과민성 대장 증후군 환자에서 Colpermin 투여의 임상 효과

금민수,조창민,김대현,이창형,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 과민성 대장 증후군은 장기능 이상의 증상군으로, 인지할 수 있는 기질적 위장관 병태 생리가 없는 경우로 기능적인 장관의 이상 경축과 가장 밀접한 관련이 있을 것으로 생각된다. 그러나 치료면에서는 아직 뚜렷한 방침이 정립되어 있지 않고 다양한 방법들이 제시되고 있는 실정이다. 저자들은 장용성 캅셀로 조제된 박하유 성분인 Colpermin® 의 임상 효과를 평가하고자 본 연구를 시행하였다. 대상 및 방법 : 1996년 2월부터 1996년 11월까지 경북대학교병원 소화기 내과를 방문하여 과민성대장 증후군으로 진단된 34명의 환자를 대상으로 Colpermin® 을 1회 2캅셀씩, 1일 3회, 경구로 2주간 투여하였다. 결과 : 투여전의 증상의 빈도는 복통 88.2%(30/34) 및 설사 73.5%(25/34)를 호소하는 경우가 가장 많았으며, 그 다음으로 변비 50.0%(17/34), 복부 팽만 47.1%(16/34), 고창 38.2%(13/34)순이었다. 약물 투여후 증상별 개선율은 설사를 보였던 환자들에서 호전 11예와 매우 호전 11예로 88.0%(22/25)의 가장 높은 개선율을 보였고, 그 다음으로 복통 73.3%(22/30), 고창 69.2%(9/13), 변비 64.7%(11/17), 복부 팽만 56.3%(9/16)의 순이었다. 종합적인 증상의 개선도는 현저한 개선이 2예(5.9%), 중등도 개선이 9예(26.5%), 약간 개선이 18예(52.9%), 불변이 4예(11.8%), 악화가 1예(2.9%)였으며, 종합적인 유효율은 85.3%(29/34)였다. 약물의 부작용으로 3예의 환자에서 각각 복부 팽만의 발생, 변비의 악화, 복통의 발생이 있었으나, 그 외의 환자들에서는 아무런 부작용도 관찰되지 않았다. 결론 : 과민성 대장 증후군의 약물치료에 있어서 Colpermin®이 유용한 약제가 될 수 있을 것으로 기대된다. Irritable bowel syndrome (IBS) is a disease characterized by a collection of symptoms of intestinal dysfunctions, without any recognized organic gastrointestinal pathology. This study was performed to evaluate clinical effectiveness of peppermint oil (Colpermin®) in the treatment of patients with IBS. 34 patients (18 males and 16 females) with IBS were treated with peppermint oil 0.4ml (as menthol 176㎎) three times daily for 2 weeks and the efficacy of the treatment was evaluated according to the degree of the improvement. The improvement of symptoms was 88.0% (22/25) in diarrhea, 73.3% (22/30) in abdominal pain, 69.2% (9/13) in flatulence, 64.7% (11/17) in constipation, and 56.3% (9/16) in abdominal distension, respectively. Overall effectiveness of subjective symptoms was 85.3% (29/34). Side effects of the drug were noted in only 3 cases, those were aggravation of constipation, development of abdominal distension and abdominal pain. As a result, Colpermin® might be considered as an effective drug in relieving symptoms of IBS.

Prepregnancy Factors as Determinants of the Development of Diabetes Mellitus After First Pregnancy

Cho, Geum Joon,Park, Jong Heon,Lee, Heeyoung,Yoo, Seughyun,Shin, Soon-Ae,Oh, Min-Jeong Issued for the Endocrine Society by the Williams & 2016 The Journal of clinical endocrinology & metabolism Vol.101 No.7

