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Joung, Boyoung,Kim, Il-kwon,Lee, Moon-Hyoung,Yoo, Kyung-Jong,Kim, Sung-Soon Yonsei University College of Medicine 2007 Yonsei medical journal Vol.48 No.5
<P><B>Purpose</B></P><P>The arrhythmogenic effect of stem cells transplantation (SCT) in an infarct myocardium is still unknown. We investigated arrhythmogenicity of SCT in rat cryo-infarct model.</P><P><B>Materials and Methods</B></P><P>In rat cryo-infarct model, bone marrow mononuclear stem cells (MNSC, 1 × 10<SUP>7</SUP> cells) were transplanted into the infarct border zone (BZ) of the LV epicardium. We compared the optical mapping and inducibility of ventricular tachycardia/fibrillation (VT/VF) among normal (n = 5), cryo-infarct (n = 6), and SCT rats (n = 6).</P><P><B>Results</B></P><P>The VT/VF inducibility was higher in the cryoinfarct (47.2%, <I>p</I> = 0.001) and SCT groups (34.6%, <I>p</I> = 0.01) than in the normal group (12.8%). The induced VT/VF episodes persisted for more than 2 minutes in 4.3%, 26.4% and 17.3% in the normal, cryo-infarct and SCT group, respectively. In the SCT group, the action potential duration at 70% was shorter at the SCT site than the BZ during SR (75.2 ± 8.1 vs. 145.6 ± 4.4 ms, <I>p</I> = 0.001) and VT (78.2 ± 13.0 vs. 125.7 ± 21.0 ms, <I>p</I> = 0.001). Conduction block was observed at the SCT site and BZ during VT. However, no reentry or ectopic foci were observed around the SCT sites.</P><P><B>Conclusion</B></P><P>The electrical conduction was improved by SCT without evidence of augmentation of arrhythmia in the rat cryo-infarct model.</P>
JOUNG, BOYOUNG,ZHANG, HONG,SHINOHARA, TETSUJI,MARUYAMA, MITSUNORI,HAN, SEONGWOOK,KIM, DAEHYEOK,CHOI, EUE‐,KEUN,ON, YOUNG‐,KEUN,LIN, SHIEN‐,FONG,CHEN, PENG‐,SHENG Blackwell Publishing Inc 2011 Journal of cardiovascular electrophysiology Vol.22 No.4
<P> <B>Delayed Afterdepolarization in Sinoatrial Node. <I>Introduction:</I></B> Recent evidence indicates that spontaneous sarcoplasmic reticulum Ca release and Na‐Ca exchanger current activation contribute to the sinoatrial node (SAN) automaticity. These findings suggest that SAN activity may share mechanisms that underlie both automaticity and triggered activity. The aim of this study is to test the hypothesis that spontaneous, nonvoltage gated, intracellular Ca (Ca<SUB>i</SUB>) elevation may induce delayed afterdepolarization (DAD) in intact SAN during isoproterenol infusion.</P><P> <B> <I>Methods and Results:</I> </B> We simultaneously mapped Ca<SUB>i</SUB> and membrane potential in 31 isolated Langendorff‐perfused canine right atriums (RA). Isoproterenol increased heart rate and late diastolic Ca<SUB>i</SUB> elevation (LDCAE) of the superior SAN, leading to consistent SAN automaticity in all 31 RAs. However, DAD‐like diastolic depolarizations (DD) were transiently observed in 4 RAs during isoproterenol infusion. These DAD‐like DDs were preceded by LDCAE, but did not trigger a full action potential. The LDCAE preceding DAD‐like DDs had smaller amplitude (0.41 ± 0.08 AU vs 0.48 ± 0.07 AU, P = 0.001) and less steep slopes (3.7 ± 1.3 AU/s vs 4.8 ± 1.4 AU/s, P = 0.001) than that of sinus beats. The coupling interval of DAD‐like DDs was longer than that of the preceding normal beats (407 ± 48 ms vs 371 ± 44 ms, P = 0.002).</P><P> <B> <I>Conclusion:</I> </B> The isoproterenol‐induced LDCAE of superior SAN induced a full action potential in most cases. However, if the LDCAE was too small to trigger an action potential, then it induces only DAD‐like DD. The failure of DAD‐like DD to consistently trigger a sinus beat is a novel mechanism of atrial arrhythmogenesis. <I>(J Cardiovasc Electrophysiol, Vol. 22, pp. 448‐454)</I></P>
