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Chang-Shuo Chang,Kuan-Ta Wu,Chang-Fu Han,Tsung-Wen Tsai,Sung-Ho Liu,Jen-Fin Lin 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.1
The thermally affected material properties operating in the three phases and porosity variations in the SS316L steel powder have been introduced to the numerical analyses for the transient volumetric heat source (Q) models developed for the solid powder, melting, and vaporization regions in the selective laser melting (SLM). The bulk Q is thus a function of these heat sources and their ratio defined for the liquid and vapor phases. The heat conduction developed for the solid powders with porosity strings the heat convection with Q as the moving heat source to solve two-dimensional temperature distributions efficiently without the confinement of operating conditions and phase presumption. The specimens with single- and multiple-track printings are prepared to investigate the effects of incident energy density (E) and power intensity (I o) on the geometries of single-track printings and the areal surface roughness (Sa) values of the multiple-track printings with 0 and 50% overlap ratios. Laser power and scanning velocity are the controlling factors for the melting pool depth D and width W . D and W become the governing factors for the keyhole with evaporations, which affects the height H of single track after solidification. The W and D results predicted by the theoretical models developed in this study have an error range, 5–20%, compared to the experimental ones, which is much lower than those reported in the literatures (Gusarov et al. in J Heat Transf 131(7):072101, 2009. https ://doi.org/10.1115/1.31092 45 ; Hussein et al. in Mater Des 52:638–647, 2013. https ://doi.org/10.1016/j.matde s.2013.05.070 ; Yin et al. Int J Adv Manuf Technol 83(9–12): 1847–1859, 2016. https ://doi.org/10.1007/s0017 0-015-7609-x ; Andreotta et al. in Finite Elem Anal Des 135: 36–43, 2017. https ://doi.org/10.1016/j.finel .2017.07.002 ). The contact angle ( ϕ * ) is defined as a function of single-track width ( W ) and solidification height ( H ). ϕ * and Sa are significantly reduced as an E is applied beyond its critical value (47.62–57.14 J/mm 3 ). Significant change in Sa is ascribed to the big difference in the morphology and its surface pattern when E or I o reaches its critical value.
New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis
Chang-chang Han,Fu-sheng Wan 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To accommodate the occurrence of ERS, cells have evolved a highly conserved, selfprotecting signal transduction pathway called the unfolded protein response. Notably, ERS signaling is involved in the development of a variety of diseases and is closely related to tumor development, particularly in breast cancer. This review discusses recent research regarding associations between ERS and tumor metastasis. The information presented here will help researchers elucidate the precise mechanisms underlying ERS-mediated tumor metastasis and provide new directions for tumor therapies.
Fu-Liang Han,Shou-Mei Jiang,Jian-Jun He,Qiu-Hong Pan,Chang-Qing Duan,Ming-Xia Zhang 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.3
Anthocyanins are considered one of the main color determinants in aged red wine. The anthocyanins in aged red wine made from ‘Cabernet Gernischet’ (Vitis vinifera L. cv.) grape were investigated by high performance liquid chromatography- electronic spray ionization- mass spectrometry (HPLC-ESI-MS) and their color presented in aqueous solution were evaluated using partial least square regression (PLS). The results showed that there were 37 anthocyanins identified in this wine, including 22 pyranoanthocyanins. The analysis of PLS indicated that different anthocyanins showed distinct color values: malvidin 3-O-(6-O-acetyl)-glucoside-4-vinylguaiacol (Mv3-acet-glu-vg) presented the highest color values, while malvidin 3-O-glucoside (Mv3-glu) showed least. Among the free non-acylated anthocyanins, peonidin 3-Oglucoside (Pn3-glu) showed the highest color values; the coumarylated anthocyanins presented higher color values than their corresponding acetylated anthocyanins and parent anthocyanins; pyranoanthocyanins presented also higher color values than their original anthocyanins; the color of anthocyanins depended on their structure. This work will be helpful to reveal evolution in aged red wine.
Fu, Teng,Park, Gi-Chang,Han, Joon Hee,Shin, Jong-Hwan,Park, Hyun-Hoo,Kim, Kyoung Su The Korean Society of Plant Pathology 2019 Plant Pathology Journal Vol.35 No.6
Like many fungal pathogens, the conidium and appressorium play key roles during polycyclic dissemination and infection of Magnaporthe oryzae. Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein. In animalia, RanBPM has been implicated in apoptosis, cell morphology, and transcription. However, the functional roles of RanBPM, encoded by MGG_00753 (named MoRBP9) in M. oryzae, have not been elucidated. Here, the deletion mutant ΔMorbp9 for MoRBP9 was generated via homologous recombination to investigate the functions of this gene. The ΔMorbp9 exhibited normal conidial germination and vegetative growth but dramatically reduced conidiation compared with the wild type, suggesting that MoRBP9 is involved in conidial production. ΔMorbp9 conidia failed to produce appressoria on hydrophobic surfaces, whereas ΔMorbp9 still developed aberrantly shaped appressorium-like structures at hyphal tips on the same surface, suggesting that MoRBP9 is involved in the morphology of appressorium-like structures from hyphal tips and is critical for development of appressorium from germ tubes. Taken together, our results indicated that MoRBP9 played a pleiotropic role in polycyclic dissemination and infection-related morphogenesis of M. oryzae.
