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Chu, Jia-Qi,Jing, Kai-Peng,Gao, Xiang,Li, Peng,Huang, Rui,Niu, Yan-Ru,Yan, Shou-Quan,Kong, Jun-Chao,Yu, Cai-Yuan,Shi, Ge,Fan, Yi-Ming,Lee, Young-Ha,Zhou, Yu,Quan, Juan-Hua Landes Bioscience 2017 Cell Cycle Vol.16 No.5
<P>Autophagy and apoptosis are critical for controlling Toxoplasma gondii (T. gondii) infection. T. gondii infection during pregnancy can damage the fetus and cause birth defects; however, the molecular mechanisms of this process are poorly understood. This study aims to determine the activities of autophagy and apoptosis as well as their regulatory mechanisms during T. gondii infection by using human umbilical cord mesenchymal stem cells (hUC-MSCs) as a model of congenital diseases. LC3B, a hallmark protein of autophagy was incrementally upregulated with the infection duration, whereas p62 was downregulated in T. gondii-infected hUC-MSCs. Concurrent to this result, the invasion of T. gondii into hUC-MSCs increased in a time-dependent manner. The expression levels of Bcl-2 family proteins including Bcl-2, Bcl-xL, Bim, Bax, Bid and Bak were not altered; however, Mcl-1 levels in hUC-MSCs were dramatically decreased upon T. gondii infection. In addition, at 24h post-infection, cleaved PARP and cleaved caspase-3 protein levels were elevated in hUC-MSCs. Importantly, Mcl-1 overexpression reduced the levels of autophagy- and apoptosis-related proteins in T. gondii-infected hUC-MSCs. Mcl-1 proteins were primarily expressed in the fraction containing mitochondria and strongly interacted with Beclin-1 under normal conditions; however, these interactions were remarkably attenuated by T. gondii infection. These results suggest that mitochondrial Mcl-1 is an essential signaling mediator regulating the activation of autophagy and apoptosis during T. gondii infection.</P>
Non-uniform Weighted Vibration Target Positioning Algorithm Based on Sensor Reliability
Yanli Chu,Yuyao He,Junfeng Chen,Qiwu Wu 한국정보처리학회 2023 Journal of information processing systems Vol.19 No.4
In the positioning algorithm of two-dimensional planar sensor array, the estimation error of time difference-ofarrival(TDOA) algorithm is difficult to avoid. Thus, how to achieve accurate positioning is a key problem ofthe positioning technology based on planar array. In this paper, a method of sensor reliability discrimination isproposed, which is the foundation for selecting positioning sensors with small error and excellent performance,simplifying algorithm, and improving positioning accuracy. Then, a positioning model is established. Theestimation characteristics of the least square method are fully utilized to calculate and fuse the positioningresults, and the non-uniform weighting method is used to correct the weighting factors. It effectively handlesthe decreased positioning accuracy due to measurement errors, and ensures that the algorithm performance isimproved significantly. Finally, the characteristics of the improved algorithm are compared with those of otheralgorithms. The experiment data demonstrate that the algorithm is better than the standard least square methodand can improve the positioning accuracy effectively, which is suitable for vibration detection with large noiseinterference.
Living Donor Liver Transplant Confers Better Survival for Elderly Recipients
( Chu Kevin Ka-wan ),( Chok Kenneth Siu-ho ),( Fung James Yan-yue ),( Chan Albert Chi-yan ),( Lo Chung Mau ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Increasing elderly patients are undergoing liver transplant as well as the relative percentage of elderly population. However, the perceived poor outcomes in the elderly prohibits the acceptance of living donor liver transplant in many centres. We reviewed current status of liver transplant in our centre and analyzed factors predicting survival outcome in elderly liver transplant recipients. Methods: Consecutive liver transplants for elderlies who reached age 65 performed between 2001 and 2016 were reviewed. The overall survival were compared between the deceased donor liver transplant (DDLT) and the living donor liver transplant (LDLT) groups. Results: DDLT and LDLT groups consisted of 24 and 17 recipients respectively. The overall 1-year and 3-year survival rates for the elderlies (n=41) were 87%, 78% respectively. LDLT recipients had better survival compared with DDLT, 94% vs 83% for 1-year and 94% vs 67% for 3-year, p=0.036. Univariate analysis was performed and identified predictive factors including pre-operative ICU stay (relative risk 3.74, 95% confidence interval 1.06-13.14, p=0.039), pre-operative hepatorenal syndrome (relative risk 6.01, 95% confidence interval 1.67-21.68, p=0.006) and mode of graft donation - LDLT (relative risk 0.09, 95% confidence interval 0.01-0.86, p=0.036). Long cold ischaemic time also had a negative correlation with survival (relative risk 4.30, 95% confidence interval 0.81-22.90, p=0.087). In multi multivariate analysis, LDLT (hazard ratio 0.11, 95% confidence interval 0.01-0.94, p=0.043) and pre-operative ICU stay (hazard ratio 5.60, 95% confidence interval 1.30-24.03, p=0.021) were independent predictive factors for survival. Conclusions: Good survival outcomes was achieved in selected elderly liver transplant recipients. Elderly recipients with living donors had better survival outcomes in contrast to those with deceased donors and LDLT was an independent protective factor for long term survival. Pre-operative ICU status was also an independent predictive of poorer long term survival.
