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      • Skin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model

        Choi, Jonghye,Kim, Hyejin,Choi, Jinhee,Oh, Seung Min,Park, Jeonggue,Park, Kwangsik The Korean Society of Environmental Toxicology 2014 환경독성보건학회지 Vol.29 No.-

        Objectives Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models ($KeraSkin^{TM}$) and the results were compared to those of an in vivo animal test. Methods Skin models were incubated with nanoparticles for a definite time period and cell viability was measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide method. Skin corrosion and irritation were identified by the decreased viability based on the pre-determined threshold. Results Cell viability after exposure to nanomaterial was not decreased to the pre-determined threshold level, which was 15% after 60 minutes exposure in corrosion test and 50% after 45 minutes exposure in the irritation test. IL-$1{\alpha}$ release and histopathological findings support the results of cell viability test. In vivo test using rabbits also showed non-corrosive and non-irritant results. Conclusions The findings provide the evidence that zinc oxide nanoparticles, titanium oxide nanoparticles and their mixture are 'non corrosive' and 'non-irritant' to the human skin by a globally harmonized classification system. In vivo test using animals can be replaced by an alternative in vitro test.

      • Skin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model

        Jonghye Choi,Hyejin Kim,Jinhee Choi,Seung Min Oh,Jeonggue Park,Kwangsik Park 환경독성보건학회 2014 환경독성보건학회지 Vol.29 No.-

        Objectives : Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models (KeraSkinTM) and the results were compared to those of an in vivo animal test. Methods : Skin models were incubated with nanoparticles for a definite time period and cell viability was measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide method. Skin corrosion and irritation were identified by the decreased viability based on the pre-determined threshold. Results : Cell viability after exposure to nanomaterial was not decreased to the pre-determined threshold level, which was 15% after 60 minutes exposure in corrosion test and 50% after 45 minutes exposure in the irritation test. IL-1α release and histopathological findings support the results of cell viability test. In vivo test using rabbits also showed non-corrosive and non-irritant results. Conclusions : The findings provide the evidence that zinc oxide nanoparticles, titanium oxide nanoparticles and their mixture are ‘non corrosive’ and ‘non-irritant’ to the human skin by a globally harmonized classification system. In vivo test using animals can be replaced by an alternative in vitro test.

      • KCI우수등재

        비점오염 발생 원단위 산정방법에 대한 고찰 - 논 비점오염 원단위를 중심으로 -

        최동호 ( Choi Dongho ),최순군 ( Choi Soon-kun ),김민경 ( Kim Min-kyeong ),허승오 ( Hur Seung-oh ),홍성창 ( Hong Sung Chang ),엽소진 ( Yeob So-jin ),윤광식 ( Yoon Kwangsik ) 한국농공학회 2019 한국농공학회논문집 Vol.61 No.3

        In order to preserve water environment, Total Maximum Daily Load(TMDL) is used to manage the total amount of pollutant from various sources, and the annual average load of source is calculated by the unit load method. Determination of the unit load requires reliable data accumulation and analysis based on a reasonable estimation method. In this study, we propose a revised unit load estimation method by analyzing the unit load calculation procedure of National Institute of Environment Research(NIER) method. Both methods were tested using observed runoff ratio and water quality data of rice paddy fields. The estimated values with the respective NIER and revised NIER methods were highly correlated each other. However, the Event Mean Concentration(EMC) and the runoff ratio considered in the NIER method appeared to be influenced by rainfall classes, and the difference in unit load increases as the runoff and EMC increase. The error can be further increased when the EMC and runoff ratio are changed according to changes in rainfall patterns by climate change and change of agricultural activities. Therefore, it is recommended to calculate unit load by applying the revised NIER method reflecting the non point pollution runoff characteristics for different rainfall classes.

      • KCI등재

        어린이 수학 체험전시관의 디자인 기획에 관한 연구

        최광식 ( Kwangsik Choi ),임진이 ( Jeanny Lim ) 한국공간디자인학회 2019 한국공간디자인학회논문집 Vol.14 No.3

        (Background and Purpose) It is important for children to develop mathematical abilities necessary to understand basic concepts of mathematics, develop thinking skills, and resolve individual and social problems creatively. However, it is difficult for them to achieve those goals and resolve those problems by relying only to school education. Thus, we intend to create a math experience exhibition hall as an alternative solution for creative mathematics education. (Method) This study was intended to understand children through literature review and designed an effective exhibition planning. Chapter 2 includes a theoretical examination of children’s experiential exhibition hall. Chapter 3 presents examination of the measures for exhibition in connection with the planning of experiential exhibition hall. Chapter 4 presents specific plans, such as the plan on the line of traffic flows and exhibition operation programs, while looking into the design planning of children’s mathematics experiential exhibition. Chapter 5 draws drew conclusions, summarizing the findings and implications of this study. (Results) It would be effective to plan the experiential exhibition on the basis of Piaget’s stages of children's cognitive development. The experiential exhibition would need to be designed in such a way that children can participate spontaneously with pleasure by taking the degree of psychological development of children into consideration. Edutainment, based on amusement that arouses interest, allows the user to be immersed in learning with the spirit of challenge, rather than the rigid structure of cramming education. The theme of the exhibition was based on four 4 themes. This area was planned to increase the immersion of children of the upper grades through gamification in order to ensure the effectiveness. (Conclusions) The conclusions were drawn from this study as below: First, the mathematics experiential exhibition hall was planned as an entertainment type uniquely suited for various experiences of children based on their cognitive development, thus ensuring that they could be fully immersed. Second, various exhibition methods for exhibitions in children's experiential hall were researched and planned. The exhibition theme consisted of four 4 sub-themes which could induce children to think from the perspective of mathematics, understand the figures, analyze the properties of numbers, and imagine them through the prism of mathematics. Third, the operation of the exhibition hall was planned with a focus on simplicity and promotion of intuitive thinking by children. The exhibition system was planned as a modular structure that could be updated through assembly and dismantling at any time, thus ensuring the changeability flexibility of the exhibition space. A very important educational impact can be anticipated if children, the leaders of future society, are able to comprehend mathematical concepts without aversion. Based on the results of this study, succeeding studies should be conducted which can contribute to the diversification and promotion of children’s experiential hall.