Fu-Yan Zhuge,CONG-WANG ZHANG,CHANG-CHUN ZENG,Han-Ping Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.7
Gold nanoparticles (Au NPs) have promising applications in the fields of drug delivery and photothermal therapy. 5-hydroxydecanoate (5-HD) is a kind of highly selective mitochondrial ATP sensitive potassium (mitoKATP) channel blocker. In this research, firstly, 5-HD was studied whether it could induce human lung adenocarcinomas (A549) cells apoptosis; secondly, PEGylated gold nanoparticles loaded with 5-HD (Au NPs-PEG-5-HD) were prepared to develop a new chemotherapy and photothermal therapy in one system under the irradiation of green light-emitting diode (LED). Subsequently, in vitro cytotoxicity test was analyzed by cell counting kit-8 (CCK-8), the change of mitochondrial membrane potential (Δψm) was determined by immunofluorescence microscopy with R-123 fluorescence, and cell apoptosis and necrosis rate were detected by flow cytometry. The results of CCK8 revealed that the inhibition rates of A549 cells were all greatly increased when cells were treated with free 5-HD, free 5-HD +LED irradiation, Au NPs-PEG-5-HD and Au NPs-PEG-5-HD+LED irradiation, and Au NPs-PEG-5-HD had enhanced cell-killing effect compared with 5-HD, furthermore, the Au NPs-PEG-5-HD and LED irradiation played a very great synergy effect. The immunofluorescence microscopy data also exhibited a reduction of Δψm correspondingly. Flow cytometric analysis showed that the apoptosis rate of cells that were incubated with free 5-HD, 5-HD+LED irradiation, Au NPsPEG-5-HD or Au NPs–PEG–5-HD+LED irradiation significantly increased to about 9.2%, 10.7%, 18.3% or 12.4% and the percentage of necrosis cells increased to around 8.8%, 9.7%, 48.0% or 69.8%, respectively. In a word, all the results indicated that the 5-HD had shown the ability to induce A549 cells apoptosis as a chemotherapy agent, and its ability would be improved when 5-HD is loaded on PEGylated Au NPs, as well as Au NPs-PEG-5-HD exhibited significantly enhanced photothermal effects for treatment of lung adenocarcinomas.
Daliang Chang,Haibo Shi,Chao Han,Fu Meng 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.12
This study proposes a method to combine the improved gene expression programming (IGEP) and buffer-local scheduling to solve the optimization problem of flexible job shop production scheduling with buffer capacity limitation (BLFJSP). The IGEP algorithm was first used for the overall optimization and later combined with the flexible job shop production mode to design a multi-gene chromosome coding method to realize the overall optimization of the production schedule using the genetic biological evolution function. Furthermore, when the algorithm fell into a local extremum, the Jaccard similarity coefficient method was used to filter the approximate chromosomes, and the historical excellent chromosome backtracking method was used to increase the diversity of the population. Lastly, we designed the local scheduling rules of the job in and out of the buffer area. Based on the IGEP algorithm and considering the influence of buffer capacity limitation on the scheduling scheme, the final production scheduling scheme was generated by dual optimization methods aiming at minimizing blocking time and minimizing maximum completion time. Based on the actual production data of an assembly manufacturing company, multiple sets of simulation programs were designed to validate the IGEP algorithm for solving the optimization problem of BLFJSP.
( Ching Han Chang ),( Yen Shiang Chen ),( Wen Fu Wu ),( Ying Chen Lu ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
The purpose of this study is to investigate the effect of green tea (Camellia sinensis) powders on fermentation and survival of probiotic yogurt. Green tea powders were added to milk, sterilized, fermented with Lactobacillus reuteri LYC184 and stored at 4°C for 14 days. The quality parameters of green tea powder yogurt (TP) included bacterial number, pH, titratable acidity, color and physicochemical properties were analyzed. Results showed that the adhesiveness and pH value decrease as the storage time increases; the value of titratable acidity, viscosity and hardness are proportional to the storage time. The phenolic compounds in green tea yogurts were analyzed by HPLC. The novel yogurts showed significantly higher probiotic cell viabilities during storage at 4°C. In conclusion, adding the green tea powders to Lactobacillus reuteri LYC184 fermented yogurt is an excellent functional food that has great potential for the beneficial properties of human health.