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골반장기탈출환자에서 Miya hook 을 이용한 천골가시인대현수법에 대한 임상적 고찰
허주엽(Chu Yeop Huh),김세용(Se Yong Kim),오일영(Il Young Oh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : To assess the results of the sacrospinous ligament suspension using Miya hook for the treatment of uterovaginal prolapse or vault prolapse following hysterectomy. Methods : Between October 1997 and December 2000, in Kyung Hee Medical Center, 50 pelvic organ prolapse patients underwent vaginal hysterectomy and sacrospinous ligament suspension or sacrospinous ligament suspension only. We evaluated age, parity, operation time, recovery time, duration of hospitalization, change of Hemoglobin level, number of vaginal delivery, type of prolapse, and complications. Results : Forty-four patients (88%) had uterine prolapse and six patients (12%) had vaginal vault prolapse. All patients underwent sacrospinous suspension and anterior- posterior colporraphy in which forty-one patients (82%) underwent concomitant vaginal hysterectomy. There has been one failure case. And then repeat sacrospinous ligament suspension with anterior and posterior vaginal repair was performed successfully. Recurrent prolapse hasn`t been developed yet. Most common problems were transient voiding difficulty and vague buttock pain. Conclusion : The sacrospinous ligament suspension is considered to be effective and safe in the treatment of vault and uterine prolapse. It avoids major abdominal surgery and allows the surgeon to correct coexistent cystocele and rectocele.
Intrafascial Vaginal Hystrectomy ( IVH ) 수술법
허주엽(Chu Yeop Huh),이상욱(Sang Wook Yi) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
N/A Objective: Intrafascial vaginal hystrectomy(IVH) is an intrafascial cylindriform enucleation of the cervix and supracervical amputation of the uterus through vagina, leaving the highly vascularized extrafascial cervical tissue and corresponding nerves intact. The supracervical amputation of the uterus through vagina and intrafascial cylindriform enucleation of cervix enable to perform an minimal invasive surgery and organ-preserving surgery. Pelvic floor support is maintained and sexual sensation is preserved. Physical stress to the patient is minimalized. Our purpose is to evaluate the outcomes of IVH. Method: 21 patients were performed IVH from January 1996 to July 1998. Result: The mean age was 43.4+7.2 years and the mean parity was 2.6+0.8. The mean operation time was 116.1+21.4 minutes and the mean postoperative hemoglobin change was 2.0+1.6gm/dL. The mean postoperative hopitalization time was 8.2 + 2.7days. Conclusion: The IVH is an operation technique for the patients who are sexually active and want to remain their uterus.
타액선모세포종과 간모세포종 및 1번 염색체 장완소실이 동반된 신생아 1 예
허주엽(Chu Yeop Huh),최혜진(Hye Jin Choi),김승보(Seung Bo Kim),이선(Sun Lee),임성직(Sung Jik Lim),양문호(Moon Ho Yang) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
Sialoblastoma and hepatoblastoma of neonate were very rare cancer. We present a case of concurrent sialoblastoma with hepatoblastoma associated with chromosomal anomaly.
