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Alteration of $CD4^+CD25^+Foxp3^+$ T cell level In Kawasaki disease
Sohn, Su-Ye,Song, Young-Wooh,Yeo, Yun-Ku,Kim, Yun-Kyung,Jang, Gi-Young,Woo, Chan-Wook,Lee, Jung-Hwa,Lee, Kwang-Chul The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.4
Purpose: Exaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD. We investigated the profiles of T regulatory cells and their correlation with the clinical course of KD. Methods: Peripheral blood mononuclear cells were collected from 17 KD patients during acute febrile and subacute afebrile phases. T cells expressing CD4, CD25, and Foxp3 were analyzed using flow cytometry, and the results were correlated with the clinical course of KD. Results: The percentage of circulating $CD4^+CD25^{high}Foxp3^+$ T cells among $CD4^+$ T cells was Significantly higher during the subacute afebrile phase than during the acute febrile phase ($1.10%{\pm}1.22%$ vs. $0.55%{\pm}0.53%$, P=0.049). Although levels of $CD4^+CD25^{low}Foxp3^+$ T cells and $CD4^+CD25^-Foxp3^+$ T cells were only slightly altered, the percentage of $CD4^+CD25^+Foxp3^-$ T cells among $CD4^+$ T cells was significantly lower during the subacute afebrile phase than during the acute febrile phase ($2.96%{\pm}1.95%$ vs. $5.64%{\pm}5.69%$, P=0.036). Consequently, the ratio of $CD25^{high}Foxp3^+$ T cells to $CD25^+Foxp3^-$ T cells was higher during the subacute afebrile phase than during the acute febrile phase ($0.45%{\pm}0.57%$ vs. $0.13%{\pm}0.13%$, P=0.038). Conclusion: Decreased $CD4^+CD25^{high}Foxp3^+$ T cells and/or an imbalanced ratio of $CD4^+CD25^{high}Foxp3^+$ T cells to $CD4^+CD25^+Foxp3^-$ T cells might playa role in KD development. Considering that all KD patients were treated with intravenous immunoglobulin (IVIG), recovery of $CD4^+CD25^{high}Foxp3^+$ T cells during the subacute afebrile phase could be a mechanism of IVIG.
Pharmacophore Identification for Peroxisome Proliferator-Activated Receptor Gamma Agonists
Sohn, Young-Sik,Lee, Yu-No,Park, Chan-In,Hwang, S-Wan,Kim, Song-Mi,Baek, A-Young,Son, Min-Ky,Suh, Jung-Keun,Kim, Hyong-Ha,Lee, Keun-Woo Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.1
Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptors and their activation induces regulation of fatty acid storage and glucose metabolism. Therefore, the $PPAR\gamma$ is a major target for the treatment of type 2 diabetes mellitus. In order to generate pharmacophore model, 1080 known agonists database was constructed and a training set was selected. The Hypo7, selected from 10 hypotheses, contains four features: three hydrogen-bond acceptors (HBA) and one general hydrophobic (HY). This pharmacophore model was validated by using 862 test set compounds with a correlation coefficient of 0.903 between actual and estimated activity. Secondly, CatScramble method was used to verify the model. Hence, the validated Hypo7 was utilized for searching new lead compounds over 238,819 and 54,620 chemical structures in NCI and Maybridge database, respectively. Then the leads were selected by screening based on the pharmacophore model, predictive activity, and Lipinski's rules. Candidates were obtained and subsequently the binding affinities to $PPAR\gamma$ were investigated by the molecular docking simulations. Finally the best two compounds were presented and would be useful to treat type 2 diabetes.
