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전치완 ( Chi Wan Jeon ),채수천 ( Su Chun Choi ),방준환 ( Jun Hwan Bang ),장영남 ( Young Nam Jang ) 한국공업화학회 2013 응용화학 Vol.17 No.1
공업적으로 페인트, 플라스틱 등의 고분자 충전제로 주로 사용되는 탄산칼슘의 고도 이용화를 위한 목적으로 지방산을 이용한 표면개질화 방법에 대하여 논하였다. 대표적 지방산인 스테아린산을 유기 용매에 용해하여 만든 개질제용액을 침강성 방해석 형태의 탄산칼슘과 혼합하는 방법으로 극성을 띤 분체의 표면 특성을 비극성화로 개질화하였으며, 이 과정에서 유기 용매의 종류에 따른 개질제의 농도, 반응시간, 분체의 입도 및 전처리 온도 변화 등에 따른 흡착효율 및 공정의 용이성 등에 대하여 고찰하였다. 이 결과 유기 용매의 종류에 따른 최적 반응시간 및 농도에 따른 효율적 개질화 흡착 방법이 제시되었으며, 이러한 전 과정은 열에너지의 소모를 완전히 배제함으로써 저비용 고효율의 공정 개선효과를 도모하였다. 개질화된 탄산칼슘 분체의 물리 화학적 특성 변화를 파악하기 위한 방법으로 소수성평가, 친유성 정착부피를 구하는 방법을 제시하였고, 역상크로마토그래피 및 접촉각 측정 방법을 이용하여 개질화된 분체의 표면에너지 변화값을 측정하였다.
Chang, Chih-Chun,Sun, Jen-Tang,Liou, Tse-Hsuan,Kuo, Chin-Fu,Bei, Chia-Hao,Lin, Sheng-Jun,Tsai, Wei-Ting,Tan, N-Chi,Liou, Ching-Biau,Su, Ming-Jang,Yen, Tzung-Hai,Chu, Fang-Yeh Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: It is reported that the percentage of smudge cells in the blood smear could be a prognostic indicator in chronic lymphocytic leukemia. However, the clinical significance of smudge cells in other hematological malignancies, solid tumors or non-malignant diseases is less clear. Hence, this study was conducted to survey the clinical significance of smudge cells in hematological cancers and other disorders. Materials and Methods: From January to November, 2015, the clinical data of patients who received blood examination with differential counts for clinical purpose and were found to have smudge cells in the peripheral blood film in Far Eastern Memorial Hospital were selected. The percentage of smudge cells and patient outcomes were evaluated for further univariate and survival analyses. Results: A total of 102 patients with smudge cells in their blood smears were included. Smudge cells were frequently presented in out-of-hospital cardiac arrest (OHCA; n=30), infections (n=23), hematological cancers (n=23) and solid cancers (n=10). There was no relationship between the percentage of smudge cells and the patient mortality in all diseases (OR: 1.08, 95% CI: 0.47-2.48, P=1.000) as well as the OHCA group (OR: 1.91, 95% CI: 0.38-9.60, P=0.694). It was observed that in patients with all cancers with the percentage of smudge cells less than 50% had a lower mortality rate in comparison with those who had the percentage of smudge cells of 50% or more (OR: 22.29, 95% CI: 2.38-208.80, P<0.001). Additionally, it was seemingly that patients with smudge cells of 50% or more had a lower survival rate than those with smudge cells less than 50% in all cancers with follow-up at 2-month intervals, but without statistical significance (P=0.064). Conclusions: Our survey indicated that in all cancers, those who had higher percentage of smudge cells were prone to have poor outcomes when compared with the subjects with lower percentage of smudge cells. This finding was quite different from the results of previous studies in which the race-ethnicity of most study populations was non-Asian; hence, further investigations are required. Besides, there was no apparent association of the percentage of smudge cells with patient outcomes in all diseases, including OHCA.
