기능형 중재자 기반의 교육자원 서비스 시스템의 구현

최병석,오지훈,한성국 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.4

대부분의 웹 기반의 교육 시스템은 교육 정보 제공에만 중점을 두고 있다. 웹이 점차 교육 정보를 제공하는 보편적인 기반이 되어 감에 따라서, 웹은 이제 정보 제공의 차원을 넘어 다양한 서비스를 제공하는 플랫폼으로 변모하고 있다. 이에 새롭게 변화된 웹 환경에 맞는 교육 서비스 모델이 시급히 요청되고 있다. 본 논문에서는 기존의 웹 기반 교육의 여러 한계성을 해결하기 위하여 새로운 기능형 중재자 기반의 교육자원 서비스 모델을 제시하고자 한다. 본 논문의 기능형 중재자기반의 교육자원 서비스 시스템은 웹상에 산재되어 있는 교육 자원들을 효율적으로 관리하고 사용자의 요청에 맞는 교육 서비스 정보를 제공하여 줌으로써, 교육 서비스 자원들의 재사용 효율과 생산성을 높일 수 있다 Most of web-based education systems are only to supply education information. As the web becomes the common basis to support the effective education, it is used for not only applying education information but also developing to the dimension to provide various services. The education service models prospering to the newly diverse environment are necessary. In this paper, a education resource service system based on functional broker is implemented to overcome the weakness of the traditional Web-based instruction. This paper shows that the web-based education service system such as functional broker can manage the varied education resources efficiently and so contribute to realize the life-long education.

hCG에 대한 단일클론 항체 생산과 그 이용에 관한 연구

崔尙勳,李丙哲,李承培 건국대학교 1987 論文集 Vol.25 No.1

This study was carried out to produce monoclonal antibody against hCG secreted by the tr-ophoblast of developing embryo. Produced monoclonal antibody to hCG was regarded as IgG class since it had a strong affinity for a protein A. The concentration of monoclonal antibody in cell culture supernatant and in mouse ascitic fluid was 250㎍ and 30mg perml, respectively. The titer of antibody in mouse ascitic fluid was about 1 : 106~107 on ELISA

