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Anti-Human Immunodeficiency Virus-Type 1 Activity of Constituents from Juglans mandshurica
ByungSunMin,HyeongKyuLee,이상명,YoungHoKim,KiHwanBae,ToruOtake,NorioNakamura,MasaoHattori 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.4
Three naphthalene glycosides (1-3), four flavonoids (4-7), and two galloyl glycosides (8-9) were isolated from the stem-bark of Juglans mandshurica (Juglandaceae). Their structures were determined by chemical and spectral means, including to 2D-NMR (COSY, HMQC, and HMBC) experiments. Amongst the isolated compounds, taxifolin (4) showed the most potent HIV-induced cytopethic activity against MT-4 cells with complete inhibitory concentration (IC100) value of 25 mg/ml and maximum cytotoxic concentration (CC100) value of above 100 mg/ml. However, naphthalene glycosides (1-3), flavonoids (5-7)), and galloyl tannins (8-9) were inactive against anti-HIV-1 activity.
Byung-Sun Min,Ok-Kyoung Kwon,Bo-Young Park,Young-Ho Kim,Masao Hattori,Hyouk Joung,Hyeong-Kyu Lee 한국생약학회 2004 Natural Product Sciences Vol.10 No.1
Two galloyl monosaccharides, 1,2,6-trigalloylglucose (1, TRgG) and 1,2,3,6-tetragalloylglucose (2,TEgG), were isolated from the stem-bark of Juglans mandshurica. Two galloylglucoses showed cytotoxic effects on human promyelocytic leukemia HL-60 cells. In order to elucidate their mechanism of action, we have investigated the flow cytometric analysis after Annexin V-FITC and PI staining, caspase-3 activity, and internucleosomal DNA fragmentation in HL-60 cells. HL-60 cells treated with both compounds 1 and 2 at 150 and 100 μM, respectively, led to a morphological features of apoptosis, such as plasma membrane blebbing and cell shrinkage. TRgG (1) and TEgG (2) increased the percentage of FITC+ and FITC+PI+ cells in flow cytometry after Annexin V-FITC and PI staining. The increase of apoptotic cells was preceded by the activation of caspase-3 reported to play a central role in apoptotic process and inducing internucleosomal DNA fragmentation. TEgG (2) showed to have stronger apoptosis inducing activity in HL-60 cell lines as compared with TRgG (1).
Inhibitory Activities of Korean Plants on HIV-1 Protease
Byung Sun Min,Ki Hwan Bae,Young Ho Kim,Kunitada Shimotono,Hirotsugu Miyashiro,Masao Hattori 한국생약학회 1998 Natural Product Sciences Vol.4 No.4
For the development of anti-AIDS agents, thirty-seven methanol extracts of Korean plant materials were tested for their inhibitory effects on human immunodeficiency virus type-1 (HIV-1) protease. Extracts of seven plants showed more than 30% inhibitory activities on HIV-1 protease at a concentration of 100 ㎍/㎖. The bark of Berekemia berchemiaefolia, the leaf of Lindera erythrocarpa and the whole plant of Siegesbsekia pubescens exhibited significant inhibititory activities on HIV-1 protease with 56.2, 50.8, and 46.6%, respectively.
Byung Sun Min,Jeong Ah Kim 한국생약학회 2023 Natural Product Sciences Vol.29 No.4
Diabetes, characterized by elevated blood glucose levels, has a significant impact on cardiovascular, neural, and vascular systems. α-Glucosidase inhibitors have emerged as potential therapeutic agents for type 2 diabetes, as they slow carbohydrate digestion and reduce postprandial blood sugar levels. In this study, we investigated the phytochemical and pharmacological properties of Celastrus orbiculatus Thunb., renowned for its diverse phytochemical constituents and potential medicinal applications. Through the application of chromato- graphic and spectroscopic techniques, we successfully isolated and structurally elucidated 16 compounds from the stems of C. orbiculatus. The in vitro α-glucosidase inhibitory activity of these compounds was evaluated. Notably, celaphanol A (1) and (+) lariciresinol (7) exhibited strong α-glucosidase inhibition, with IC50 values of 8.06 ± 0.30 and 48.02 ± 0.47 µM, respectively. Enzyme kinetics analysis revealed that the most active compound 1 acted as a non-competitive inhibitor against α-glucosidase, with a Ki value of 7.77 ± 0.16 µM. These findings underscore C. orbiculatus as a valuable source for discovering and developing new α-glucosidase inhibitors. Furthermore, compound 1 shows promise as a candidate for natural herbal therapy targeting α-glucosidase inhibition. This suggests the potential for further investigation into its effectiveness through in silico or in vivo studies using a diabetes model.