A study on pushover analyses of reinforced concrete columns
Sung, Yu-Chi,Liu, Kuang-Yen,Su, Chin-Kuo,Tsai, I-Chau,Chang, Kuo-Chun Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.21 No.1
This paper proposes a realistic approach to pushover analyses of reinforced concrete (RC) structures with single column type and frame type. The characteristic of plastic hinge of a single RC column subjected to fixed axial load was determined first according to column's three distinct failure modes which were often observed in the experiments or earthquakes. By using the determined characteristic of plastic hinge, the pushover analyses of single RC columns were performed and the analytical results were investigated to be significantly consistent with those of cyclic loading tests. Furthermore, a simplified methodology considering the effect of the variation of axial force for each RC column of the frame structure during pushover process is proposed for the first time. It would be helpful in performing pushover analysis for the structures examined in this study with efficiency as well as accuracy.
Tsai Li-Jen,Chung Chi-Hsiang,Lin Chien-Jung,Su Sheng-Chiang,Kuo Feng-Chih,Liu Jhih-Syuan,Chen Kuan-Chan,Ho Li-Ju,Kuo Chih-Chun,Chang Chun-Yung,Lin Ming-Hsun,Chu Nain-Feng,Lee Chien-Hsing,Hsieh Chang-H 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.2
Background: Diabetic patients are at high risk of developing cancer. Traditional Chinese medicine (TCM) has become increasingly popular as an adjuvant treatment for patients with chronic diseases, and some studies have identified its beneficial effect in diabetic patients with cancer. The purpoes of this study was to outline the potential of TCM to attenuate hospitalization and mortality rates in diabetic patients with carcinoma in situ (CIS). Methods: A total of 6,987 diabetic subjects with CIS under TCM therapy were selected from the National Health Insurance Research Database of Taiwan, along with 38,800 of 1:1 sex-, age-, and index year-matched controls without TCM therapy. Cox proportional hazard analysis was conducted to compare hospitalization and mortality rates during an average of 15 years of follow-up. Results: A total of 3,999/1,393 enrolled-subjects (28.62%/9.97%) had hospitalization/mortality, including 1,777/661 in the TCM group (25.43%/9.46%) and 2,222/732 in the control group (31.80%/10.48%). Cox proportional hazard regression analysis showed a lower rate of hospitalization and mortality for subjects in the TCM group (adjusted HR=0.536; 95% CI=0.367–0.780, P<0.001; adjusted HR=0.783; 95% CI=0.574– 0.974, P = 0.022). Kaplan-Meier analysis showed that the cumulative risk of hospitalization and mortality in the case and control groups was significantly different (log rank, P<0.001 and P = 0.011, respectively). Conclusions: Diabetic patients with CIS under TCM therapy were associated with lower hospitalization and mortality rates compared to those without TCM therapy. Thus, TCM application may reduce the burden of national medical resources.
생명주기 지원 시스템에서의 시스템 기술 관리자에 관한 연구
천유식(You Seek Chun),우치수(Chi Su Wu) 한국정보과학회 1988 정보과학회논문지 Vol.15 No.1
새로운 개발 방법론을 제안하고 그 방법론에 의거한 시스템 기술 관리자(SDM)를 논하였다. 구조를 기술한 후 요구사항을 정의하여 ER 모델로 표현하고 정의된 ER 모델 및 요구사항을 LDM/SEM을 통하여 처리하였다. 시스템 기술에 이와같이 형식화된 언어와 모델을 사용하므로써 문법 및 의미 확인 기능을 함께 제공하게 된다. 제안된 SDM은 새로운 개발 방법론과 최신의 모델링 기술을 사용한 모델을 제공하는데, 모델 및 SDM을 통하여 기술된 내용을 분석한 결과 강력한 기술 능력을 보였다. A new development methodology is proposed and a system description manager (SDM) based on the proposed methodology is discussed. The architecture is described first. Requirements are defined and formalized with ER modeling technique, and they are implemented through LDM/SEM. The use of the formal language and model provides both syntactic and semantic checking of system description. The proposed SDM provides the new development methodology and the model with state-of-the-art modeling technique. The analysis of the model and the descriptions through the SDM show that it has a powerful description capability.
