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Ursolic Acid of Origanum majorana L. Reduces Aβ-induced Oxidative Injury
Ho-Jin Heo,Hong-Yon Cho,Bumshik Hong,Hye-Kyung Kim,허태련,Eun-Ki Kim,김성구,김창주,Dong-Hoon Shin 한국분자세포생물학회 2002 Molecules and cells Vol.13 No.1
Amyloid â protein (Ab) increases free radical production and lipid peroxidation in PC12 nerve cells, leading to apoptosis and cell death. The effect of ursolic acid from Origanum majorana L. on Aâ-induced neurotoxicity was investigated using PC12 cells. Pretreatment with isolated ursolic acid and vitamin E prevented the PC12 cell from reactive oxygen species (ROS) toxicity that is mediated by Aâ. The ursolic acid resulted in decreased Aâ toxicity assessed by 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH), and trypan blue assay. Thus, treatment with these antioxidants inhibited the Aâ-induced neurotoxic effect. Therefore, these results indicate that micromolar Aâ-induced oxidative cell death is reduced by ursolic acid from Origanum majorana L.
Hye-Kyung Kim,Youn-Jeong Chang,Ho-Jin Heo,Hong-Yon Cho,Bumshik Hong,Dong-Hoon Shin 한국식품영양과학회 2003 Preventive Nutrition and Food Science Vol.8 No.1
In experiment 1, rats (n=6) fed diet containing 10 g/kg cholesterol for 4 wk (control) with either no amaranth (control), amaranth grain (300 g/kg, AG) or amaranth oil (90 g/kg, AO). Both the AG and AO groups had lower concentration of serum and hepatic cholesterol and triglyceride than the controls (p<0.05). Fecal excretions of cholesterol and bile acid in AO group increased about 4 fold and 2 fold, respectively, while AG affected only bile acid excretion (p<0.05). In experiment 2, rats (n=6) were fed the cholesterol diet for 4 wk and injected intraperitoneally with saline (control) or amaranth squalene (AS) for 7 d. The hypolipidemic effect of AS was evident in both serum and liver. Fecal excretions of cholesterol and bile acid were greater (p<0.05) in AS than control. HMG - CoA (3 - hydroxy - 3 - methylglutaryl coenzyme A) reductase activity was reduced in AS group (11.6%, p=0.13). This study suggests that the cholesterol - lowering effect of AS is mediated by greater fecal elimination of steroids through interference with cholesterol absorption.
Protective effect of Rosa laevigata against amyloid beta peptide-induced oxidative stress
Choi, Soo Jung,Kim, Mi Jeong,Heo, Ho Jin,Kim, Hye Kyung,Hong, Bumshik,Kim, Chang-Ju,Kim, Byung-Gee,Shin, Dong Hoon Taylor Francis 2006 Amyloid Vol.13 No.1
<P>The amyloid beta (Aβ) peptide is known to increase free radical production in nerve cells, leading to cell death. To investigate the effect of Rosa laevigata against Aβ-induced oxidative damage, in vitro assays and in vivo behavioral tests were performed. R. laevigata showed cell protective effects against oxidative stress-induced cytotoxicity. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) reduction assay exhibited significant increase in cell viability when rat pheochromocytoma (PC 12) cells were treated with R. laevigata extracts. Administration of R. laevigata extracts to mice significantly reversed the Aβ-induced learning and memory impairment in in vivo behavioral tests. These results suggest that R. laevigata extracts can reduce the cytotoxicity of Aβ in PC 12 cells, possibly by the reduction of oxidative stress, and these extracts may be useful in the prevention of Alzheimer's disease.</P>
Activation Effects of <i>Allium Tuberosum</i> Rottl. on Choline Acetyltransferase
KIM, Mi Jeong,CHOI, Soo Jung,KIM, Hye Kyung,KIM, Chang-Ju,HONG, Bumshik,KIM, Young Jun,SHIN, Dong-Hoon Japan Society for Bioscience, Biotechnology, and A 2007 Bioscience, biotechnology, and biochemistry Vol.71 No.1
<P>An ethanolic extract of <I>Allium tuberosum</I> Rottl. demonstrated potent choline acetytrasferase (ChAT) activating activity (45%) among 30 screened Korean edible plants. The ChAT activator of <I>A. tuberoum</I> Rottl. was purified and identified as ferulic acid [4-hydroxy-3-methoxycinnamic acid] <I>via</I> silica-gel open-column chromatography, HPLC, EI-MS, and <SUP>1</SUP>H/<SUP>13</SUP>C-NMR. The ferulic acid from <I>A. tuberoum</I> Rottl. exhibited ChAT activity in a dose-dependent manner and showed notoxicity in a cell viability assay (MTT assay). We suggest that the ferulic acid from <I>A. tuberoum</I> Rottl. was the strong ChAT activator.</P>