Inhibition of α-Glucosidase by Abietane-Type Diterpenoids Isolated from Roots of Salvia miltiorrhiza
Byung Sun Min,Jeong Ah Kim 한국생약학회 2023 Natural Product Sciences Vol.29 No.4
Salvia miltiorrhiza is a traditional medicinal plant used in Asian medicine for various therapeutic purposes. This plant contains numerous bioactive secondary metabolites, particularly abietane-type diterpenoids. In this study, 16 abietane-type diterpenoids were isolated from S. miltiorrhiza root extracts and structurally identified through advanced spectroscopic techniques. Among them, tanshinone IIA (6) and 15,16-dihydro- tanshinone I (11) exhibited potent α-glucosidase inhibition, with IC50 values of 48.38 ± 0.57 and 48.02 ± 0.47 µM, respectively. Enzyme kinetic studies revealed that these compounds served as non-competitive inhibitors of α-glucosidase. Our findings indicate that natural compounds from S. miltiorrhiza show promise as safe and effective α-glucosidase inhibitors, providing an alternative approach to diabetes treatment. This study contributes to the growing interest in utilizing natural sources for α-glucosidase inhibition and their potential application in healthcare and disease management.
Byung Sun Min 한국생약학회 2023 Natural Product Sciences Vol.29 No.4
In this study, twenty known compounds were isolated from Houttuynia cordata Thunb., including four megastigmanes (1‒4), four phenolics (5, 6, 9, and 10), one tetrahydro-2-one derivative (12), four coumarins (7, 13, 14, and 16), six caffeic acid derivatives (8, 11, 15, 17, 18, and 19), and one triterpenoid (20). Their chemical structures were established using NMR spectra and comparison with literature. The anti-diabetic activity of the isolated compounds was assessed by investigating their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase. The results revealed that ginnalin A (10) and 3-(4′-hydroxyphenyl)-2-propenoic acid (4′′-carboxyl)-phenyl ester (13) exhibited significant inhibitory effects on both PTP1B and α-glucosidase with IC50 values of 7.9 ‒ 37.6 and 13.9 ‒ 31.9 μM, respectively. In the kinetic study, these two compounds showed noncompetitive-type PTP1B and α-glucosidase inhibition, with Ki values of 35.6 and 7.3 μM for PTP1B and 13.9 and 31.0 μM for α-glucosidase, respectively. These findings highlight the potential of the isolated compounds as candidates for the development of novel therapeutic agents for diabetes.
The Analysis of MOUs and their Activities Related to Port State Control
Byung-Sun Min,Soon-Kap Kim,Gil-Young Kong,Chol-Seong Kim,Yoon-Sok Lee,Jung-Man Kim,Chung-Ro Lee 한국항해항만학회 2003 한국항해항만학회지 Vol.27 No.3
The Memorandum of Understanding (MOU) is the document of intent signed between the Port States Control(PSC) to undertake a uniform manner as agreed. Though the MOU is not a legally binding, in case where the agreed items are violated without a just cause, the denunciation will follow. International Maritime Organization (IMO) and regional MOUs have been making amendments and reinforcing the relevant requirements, so that port State Authorities can effectively eradicate the substandard vessels. However, the various problems have arisen due to the existence of different requirements of each MOU, the lack of information exchange between each MOU, the lack of uniform PSC implementation within the same MOU and the lack of adequate system due to the short history of MOUs. In this paper, the MOU records for three years (1999~2001) were analyzed according to each MOU, type of ship, deficiency code, classification society, the number of inspected ships and the number of detained ships to assess the problems (Statistics during 2002 will be published after August 2003). The purpose of this study is to help better understand the PSC activities within each MOU and to establish effective countermeasures by grasping the problems that exist in the PSC at present.
Chemical Modification of Alisol B 23-acetate and Their Cytotoxic Activity
이상명,ByungSunMin,KiHwanBae 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.5
Seven ergosterol derivatives (1~7) were isolated from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic means, their structures have been elucidated as 3b,5a-dihydroxy-ergosta-7,22-diene (1), 5a,6a-epoxy-(22E,24R)-ergosta-8(14), 22-diene- 3b,7a-diol (2), 5a,6a-epoxy-(22E,24R)-ergosta-8,22-diene-3b,7a-diol (3), ergosta-4,6,8(14),22- tetraene-3-one (4), ergosterol (5), ergosterol endoperoxide (6), 3b,5a-dihydroxy-6b-methoxyergosta- 7,22-diene (7). Compounds 3~7 showed moderate cytotoxicity against five tumor cells.