Prioritization of Realignment Associated With Superior Clinical Outcomes for Cervical Deformity Patients

Katherine E. Pierce,Peter G. Passias,Avery E. Brown,Cole A. Bortz,Haddy Alas,Lara Passfall,Oscar Krol,Nicholas Kummer,Renaud Lafage,Dean Chou,Douglas C. Burton,Breton Line,Eric Klineberg,Robert Hart,J 대한척추신경외과학회 2021 Neurospine Vol.18 No.3

Objective: To prioritize the cervical parameter targets for alignment. Methods: Included: cervical deformity (CD) patients (C2–7 Cobb angle>10°, cervical lordosis>10°, cervical sagittal vertical axis [cSVA]>4 cm, or chin-brow vertical angle>25°) with full baseline (BL) and 1-year (1Y) radiographic parameters and Neck Disability Index (NDI) scores; patients with cervical [C] or cervicothoracic [CT] Primary Driver Ames type. Patients with BL Ames classified as low CD for both parameters of cSVA (<4 cm) and T1 slope minus cervical lordosis (TS–CL) (<15°) were excluded. Patients assessed: meeting minimum clinically important differences (MCID) for NDI (<-15 ΔNDI). Ratios of correction were found for regional parameters categorized by primary Ames driver (C or CT). Decision tree analysis assessed cutoffs for differences associated with meeting NDI MCID at 1Y. Results: Seventy-seven CD patients (mean age, 62.1 years; 64% female; body mass index, 28.8 kg/m2). Forty-one point six percent of patients met MCID for NDI. A backwards linear regression model including radiographic differences as predictors from BL to 1Y for meeting MCID for NDI demonstrated an R2 of 0.820 (p=0.032) included TS–CL, cSVA, McGregor’s slope (MGS), C2 sacral slope, C2–T3 angle, C2–T3 SVA, cervical lordosis. By primary Ames driver, 67.5% of patients were C, and 32.5% CT. Ratios of change in predictors for MCID NDI patients for C and CT were not significant between the 2 groups (p> 0.050). Decision tree analysis determined cutoffs for radiographic change, prioritizing in the following order: ≥42.5° C2–T3 angle, >35.4° cervical lordosis, <-31.76° C2 slope, <-11.57-mm cSVA, <-2.16° MGS, >-30.8-mm C2–T3 SVA, and ≤-33.6° TS–CL. Conclusion: Certain ratios of correction of cervical parameters contribute to improving neck disability. Prioritizing these radiographic alignment parameters may help optimize patient-reported outcomes for patients undergoing CD surgery.

Conformation-specific spectroscopy of capped glutamine-containing peptides: role of a single glutamine residue on peptide backbone preferences

Walsh, Patrick S.,Dean, Jacob C.,McBurney, Carl,Kang, Hyuk,Gellman, Samuel H.,Zwier, Timothy S. The Royal Society of Chemistry 2016 Physical chemistry chemical physics Vol.18 No.16

<P>The conformational preferences of a series of short, aromatic-capped, glutamine-containing peptides have been studied under jet-cooled conditions in the gas phase. This work seeks a bottom-up understanding of the role played by glutamine residues in directing peptide structures that lead to neurodegenerative diseases. Resonant ion-dip infrared (RIDIR) spectroscopy is used to record single-conformation infrared spectra in the NH stretch, amide I and amide II regions. Comparison of the experimental spectra with the predictions of calculations carried out at the DFT M05-2X/6-31+G(d) level of theory lead to firm assignments for the H-bonding architectures of a total of eight conformers of four molecules, including three in Z-Gln-OH, one in Z-Gln-NHMe, three in Ac-Gln-NHBn, and one in Ac-Ala-Gln-NHBn. The Gln side chain engages actively in forming H-bonds with nearest-neighbor amide groups, forming C8 H-bonds to the C-terminal side, C9 H-bonds to the N-terminal side, and an amide-stacked geometry, all with an extended (C5) peptide backbone about the Gln residue. The Gln side chain also stabilizes an inverse gamma-turn in the peptide backbone by forming a pair of H-bonds that bridge the gamma-turn and stabilize it. Finally, the entire conformer population of Ac-Ala-Gln-NHBn is funneled into a single structure that incorporates the peptide backbone in a type I beta-turn, stabilized by the Gln side chain forming a C7 H-bond to the central amide group in the beta-turn not otherwise involved in a hydrogen bond. This beta-turn backbone structure is nearly identical to that observed in a series of X-(AQ)-Y beta-turns in the protein data bank, demonstrating that the gas-phase structure is robust to perturbations imposed by the crystalline protein environment.</P>

Creep failure simulations of 316H at 550^oC: Part II - Effects of specimen geometry and loading mode

Kim, N.H.,Oh, C.S.,Kim, Y.J.,Davies, C.M.,Nikbin, K.,Dean, D.W. Pergamon Press ; Elsevier Science Ltd 2013 Engineering fracture mechanics Vol.105 No.-

<P>In this paper, the FE damage analysis method, proposed in Part I, is applied to simulate creep crack growth in six different types of cracked specimens of 316H at 550 degrees C. Comparison with experimental results shows that simulated creep crack growth rates agree well with experimental data. Shortcomings of the present method to predict creep crack initiation is briefly discussed. (C) 2013 Elsevier Ltd. All rights reserved.</P>

Validation of Run-time Doppler Broadening in MONK with JEFF3.1

C. Dean,R. Perry,R. Neal,A. Kyrieleis 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

A fast and adequate method of run-time Doppler broadening has been developed within the MONK Monte Carlo code to give cross sections at the temperature defined by the user. The method utilises Gauss Quadrature to broaden continuous energy cross-sections and is applied to data generated by NJOY at a base temperature. It was not believed to dramatically increase the run time of the Monte Carlo code. It is less accurate than methods in NJOY so error builds up as temperature increases. To prevent this error becoming significant, data at several temperatures are pre-generated via NJOY. This allows new raised base temperatures to be used, minimising any broadening error. This method functions within the resolved resonance range, with interpolation methods being applied in the unresolved range. For bound nuclides methods of temperature interpolation have been developed in the thermal region. A JEFF3.1 based nuclear data library has been created with the features necessary to apply these methods. This "BINGO" library was generated with a module called the BINGO Pre-processor, whilst application within the MONK code required development of the "BINGO Collision Processor". The method, pre- and collision processors and library have been validated by applying them to the KRITZ benchmark.