      • KCI등재

        박물관에서 VR 전시 경험 및 서비스 품질의 지각이 박물관 만족과 재방문 의도에 미치는 영향에 관한 연구

        최광식(Choi, Kwangsik),남윤재(Nam, Yoonjae) 대한관광경영학회 2022 觀光硏究 Vol.37 No.2

        본 연구는 최근 박물관에서 관람객 만족과 경험향상을 위해 도입하고 있는 VR(가상현실) 전시의 다양한 경험적 측면들을 탐색하면서, VR 전시의 경험적 요인 뿐 아니라 VR 경험 환경의 서비스 품질 요인들이 관람객 만족과 재방문 의도에 어떠한 영향을 미치는 가를 실증적으로 확인하는 것을 목적으로 한다. 이를 위한 이론적 배경으로, 본 연구는 VR 전시 경험을 경험경제(Experience Economy) 모델의 네 가지 차원을 바탕으로 하여 분석하였고, VR 경험을 위한 서비스 환경은 SERVQUAL 모델의 다섯 가지 차원을 바탕으로 하여 분석하였으며, 이를 토대로 VR 전시경험 및 서비스 품질이 박물관 만족과 재방문에 미치는 영향에 대해 가설을 설정하였다. 이를 검증하기 위해 본 연구는 국립중앙박물관 디지털실감영상관의 VR 전시를 실제 경험한 관람객들을 대상으로 설문조사를 실시하였으며, 해당 자료를 바탕으로 회귀분석을 실시하였다. 분석 결과, VR 경험 중에서는 오락적 경험만이 박물관 만족에 유의미한 영향을 보여주었으며, 서비스 품질에서는 반응성과 확신성이 박물관 만족에 유의미한 영향을 나타냈다. 재방문 의도에 있어서도 오락적 경험만이 유의미했으며, 서비스 품질에서는 신뢰성과 반응성이 유의미한 결과를 보여주었다. 이러한 결과, 본 연구는 학문적으로 기존의 박물관 경험 연구를 더욱 확장하여, VR 맥락에서 경험경제모델을 바탕으로 VR 경험의 다양한 측면들을 탐색한 의의를 지니며, 실무적으로는 VR 경험의 마케팅적 효과를 확인했다는 점에서 박물관 운영 측면에서 중요한 통찰을 제공한 의의를 지닌다. Recently, museums have adopted new technologies, like AR and VR, to meet the museum visitors needs and enhance their experience. In this trend, this study explored VR experience in a museum, identifying the effects of the VR technology, as well as the influence of the perception of service quality in a VR experience setting on visitors satisfaction and revisit intention. For this purpose, this study analyzed the VR experience and its service quality using the Experience Economy model and the five dimensions of SERVQUAL. According to these theoretical backgrounds, the research examined eighteen hypotheses regarding museum visitors attitudes toward museums based on their VR experiences and perceptions of service quality. An online questionnaire was given to visitors who experienced the VR exhibition at the Korean National Museum and a regression analysis was carried out using the collected data to verify these hypotheses. As results, it was found that only the entertainment variable among four dimensions of experience economy affected positive visitor satisfaction, and that among five variables in service quality, only two variables of responsiveness and assurance affected positive satisfaction. For the revisit intention, it was also discovered that the entertainment had a statistically significant effect, while in the service quality only reliability and responsiveness were statistically significant. These findings have theoretic implications not only for exploring different VR experiences based on experience economy extending prior studies on museum experiences, but also for integrating experience studies into service quality studies in a museum setting. In addition, the findings provide managerial insights for museum professionals responsible for planning VR projects and attracting new visitors by showing that VR exhibition is a valuable marketing tool in a museum.

      • KCI등재

        산정방법에 따른 논 원단위 비교

        최동호 ( Dongho Choi ),정재운 ( Jaewoon Jung ),윤광식 ( Kwangsik Yoon ),최우정 ( Woojung Choi ),조소현 ( Sohyun Cho ),범진아 ( Jina Beom ),유승화 ( Seungwha Yoo ) 한국환경영향평가학회 2015 환경영향평가 Vol.24 No.5

        The unit load of paddy field was estimated by several methods and compared in this study. Four year field study was conducted at the paddy fields located in Yeongsan river and Sumjin river basins. The unit load was estimated by four methods; ① averaging field monitored load; ② NIER (National Institute of Environmental Research) method which use EMC(Event Mean Concentration) and runoff ratio of rainfall groups with rainfall weighting factors; ③method using EMC determined by best fit probability distribution; ④method using arithmetic mean EMC and runoff ratio. The result of this study showed that the unit loads of water quality constituents by field monitoring was similar to those of NIER method whereas those by probability distribution(log-normal, gamma) method were less than unit loads of NIER method. The unit loads by arithmetic mean EMC and runoff ratio were larger than those by NIER method. The unit load by NIER method showed higher BOD, COD, SS, lesser T-N, and similar T-P values when compared to unit loads determined by MOE in 1995.

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