Boyoung Joung,Minjeong Kim,Jun Kim,Jin-Bae Kim,Junbeom Park,Jin-Kyu Park,Ki-Woon Kang,Jaemin Shim,Eue-Keun Choi,Young Soo Lee,Hyung Wook Park 대한심장학회 2022 Korean Circulation Journal Vol.52 No.8
Background and Objectives: In patients with atrial fibrillation (AF), females taking vitamin K antagonist are at higher risk of stroke or systemic embolism (SSE), bleeding and all-cause death than males. This study investigated the relationship between sex and adverse clinical events in a contemporary AF patient cohort taking anticoagulation. Methods: This prospective multicenter AF registry study comprised 6,067 patients with AF (mean age, 70±9 years; men, 59%) with intermediate to high risk of stroke (CHA2DS2-VAscore ≥1) and receiving oral anticoagulation therapy. Adverse clinical outcomes, including SSE, bleeding, death were evaluated in patients stratified by sex and anticoagulation patterns. Results: Women were older and used more direct oral anticoagulants (85% vs. 78%, p<0.001) than men. During a median (25th and 75th percentiles) follow-up of 30 (24, 38) months, the incidence rate and risk of SSE (0.7 in women vs. 0.7 in men per 100 person-years) and major bleeding (0.1 in women vs. 0.1 in men per 100 person-years) were not different between the sexes. However, women had a lower all-cause death rate (0.4 in women vs. 0.6 in men per 100 person-years, hazard ratio: 0.48, 95% confidence interval: 0.25–0.91, p=0.025) than men. Conclusions: In contemporary anticoagulation for AF, SSE and major bleeding risks did not differ between sexes. However, women showed a lower risk of all-cause death rate than men, indicating that the use of oral anticoagulants for treating AF in females does not appear to be a risk factor for adverse clinical events.
Joung Yeo Angela No,Boyoung Seo 한국경제연구학회 2014 Korea and the World Economy Vol.15 No.2
In the literature on innovation and competition, consideration of the ‘innovativeness’ of innovation has been neglected. This paper investigates the relationship between innovation and competition conditional on the innovativeness of innovation and the distance to frontier. We measure the innovativeness of innovation by analyzing whether it is a new-to-the-market innovation or a new-to-the-firm innovation. Further, we develop a new measure of firms’ technological level using firms’ main objective of innovation. Using a dataset from surveys of Korean manufacturing firms from 2002 to 2004, this paper finds that the relationship between competition and innovation is conditional on both the quality of innovation and distance to frontier. The results are: (1) frontiers are more likely to innovate than technological laggard firms, (2) competition has an inverted-U shape relation with new to the market innovation, while there is no such relation with new to the firm only innovation, (3) the inverted-U shape relation between competition and innovation is driven by frontiers, not followers or laggards, and (4) new to the market innovation and R&D expenditure show a similar pattern of an inverted-U shape relation with competition, while new to the firm only innovation and patents exhibit a similar pattern of no relation with competition.