상아질-레진 계면의 공초점 현미경적 형태 및 전단결합강도와의 관계

손호현,조병훈,최낙원 大韓齒科保存學會 1999 Restorative Dentistry & Endodontics Vol.24 No.2

직접치수복조재에 따른 비글견 치수의 조직반응에 대한 연구

배지현,김영균,윤필영,조병훈,최용훈 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.1

본 연구에서는 인위적으로 노출시킨 비글견의 치수조직을 기존의 수산화칼슘제재와 MTA, 접착성 레진, 광중합형 수산화칼슘제재를 사용하여 직접치수복조한 후 각 재료에 따른 치수의 반응을 광학현미경 하에서 조직학적으로 관찰하여 비교분석하였다. 2마리 비글견의 36개 치아를 이용하여, 실험적으로 치수를 노출시키고 노출된 치수에 치수복조재를 적용한 후 와동은 복합레진으로 충전하여 직접치수복조술을 시행하였다: (1) Mineral Trioxide Aggregate (MTA: ProRoot MTA, Dentsply, Tulsa, USA), (2) Clearfil SE Bond (Dentin adhesive system: Kuraray, Osaka, Japan), (3) Ultra-Blend (Photopolymerized Calcium hydroxide: Ultradent, South Jordan, USA), (4) Dycal (Quick setting Calcium hydroxide: LD Caulk Co., Milford, USA). 희생전 90일, 30일, 7일 전에 각 복조재별로 3개씩의 와동을 충전하였고 비글견을 희생시키고 조직시편을 제작하였다. 시편을 H&E 염색 후 광학 현미경으로 치수염증반응과 경조직 형성 정도를 관찰하였다. MTA 군은 초기에는 경조직 형성이 관찰되지 않고 치수조직의 위축과 부분괴사가 관찰되었으나 시간이 지나면서 경조직 형성이 관찰되었다. Clearfil SE Bond군은 초기에 염증세포의 침윤과 치수세포의 괴사를 관찰할 수 있었고 시간이 지날수록 치수 세포의 괴사가 더욱 진행한 양상을 보였다. Ultra-blend 군과 Dycal 군은 MTA 군과 비슷하게 초기에는 경조직 형성을 보이지 않고 중등도의 염증반응이 관찰되었으며 시간이 지나면서 경조직 형성이 관찰되었다. MTA, 수산화칼슘제재와 광중합 수산화칼슘제재는 초기의 치수염증반응 이후 조상아세포층, 상아질교 형성을 보여 직접치수복조재로 적당하였으며, 접착성 레진은 심한 염증반응과 치수 조직의 괴사 양상을 보여 직접치수복조재로 부적당하다는 결론을 얻을 수 있었다. The purpose of this study was to evaluate the pulp tissue reaction to direct pulp capping of mechanically exposed beagle dogs' pulp with several capping materials. A total of 36 teeth of 2 healthy beagle dongs were used. The mechanically exposed pulps were capped with one of the followings: (1) Mineral Trioxide Aggregate (MTA: ProRoot MTA. Dentsply, Tulsa, USA), (2) Clearfil SE Bond (Dentin adhesive system: Kuraray, Osaka, Japan), (3) Ultra-Blend (Photo-polymerized Calcium hydroxide: Ultradent, South Jordan, USA), (4) Dycal (Quick setting Calcium hydroxide: LD Caulk Co., Milford, USA) at 7, 30, and 90 days before sacrificing. The cavities were restored with Z350 flowable composite resin (3M ESPE, St. Paul. MN, USA). After the beagle dogs were sacrificed, the extracted teeth were fixed, decalcified, prepared for histological examination and stained with HE stain. The pulpal tissue responses to direct pulp capping materials were assessed. In MTA calcium hydroxide, and photo-polymerized calcium hydroxide groups, initial mild inflammatory cell infiltration, newly formed odontoblast-like cell layer and hard tissue bridge formation were observed. Compared with dentin adhesive system, these materials were biocompatible and good for pulp tissue regeneration. In dentin adhesive system group, severe inflammatory cell infiltration, pulp tissue degeneration and pulp tissue necrosis were observed. It seemed evident that application of dentin adhesive system in direct pulp capping of beagle dog teeth cannot lead to acceptable repair of the pulp tissue with dentine bridge formation.

.Pseudomonas stutzeri 감염에 의한 맥락총염에서 초래된 포착성 측뇌실 확장 1예

김남곤,권오영,박기종,최낙천,임병훈 대한신경과학회 1997 대한신경과학회지 Vol.15 No.2

Exploring transient receptor potential (TRP) channel for study of thermo sensory neurotransmission pathway in fish

Byeong-Hoon Kim,Song-Hee Choi,Chi-Hoon Lee,Young-Don Lee,Sung-Pyo Hur 한국수산과학회 양식분과 2023 한국수산과학회 양식분과 학술대회 Vol.2023 No.6

Changes in Body Growth and Growth-Related Genes under Different Photoperiods in Olive Flounder, Paralichthys olivaceus

Byeong-Hoon Kim,Chi-Hoon Lee,Song-Hee Choi,Young-Don Lee 제주대학교 해양과학연구소 2019 해양과환경연구소 연구논문집 Vol.43 No.-

Versatile surface plasmon resonance of carbon-dot-supported silver nanoparticles in polymer optoelectronic devices

Choi, Hyosung,Ko, Seo-Jin,Choi, Yuri,Joo, Piljae,Kim, Taehyo,Lee, Bo Ram,Jung, Jae-Woo,Choi, Hee Joo,Cha, Myoungsik,Jeong, Jong-Ryul,Hwang, In-Wook,Song, Myoung Hoon,Kim, Byeong-Su,Kim, Jin Young Springer Science and Business Media LLC 2013 Nature photonics Vol.7 No.9

CCR2b-64I Allelic Polymorphisms in Advanced HIV-Infected Koreans Accelerate Disease Progression

Choi, Byeong-Sun,Choi, Jang-Hoon,Kim, Sung Soon,Kee, Mee-Kyung,Lee, Joo-Shil MARY ANN LIEBERT INC PUBL 2007 AIDS RESEARCH AND HUMAN RETROVIRUSES Vol.23 No.6

