http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Agraphia in Korean patients with early onset Alzheimer's disease
Yoon, Ji Hye,Suh, Mee Kyung,Jeong, Yong,Ahn, Hyun-Jung,Moon, So Young,Chin, Juhee,Seo, Sang Won,Na, Duk L. Cambridge University Press 2011 INTERNATIONAL PSYCHOGERIATRICS - Vol.23 No.8
<B>ABSTRACT</B><P>Background: Agraphia in Korean patients may be different from agraphia in other patients who use alphabetical writing systems due to the “visuoconstructional script” characteristics of the Korean writing system, Hangul. Patients with early onset Alzheimer's disease (EOAD) have a severe degree of hypometabolism in the parietal area, which is known to be involved in processing visuospatial function. Thus, we explored the diverse error patterns manifested in writing single syllables in Korean patients with EOAD.</P><P>Methods: A study sample of 35 patients with EOAD and 18 healthy controls (HC) performed a Hangul writing task. We analyzed the erroneous responses of the subjects according to visuoconstructional and linguistic characteristics. In addition, we evaluated the relationship between Hangul writing and the neuropsychological variables as well as the severity of dementia.</P><P>Results: When comparing the total number of erroneous responses between EOAD and HC groups, the performances of EOAD patients were significantly worse than those of HC. EOAD patients demonstrated visuoconstructional errors even in the early stages of the disease. Severity of dementia and multiple cognitive domains such as attention, language, immediate memory, and frontal executive functions significantly correlated with the performance of Hangul writing.</P><P>Conclusion: Our findings suggest that patients with EOAD exhibit not only linguistic errors but also visuoconstructional manifestations of agraphia, which are associated with cognitive impairments in the multiple domains.</P>
Summary of Korean Asthma Guideline
( Chin Kook Rhee ),( Ji Yong Moon ),( Hyonsoo Joo ),( Ji Ye Jung ),( Jung-kyu Lee ),( Kyung Hoon Min ),( Hyeon-kyoung Koo ),( Seong Yong Lim ),( Hyoung Kyu Yoon ),( Sang Yeub Lee ) 대한결핵 및 호흡기학회 2023 Tuberculosis and Respiratory Diseases Vol.86 No.3
Asthma is a chronic inflammatory airway disease that is characterized by variable airflow obstruction. The Korean Asthma Study Group of the Korean Academy of Tuberculosis and Respiratory Diseases has recently updated the Korean Asthma Guideline. This review summarizes the updated Korean Asthma Guideline. Asthma prevalence is increasing worldwide, and in Korea. Variable airflow obstruction can be confirmed by bronchodilator response or other tests, and should be established prior to the controller medication. A low-dose inhaled corticosteroid-formoterol is used to alleviate symptoms in all treatment step, and it can be used as a controller as well as reliever in steps 3-5. This approach is preferred, because it reduces the risk of severe exacerbations, compared to the use of short-acting β2-agonist as reliever. In severe asthma, phenotype/ endotype based on the underlying inflammation should be evaluated. For type 2 severe asthma, the biologics should be considered.
Yoon, Chang Hyo,Park, Yoon Kyung,Kim, Suk Jae,Lee, Mi-ji,Ryoo, Sookyung,Kim, Gyeong-Moon,Chung, Chin-Sang,Lee, Kwang Ho,Kim, June Soo,Bang, Oh Young American Heart Association, Inc. 2014 Stroke Vol.45 No.10
<P>Background and Purpose-Recent randomized clinical trials (RCTs) have evaluated the benefit of new oral anticoagulants in reducing the risk of vascular events and bleeding complications in patients with atrial fibrillation (AF). However, abundant and strict enrollment criteria may limit the validity and applicability of results of RCTs to clinical practice. We estimated the eligibility for participation in RCTs of an unselected group of patients with AF. In addition, we compared features favoring new oral anticoagulant use between patients with versus without stroke. Randomized Evaluation of Long-Term Anticoagulation Therapy Methods-We applied enrollment criteria of 4 RCTs (RE-LY, ROCKET-AF, ARISTOTLE, and ENGAGE-AF-TIMI 48) to 695 patients with AF taking warfarin, prospectively and consecutively collected at a university medical center; 500 patients with and 195 patients without stroke. Time in therapeutic range and bleeding risk scheme (anticoagulation and risk factors in atrial fibrillation) were also measured. Results-The proportions of patients fulfilling the trial enrollment criteria varied, ranging from 39% to 72.8%, depending on the differences in indications/contraindications among studies and presence/absence of stroke. The main reasons for ineligibility for RCTs were hemorrhagic risk (anticoagulation and risk factors in atrial fibrillation [ATRIA] score) (10.8%-40.5%) and planned cardioversion (5.1%-7.7%) for nonstroke patients, and a low creatinine clearance (5.6%-9.2%) and higher risk of bleeding (15.2%-20.8%) for patients with stroke. When compared with nonstroke patients, patients with stroke showed a lower time in therapeutic range (54.4 +/- 42.8% versus 65.4 +/- 34.9%, especially with severe disability) and a high hemorrhagic risk (ATRIA score) (3.06 +/- 2.30 versus 2.18 +/- 2.16) (P<0.05 in both cases). Conclusions-Patients enrolled in RCTs are partly representative of patients with AF in clinical practice. When time in therapeutic range and bleeding tendency with warfarin use were considered, the use of new oral anticoagulants was preferred in patients with stroke than in nonstroke patients, but they were more likely to be excluded in RCTs.</P>
