Health Insurance Research Database were analyzed. Latent class analysis was performed using 16 common chronic conditions to identify mortality risk among potentially different latent classes. Logistic regression was performed to determine the adjusted association of the determined latent classes with the 5-year mortality rate.Results With adjustment for age, a three-class model was identified, with 42.7% of participants classified as “low comorbidity class (cluster 1)”, 44.2% as “cardiometabolic multimorbidity class (cluster 2)”, and 13.1% as “FRINGED class (cluster 3, characterized by FRacture, Infection, NasoGastric feeding, and bleEDing over upper gastrointestinal tract).” The incidence of 5-year mortality was 17.6% in cluster 1, 26.7% in cluster 2, and 59.6% in cluster 3. Compared with cluster 1, the odds ratio for mortality was 9.828 (95% confidence interval [CI]=6.708–14.401; p<0.001) in cluster 2 and 1.582 (95% CI=1.281–1.953; p<0.001) in cluster 3.Conclusion Among patients with dementia, the risk for 5-year mortality was highest in the subpopulation characterized by fracture, urinary and pulmonary infection, upper gastrointestinal bleeding, and nasogastric intubation, rather than cancer or cardiometabolic comorbidities. These findings may improve decision-making and advance care planning for patients with dementia.
SEMI-DISCRETE CENTRAL DIFFERENCE METHOD FOR DETERMINING SURFACE HEAT FLUX OF IHCP
Qian, Zhi,Fu, Chu-Li Korean Mathematical Society 2007 대한수학회지 Vol.44 No.6
We consider an inverse heat conduction problem(IHCP) in a quarter plane which appears in some applied subjects. We want to determine the heat flux on the surface of a body from a measured temperature history at a fixed location inside the body. This is a severely ill-posed problem in the sense that arbitrarily "small" differences in the input temperature data may lead to arbitrarily "large" differences in the surface flux. A semi-discrete central difference scheme in time is employed to deal with the ill posed problem. We obtain some error estimates which also give the information about how to choose the step length in time. Some numerical examples illustrate the effects of the proposed method.
Ma Qian,Li Hui,Liu Yu,Liu Mingle,Fu Xinghua,Chu Shushu,Li Hang,Guo Jia 한국물리학회 2021 Current Applied Physics Vol.21 No.-
Uniform flower-like α-Fe2O3 architectures with self-assembled core-shell nanorods are constructed and successfully prepared via the facile process. The concentration of Fe salt plays a great significance for morphological evolution from nanorods to self-assembled microflowers. Flower-like α-Fe2O3/ZnFe2O4 consisting of α-Fe2O3 core and ZnFe2O4 shell nanorods are derived from FeOOH/ZIF-8 precursors. The detailed studies reveal that the tunable growth of ZIF-8 nanoparticles on three-dimensional FeOOH microflowers at room temperature and the availble calcination regulation are responsible for the formation of core-shell Fe2O3/ZnFe2O4 composites. The highest response value of flower-like α-Fe2O3/ZnFe2O4 architectures to 100 ppm triethylamine (TEA) has been improved to 141 at 280 ◦C, which is calculated to be 6.2 times compared with flower-like α-Fe2O3 architectures (22.7). The enhanced gas-sensing mechanism of α-Fe2O3/ZnFe2O4 composites can be attributed to the typical microflowers structures, the large specific surface area, the effective heterojunctions between α-Fe2O3 core and ZnFe2O4 shell, and the improved electron transfer process.
An investigation on dicing 28-nm node Cu/low-k wafer with a Picosecond Pulse Laser
Hsu, Hsiang-Chen,Chu, Li-Ming,Liu, Baojun,Fu, Chih-Chiang The Korean Microelectronics and Packaging Society 2014 마이크로전자 및 패키징학회지 Vol.21 No.4
For a nanoscale Cu/low-k wafer, inter-layer dielectric (ILD) and metal layers peelings, cracks, chipping, and delamination are the most common dicing defects by traditional diamond blade saw process. Sidewall void in sawing street is one of the key factors to bring about cracks and chipping. The aim of this research is to evaluate laser grooving & mechanical sawing parameters to eliminate sidewall void and avoid top-side chipping as well as peeling. An ultra-fast pico-second (ps) laser is applied to groove/singulate the 28-nanometer node wafer with Cu/low-k dielectric. A series of comprehensive parametric study on the recipes of input laser power, repetition rate, grooving speed, defocus amount and street index has been conducted to improve the quality of dicing process. The effects of the laser kerf geometry, grooving edge quality and defects are evaluated by using scanning electron microscopy (SEM) and focused ion beam (FIB). Experimental results have shown that the laser grooving technique is capable to improve the quality and yield issues on Cu/low-k wafer dicing process.