<P>Genetic polymorphisms of chemokine genes and chemokine-receptor genes in HIV-infected patients have been associated with delayed progression of this disease. The allelic frequencies of these genetic variants also differ between ethnic groups. To investigate the effects of the SDF1 and CCR2b genotypes on disease progression, survival of 200 HIV-infected persons for whom at least four subsequent immunologic data items had been collected was analyzed. A genotyping assay of SDF1 and CCR2b genes was carried out using polymerase chain reaction-restriction fragment length polymorphism analyses. HIV-infected persons heterozygous for the SDF1-3'A or CCR2b-64I alleles were included in the survival analysis, but homozygotes were excluded because of a very small sample number. Neither the CCR2b-+/64I allele nor the SDF1-+/3'A allele, separately or in combination, had a significant impact on survival during the asymptomatic period of HIV infection. However, CCR2b-+/64I alleles were associated with accelerated disease progression during the advanced period of HIV infection. The survival time of HIV-infected people with CCR2b-+/64I and SDF1-+/+ genotypes was significantly shorter than those of the other groups (p < 0.01), but this effect was not apparent in persons with CCR2b-+/64I alleles and SDF1-+/3'A genotypes. These results suggest that the effect of CCR2b-64I polymorphisms on disease progression may differ according to the stage of HIV infection and interactions with other gene variants.</P>

Influence of the curing time for the adhesive on the oxygen-inhibited layer thickness and the shear bond strength to dentin

Choi, Yong-Hoon,Bae, Ji-Hyun,Son, Ho-Hyun,Lee, In-Bog,Um, Chung-Moon,Baek, Seung-Ho,Kim, Oh-Young,Kim, Chang-Keun,Cho, Byeong-Hoon 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.2

본 연구는 광중합형 상아질 접착제에서 광조사 시간의 증가가 접착제 표면의 미중합층에 대한 영향과 그에 따른 전단접착강도에 대해 연구하고자 120개의 치아를 아크릴 몰드에 식립한 후 상아질이 노출되도록 연마하였다. 3종류의 접착제 [All Bond2 (AB2), One-Step (OS) and Adper Prompt (AP)]를 40개 치아에 제조사의 지시대로 도포한 후 각각 다른 광조사 시간 (10, 20, 30 and 60 sec)동안 광조사 하고 복합레진을 접착한 24시간 후 전단접착강도를 측정하였다. 미중합층의 두께와 중합률은 슬라이드 글라스와 FT-NIR을 이용하여 FT-NIR spectrum에서의 peak height를 비교 측정하여 다음과 같은 결론을 얻었다. 1. 전단접착강도에서 AB2는 20초 이후 감소하고, AP는 30초까지 증가하였으며, OS는 차이를 보이지 않았다. 2. 미중합층 두께는 3가지 접착제 모두 유의성 있는 차이를 보이지 않았다. 3. 중합률에서 OS는 10초와 나머지군 사이에 유의성 있는 차이를, AP는 60초에서 유의성 있게 증가되고, AB2의 경우 차이를 나타내지 않았다. Objectives : This study investigated the hypothesis that increasing light-curing time would leave the oxygen-inhibited layer (OIL) of the adhesive thinner, and in turn, result in lower shear bond strength (SBS) than those obtained by the routine curing procedures. Methods : 120 human extracted posterior teeth were randomly divided into three groups for bonding with three adhesives: All Bond 2®, One Step®, and Adper Prompt®. They were subsequently divided into four subgourps with different light-curing time (10, 20, 30 and 60 s). The assigned adhesives were applied on superficial occlusal dentin according to the manufacturer's instructions and cured with one of the four curing times. Composite resin cylinder, 2.35 mm in diameter, were built on the cured adhesive and light-cured for 40 s. SBS were measured after 24 h from the bonding using a universal testing machine (crosshead speed 1.0 mm/min). The relative thickness of the OIL and the degree of conversion (DC) were determined from the adhesive on a slide glass using FT-NIR in an absorbance mode. Data were analysed with One-way ANOVA and Duncan s multiple test (p < 0.05). Results : With increasing cure time, although there were no significant difference in th SBS of One-step and Adper Prompt (p > 0.05), those of All Bond 2 decreased significantly (p < 0.05). The relative thicknesses of the OIL on each adhesive were not affected by the cure time (p > 0.05). Although the DC of All-Bond 2 were statistically not different with increasing cure time (p < 0.05), those of One-Step and Adper Prompt showed an increasing trends with increasing cure time (p < 0.05). Conclusions : Increasing light-curing time did not affect on the relative thickness of the OIL of the adhesives, and in turn, on the SBS to dentin.