<P>Context: The identification of modifiable factors at prepregnancy or early pregnancy as well as continued monitoring and management of these factors before and during pregnancy may reduce the incidence of diabetes mellitus (DM) among women, regardless of gestational diabetes mellitus (GDM) status. Objective: This study aimed to identify prepregnancy factors for the development of DM in women with or without GDM in their first pregnancy. Design and Participants: This retrospective, observational, cohort study included data for 53 109 women who underwent a National Health Screening Examination through the National Health Insurance Corporation between 2002 and 2003 and had their first delivery in 2004 with follow-up until 2012. Main Outcomes: The main outcome of the study was the risk of developing DM after 8 years in women with and without GDM during their first pregnancy. Results: The cumulative risks of developing DM after 8 years were 8.4% and 3.3% in women with and without GDM during their first pregnancy, respectively. Old age, a family history of DM, obesity, a high fasting glucose level, and high total cholesterol level were associated with DM development in women without GDM. In women with GDM, a family history of DM, prepregnancy obesity, a high fasting glucose level, and a high total cholesterol level were associated with DM. When stratified by GDM status and the number of prepregnancy risk factors, the number of prepregnancy risk factors was associated with the risk of DM in women with or without GDM. Women with GDM had a higher risk of DM for the same number of prepregnancy risk factors than women without GDM. Conclusion: The results show that GDM may be a marker for development of DM in the future because it shares the same risk factors with DM development. Thus, eliminating other risk factors in women with GDM may lead to a reduction in the risk of DM.</P>

Effects of estradiol on HIF-1α expression and trophoblast differentiation in first trimester villous explant cultures

( Geum Joon Cho ),( Lyn Hwa Lee ),( Bona Lee ),( Jaeeun Lee ),( Ki-Hoon Ahn ),( Soon-Cheol Hong ),( Hai-Joong Kim ),( Min-Jeong Oh ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.1

Objective The purpose of this study was to investigate the effects of estradiol on the expression of hypoxia-inducible factor (HIF)-1α and the differentiation of trophoblasts in human first trimester villous explant cultures. Methods Villous explant cultures were established from first trimester human placentas (6-8 weeks of gestation, n=3). Normal villous tissues were explanted on Matrigel and incubated under 3% O₂ tension for 5 days. To evaluate the effects of estradiol on the villous explant cultures, 1 ng/mL of estradiol was added to the culture medium. The morphological integrities and viabilities of the villous explants were monitored. Immunohistochemistry for α5 and α1 integrin was performed to assess differentiation of extravillous trophoblasts (EVTs). Expression of HIF-1α in villous explant cultures was evaluated by western blotting and densitometry. Results EVTs emerging from first trimester villous explant cultures formed outgrowths of cells from the distal ends and invaded the surrounding Matrigel. Exposure of villous explants to estradiol resulted in the decreased outgrowth of cells from the distal end and decreased expression of α5 integrin. However, estradiol treatment increased the invasion of villous explants into the surrounding Matrigel, concomitant with the increased expression of α1 integrin, indicating differentiation of EVTs into more invasive EVTs. On western blots, the expression of HIF-1α decreased significantly after treatment with estradiol under 3% O₂ tension. Conclusion Our findings suggest that estradiol may downregulate expression of HIF-1α in placenta, which in turn promote trophoblast differentiation into invasive phenotype.

A novel rat model of preeclampsia using sFlt-l overexpressing human adipose ti ssue-derived mesenchymal stem cells

( Geum Joon Cho ),( Hee Woo Lee ),( Hye Mi Jin ),( Ki Hoon Ahn ),( Soon Cheol Hong ),( Min Jeong Oh ),( Hai Joong Kim ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

OB-55 : The altered vascular reactivity in offspring from pregnant mice model of preeclampsia

( Geum Joon Cho ),( Hye Mi Jin ),( Oye Sun Seok ),( Min Woo Kim ),( Suhng Wook Kim ),( Suk Hyo Suh ),( Soon Cheol Hong ),( Hai Joong Kim ),( Min Jeong Oh ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: The aim of this was to evaluate the effect of maternal preeclampsia on vascular reactivity of offspring in a pregnant mouse model of preelampsia. 방법: At day 8 of gestation pregnant CD-1 mice were randomly allocated to injection using the tail vein of the lentivirus carring sFlt-1 (109 plaque- forming units in 100 microliters; sFlt-1 group) or the mock lentivirus (109 plaque-forming units in 100 microliters; mock group used as a control for the virus) or control group. After delivery, nursing dams and offspring were kept together in individual cages. Offspring from each group were sacrificed at 8 weeks of age, and abdominal aorta was harvested for the study of vascular reactivity. 결과: The vasorelaxant responses to acetylcholine (endothelium-dependent relaxant) were decreased in offspring from sFlt-1 group compared with offspring from control and mock groups. However, there was no difference in vasorelaxant responses to sodium nitroprusside (the endothelium- independent relaxant) between four groups. 결론: Maternal preeclampsia has detrimental effects on vascular reactivity in offspring. Our findings show hypertension of fetal programming in offspring born to preeclamptic mothers.

