http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Bumsang,Shin, Youngchan Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of applied polymer science Vol.105 No.6
<P>The pH-sensitive swelling and release behaviors of the anionic P(MAA-co-EGMA) hydrogels were investigated as a biological on–off switch for the design of an intelligent drug delivery system triggered by external pH changes. There was a drastic change of the equilibrium weight swelling ratio of P(MAA-co-EGMA) hydrogels at a pH of around 5, which is the pK<SUB>a</SUB> of poly (methacrylic acid) (PMAA). At a pH below 5, the hydrogels were in a relatively collapsed state but at a pH higher than 5, the hydrogels swelled to a high degree. When the molecular weight of the pendent poly(ethylene glycol) (PEG) of the P(MAA-co-EGMA) increased, the swelling ratio decreased at a pH higher than 5. The pK<SUB>a</SUB> values of the P(MAA-co-EGMA) hydrogels moved to a higher pH range as the pendent PEG molecular weight increased. When the feed concentration of the crosslinker of the hydrogel increased the swelling ratio of the P(MAA-co-EGMA) hydrogels decreased at a pH higher than 5. In release experiments using Rhodamine B (Rh-B) as a model solute, the P(MAA-co-EGMA) hydrogels showed a pH-sensitive release behavior. At low pH (pH 4.0) a small amount of Rh-B was released while at high pH (pH 6.0) a relatively large amount of Rh-B was released from the hydrogels. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007</P>
Ha, ByungChul,Ko, HyunSuk,Kim, BongLee,Sohn, Eun Jung,Jung, Ji Hoon,Kim, Ji Sung,Yoon, Jung Jae,Won, Gunho,Kim, Ji-Hyun,Jung, Deok-beom,Yun, Miyong,Shim, BumSang,Kim, Sung-Hoon American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.1
<P>The underlying antimetastatic mechanism of anethole (<B>1</B>) still remains unclear in association with the molecules of the epithelial to mesenchymal transition (EMT). Herein, the role of the EMT molecules was elucidated in terms of the antimetastatic activity of <B>1</B> using DU145 cells. Anethole significantly inhibited the adhesion of DU145 cells to vitronectin-coated plates, as well as migration in a wound-healing assay and invasion using a Boyden chamber. Also, anethole suppressed the expression of MMP-9 in DU145 cells by zymography, ELISA, and RT-PCR. Consistently, the silencing of MMP-9 enhanced the activity of <B>1</B> to upregulate the expression of E-cadherin and to attenuate the expression of Vimentin in DU145 cells. Compound <B>1</B> enhanced E-cadherin, which is an epithelial marker and attenuated the expression of Vimentin, Twist, and Snail as mesenchymal molecules at the mRNA level. Consistently, anethole upregulated E-cadherin and downregulated the expression of Vimentin, Twist and PI3K, and AKT at the protein level in DU145 cells. Conversely, the antimetastatic effects of <B>1</B> to inhibit invasion and the expression of MMP-9 and upregulate E-cadherin were reversed by the EMT inducer TGF-β in DU145 cells. Overall, the present findings suggest that anethole exerts antimetastatic activity via regulation of crosstalk between EMT molecules and MMP-9 on the basis of the in vitro data obtained.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-1/np4006376/production/images/medium/np-2013-006376_0006.gif'></P>
한 용기 내 중합반응에 의한 금 나노입자를 함유한 PEG 수화젤 입자의 합성
김연희(Youn-Hee Kim),김범상(Bumsang Kim) 한국고분자학회 2020 폴리머 Vol.44 No.6
금 입자와 고분자 입자를 결합한 유무기 복합재료를 컴퓨터단층촬영(CT)의 조영제로 사용하기 위한 첫 단계로, PEG 수화젤 입자 내부에 금 나노입자를 고농도로 탑재하여 최종적으로 합성된 Au-PEG 수화젤 입자의 CT세기를 향상시킬 수 있는 합성방법을 개발하였다. 다양한 방법을 이용하여 Au-PEG 수화젤 입자를 제조한 결과, PEG 수화젤 입자를 중합하는 동안 금 나노입자를 수화젤 내부에 탑재하는 한 용기내 중합(in situ 법)을 사용할 경우, 가장 높은 CT세기를 보이고 탑재된 금 입자가 수화젤로부터 방출되지 않는 안정적인 Au-PEG 수화젤 입자를 합성할 수 있었다. In situ법을 사용하여 입자를 제조할 경우, 투입한 금 전구체의 농도가 증가할수록 그리고 중합과정에서 1차 중합시간이 증가할수록, 합성된 Au-PEG 수화젤 입자의 CT세기가 증가하였으며, 비이온성 계면활성제를 분산안정제로 사용할 경우, 가장 높은 CT세기를 가지는 입자를 제조할 수 있었다. As the first step to use an organic/inorganic composite combining gold nanoparticles (AuNPs) and polymer particles as a contrast agent for computed tomography (CT), PEG hydrogel particles containing AuNPs, Au-PEG hydrogel particles, were prepared and the synthetic conditions were established to improve the CT intensity of the Au-PEG hydrogel particles. Au-PEG hydrogel particles that had the highest CT intensity were obtained and the encapsulated AuNPs were not released from the hydrogel particles when Au-PEG hydrogel particles were synthesized by in situ polymerization with which the AuNPs were loaded in the PEG hydrogel particles during the polymerization. The CT intensity of the Au-PEG hydrogel particles increased, as the concentration of the loaded AuNPs and the 1st polymerization time of the polymerization process increased. In addition, when the non-ionic surfactant was used as a dispersion stabilizer, Au-PEG hydrogel particles showed good dispersibility and the highest CT density.
지능형 약물 전달시스템을 위한 PH 감응성 하이드로젤의 합성과 특성 연구
金範相,申泳璨 홍익대학교 과학기술연구소 2006 科學技術硏究論文集 Vol.17 No.-
Stimuli-sensitive hydrogels are sensitive to environmental changes such as external pH, temperature, ionic strength, electrical or magnetic stimulus and specific chemical compounds. Especially, pH-responsive hydrogels can respond to their surrounding pH by forming polymer complexes. In this study, pH-responsive copolymers with various compositions of monomers and cross-linking agents were synthesized by free radical photopolymerization as intelligent drug delivery carriers. These copolymer networks are collapsed in the acidic condition but in the basic or neutral condition the polymer networks are swollen to high degree. MAA(methacrylic acid) and PEGMA(poly(ethylene glycol) methacrylate) having several molecular weights of PEG were used as monomers. PEGDMA(poly(ethylene glycol) dimethacrylate) was used as a cross-linking agent. The swelling behavior of pH-responsive copolymers was examined to determine the pH-sensitivity of copolymers. The release experiments of Rh-B(Rhodamine-B) from the copolymers were performed to investigate the feasibility of copolymers for the intelligent drug delivery system.