New records of 10 species of Pyraloidea (Lepidoptera: Pyralidae and Crambidae) in South Korea
Sohn, Jae-Cheon,Kim, Sung-Soo,Kwon, Tae Sung,Park, Chan-Woo,Shin, Yujin,Park, Young-Seuk Elsevier Science B.V. Amsterdam 2018 Journal of Asia-Pacific biodiversity(Online) Vol.11 No.4
<P><B>Abstract</B></P> <P>We collected moth samples from high altitude areas on Mount Gariwangsan, South Korea, from 2011 to 2014. We identified 10 species of the superfamily Pyraloidea (2 Pyralidae species and 8 Crambidae species) that were new to South Korea, namely, <I>Hoeneodes vittatellus</I> (Ragonot, 1887), <I>Patagoniodes nipponellus</I> (Ragonot, 1901), <I>Anania fuscalis</I> (Denis et Schiffermüller, 1775), <I>Eudonia truncicolella</I> (Stainton, 1849), <I>Evergestis holophaealis</I> (Hampson, 1913), <I>Hendecasis apiciferalis</I> (Walker, 1866), <I>Nomis albopedalis</I> (Motschulsky, 1861), <I>Piletocera penicillaris</I> (Christoph, 1881), <I>Udea exigualis</I> (Wileman, 1911), and <I>Udea montensis</I> (Mutuura, 1954). The description, distribution, adult photographs, and pictures of female genitalia of all 10 species are provided.</P>
孫鍾錄,崔宇永,金燦祚 충남대학교 농업과학연구소 1983 農業技術硏究報告 Vol.10 No.1
Fundamental study was carried out to elucidate the mechanisms of biological degradation of dyestuff in environments. A few bacterial strains which were capable of degrading amarnath were obtained from soil through an extensive screening program and identified by microbiolological properties. Conditions for bacterial growth and amaranth degradation were characterized and optimized, and the degradation products were identified. The results were as follows. 1. The most active strain A12-1 to be capable of degradation of amaranth was identified as Pseudomonas sp. 2. Optimal conditions for growth of the strain A12-1 were:35℃ and pH 7.5, and growth was markedly increaesd by aeration. 3. Degradation of amaranth by the strain was accessed under similar conditions for growth, however significantly inhibited when the culture was aerated. 4. Both bacterial growth and amaranth degradation were gradually decreased with increased concentration of amaranth in the culture. 5. Reaction of the crude enzyme from the strain A12-1 was optimal at 35℃ and pH 7.5 for degrading amaranth. 6. Sodium naphthionate and R-amino salt were found to be the products of amaranth degradation by the strain A12-1.
Sohn, Kook Ho,Jo, Mi Jeong,Cho, Won Joon,Lee, Jong Rok,Cho, Il Je,Kim, Sang Chan,Kim, Young Woo,Jee, Seon Young Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-
<P><I>Bojesodok-eum</I> (BSE) is a herbal prescription consisting of <I>Coptidis Rhizoma</I> and <I>Scutellariae Radix</I> as main components. This paper investigated the effects of BSE on the induction of nitric oxide (NO), prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>), and proinflammatory cytokines that are caused by lipopolysaccharide (LPS) in murine macrophage cell line and on the paw edema formation in animals. Administration of BSE (0.3 g/kg and 1 g/kg) in rats significantly inhibited carrageenan-induced paw edema formation, as did dexamethasone, an anti-inflammatory positive control drug. In cell model, treatment of BSE decreased the production of NO and PGE<SUB>2</SUB> in RAW264.7 cells stimulated by LPS. BSE also inhibited the expression of iNOS and COX-2 protein as well as COX activity in a concentration-dependent manner. Consistently, BSE suppressed the ability of LPS to produce TNF-<I>α</I>, interleukin-1<I>β</I>, and interleukin-6. LPS treatment induced nuclear NF-<I>κ</I>B level and I-<I>κ</I>B<I>α</I> phosphorylation, which were inhibited subsequent treatment of BSE, suggesting its repression of LPS-inducible NF-<I>κ</I>B activation. BSE abrogated the induction of NO, PGE<SUB>2</SUB>, and proinflammatory cytokines, as well as iNOS and COX-2 protein expression in RAW264.7 cells stimulated by LPS as mediated with NF-<I>κ</I>B inhibition.</P>
Effect of Phenylalanine on Differentiation of Myoblast C1C12 and L6 Cells Into Myocytes
Hyun Woo Jeong,Jong Hyun Kim,Chan-Su Rha,Sohn Jonghee,Wangi Kim,Jonghwa Roh 건강기능식품미래포럼 2023 건강기능식품미래포럼 학술지 Vol.3 No.4
In the present study, we aimed to find any essential amino acids (EAAs) that can promote muscle protein synthesis. For this purpose, we examined how the removal of each EAA from the differentiation-inducing medium (Diff.) that is the Dulbecco’s Modified Eagle’s Medium with 2% horse serum affects the differentiation of C2C12 (mouse myoblasts) or L6 (rat myoblasts) cells into mature myocytes. This method was chosen because muscle protein synthesis is significantly enhanced during the differentiation process. This rationale was confirmed by the observation that C2C12 cells showed increased expressions of myosin heavy chain when induced to differentiate by culturing them in the Diff.. When we induced the C2C12 or L6 cells in the Diff. with each EAA depletion, we found that their differentiation rate and the expression of myogenic marker proteins (MyoD and MyoG) was blunted. This decreases were most noticeable when cultured in the Diff. with phenylalanine removed (Diff.-Phe). This effect was comparable to that of leucine. Further, the phenylalanine-removing effect could be recovered by supplementing this EAA back to the Diff.-Phe but not by adding tyrosine, indicating that the effect on differentiation is due to phenylalanine itself. These findings suggest that phenylalanine plays a role in the differentiation of myoblasts, particularly when muscle protein synthesis is enhanced, implying that phenylalanine could contribute to the promotion of muscle protein synthesis. Based on these findings, it is expected that phenylalanine, like leucine, could provide benefits in preventing the loss of muscle mass.