Microbiological survey of Korean animal facilities from 2014 to 2019
Sang woon Kim,Hi jo SHIN,Se hee PARK,Teak chang LEE,Hae jin LEE,Ok sung MOON,Ki hoan NAM,Won kee YOON,Hyoung chin KIM,Hyo jung KWON,Young Suk WON 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
To survey the mouse microbiological contamination rate in Korean animal facilities, we tested for common contaminants in these facilities using serological, culture, and parasitological methods. A total of 21,292 experimentally housed mice from 206 animal facilities, including hospitals, universities, companies and research institutes, were tested over a 6-year period from 2014 to 2019. The most commonly found contaminants were various species of non-pathogenic protozoa (47.2%). The most common pathogenic bacteria were Staphylococcus aureus (21.2%), Pasteurella pneumotropica (12.5%) and Pseudomonas aeruginosa (5.8%). Mouse hepatitis virus (6.1%) was detected, but no other viral or bacterial pathogens were found. These results establish that the main pathogens that currently contaminate animal facilities in Korea are opportunistic pathogens, whereas important such as those in categories B or C, were decreased.
Protein kinase A-dependent phosphorylation of B/K protein
Chin, Hemin,Choi, Sung-Ho,Jang, Yoon-Seong,Cho, Sung-Min,Kim, Ho-Shik,Lee, Jeong-Hwa,Jeong, Seong-Whan,Kim, In-Kyung,Kim, Grace J,Kwon, Oh-Joo Springer Science and Business Media LLC 2006 Experimental and molecular medicine Vol.38 No.2
<P>We have previously isolated a novel protein 'B/K' that contains two C2-like domains. Here, we report the isolation and mRNA distribution of a human B/K isoform, and protein kinase A (PKA)-dependent phosphorylation of the B/K protein. The 1.5 kb human B/K cDNA clone exhibits 89% and 97% identities with rat B/K in the sequences of nucleotide and amino acid, respectively. Human B/K isoform encodes a 474 amino acid protein and shows structural features similar to the rat counterpart including two C2 domains, three consensus sequences for PKA, absence of a transmembrane region, and conservation of the N-terminal cysteine cluster. On Northern and dot blot analyses, a 3.0 kb B/K transcript was abundantly present in human brain, kidney, and prostate. Among the brain regions, strong signals were observed in the frontal and temporal lobes, the hippocampus, the hypothalamus, the amygdala, the substantia nigra, and the pituitary. Recombinant B/K proteins containing three consensus sites for PKA was very efficiently phosphorylated in vitro by PKA catalytic subunit. B/K protein which was overexpressed in LLC-PK1 cells was also strongly phosphorylated in vivo by vasopressin analog DDAVP, and PKA-specific inhibitor H 89 as well as type 2 vasopressin receptor antagonist specifically suppressed DDAVP-induced B/K phosphorylation. These results suggest that B/K proteins play a role as potential substrates for PKA in the area where they are expressed.</P>
( Sang Soo Lee ),( Ra Ri Cha ),( Chang Min Lee ),( Wan Soo Kim ),( Hyun Chin Cho ),( Jin Joo Kim ),( Jae Min Lee ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims:HepaticCvirus(HCV)genotype3infectionisthemostdifficultformofHCVtotreat,withamorerapidprogressiontofibrosisandcirrhosiscomparedwithothergenotypes.Theaimsofthisretrospectiveobservationalstudyweretoelucidatetheimpactofgenotype3infectiononhepatocellularcarcinoma(HCC)developmentandoverallmortalityinpatientswithHCV-relatedcirrhosis,comparedtoHCVgenotype1and2intheGyeongnamProvince,locatedonthesoutheastcoastofKorea.Methods:Atotal153patientswithHCV-relatedcirrhosiswereincludedbetweenJanuary2005andDecember2014.Amongthese,74hadgenotype1,55genotype2,and24patientshadgenotype3infection.Results:Theprevalenceofgenotype3inHCV-relatedcirrhosiswas16%.Individualsatriskforgenotype3infectionwereyoung,malegender,andpeoplewhoinjectdrugs.Duringmedianamedianfollow-up40.1months,38patientsdevelopedHCC,and23patientsdied.TheincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithgenotype1and2inthelogranktest.Despitebeingyounger,HCVgenotype3wasaindependentriskfactorforHCCdevelopment(adjustedhazardratio[HR〕=2.55)andoverallmortality(adjustedHR=3.69)onmultivariateanlalysis.Afterexclusionofpatientswithachievedsustainedvirologicresponse,theincidenceofHCCdevelopmentandoverallmortalitywassignificanthigherinpatientswithgenotype3comparedtopatientswithnogenotype3.Conclusions:HCVgenotype3infectionisassociatedwithanincreasedriskofHCCandoverallmortalityinpatientswithcirrhosisafteradjustingwithconfoundingfactors.