2018 대한부정맥학회 심방세동 환자의 통합적 관리 지침
박준범 ( Junbeom Park ),정보영 ( Boyoung Joung ),김준 ( Jun Kim ),김진배 ( Jin-bae Kim ),박형욱 ( Hyung Wook Park ),박예민 ( Yae Min Park ),엄재선 ( Jae-sun Uhm ),안진희 ( Jinhee Ahn ),이대인 ( Dae In Lee ),김준수 ( June Soo Kim 대한내과학회 2018 대한내과학회지 Vol.93 No.4
Atrial fibrillation (AF) is the most common form of sustained arrhythmia in elderly patients. However, AF is often detected during health screening, or accidentally during testing for other diseases; some patients lack clinical symptoms. Nevertheless, AF increases the incidence of ischemic stroke and other thrombotic events, and compromises cardiovascular prognosis in terms of heart failure, dementia, and hospitalization. Therefore, initial AF management should be performed at the point of primary care, not only in specialized medical centers. We wish to propose a five-step management protocol for AF. We review the evidence supporting integrated management by primary care physicians new to AF, and by specialized physicians who often diagnose and manage AF. Further, we also outline a structured goal-based follow-up protocol; this is an important part of integrated management. (Korean J Med 2018;93:336-343)
Mun, Hee-Sun,Joung, Boyoung,Shim, Jaemin,Hwang, Hye Jin,Kim, Jong Youn,Lee, Moon-Hyoung,Pak, Hui-Nam BMJ Group 2012 Heart Vol.98 No.6
<P><B>Objective</B></P><P>Circumferential pulmonary vein isolation (CPVI) has been considered the cornerstone of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). However, it is unclear whether linear ablation in addition to CPVI improves clinical outcome.</P><P><B>Design</B></P><P>Prospective randomised study to compare the efficacy of CPVI and CPVI with additional linear ablation in patients with paroxysmal AF (PAF).</P><P><B>Setting</B></P><P>University hospital.</P><P><B>Patients</B></P><P>This study enrolled 156 patients (male 76.3%, 55.8±11.5 years old (mean±SD)) who underwent RFCA for PAF.</P><P><B>Interventions</B></P><P>CPVI (n=52), CPVI+roof line (CPVI+RL; n=52) and CPVI+RL+posterior inferior line (CPVI+PostBox; n=52).</P><P><B>Main outcome measures</B></P><P>Procedure time, ablation time and clinical outcome.</P><P><B>Results</B></P><P>(1) The CPVI group showed shorter total procedure time (180.4±39.5 min vs 189.6±29.0 min and 201.7±51.7 min, respectively (mean±SD); p=0.035) and ablation time (4085.5±1384.1 s vs 5253.5±1010.9 s and 5495.0±1316.0 s, respectively; p<0.001) than the CPVI+RL and CPVI+PostBox groups. (2) During 15.6±5.0 months of follow-up, the recurrence rates 3 months after RFCA were 11.5% in CPVI, 21.2% in CPVI+RL and 19.2% in CPVI+PostBox (p=0.440). (3) The achievement rate of CPVI was 100.0%, and bidirectional block rate was 80.8% in CPVI+RL and 59.6% in CPVI+PostBox. The clinical recurrence rates with or without achieving bidirectional block were not significantly different from each other (p=0.386).</P><P><B>Conclusion</B></P><P>In patients with PAF, linear ablation in addition to CPVI did not improve clinical outcome, regardless of bidirectional block achievement, while it prolonged the total procedure and ablation time.</P>
Intracardiac Signal의 스펙트럼 분석을 통한 Atrial Tachycardia 및 Atrial Fibrillation 검출
申伉植(Hangsik Shin),李忠根(Chungkeun Lee),鄭報寧(Boyoung Joung),李明鎬(Myoungho Lee) 대한전기학회 2006 전기학회논문지 D Vol.55 No.3
Detection methods for atrial tachycardia and atrial fibrillation on the time axis have the advantages of light operational load and are easy to apply to various applications. Despite these advantages, arrhythmia detection algorithm on the time axis cannot stand much noise such as motion artifacts, moreover the peak detection algorithm has high complexity. In this paper, we use a spectrum analysis method for the detection of atrial tachycardia and atrial fibrillation. By applying spectrum analysis and digital filtering on obtained electrogram signals, we can diagnose heart arrhythmia without using peak detection algorithm.