( Chen-hua Liu ),( Chi-yi Chen ),( Wei-wen Su ),( Chun-jen Liu ),( Ching-chu Lo ),( Ke-jhang Huang ),( Jyh-jou Chen ),( Kuo-chih Tseng ),( Chi-yang Chang ),( Cheng-yuan Peng ),( Yu-lueng Shih ),( Chia 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.4
Background/Aims: Real-world studies assessing the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) plus ribavirin (RBV) for Child-Pugh B/C hepatitis C virus (HCV)-related cirrhosis are limited. Methods: We included 107 patients with Child-Pugh B/C HCV-related cirrhosis receiving SOF/VEL plus RBV for 12 weeks in Taiwan. The sustained virologic response rates at off-treatment week 12 (SVR<sub>12</sub>) for the evaluable population (EP), modified EP, and per-protocol population (PP) were assessed. The safety profiles were reported. Results: The SVR<sub>12</sub> rates in the EP, modified EP and PP were 89.7% (95% confidence interval [CI], 82.5-94.2%), 94.1% (95% CI, 87.8-97.3%), and 100% (95% CI, 96.2-100%). Number of patients who failed to achieve SVR<sub>12</sub> were attributed to virologic failures. The SVR<sub>12</sub> rates were comparable regardless of patient characteristics. One patient discontinued treatment because of adverse events (AEs). Twenty-four patients had serious AEs and six died, but none were related to SOF/VEL or RBV. Among the 96 patients achieving SVR<sub>12</sub>, 84.4% and 64.6% had improved Child-Pugh and model for endstage liver disease (MELD) scores. Multivariate analysis revealed that a baseline MELD score ≥15 was associated with an improved MELD score of ≥3 (odds ratio, 4.13; 95% CI, 1.16-14.71; P=0.02). Patients with chronic kidney disease (CKD) stage 1 had more significant estimated glomerular filtration rate declines than patients with CKD stage 2 (-0.42 mL/min/1.73 ㎡/month; P=0.01) or stage 3 (-0.56 mL/min/1.73 ㎡/month; P<0.001). Conclusions: SOF/VEL plus RBV for 12 weeks is efficacious and well-tolerated for Child-Pugh B/C HCV-related cirrhosis. (Clin Mol Hepatol 2021;27:575-588)
Kwon, Shin Won,Kim, Chi Heon,Chung, Chun Kee,Park, Tae Hyun,Woo, Su Heon,Lee, Sung-Jae,Yang, Seung Heon The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.6
Objective : In addition to bone bridging inside a cage or graft (intragraft bone bridging, InGBB), extragraft bone bridging (ExGBB) is commonly observed after anterior cervical discectomy and fusion (ACDF) with a stand-alone cage. However, solid bony fusion without the formation of ExGBB might be a desirable condition. We hypothesized that an insufficient contact area for InGBB might be a causative factor for ExGBB. The objective was to determine the minimal area of InGBB by finite element analysis. Methods : A validated 3-dimensional, nonlinear ligamentous cervical segment (C3-7) finite element model was used. This study simulated a single-level ACDF at C5-6 with a cylindroid interbody graft. The variables were the properties of the incorporated interbody graft (cancellous bone [Young's modulus of 100 or 300 MPa] to cortical bone [10000 MPa]) and the contact area between the vertebra and interbody graft (Graft-area, from 10 to $200mm^2$). Interspinous motion between the flexion and extension models of less than 2 mm was considered solid fusion. Results : The minimal Graft-areas for solid fusion were $190mm^2$, $140mm^2$, and $100mm^2$ with graft properties of 100, 300, and 10000 MPa, respectively. The minimal Graft-areas were generally unobtainable with only the formation of InGBB after the use of a commercial stand-alone cage. Conclusion : ExGBB may be formed to compensate for insufficient InGBB. Although various factors may be involved, solid fusion with less formation of ExGBB may be achieved with refinements in biomaterials, such as the use of osteoinductive cage materials; changes in cage design, such as increasing the area of polyetheretherketone or the inside cage area for bone grafts; or surgical techniques, such as the use of plate/screw systems.