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RISS 인기검색어
- 검색키워드
- 저자 : Cheng‑Han Dai (검색결과 7 건)
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Targeting SHCBP1 Inhibits Cell Proliferation in Human Hepatocellular Carcinoma Cells
Tao, Han-Chuan,Wang, Hai-Xiao,Dai, Min,Gu, Cheng-Yu,Wang, Qun,Han, Ze-Guang,Cai, Bing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Src homology 2 domain containing (SHC) is a proto-oncogene which mediates cell proliferation and carcinogenesis in human carcinomas. Here, the SHC SH2-domain binding protein 1 (SHCBP1) was first established to be up-regulated in human hepatocellular carcinoma (HCC) tissues by array-base comparative genome hybridization (aCGH). Meanwhile, we examine and verify it by quantitative real-time PCR and western blot. Our current data show that SHCBP1 was up-regulated in HCC tissues. Overexpression of SHCBP1 could significantly promote HCC cell proliferation, survival and colony formation in HCC cell lines. Furthermore, knockdown of SHCBP1 induced cell cycle delay and suppressed cell proliferation. Furthermore, SHCBP1 could regulate the expression of activate extracellular signal-regulated kinase 1/2 (ERK1/2) and cyclin D1. Together, our findings indicate that SHCBP1 may contribute to human hepatocellular carcinoma by promoting cell proliferation and may serve as a molecular target of cancer therapy.
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Gene expression involved in dark-induced leaf senescence in zoysiagrass (Zoysia japonica)
Xiaoxia Cheng,Xiaomei Dai,Huiming Zeng,Yunxia Li,Wei Tang,Liebao Han 한국식물생명공학회 2009 Plant biotechnology reports Vol.3 No.4
Zoysiagrass (Zoysia japonica) is one of the important turfgrass species. Extending green period of zoysiagrass via delaying leaf senescence will make this species have more potential in the turfgrass industry. In this study, we found that zoysiagrass seedlings treated with GA3 could delay the leaf senescence induced by darkness. To study expression of genes responsive to staying green in zoysiagrass, suppression subtractive hybridization (SSH) was used to identify differentially expressed genes between non-GA3-treated and GA3-treated seedlings subjected to darkness. A total of 307 ESTs were generated, of which 226 ESTs clustered into 54 contigs and 81 were singlets. Differentially expressed genes selected by subtractions were classified into six categories according to their putative functions generated by BLAST analysis. Expression of five selected genes, Met, SAM, V-ATPase, Cry (Cryptochrome gene), and An (diphthine synthase gene) were examined by RT-PCR and Real-time PCR. Both RT-PCR and Real-time PCR results demonstrated that the differential expressions of these genes were attributable to delaying senescence by exogenously applied gibberellic acid. This is the first genome-wide study of senescence in a species of turfgrass. Zoysiagrass (Zoysia japonica) is one of the important turfgrass species. Extending green period of zoysiagrass via delaying leaf senescence will make this species have more potential in the turfgrass industry. In this study, we found that zoysiagrass seedlings treated with GA3 could delay the leaf senescence induced by darkness. To study expression of genes responsive to staying green in zoysiagrass, suppression subtractive hybridization (SSH) was used to identify differentially expressed genes between non-GA3-treated and GA3-treated seedlings subjected to darkness. A total of 307 ESTs were generated, of which 226 ESTs clustered into 54 contigs and 81 were singlets. Differentially expressed genes selected by subtractions were classified into six categories according to their putative functions generated by BLAST analysis. Expression of five selected genes, Met, SAM, V-ATPase, Cry (Cryptochrome gene), and An (diphthine synthase gene) were examined by RT-PCR and Real-time PCR. Both RT-PCR and Real-time PCR results demonstrated that the differential expressions of these genes were attributable to delaying senescence by exogenously applied gibberellic acid. This is the first genome-wide study of senescence in a species of turfgrass.
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Nanoscale Etching of La0.7Sr0.3MnO3 without Etch Lag using Chlorine Based Inductively Coupled Plasma
Nimphy Sarkar,Jaewoo Han,Daryll Joseph Chavez Dalayoan,Satyabrat Behera,Sang-Hyuk Lee,Cheng Chen,Dai-Sik Kim,Changhee Sohn,남궁선 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.4
La0.7Sr0.3MnO3 (LSMO) has been considered as a promising material for future electronic and spintronic device applicationdue to its unique properties such as pure spin polarization, colossal magnetoresistance, and high temperature coefficient ofresistance (TCR). To apply this promising material for practical application, large epitaxial LSMO layers should be etchedinto micro- and nano-scale device structures. However, a comprehensive study on the etch of LSMO has not been demonstratedyet. Herein, the etch rates of LSMO are studied using inductively coupled plasma reactive ion etching (ICP-RIE)method, while controlling critical etching parameters such as ICP source power, radio frequency (rf) chuck power, etchinggas ratio, and chamber pressure. We found that the etching process can be applied to nanoscale structures (down to 100 nm)without etch lag effect, exhibiting smaller etch depth in smaller features. This study will provide a good reference for theetching and the engineering of LSMO toward future electronic and spintronic devices such as highly sensitive bolometersand low-power memory devices.
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Kuan‑Jung Chung,Cheng‑Han Dai,Tung‑Chun Chiang,June‑Jia Xie,Ming-Tzer Lin 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.9
This study adopted AI to identify the normal and abnormal vibration signals generated during robotic grinding. This study classified four fundamental factors affecting grinding into three levels to obtain a widely used result and designed an L9(34)orthogonal array for the grinding experiment. During experimentation, part of the grinding wheels was added weight to produce abnormal vibration signals, which an accelerometer would measure. The study transformed the collected vibration signals into recurrence plots and conducted model training with VGG16 CNN architecture. Finally, this study tested a model with 89.6% training accuracy. The results showed the model could identify whether the recurrence plots stand for normal or abnormal vibrations, with an accuracy of 85%. This means it could predict normal and abnormal grinding conditions and help avoid problems caused by abnormal vibrations.
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The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.
Qi-rui Hu,Yao Pan,Han-cheng Wu,Zhen-zhen Dai,Qing-xin Huang,Ting Luo,Jing Li,Ze-yuan Deng,Fang Chen The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2
Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2.
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