Regulation of drug transporters by microRNA and implications in disease treatment

Chae Yoon-Jee,Chang Ji-Eun,Lee Mi-Kyung,Lim Juhee,Shin Kwang-Hee,Lee Kyeong-Ryoon 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.1

Background Transporters play crucial roles in the pharmacokinetics of drugs, consequently influencing efficacy and toxicity by unexpectedly altering drug concentrations. Epigenetic regulation by microRNAs (miRNAs) is a critical determinant of transporter function. Several miRNAs have been reported to regulate transporter expression via direct or indirect pathways, resulting in altered pharmacokinetics and drug responses. Area covered In this review, we provide an overview of the regulatory mechanisms of transporters, particularly with regard to clinically important transporters, via miRNAs and also summarize the associations between miRNAs and transporter expression. We also present clinical implications for miRNA-dependent alterations in transporter expression to highlight the importance of miRNAs in pharmacokinetics and drug responses. Expert opinion Available information on the implications of miRNAs in drug transporter have been mainly reported in cancers for ATP binding cassette (ABC) transporters. Although solute carrier (SLC) transporters are essential for drug pharmacokinetics, information on the regulatory mechanisms of SLC transporters by miRNAs is still limited compared with ABC transporters. Additional information on the pharmacokinetic implications of the interplay between miRNAs and transporters is necessary for improving drug therapies; thus, investigations of the miRNA-dependent regulatory mechanisms of transporters and their implications need to be expanded to provide insights into safe and effective drug regimens.

Bow-tie genioplasty: a novel technique for sagittal reduction of chin using segmental rotation setback movement

Sang-Yoon Lee(Sang-Yoon Lee),Hye-Min Oh(Hye-Min Oh),Hyun-Jee Chae(Hyun-Jee Chae) 대한미용의학회 2022 대한미용의학회지 Vol.6 No.2

Since genioplasty was first described by Hofer in 1942, various genioplasty techniques have been developed and modified. However, the literature on sagittal reduction genioplasty is scarce. Most of these are modifications of the traditional two methods—grinding and sliding setback, with potential complications. The purpose of this article is to introduce a novel technique (bow-tie genioplasty) to achieve favorable sagittal reduction of the chin without potential complications from the traditional methods. Bow-tie genioplasty is a technique that uses bilateral wedge-shaped osteotomy on the chin. This osteotomy was designed to rotate the distal segment posteriorly, as shown in the diagrams. We present an example of a patient with a protruding chin treated with bow-tie genioplasty. There were no significant adverse effects or complications that could be triggered by the traditional setback methods, and the surgeon and patients were satisfied with the esthetic results. Bow-tie genioplasty is the most innovative technique for sagittal reduction of the chin. This novel technique may optimize the chin setback effect while minimizing the complications associated with the traditional method.

A case of solitary Langerhans cell histiocytosis

( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Langerhans cell histiocytosis is caused by infiltration of the skin, and in some cases, other organs, by Langerhans cells. The spectrum of disease is broad. It can be presented with a solitary lesion and also presented with visceral and skin involvement. In childhood LCH, boys are slightly more often affected than girls. About 10% of children have single-organ disease involving only the skin, and 50% of children with multisystem LCH have skin involvement. A 17-year-old girl presented with solitary brownish nodule on the abdomen. It was occurred 3~4 months ago. Itching sense was mild and size change was not prominent. Histopathologic findings showed dermal infiltrate of Langerhans cells. On the immunohistochemistry, S-100 and CD1a was positive. There was no other skin lesion and no other organ involvement. Based on these findings, a diagnosis of solitary Langerhans cells histiocytosis was made. Herein, we report a rare case of solitary Langerhans cell histiocytosis in the Korean literatures.

Autophagy Activation by <i>Crepidiastrum Denticulatum</i> Extract Attenuates Environmental Pollutant-Induced Damage in Dermal Fibroblasts

Yoon, Seok Jeong,Lim, Chae Jin,Chung, Hwa-Jee,Kim, Joo-Hwan,Huh, Yang Hoon,Park, Keedon,Jeong, Sekyoo MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.3

<P>Pollution-induced skin damage results in oxidative stress; cellular toxicity; inflammation; and, ultimately, premature skin aging. Previous studies suggest that the activation of autophagy can protect oxidation-induced cellular damage and aging-like changes in skin. In order to develop new anti-pollution ingredients, this study screened various kinds of natural extracts to measure their autophagy activation efficacy in cultured dermal fibroblast. The stimulation of autophagy flux by the selected extracts was further confirmed both by the expression of proteins associated with the autophagy signals and by electron microscope. <I>Crepidiastrum denticulatum</I> (CD) extract treated cells showed the highest autophagic vacuole formation in the non-cytotoxic range. The phosphorylation of adenosine monophosphate kinase (AMPK), but not the inhibition of mammalian target of rapamycin (mTOR), was observed by CD-extract treatment. Its anti-pollution effects were further evaluated with model compounds, benzo[a]pyrene (BaP) and cadmium chloride (CdCl<SUB>2</SUB>), and a CD extract treatment resulted in both the protection of cytotoxicity and a reduction of proinflammatory cytokines. These results suggest that the autophagy activators can be a new protection regimen for anti-pollution. Therefore, CD extract can be used for anti-inflammatory and anti-pollution cosmetic ingredients.</P>

A case of subcutaneous granuloma annulare on the thigh in an elderly.