Polymorphisms in <i>PDE4D</i> are Associated with a Risk of COPD in Non-Emphysematous Koreans
Yoon, Hyoung-Kyu,Hu, Hae-Jin,Rhee, Chin-Kook,Shin, Seung-Hoon,Oh, Yeon-Mok,Lee, Sang-Do,Jung, Seung-Hyun,Yim, Seon-Hee,Kim, Tae-Min,Chung, Yeun-Jun Informa Healthcare 2014 COPD Vol.11 No.6
<P>Despite extensive effort, only a few chronic obstructive pulmonary disease (COPD)-associated genes have been suggested, indicating that there must be additional risk-associated loci. Here we aimed to identify additional COPD-associated SNPs and to explore the potential relationship between COPD subgroups and the SNPs in the Korean population. We performed a genome-wide association study (GWAS) with 990 Korean individuals; 102 COPD cases and 544 controls for GWAS using Affymetrix SNP array 5.0, and 173 COPD cases and 171 controls for replication. After validating the candidate single nucleotide polymorphisms (SNP), we performed subgroup analysis by disease phenotype. Through GWAS, we identified a novel SNP in the <I>phosphodiesterase-4D</I> (<I>PDE4D</I>) gene [rs16878037 (C>T), <I>p</I> = 1.66 ◊ 10<SUP>−6</SUP>] that was significantly associated with COPD. This signal in <I>PDE4D</I> was successfully replicated in the independent set (<I>p</I> = 0.041). When we combined the discovery and replication data, the association signal became more significant (<I>p</I> = 5.69 ◊ 10<SUP>−7</SUP>). In the COPD subgroup analysis, the T allele of rs16878037 was significantly more frequent in COPD patients without severe diffusion capacity impairment (mild mixed and obstruction-dominant group) than in patients with severe impairment (severe mixed and emphysema-dominant groups). This result supports that <I>PDE4D</I> polymorphisms might be involved in the susceptibility to COPD especially in non-emphysematous individuals and that they could also affect the responsiveness of the PDE4 inhibitor treatment.</P>
Yoon, Myung Hun,Park, Sang Jun,Kim, Chan Yun,Chin, Hee Seung,Kim, Na Rae British Medical Association 2014 British journal of ophthalmology Vol.98 No.3
<P><B>Aims</B></P><P>This study examined the diagnostic value of the perimacular ganglion cell-inner plexiform layer (GCIPL) thickness in the detection of glaucoma according to the optic disc area.</P><P><B>Methods</B></P><P>The participants underwent reliable standard automated perimetry tests and Cirrus optical coherence tomography. The area under the receiver operating characteristic curve (AUC) was used to determine the diagnostic ability of the GCIPL, total macular thickness, retinal nerve fibre layer (RNFL) and optic nerve head parameters. Subsequently, optic disc areas of ≤1.9, ≤2.4 and >2.4 mm<SUP>2</SUP> were chosen arbitrarily, and the AUCs and sensitivities at fixed specificities were compared for each.</P><P><B>Results</B></P><P>87 normal subjects and 96 glaucoma patients were enrolled. The mean GCIPL thickness and RNFL showed similar ability to diagnose glaucoma (p=0.911). The mean GCIPL thickness had higher diagnostic ability than the central retinal subfield thickness (p=0.001), comparable with that of the retinal cube volume (p=0.840) and mean retinal cube thickness (p=0.840). The mean RNFL (0.866), the minimum GCIPL (0.840) and the inferior and inferotemporal (0.853) disc had the highest AUCs for small, medium and large discs, respectively.</P><P><B>Conclusions</B></P><P>The macular GCIPL thickness, total macular cube thickness, circumpapillary RNFL thickness and disc rim area showed similar performance in diagnosing glaucoma, irrespective of the optic disc size.</P>