Boron nitride substrates for high-quality graphene electronics

Dean, C. R.,Young, A. F.,Meric, I.,Lee, C.,Wang, L.,Sorgenfrei, S.,Watanabe, K.,Taniguchi, T.,Kim, P.,Shepard, K. L.,Hone, J. Springer Science and Business Media LLC 2010 Nature nanotechnology Vol.5 No.10

자동차 트랜스미션 스타터-제너레이터의 수학적 모델 개발

장봉춘(BongChoon Jang),Dean C. Karnopp(Dean C. Karnopp) 한국자동차공학회 2006 한국 자동차공학회논문집 Vol.14 No.1

The proposed mathematical model of the starter-generator system incorporates the motor speed, battery voltage and the desired current to estimate the moment generation capabilities of the starter-generator and the actual current of the battery system. The fundamentals for this mathematical modeling are the simulated results of the experimental data. These pertinent data are used in establishing the governing equations for the determination of motor moments, actual battery currents and efficiencies of the system's operation at different loading characteristics and speed regions. The derived equations will be used into simulation programs to predict the fuel efficiency, vehicle characteristics of a hybrid electric vehicle equipped with a transmission starter-generator which will be developed.

Characterization of Large Structural Genetic Mosaicism in Human Autosomes

Machiela, Mitchell J.,Zhou, W.,Sampson, Joshua N.,Dean, Michael C.,Jacobs, Kevin B.,Black, A.,Brinton, Louise A.,Chang, I.S.,Chen, C.,Chen, C.,Chen, K.,Cook, Linda S.,Crous Bou, M.,De Vivo, I.,Doherty University of Chicago Press [etc.] 2015 American journal of human genetics Vol.96 No.3

Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 x 10<SUP>-31</SUP>) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.

Immune correlates of protection for dengue: State of the art and research agenda

Katzelnick, Leah C.,Harris, Eva,Baric, Ralph,Coller, Beth-Ann,Coloma, Josefina,Crowe Jr., James E.,Cummings Jr., Derek A.T.,Dean Jr., Hansi,de Silva Jr., Aravinda,Diamond Jr., Michael S.,Durbin Jr., A Elsevier 2017 Vaccine Vol.35 No.36

<P><B>Abstract</B></P> <P>Dengue viruses (DENV1-4) are mosquito-borne flaviviruses estimated to cause up to ∼400 million infections and ∼100 million dengue cases each year. Factors that contribute to protection from and risk of dengue and severe dengue disease have been studied extensively but are still not fully understood. Results from Phase 3 vaccine efficacy trials have recently become available for one vaccine candidate, now licensed for use in several countries, and more Phase 2 and 3 studies of additional vaccine candidates are ongoing, making these issues all the more urgent and timely. At the “<I>Summit on Dengue Immune Correlates of Protection</I>”, held in Annecy, France, on March 8–9, 2016, dengue experts from diverse fields came together to discuss the current understanding of the immune response to and protection from DENV infection and disease, identify key unanswered questions, discuss data on immune correlates and plans for comparison of results across assays/consortia, and propose a research agenda for investigation of dengue immune correlates, all in the context of both natural infection studies and vaccine trials.</P>

Managing Deep Postanal Space Sepsis via an Intersphincteric Approach: Our Early Experience

Ker-Kan Tan,Dean C. Koh,Charles B. Tsang 대한대장항문학회 2013 Annals of Coloproctolgy Vol.29 No.2

Purpose: Managing deep postanal (DPA) sepsis often involves multiple procedures over a long time. An intersphincteric approach allows adequate drainage to be performed while tackling the primary pathology at the same sitting. The aim of our study was to evaluate this novel technique in managing DPA sepsis. Methods: A retrospective review of all patients who underwent this intersphincteric technique in managing DPA sepsis from February 2008 to October 2010 was performed. All surgeries were performed by the same surgeon. Results: Seventeen patients with a median age of 43 years (range, 32 to 71 years) and comprised of 94.1% (n = 16) males formed the study group. In all patients, an internal opening in the posterior midline with a tract leading to the deep postanal space was identified. This intersphincteric approach operation was adopted as the primary procedure in 12 patients (70.6%) and was successful in 11 (91.7%). In the only failure, the sepsis recurred, and a successful advancement flap procedure was eventually performed. Five other patients (29.4%) underwent this same procedure as a secondary procedure after an initial drainage operation. Only one was successful. In the remaining four patients, one had a recurrent abscess that required drainage while the other three patients had a tract between the internal opening and the intersphincteric incision. They subsequently underwent a drainage procedure with seton insertion and advancement flap procedures. Conclusion: Managing DPA space sepsis via an intersphincteric approach is successful in 70.6% of patients. This single-staged technique allows for effective drainage of the sepsis and removal of the primary pathology in the intersphincteric space.

CIVIL AERO GAS TURBINES

Professor Riti Singh,Dean C Roberts 한국항공우주학회 2000 한국항공우주학회 단행본 Vol.- No.-