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- 저자 : Can Cao (검색결과 7 건)
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Myosin18B predicts favorable prognosis of cutaneous squamous-cell carcinoma
Can Cao,Chao Zhang,Ying Sun,Zhen Mu,Qin Shen 한국유전학회 2021 Genes & Genomics Vol.43 No.4
Background Myosin18 family, including Myosin18A (MYO18A) and Myosin18B (MYO18B), are newly-identifed Myosins in Myosin superfamily. The expression and function of Myosin18 family in cancer progression is still controversial, and in cutaneous squamous-cell carcinoma (cSCC) is totally unknown. Objective To investigate the expression and prognostic signifcance of Myosin18 family in cSCC. Methods In this study, the expressions of MYO18 family, including MYO18A and MYO18B were detected in six pairs of cSCCs and corresponding normal tissues with qRT-PCR. MYO18A and MYO18B expressions and intracellular locations in 80 cSCCs were detected with immunohistochemistry. The clinical signifcance was evaluated by analyzing the correlation between MYO18 family and clinicopathological factors. The prognostic signifcance of MYO18 family was estimated by univariate analysis with log-rank test, and by multivariate analysis by Cox-regression model. Results The percentages of high MYO18A and MYO18B in cSCC were 43.75% and 36.25%, respectively. High expression of MYO18A (P=0.035) and MYO18B (P=0.032) were both associated with less tumor size. MYO18A had no signifcant infuence on sSCC prognosis (P=0.686), but low expression of MYO18B was proved to be signifcantly associated with poor outcome of cSCC (P=0.014). MYO18B was confrmed as an independent prognostic biomarker of cSCC (P=0.002), indicating the favorable outcome. Conclusion The expression of MYO18B was an independent prognostic biomarker of cSCC, predicting the favorable prognosis independently. Investigating the expression of MYO18B can help stratify the subset of high-risk cSCC patients for more potent treatment and post-operational surveillance.
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Cao, Fang,Hu, Yong-Wei,Li, Ping,Liu, Ying,Wang, Kuo,Ma, Lei,Li, Peng-Fei,Ni, Can-Rong,Ding, Hou-Zhong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
The incidence of gastric cancer worldwide, and in particular in developing countries, has shown a marked increase. Poor prognosis of gastric cancer patients occurs due to the rapid metastasis of the disease via the lymphatic and blood vessels. The aim of this study was to investigate the expression and the clinical significance of D2-40 and CD34 in human gastric cancer. D2-40 and CD34 expression wasdetected in 1,072 cases of Chinese patients with gastric carcinoma using immunohistochemistry. The lymphatic vessel density (LVD) and microvessel density (MVD) were calculated and analyzed and the correlation with the clinicopathological factors and prognosis was determined. The LVD and MVD of the gastric cancer cases were significantly higher compared to those of normal tissues (P < 0.05). The expression of D2-40-LVD and CD34-MVD in the malignancies were positively related to the age, tumor size, invasion depth, lymphatic metastasis and pathological tumor-node-metastasis (pTNM) (P < 0.05); However, no statistically significant difference was identified between them with the patient gender (P > 0.05). Up-regulation of D2-40 and CD34 expression was significantly correlated with the poor survival rate in univariate and multivariate analyses. The LVD marked by D2-40 and the MVD marked by CD34 were positively correlated to the clinicopathological factors of the malignancies and may play important role in the development and progression of gastric cancer.
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( Lanqin Cao ),( Qian Wan ),( Fengjie Li ),( Can-e Tang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.9
Chemoresistance is a major barrier to successful cisplatinbased chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC. [BMB Reports 2018; 51(9): 456-461]
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Design of a Cost Effective Soil Monitoring System to Support Agricultural Activities for Smallholder
Tien Cao-Hoang,Trong Tinh Pham Van,Can Nguyen Duy 한국디지털융합학회 2017 IJICTDC Vol.2 No.2
The moisture, temperature and electrical conductivity of soil are the important properties for agriculture. It is necessary to monitor such data in order to support the agricultural activities, especially improve the yield and reduce the irrigation water. However, the currently commercialized monitoring systems are too expensive for the smallholder who has less than two hectares of farmland. The objective of this study is to develop a cost effective system for monitoring the soil data, which consists of a monitoring device and a web-based application. The monitoring device measures the soil information every one hour and then transmits such data to the cloud for storing and visualizing. The system has been testing in the experiment field to evaluate the system’s stability.
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Analysis and Development of the CFRP Boring Bar for Stability Improvement
Licheng Lu,Can Ni,Gang Liu,Bo Qian,Qinglong An,Zhenzhen Cao,Liqiang Zhang,Junli Li 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12
Boring bars with a large length-to-diameter ratio have become increasingly indispensable for deep hole machining. However, the dynamic performance of conventional boring bars may be inadequate, resulting in vibrations. In this paper, a novel boring bar with composites and a constrained layer damping structure was fabricated to suppress vibrations during the boring operation. Initially, the configuration of the CFRP boring bar was proposed based on theoretical analysis, and then the modal parameters were calculated using the bending strain energy method and cantilever beam theory. Subsequently, the geometric design parameters were optimized analytically using the finite element method. Modal and cutting tests were then conducted to evaluate the cutting stability of a CFRP boring bar with a length-to-diameter ratio of 8.4. The modal parameters, vibration signals, and cutting force signals were measured and compared with a carbide boring bar. The experimental results indicated that there was a significant improvement in the cutting stability of the CFRP boring bar.
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The implications of signaling lipids in cancer metastasis
Xiangjian Luo,Xu Zhao,Can Cheng,Namei Li,Ying Liu,Ya Cao 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Metastasis is the most malignant stage of cancer. Lipid metabolic abnormalities are now increasingly recognized as characteristics of cancer cells. The accumulation of certain lipid species, such as signaling lipids, due to the avidity of lipid metabolism may be a causal factor of tumor malignant progression and metastatic behavior. In this review, we first describe signaling lipids implicated in cancer migration, invasion and metastasis. Next, we summarize the regulatory signaling hubs of lipid anabolic and catabolic metabolism. We then address lipid-rich circulating tumor cells (CTCs) and the lipid composition of exosomes budded off from tumor cells. We also present advances in targeting the regulatory hubs of lipid metabolism and signaling lipids in cancer therapy. Given the complexity of metabolic disorders in cancer, the development of significant portfolios of approaches to target signaling lipids by the integration of multiple chemical modulations, as well as molecular imaging modalities, should offer promising strategies for cancer therapy.
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