John Man Tak Chu,Wei Xiong,Ke Gang Linghu,Yan Liu,Yan Zhang,Guan Ding Zhao,Michael G. Irwin,Gordon Tin Chun Wong,Hua Yu 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.6
A proportion of patients experience acute or even prolonged cognitive impairment after surgery, a condition known as postoperative cognitive dysfunction (POCD). It is characterized by impairment in different cognitive domains and neuroinflammation has been implicated as one of the inciting factors as strategies targeting inflammation tend to improve cognitive performance. Siegesbeckia Orientails L. (S. Orientails) is a common Chinese medicinal herb used for managing chronic inflammatory diseases. We investigated if pretreatment with S. Orientails before surgery confers any neuroprotective effects in postoperative animals in terms of reducing inflammation and mitigating cognitive impairment. Three-month-old male C57BL/6N mice were fed different doses of S. Orientails extract for 14 days before they underwent a laparotomy. After cognitive testing they were sacrificed on postoperative day (POD) 3. Our results showed that animals with extract pretreatment demonstrated memory improvement in a dose-dependent manner compared with control. Further, evidence for the attenuation of systemic and neuroinflammation was found in the pretreated animals, along with the inhibition of inflammatory pathways and significantly reduced tau phosphorylation in the hippocampus. Taken together, these results demonstrated a neuroprotective effect of S. Orientails in postoperative animals, indicating a therapeutic potential of S. Orientails in minimizing POCD and the possibility of utilizing this traditional Chinese medicine perioperatively.
Chu Cai Peng,Jia You Yan,Bin Dong,Lin Zhu,Yao Yao Tian,Li Min Gong 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.4
Objective: The goal of this study was to investigate the effects of cupric citrate (CuCit) on growth performance, antioxidant indices, serum lipid metabolites, serum immune indices, and tissue residues of copper (Cu), zinc, and iron in weaned pigs. Methods: A total of 180 weaned pigs (Duroc×Landrace×Large White) with an average body weight of 8.98±1.21 kg were randomly assigned to a corn-soybean meal control ration, or 4 similar rations with 30, 60, 120, or 240 mg/kg Cu as CuCit. All diets contained 10 mg/kg Cu as cupric sulfate from the vitamin-mineral premix. The experiment was divided into two phases: 0 to 14 d (phase 1) and 15 to 28 d (phase 2). Results: Average daily gain (ADG; linearly, p<0.01) and average daily feed intake (ADFI; linearly and quadratically, p<0.05) were affected by an increase in CuCit during phase 2. Overall period, ADG (p<0.05) and ADFI (p<0.01) were linearly increased with increasing dietary levels of CuCit. Serum malondialdehyde concentrations (p<0.05) and glutathione peroxidase activity (p<0.01) linearly decreased and increased respectively with an increase in CuCit. Serum levels of Cu-Zn superoxide dismutase were linearly affected with an increase in CuCit (p<0.01). Hepatic malondialdehyde levels decreased with an increase in CuCit (linearly and quadratically, p<0.01). Serum total cholesterol concentrations were quadratically affected (p<0.05) and decreased in pigs fed Cu as CuCit at 60 and 120 mg/kg and increased in pigs fed 240 mg/kg Cu as CuCit. Serum high-density lipoprotein concentrations were linearly affected with an increase in CuCit (p<0.01). Serum IL-1β levels were quadratically affected (p<0.05) by dietary treatment. Compared with other treatments, 240 mg/kg Cu from CuCit quadratically increased hepatic (p<0.01) and renal (p<0.05) Cu concentrations, and quadratically decreased hepatic and renal iron concentrations (p<0.05). Conclusion: Cu administered in the form of CuCit at a dosage range of 30 to 60 mg/kg, effectively enhanced the growth performance and antioxidant status of weaned pigs.