( Jee Yon Shin ),( Myeong Heon Chae ),( Su Hyun Park ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Granuloma annulare (GA) is a benign granulomatous disease of unknown etiology. Subcutaneous GA is a type of GA presented as asymptomatic firm and hard subcutaneous nodules. The predominant site of subcutaneous GA is the anterior lower leg, and it also appears on the ankles, dorsal feet, buttocks, and hands. Generally, subcutaneous GA is occurred in children. A 73-year-old woman presented with a brownish nodule on the right thigh for 2 years. Histopathologic findings showed histiocytic palisades surrounding mucin and degenerated collagen in the subcutaneous tissue. Based on these findings, a diagnosis of subcutaneous GA was made. Herein, we report a rare case of subcutaneous type GA on the thigh which was occurred in the old age.

운동형태의 차이가 Alloxan유발 당뇨쥐의 혈당 및 인슐린 농도에 미치는 영향

윤진환,정일규,김종오,이희혁,지용석,오봉석,채정룡 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1

The Purpose of this study was to investigate the effect of exercise intensity on blood glucose and insulin levels in diabetic rats with alloxan. Twenty sprague-dawley male rats were assigned to power training groups(n=10) and endurance training groups(n=10). Diabetes was induced by single injection of alloxan(50 mg/kg B.W) Blood glucose and insulin were determined every week for 4-weeks. The conclusion of this study follows as below: 1) There was significantly different on blood glucose levels in two groups. 2) There was significantly different on insulin levels in two groups These results suggest that proper exercise intensity in diabetic rats can significantly decrease blood glucose and insulin level and make good glycemic control. In conclusion, it has been found that regular prolonged endurance training with diabetic rats, improves insulin and blood glucose.

A case of lichen amyloidosis in an adult

( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Lichen amyloidosis is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins. Histopathologically, amyloid deposition in the papillary dermis is the characteristic finding. It appears to be more common in males and most often occurs in people 50-60 years of age. A 49-year-old woman presented with brownish papuloplaques on the both lower legs. Itching sense was severe and the lesion was occurred 2 years ago. Histopatholgic findings showed amyloid deposit in the papillary dermis. D-PAS staining was negative. Based on these findings, a diagnosis of lichen amyloidosis was made. We think this case has typical chracteristics of lichen amyloidosis. Therefore we report a case of lichen amyloidosis for educational purposes.

A Case of Sterile Abscess Induced by Hyaluronic Acid Filler Injection

( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ),( Mi Kyeong Kim ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.Suppl

Two cases of lichen striatus in adults

( Jee Yon Shin ),( Myeong Heon Chae ),( Su Hyun Park ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Lichen striatus is a fairly uncommon dermatosis manifests as linear and papular eruptiondistributed along with Blaschko’s line. As a rule, it occurs in children from 5 to 15 years of age. We present two cases of lichen striatus occurred in adults. The first case is a 37-year-old man who presented with brownish linear papules on the trunk and left lower leg occurred about 4 months ago. The second case is a 29-year-old woman who presented with a linear brownish papules on the right lower leg occurred about 1 year ago. Histopathologic findings showed lichenoid, lymphocytic infiltrate in the papillary dermis with vacuolar degeneration of the basal layer, and periadnexal inflammatory infiltrate in the reticular dermis in the both cases. Based on these findings both of them were diagnosed with lichen striatus. Herein, we report two cases of lichen striatus occurred in adults which is rarely reported in the Korean literature.

A case of lupus erythematous panniculitis

( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Lupus panniculitis of the scalp is a rare presentation of lupus erythematous panniculitis. Lupus panniculitis of the scalp has the distinctive clinical feature of distribution along the lines of Blaschko, giving rise to linear, arched or annular alopecia. A 24-year-old man presented with linear alopecic patches on the scalp. It was occurred 7 years ago. He had received triamcinolone acetate intralesional injection 2 times when the lesion was occurred. But he stopped the treatment meanwhile. Histopathologic findings showed lymphoplasmacytic infiltration of the perifollicular dermis and subcutaneous lobules with abundant mucin deposition. Laboratory findings including CBC, chemistry, liver function test, urinalysis, ANA titer, C3, and C4 were normal and negative. Based on these findings, a diagnosis of lupus erythematous panniculitis was made. Herein, we report a rare case of lupus erythematous panniculitis on the scalp.