Cerclage is associated with the increased risk of preterm birth in women who had cervical conization

( Geum Joon Cho ),( Log Young Kim ),( Geun U Park ),( Hye Mi Jin ),( Ki Hoon Ahn ),( Soon Cheol Hong ),( Min Jeong Oh ),( Hai Joong Kim ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

OB-21 : Maternal magnesium sulfate treatment is not associated with serum calcium levels of preterm neonate

( Geum Joon Cho ),( Ji Eun Lee ),( Hye Ri Hong ),( Soon Cheol Hong ),( Young Sook Hong ),( Hai Joong Kim ),( Min Jeong Oh ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

It is well known that magnesium plays an important role in calcium homeostasis. Recently, FDA is advising health care professionals against using magnesium sulfate (MgSO4) treatment because MgSO4 treatment beyond 5-7 days to pregnant women can cause low calcium and bone abnormalities in the neonate. However, the effect of maternal MgSO4 treatment on neonatal calcium homeostasis is inconsistent among studies. The aim of this was to determine the association between maternal MgSO4 treatment and neonatal calcium level. This is a retrospective study of 570 pregnant women with preterm birth and their paired neonates. Case group of 101 neonates whose mothers had received intravenous MgSO4 treatment were compared to control of 469 neonates whose mothers had no MgSO4 treatment. Neonatal calcium levels were measured in umbilical cord blood after delivery. Neonatal calcium levels were lower in case group than control. However, the incidence of hypocalcemia (total serum calcium level< 7mg/dL) was not different between two groups. A multiple linear regression model showed that maternal preeclampsia, gestational age at delivery, beta-mimetic tocolytic treatment, maternal GDM and delivery mode were independent predictors of neonatal calcium levels. However, maternal MgSO4 treatment was not associated with serum neonatal calcium levels. Our results indicate that maternal MgSO4 treatment may not cause low calcium levels in preterm neonates. Further studies are needed to evaluate the long term effect of maternal MgSO4 treatment on neonatal bone abnormalities.

Vitamin D deficiency in GDM and the role of placenta

( Geum Joon Cho ),( Hyun Joo Seol ),( Soon Cheol Hong ),( Min Jeong Oh ),( Hai Joong Kim ) 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-

Vitamin D deficiency in preeclampsia and the role of placenta

( Geum Joon Cho ),( Hyun Joo Seol ),( Soon Cheol Hong ),( Min Jeong Oh ),( Hai Joong Kim ) 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-

The association between orexin-A and idiopathic polyhydramnios

( Geum Joon Cho ),( Hye Ri Hong ),( Soon Cheol Hong ),( Hai Joong Kim ),( Min Jeong Oh ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

Idiopathic polyhydramnios is an independent risk factor for perinatal morbidity and mortality, although the precise mechanism is unknown. Orexin-A is neuropeptide which is present in the lateral hypothalamic area of the brain and may be involved in regulating various brain functions such feeding. Orexin-A protein was also detected in the placenta and in neurons of the gastrointestinal tract, especially, the myenteric plexuses from 26 gestational weeks. In general, hunger has been found to induce an increase of orexin-A, which increases gut motility. Given the human fetus swallows large volumes of amniotic fluid, which is almost completely resorbed within the gastrointestinal tract of the fetus, orexin-A may play an important role in regulating gastrointestinal functions, including absorption of amniotic fluid (AF) or mortility of the gut in the fetus. The aim of this study was to evaluate the association of orexin-A with idiopathic polyhydramnios. This case-control study included 10 pregnant women with idiopathic polyhydramnios and 20 age and gestational age-matched pregnant women with normal AF as the control group. Orexin-A levels were determined by ELISA, and compared for correlation between umbilical cord and maternal serum orexin-A levels and neonatal birth weight and differences between control and idiopathic polyhydramnios group. Mean umbilical serum orexin-A level was significantly higher than maternal serum orexin-A level. Umbilical serum orexin-A level was positively correlated with maternal serum orexin-A level and negatively with neonatal birth weight. Umbilical serum orexin-A level in idiopathic polyhydramnios group were higher compared with those in control group. However, there was no difference in maternal serum orexin-A levels in between two groups. In this study, idiopathic polyhydramnios was associated with decreased level of orexin-A in umbilical cord. Our results provide evidence that downregulation of orexin-A may induce polyhydramnios through decreases of absorption of amniotic fluid or mortility of the gut.