난소암 세포주에서 Topotecan, Cisplatin, Taxol에 대한 화학민감도의 측정과 p53, bcl-2 및 세포고사에 관한 연구
허주엽 ( Huh Chu Yeop ),임명철 ( Lim Myong Cheol ),서병선 ( Suh Byung Sun ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.7
목적 : 본 연구는 난소암 세포주에서의 Topotecan, Cisplatin, Taxol에 의한 세포고사를 통하여 화학민감도를 측정하고 세포고사가 일어날 때 p53유전자와 bcl-2유전자와의 상호관계를 평가하기 위함이다. 연구 방법 : 이번 연구에서 저자들은 Topotecan, Cisplatin, Taxol을 5가지 인간 난소암 세포주에 반응시켜서 유도된 세포고사의 결과를 얻었고, Topotecan, Cisplatin, Taxol의 여러 농도에서의 단독, 복합 또는 연속적 투여에 대한 민감도를 조사하였다. 또한 난소암 세포주에 대한 이들 화학요법의 상호작용과 세포 사망의 정도를 정량적으로 분석을 통한 세포고사와 세포독성을 비교하였다. 세포고사가 일어날 때 p53유전자와 bcl-2유전자가 변하는가를 알기 위해 western blotting으로 유전자 검사를 시행하였다. 결과 : 5가지 세포주는 Topotecan, Cisplatin, Taxol (LD_50 range of Topotecan, 30~1000 ng/ml; Cisplatin, 3~10 ㎍/ml; Taxol 5~1000 nm)에 대한 다양한 민감도를 보여주고 있다. SKOV-3는 다른 세포주에 비하여 저항성이 있는 세포주로서 Topotecan에 대한 저항성은 다른 세포주에 비해 2~30배, Cisplatin에서는 3배, Taxol에서는 200배 저항성을 보였다. Topotecan, Cisplatin, Taxol의 세포주에 대한 민감도와 세포고사와의 관계가 SNU-840과 OVCAR-3에서 관찰되었다. Topotecan, Cisplatin, Taxol 24시간 혹은 48시간 처리시 OVCAR-3의 DNA 분절은 동일하게 나타났다. 세포독성 분석과 연관지어 염기순서분석 실험을 시행하였을 때, SNU-251을 제외한 다른 세포주에서 Topotecan, Cisplatin, Taxol간의 다른 상호관계에서 의미있는 차이를 보이지 못하였다. topotecan을 전처치하였을 경우, Cisplatin을 투여한 군에서 24시간째 세포독성이 증가하였다. 전기영동검사상 fragmented DNA의 정량화를 통하여 동일한 결과를 보인다. 결론 : Topotecan, Cisplatin, Taxol에 의해서 의미있는 세포독성이 생기는 것은 단순한 괴사에 의한다기 보다는 직접적인 세포고사의 유도와 관련이 있음을 확인하였고, 이들 약제에 대한 치료성적은 세포적 특성, 유전적 특성의 차이에 의함을 알 수가 있었다. Objective : The aim of this study was to evaluate Topotecan-, Cisplatin- and Taxol-induced apoptosis in five human ovarian cell lines as a measure of chemosensitivity and relationship between apoptosis and p53 and bcl-2 gene expression. Methods : In this study, the author is presenting data on apoptosis induced by Topotecan, Cisplatin and Taxol in five ovarian cancer cell lines, and represent different levels of sensitivities to Topotecan, Cisplatin and Taxol. This study also includes the interaction of these chemotherapeutic agents on ovarian cancer cell lines with respect to the apoptosis and cytotoxicity assay as a quantitative measure of the efficiency of killing. Presence of the p53 and bcl-2 gene product were examined by western blotting. Results : The five cell lines represent various sensitivities to Topotecan, Cisplatin, Taxol (LD_50 range of Topotecan, 30~1000 ng/ml; Cisplatin, 3~10 ㎍/ml, Taxol 5~1000 nm). SKOV-3 represent a resistant cell line which was 2~30 times resistant to Topotecan, 3 times resistant to Cisplatin, and 2~200 times resistant to Taxol when compared to others. Demonstration of apoptosis correlated with the sensitivity of the cell lines to Topotecan, Cisplatin and Taxol for SNU-840 and OVCAR-3. DNA fragmentation of OVCAR-3 was uniformly present when treated with Topotecan, Cisplatin and Taxol, 24 or 48 hours. When sequencing experiments were performed with correlated with cytotoxicity assays, except in SNU-251 cells where no significant difference was observed in different interactions of Topotecan, Cisplatin and Taxol. Pretreatment with Topotecan, Cisplatin at a 24 hour interval resulted in enhanced cytotoxicity. Quantitation of the fragmented DNA correlated with that seen on gel electrophoresis. Conclusion : The study indicate that the ability to achieve significant cytotoxicity by Topotecan, Cisplatin and Taxol may be related to the induction of apoptosis rather than necrosis. However, outcome of these treatments depend on cellular and genetic characheristics.