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- 저자 : Brinkmann, Martin (검색결과 19 건)
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FTY720: Mechanism of Action and Potential Benefit in Organ Transplantation
Volker Brinkmann 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.6
FTY720 is a novel immunomodulator that has proven effective in animal models of transplantation and autoimmunity, has achieved promising results in Phase I and Phase II studies of renal transplantation in humans, and is currently undergoing phase III studies. FTY720 acts as a high-affinity agonist at the sphingosine 1-phosphate receptor-1 (S1P1), where it internalises the receptor and causes alterations to the normal circulation of lymphocytes between the blood and lymphoid tissue. Unlike conventional immunosuppressants, FTY720 does not impair the activation, proliferation or effector functions of T- and B-cells. Further development of FTY720 is in progress, including trials in autoimmune disorders as well as transplantation. This review summarises the mechanism of action of FTY720, its effects in models of transplantation and autoimmunity, and results from clinical trials in humans.
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A Toposequence of Soils in the Karst of West-Central Florida, U.S.A
Banker, Laura,Reeder, Philip,Brinkmann, Robert The Speleological Society 1995 Journal of the speleological society of korea Vol.42 No.2
An abundance of information is available regarding soil horizons and their characteristics. Several methods can be used to gather and analyze this information. Through the use of qualitative analysis in the field, and laboratory and statistical analysis, a soil can be compared and analyzed with a great deal of scrutiny. Four soil pits were excavated in Citrus County Florida and samples were collected from each master horizon. Through the use of qualitative and quantitative analysis these samples were compared and analyzed in order to identify unique, as well as homogeneous features. It was determined that the soil profile designated Old Pit was different than other profiles because of landscape position and variations in parent material. Landscape position (ie. slope position) also influenced the genesis and evolution of the soils in the other three profiles(Profile 1, 2 and 3).
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An unusual presentation of peripheral ameloblastoma in the maxilla
Rosa María Acevedo Ocaña,Jorge Cortes-Bretón Brinkmann,Carolina Valle Rodríguez,Norberto Quispe López,María Isabel Sánchez Jorge 대한구강악안면외과학회 2024 대한구강악안면외과학회지 Vol.50 No.3
Peripheral ameloblastoma (PA) is believed to be the rarest variant of ameloblastoma and only has been described in isolated case reports. PA is usually confined to the soft tissues surrounding the supporting tissues of the teeth. Although it manifests nonaggressive behavior and can be treated with complete removal by local surgical excision, long term follow up is mandatory to prevent future recurrence and possible malignant transformation.
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Choi, Jin-Il,Cha, Bong-Kuen,Jost-Brinkmann, Paul-Georg,Choi, Dong-Soon,Jang, In-San The Korean Association Of Orthodontists 2012 대한치과교정학회지 Vol.42 No.5
Objective: The purpose of this study was to evaluate the validity of the 3-dimensional (3D) superimposition method of digital models in patients who received treatment with rapid maxillary expansion (RME) and maxillary protraction headgear. Methods: The material consisted of pre- and post-treatment maxillary dental casts and lateral cephalograms of 30 patients, who underwent RME and maxillary protraction headgear treatment. Digital models were superimposed using the palate as a reference area. The movement of the maxillary central incisor and the first molar was measured on superimposed cephalograms and 3D digital models. To determine whether any difference existed between the 2 measuring techniques, intra-class correlation (ICC) and Bland-Altman plots were analyzed. Results: The measurements on the 3D digital models and cephalograms showed a very high correlation in the antero-posterior direction (ICC, 0.956 for central incisor and 0.941 for first molar) and a moderate correlation in the vertical direction (ICC, 0.748 for central incisor and 0.717 for first molar). Conclusions: The 3D model superimposition method using the palate as a reference area is as clinically reliable for assessing antero-posterior tooth movement as cephalometric superimposition, even in cases treated with orthopedic appliances, such as RME and maxillary protraction headgear.
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Maria Isabel Sá,nchez Jorge,Jorge Corté,s-Bretó,n Brinkmann,Aranzazu Gonzá,lez Corchó,n,Rosa Acevedo Ocañ,a 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.4
Hemangioma is a benign tumor characterized by the proliferation of blood vessels. Although it often appears in soft tissues, its occurrence in bone tissue, particularly the mandible, is extremely rare. A 32-year-old female sought attention at the dental clinic complaining of a painless swelling in the posterior region of the left side of the mandible. A panoramic radiograph and computed axial tomography scan were taken, showing honeycomb and sunburst images, respectively, in the affected area. The patient underwent a biopsy, which led to the diagnosis of intraosseous hemangioma. Having assessed the characteristics of the lesion, it was decided to perform complete excision including safety margins, followed by an iliac crest bone graft to reconstruct the mandible. Awareness of the possible clinical and radiographic presentations of intraosseous hemangioma is considered important, as non-diagnosis could have severe consequences given its possible relation to dental structures.
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Jin-Il Choi,Bong-Kuen Cha,Paul-Georg Jost-Brinkmann,Dong-Soon Choi,In-San Jang 대한치과교정학회 2012 대한치과교정학회지 Vol.42 No.5
Objective: The purpose of this study was to evaluate the validity of the 3-dimensional (3D) superimposition method of digital models in patients who received treatment with rapid maxillary expansion (RME) and maxillary protraction headgear. Methods: The material consisted of pre- and post-treatment maxillary dental casts and lateral cephalograms of 30 patients, who underwent RME and maxillary protraction headgear treatment. Digital models were superimposed using the palate as a reference area. The movement of the maxillary central incisor and the first molar was measured on superimposed cephalograms and 3D digital models. To determine whether any difference existed between the 2 measuring techniques, intra-class correlation (ICC) and Bland-Altman plots were analyzed. Results: The measurements on the 3D digital models and cephalograms showed a very high correlation in the antero-posterior direction (ICC, 0.956 for central incisor and 0.941 for first molar) and a moderate correlation in the vertical direction (ICC, 0.748 for central incisor and 0.717 for first molar). Conclusions: The 3D model superimposition method using the palate as a reference area is as clinically reliable for assessing antero-posterior tooth movement as cephalometric superimposition, even in cases treated with orthopedic appliances, such as RME and maxillary protraction headgear.
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Schwartz, Pierre-Olivier,Biniek, Laure,Zaborova, Elena,Heinrich, Benoî,t,Brinkmann, Martin,Leclerc, Nicolas,Mé,ry, Sté,phane American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.16
<P>Perylenediimide-based donor–acceptor co-oligomers are particularly attractive in plastic electronics because of their unique electro-active properties that can be tuned by proper chemical engineering. Herein, a new class of co-oligomers has been synthesized with a dyad structure (AD) or a triad structure (DAD and ADA) in order to understand the correlations between the co-oligomer molecular architecture and the structures formed by self-assembly in thin films. The acceptor block A is a perylene tetracarboxyl diimide (PDI), whereas the donor block D is made of a combination of thiophene, fluorene, and 2,1,3-benzothiadiazole derivatives. D and A blocks are linked by a short and flexible ethylene spacer to ease self-assembling in thin films. Structural studies using small and wide X-ray diffraction and transmission electron microscopy demonstrate that AD and ADA lamellae are made of a double layer of co-oligomers with overlapping and strongly π-stacked PDI units because the sectional area of the PDI is about half that of the donor block. These structural models allow rationalizing the absence of organization for the DAD co-oligomer and therefore to draw general rules for the design of PDI-based dyads and triads with proper self-assembling properties of use in organic electronics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-16/ja4129108/production/images/medium/ja-2013-129108_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja4129108'>ACS Electronic Supporting Info</A></P>
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